Menée au Japon à partir de données portant sur 4 739 patients atteints d'un cancer, cette étude rétrospective analyse les stratégies thérapeutiques pour prendre en charge une neuropathie périphérique induite par une chimiothérapie à base d'oxaliplatine

Treatment strategy of oxaliplatin-induced peripheral neuropathy: a retrospective, nationwide study

Yokoyama, Satoshi ; Nakagawa, Chihiro ; Hosomi, Kouichi

Purpose : Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event of cancer treatment; however, no drug is recommended for the prevention of CIPN. In Japan, several drugs such as Gosha-Jinki-Gan and duloxetine are frequently administered as a treatment for CIPN. The aim of this study was to elucidate prescription patterns of drugs administered for CIPN caused by oxaliplatin and the association between these drugs and the duration of oxaliplatin treatment. Methods : We [...]

A partir d'une revue systématique de la littérature (18 études), cette étude identifie les besoins en soins de support de patients atteints d'un cancer du rein

Identifying the unmet supportive care needs of people affected by kidney cancer: a systematic review

O’Dea, Amy ; Gedye, Craig ; Jago, Belinda ; Paterson, Catherine

Purpose : To synthesize existing evidence on the unmet supportive care needs of people affected by kidney cancer, across the cancer care continuum. Methods : A systematic review was conducted according to the PRISMA Statement Guidelines. Electronic databases (CINAHL, MEDLINE, and PsychINFO) were searched using key search terms. Articles were assessed according to pre-specified eligibility criteria. Data extraction and quality appraisal were conducted. The findings were integrated in a narrative [...]

Menée aux Etats-Unis auprès de 127 patientes ayant survécu à un cancer du sein et médicalement et socioéconomiquement défavorisées, cette étude analyse l'intérêt d'un programme d'activité physique dispensé en groupe pour améliorer leur santé physique et leur qualité de vie

Active living after cancer: Adaptation and evaluation of a community-based physical activity program for minority and medically underserved breast cancer survivors

Tami-Maury, Irene M. ; Liao, Yue ; Rangel, Maria L. ; Gatus, Leticia A. ; Shinn, Eileen H. ; Alexander, Ashley ; Basen-Engquist, Karen

Background : An expanding body of research documents the benefits of physical activity for cancer survivors' physical functioning and quality of life, but few successful models provide community-based physical activity programs to cancer survivors. This report presents an evaluation of Active Living After Cancer, an evidence-based physical activity program for breast cancer survivors, adapted for community delivery to minority and medically underserved survivors. Methods : Survivors were [...]

A partir d'une revue systématique de la littérature, cette étude analyse les troubles du sommeil et la qualité de vie des patientes ayant survécu à un cancer de l'utérus

Sleep deprivation and quality of life among uterine cancer survivors: systematic review

Alanazi, Mashael Turqi ; Alanazi, Nouf Turqi ; Alfadeel, Mona A. ; Bugis, Bussma Ahmed

Introduction : While cancer survival might be a relief from a near-death health condition, the after-recovery period also predisposes the survivors to deteriorated quality of life as well as sleep deprivation. Patients with cancer may experience post-traumatic stress disorder (PTSD) throughout the diagnostic process and even after diagnosis is completed, especially when facing the possibility of tumor recurrence. Survivors, in particular, are frequently in a condition of uncertainty due to the [...]

Menée en Norvège à partir de données portant sur 420 655 patients atteints d'un cancer, cette étude rétrospective analyse les facteurs associés à une utilisation de médicaments anticancéreux durant leur dernier mois de vie

What are determinants of utilisation of pharmaceutical anticancer treatment during the last year of life in Norway? A retrospective registry study

Bugge, Christoffer ; Kaasa, Stein ; Sæther, Erik Magnus ; Melberg, Hans Olav ; Sonbo Kristiansen, Ivar

Objectives : The objective of this study was to investigate the use of, and predictors for, pharmaceutical anticancer treatment (PACT) towards the end of a patient’s life in a country with a public healthcare system. Design : Retrospective registry study. Setting : Secondary care in Norway. Participants : All Norwegian patients with cancer (International Classification of Diseases tenth revision (ICD-10) codes C00–99, D00–09, D37–48) in contact with a somatic hospital in Norway between 2009 and [...]

Menée aux Etats-Unis, à partir de données portant sur 2 933 patients ayant survécu 5 ans à un cancer pédiatrique (âge moyen : 33,3 ans), cette étude de cohorte analyse la concordance entre des symptômes auto-déclarés et une neuropathie périphérique confirmée cliniquement

Concordance between self-reported symptoms and clinically ascertained peripheral neuropathy among childhood cancer survivors: the St. Jude Lifetime Cohort Study

Hayek, Samah ; Dhaduk, Rikeenkumar ; Sapkota, Yadav ; Evans, William E ; Diouf, Barthelemy ; Bjornard, Kari ; Wilson, Carmen L ; Hudson, Melissa M ; Robison, Leslie L ; Khan, Raja B ; Srivastava, Deo Kumar ; Krull, Kevin R ; Ness, Kirsten K

Background : Childhood cancer survivors are at risk for motor and/or sensory neuropathy. The study evaluates concordance between self-report peripheral-neuropathy (PN) and clinically ascertained PN, and identifies factors associated with misclassification of PN among survivors. Methods: The concordance between self-report and clinically ascertained PN was evaluated among 2,933 5+ year childhood cancer survivors (mean age 33.3, SD=8.9). The sensitivity, specificity, and accuracy of self-report [...]

Menée aux Etats-Unis à partir de données portant sur des patients ayant survécu à un cancer pédiatrique diagnostiqué entre 2004 et 2015, cette étude analyse les disparités ethniques dans la survie

Racial/Ethnic Disparities in Childhood Cancer Survival in the United States

Jingxuan Zhao, ; Xuesong Han, ; Zhiyuan Zheng, ; Leticia Nogueira, ; Amy D. Lu, ; Paul C. Nathan, ; K. Robin Yabroff

Background: Non-white patients with childhood cancer have worse survival than Non-Hispanic (NH) White patients for many childhood cancers in the United States. We examined the contribution of socioeconomic status (SES) and health insurance on racial/ethnic disparities in childhood cancer survival. Methods: We used the National Cancer Database to identify NH White, NH Black, Hispanic, and children of other race/ethnicities (<18 years) diagnosed with cancer between 2004 and 2015. SES was measured [...]

Menée en Italie à partir de données portant sur 67 692 adolescents et jeunes adultes ayant survécu 5 ans à un cancer diagnostiqué entre 1976 et 2013, cette étude de cohorte analyse l'excès de risque de développer un second cancer

Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort

Trama, Annalisa ; Tittarelli, Andrea ; Barigelletti, Giulio ; Botta, Laura ; Gatta, Gemma ; Tagliabue, Giovanna ; Contiero, Paolo ; Guzzinati, Stefano ; Andreano, Anita ; Manneschi, Gianfranco ; Falcini, Fabio ; Castaing, Marine ; Filiberti, Rosa A. ; Gasparotti, Cinzia ; Cirilli, Claudia ; Mazzucco, Walter ; Mangone, Lucia ; Iacovacci, Silvia ; Vitale, Maria F. ; Stracci, Fabrizio ; Piffer, Silvano ; Tumino, Rosario ; Carone, Simona ; Sampietro, Giuseppe ; Melcarne, Anna ; Ballotari, Paola ; Boschetti, Lorenza ; Pisani, Salvatore ; Cavalieri D'Oro, Luca ; Cuccaro, Francesco ; D'Argenzio, Angelo ; D'Orsi, Giancarlo ; Fanetti, Anna C. ; Ardizzone, Antonino ; Candela, Giuseppa ; Savoia, Fabio ; Pascucci, Cristiana ; Castelli, Maurizio ; Storchi, Cinzia ; Bernasconi, Alice

Background : Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods : Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first [...]

A partir d'une revue systématique de la littérature publiée entre 2015 et 2021, cette étude analyse les modalités d'utilisation d'une immunothérapie, en première et en deuxième ligne, en combinaison ou en séquentiel, chez des patients atteints d'un carcinome à cellules rénales de stade avancé

Use of Second-line Immunotherapy in Control Arms of Randomized Clinical Trials in Kidney Cancer: A Systematic Review

Sharp, John ; Khaki, Ali Raza ; Prasad, Vinay

Importance: Immunotherapy (anti–programmed death ligand 1 antibodies) is associated with improved survival rates in advanced kidney cell carcinoma (KCC) after progression on first-line tyrosine kinase inhibitor (TKI) treatment. It is unknown whether and to what degree patients in the control arm receive postprotocol immunotherapy in trials comparing combination immunotherapy regimens with TKI in first-line advanced KCC. Objective : To characterize the proportion of patients in the control arm [...]

Menée en France à partir de données 2009-2018 portant sur 120 patients atteints d'un ostéosarcome et présentant des métastases synchrones ou métachrones (âge moyen : 30 ans), cette étude rétrospective analyse les stratégies thérapeutiques et la survie associée (survie sans progression et survie globale)

Treatment of 120 adult osteosarcoma patients with metachronous and synchronous metastases: a retrospective series of the French Sarcoma Group

Lavit, Elise ; Aldea, Mihaela ; Piperno-Neumann, Sophie ; Firmin, Nelly ; Italiano, Antoine ; Isambert, Nicolas ; Kurtz, Jean-Emmanuel ; Delcambre, Corinne ; Lebrun, Valérie ; Soibinet-Oudot, Pauline ; Chevreau, Christine ; Bompas, Emmanuelle ; Le Maignan, Christine ; Boudou-Rouquette, Pascaline ; Le Cesne, Axel ; Mancini, Julien ; Blay, Jean-Yves ; Duffaud, Florence

Treatment options for metastatic osteosarcomas are scarce. Following failure of standard first line therapy, patients who relapse present a challenging treatment dilemma, and have a poor prognosis. Surgical removal of all metastases is essential. A retrospective analysis of patients with metastatic osteosarcomas was conducted in 15 French Sarcoma Group centers. From January 2009 to December 2018, we identified 120 adult patients; 36 with synchronous and 84 with metachronous metastases with 74 [...]

Menée aux Etats-Unis à partir de données portant sur 2 023 patientes atteintes d'un cancer invasif du sein et âgées de 50 à 79 ans, cette étude analyse l'association entre une consommation de produits finaux de glycation avancée et la mortalité (durée médiane de suivi : 15,1 ans ; 630 décès)

Dietary Advanced Glycation End-Products (AGEs) and Mortality After Breast Cancer in the Women's Health Initiative (WHI)

Omofuma, Omonefe O ; Peterson, Lindsay L ; Turner, David P. ; Merchant, Anwar T ; Zhang, Jiajia ; Thomson, Cynthia A. ; Neuhouser, Marian L ; Snetselaar, Linda ; Caan, Bette J ; Shadyab, Aladdin H ; Saquib, Nazmus ; Banack, Hailey R ; Uribarri, Jaime ; Steck, Susan E

Background: Advanced glycation end-products (AGEs) are formed through nonenzymatic glycation of free amino groups in proteins or lipid. They are associated with inflammation and oxidative stress and their accumulation in the body is implicated in chronic disease morbidity and mortality. We examined the association between post-diagnosis dietary N

Menée à partir de données portant sur des patientes atteintes d'un cancer du sein et recevant une chimiothérapie à base d'anthracyclines, cette étude analyse l'association entre la microstructure de la matière blanche du cerveau avant la chimiothérapie et le risque de déclin cognitif après les traitements

Brain White Matter Microstructure as a Risk Factor for Cognitive Decline After Chemotherapy for Breast Cancer

Michiel B. de Ruiter ; Liesbeth Reneman ; Jacobien M. Kieffer ; Hester S. A. Oldenburg ; Sanne B. Schagen

PURPOSE : Cognitive decline is frequently observed after chemotherapy. As chemotherapy is associated with changes in brain white matter microstructure, we investigated whether white matter microstructure before chemotherapy is a risk factor for cognitive decline after chemotherapy. METHODS : Neuropsychologic tests were administered before and 6 months (n = 49), 2 years (n = 32), and 3 years (n = 32) after chemotherapy in patients with breast cancer receiving anthracycline-based chemotherapy (BC [...]

Menée à partir des données des registres américains des cancers portant sur 1 024 047 patientes ayant survécu à un cancer primitif du sein et sur 41 744 patientes ayant développé un second cancer du sein diagnostiqué entre 1975 et 2016, cette étude analyse, chez ces deux populations, la mortalité par maladie cardiovasculaire (durée de suivi : 994 415 911 personnes-années ; 5 403 551 décès par maladie cardiovasculaire)

Cardiovascular mortality among cancer survivors who developed breast cancer as a second primary malignancy

Wang, Chengshi ; Hu, Kejia ; Luo, Chuanxu ; Deng, Lei ; Fall, Katja ; Tamimi, Rulla M. ; Valdimarsdóttir, Unnur A. ; Fang, Fang ; Lu, Donghao

Background : To assess the risk of cardiovascular mortality among cancer survivors who developed breast cancer as a second malignancy (BCa-2) compared with patients with first primary breast cancer (BCa-1) and the general population. Methods : Using the Surveillance, Epidemiology, and End Results database, we conducted a population-based cohort study including 1,024,047 BCa-1 and 41,744 BCa-2 patients diagnosed from the age 30 between 1975 and 2016, and the corresponding US female population [...]

Menée à partir de données portant sur 171 enfants atteints d'une tumeur du système nerveux central ou de la tête et du cou, cette étude analyse les facteurs associés à la perte d'audition induite par la radiothérapie et la chimiothérapie

Hearing Loss After Radiation and Chemotherapy for CNS and Head-and-Neck Tumors in Children

Dana Keilty ; Mohammad Khandwala ; Zhihui Amy Liu ; Vicky Papaioannou ; Eric Bouffet ; David Hodgson ; Ryan Yee ; Sharon Cushing ; Normand Laperriere ; Sameera Ahmed ; Donald Mabbott ; Vijay Ramaswamy ; Uri Tabori ; Annie Huang ; Ute Bartels ; Derek S. Tsang

PURPOSE : Hearing loss (HL) is a serious secondary effect of treatment for CNS and head-and-neck tumors in children. The goal of this study was to evaluate incidence and risk factors for HL in patients with multiple ototoxic exposures. PATIENTS AND METHODS : We evaluated 340 ears from 171 patients with CNS or head-and-neck tumors treated with radiation, with or without chemotherapy, who had longitudinal audiologic evaluation. International Society of Pediatric Oncology-Boston grades were [...]

Menée au Canada à partir de données portant sur 806 910 patients atteints d'un cancer diagnostiqué entre 2007 et 2019, cette étude de cohorte rétrospective analyse les facteurs associés au risque de détresse psychologique et d'automutilation non fatale après l'annonce du diagnostic de la maladie

Incidence of and Factors Associated With Nonfatal Self-injury After a Cancer Diagnosis in Ontario, Canada

Noel, Christopher W. ; Eskander, Antoine ; Sutradhar, Rinku ; Mahar, Alyson ; Vigod, Simone N. ; Isenberg-Grzeda, Elie ; Bolton, James ; Deleemans, Julie ; Chan, Wing C. ; Vasdev, Ravleen ; Zuk, Victoria ; Haas, Barbara ; Mason, Stephanie ; Coburn, Natalie G. ; Hallet, Julie ; Enhanced Supportive Psycho-oncology Canadian Care Group

Importance : Psychological distress is a key component of patient-centered cancer care. While a greater risk of suicide among patients with cancer has been reported, more frequent consequences of distress, including nonfatal self-injury (NFSI), remain unknown. Objective : To examine the risk of NFSI after a cancer diagnosis. Design, Setting, and Participants : This population-based retrospective cohort study used linked administrative databases to identify adults diagnosed with cancer between [...]

Menée à partir des données 2018 de la base GLOBOCAN, cette étude analyse, dans 31 pays européens, les pertes de productivité et les coûts associés à la mortalité prématurée due au cancer

Paid and unpaid productivity losses due to premature mortality from cancer in Europe in 2018

Ortega-Ortega, Marta ; Hanly, Paul ; Pearce, Alison ; Soerjomataram, Isabelle ; Sharp, Linda

When someone dies prematurely from cancer this represents a loss of productivity for society. This loss can be valued and provides a measure of the cancer burden. We estimated paid and unpaid productivity lost due to cancer-related premature mortality in 31 European countries in 2018. Lost productivity was estimated for all cancers combined and 23 cancer sites, overall, by region and country. Deaths aged 15-64 were abstracted from GLOBOCAN 2018. Unpaid time lost (housework, caring, [...]

Menée aux Etats-Unis à partir de données portant sur 388 adolescents et jeunes adultes atteints d'un cancer, cette étude analyse les coûts associés aux soins de santé sur la période 2005-2020 (durée médiane de suivi : 9 ans)

Health care costs for adolescents and young adults with cancer: a Wisconsin community-based hospital study between 2005 and 2020

Taparra, Kekoa ; Fitzsimmons, Alec ; Frankki, Susan ; De Wall, Andrea ; Chino, Fumiko ; Peters, Antoinette

Introduction : Adolescents and young adults (AYA) with cancer are at risk of high cumulative healthcare system costs potentially associated with poor health and financial outcomes. Although this has been studied at academic centers, little data on AYA costs at community-based practices exist. The goals of this study were to understand direct health care costs for AYA patients, identify factors for high costs, and assess how total health care costs may relate to survival. Methods : AYA patients [...]