Trends and projections in the incidence of oesophageal cancer in the Netherlands: An age-period-cohort analysis from 1989 to 2041

Menée aux Pays-Bas, cette étude analyse l'évolution de l'incidence du cancer de l'oesophage sur la période 1989-2016, et présente des projections jusqu'en 2041

Résumé en anglais

Abstract In Western populations, the incidence of oesophageal squamous cell carcinoma (OSCC) has been declining, whereas the incidence of oesophageal adenocarcinoma (OAC) has been increasing. This study examines temporal trends in the incidence of oesophageal cancer in the Netherlands between 1989 and 2016, in addition to predicting future trends through 2041. Data from the Netherlands Cancer Registry and Statistics Netherlands were collected to obtain incidence trends of OSCC and OAC for the period 1989–2016. Age-period-cohort modelling was used to estimate the contribution of age, calendar period and birth cohort on the observed incidence trends. To predict the future numbers of new cases of both OSCC and OAC from 2017 to 2041, log-linear age-period-cohort (APC) models were fitted to the trends of 1989–2016. The age-standardised incidence rates of OSCC have decreased slightly for men and increased slightly for women. In contrast, a dramatic increase in the incidence of OAC was observed, ranging from 2.8 per 100,000 persons in 1989 to 10.1 in 2016. This increase in OAC incidence was more prominent in men, and it will result in an increased risk of OAC for successive generations. Future projections indicate that the incidence of OAC will further increase to 13.1 per 100,000 persons in 2037–2041, meaning that there will be 13,259 cases of OAC in 2037-2041, as compared to 9,386 diagnoses in 2017–2021. The changing epidemiologic trends in oesophageal cancer in the Netherlands should be reflected in the development of prevention, early detection and treatment strategies. This article is protected by copyright. All rights reserved.