Menée à l'aide d'une méthode de randomisation mendélienne et de données issues d'une méta-analyse d'études d'association sur le génome entier portant sur 61 106 témoins et sur 79 148 patients atteints d'un cancer de la prostate, et menée à partir de données génétiques de la "UK Biobank" portant sur 291 408 personnes, cette étude analyse l'association entre le niveau de phosphore circulant et le risque de développer la maladie

Circulating phosphorus level and risk of prostate cancer: a Mendelian randomization study

Lv, Linshuoshuo ; Ye, Ding ; Chen, Jie ; Qian, Yu ; Fu, Alan Nuo ; Song, Jie ; Yang, Hong ; Liu, Bin ; Sun, Xiaohui ; Du, Lingbin ; Mao, Yingying

Recent observational studies have suggested that circulating phosphorus levels are positively associated with risk of prostate cancer. However, little is known about the causal direction of the association.To explore the potential causal relationship between circulating phosphorus and risk of prostate cancer, we conducted a Mendelian randomization (MR) study.Summary statistics of prostate cancer were obtained from a meta-analysis of genome-wide association studies (GWAS) consisting of 79,148 [...]

Menée à partir de données 1992-2012 des cohortes "the Nurses’ Health Studies" et "the Health Professionals Follow-Up Study" portant sur 109 890 femmes et sur 23 831 hommes, cette étude analyse l'association entre la cholélithiase et la présence de polypes ou d'adénomes colorectaux

Gallstone disease and risk of conventional adenomas and serrated polyps: A Prospective Study

Polychronidis, Georgios ; Wang, Kai ; Lo, Chun-Han ; Wang, Liang ; He, Ming-Ming ; Knudsen, Markus Dines ; Wu, Kana ; Joshi, Amit D. ; Ogino, Shuji ; Giovannucci, Edward L ; Chan, Andrew T ; Song, Mingyang

Background: Gallstone disease (GD) has been associated with colorectal cancer and some form of polyps, although the findings are inconclusive. It remains unknown whether gallstone disease influences the initiation of colorectal cancer. Methods: We prospectively assessed the association of gallstone disease with risk of colorectal cancer precursors, including conventional adenomas and serrated polyps, in the Nurses' Health Study (1992-2012), the Nurses' Health Study II (1991-2011) and the Health [...]