Mené sur 75 patients ayant survécu à une tumeur solide et souffrant d'une neuropathie périphérique induite par la chimiothérapie, cet essai randomisé évalue l'intérêt, du point de vue de l'amélioration de la qualité de vie, d'une intervention à base d'acupuncture dispensée pendant 8 semaines

Health-Related Quality of Life in Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy: A Randomized Clinical Trial

Bao, Ting ; Baser, Raymond ; Chen, Connie ; Weitzman, Matthew ; Zhang, Yi Lily ; Seluzicki, Christina ; Li, Qing Susan ; Piulson, Lauren ; Zhi, W. Iris

Background : Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating adverse effect of neurotoxic chemotherapy that significantly worsens cancer survivors’ quality of life. Materials and Methods : Solid tumor survivors with persistent moderate-to-severe CIPN defined as numbness, tingling, or pain rated ≥4 on an 11-point numeric rating scale (NRS) were randomized in a 1:1:1 ratio to eight weeks of real acupuncture (RA) versus sham acupuncture (SA) versus usual care (UC). We [...]

Menée au Royaume-Uni par enquête auprès de patients ayant survécu à un cancer (434 cas de cancer du sein, 186 cas de cancer colorectal, 75 cas de cancer du testicule), cette étude longitudinale analyse leurs besoins en soins de support, à la fin des traitements anti-cancéreux et 8 mois après

Unmet supportive care needs of breast, colorectal and testicular cancer survivors in the first 8 months post primary treatment: A prospective longitudinal survey

Batehup, Lynn ; Gage, Heather ; Williams, Peter ; Richardson, Alison ; Porter, Katya ; Simmonds, Peter ; Lowson, Elizabeth ; Dodson, Lynne ; Davies, Nicola ; Wagland, Richard ; Winter, Jane ; Turner, Andrew ; Corner, Jessica

Objectives : To explore the supportive care needs of cancer survivors, the characteristics of patients with high levels of unmet need, changes in unmet need after treatment ends and differences in unmet needs of breast, colorectal and testicular survivors. Methods : The method used was a prospective longitudinal mailed survey. Unmet needs, measured by 25-item modified Cancer Survivors Unmet Needs survey at baseline (immediately post-treatment) and 8 months later, were analysed descriptively. [...]

A partir d'une revue systématique de la littérature publiée entre 2015 et 2021, cette étude présente les recommandations actualisées de la "Multinational Association of Supportive Care in Cancer" concernant l'utilisation d'antiémétiques chez des patients atteints d'un cancer de stade avancé

MASCC antiemetics in advanced cancer updated guideline

Davis, Mellar ; Hui, David ; Davies, Andrew ; Ripamonti, Carla ; Capela, Andreia ; DeFeo, Giulia ; Del Fabbro, Egidio ; Bruera, Eduardo

Background : Nausea and vomiting are a common clinical symptom in the advanced cancer patient. Pharmacologic management is important. Evidence for drug choices and guidelines are needed to help clinicians manage nausea and vomiting in this population Methods : Evidence from a systematic review published in 2010, initial MASCC guidelines developed from a systematic review of literature to 2015, and a new systematic review of randomized trials published between 2015 and February 2, 2021, was [...]

A partir d'une revue systématique de la littérature publiée entre 2011 et 2021 (59 articles), cette étude analyse les besoins en soins de support des patients atteints d'un cancer rare

Unmet supportive care needs of patients with rare cancer: A systematic review

de Heus, Eline ; Van der Zwan, Jan Maarten ; Husson, Olga ; Frissen, Anne-Roos ; van Herpen, Carla M. L. ; Merkx, Matthias A. W. ; Duijts, Saskia F. A.

Objective : Patients with rare cancers may experience different unmet needs than those with common cancer. The objective of this systematic review was to (1) investigate unmet supportive care needs of rare cancer patients throughout the disease trajectory and (2) identify predictive factors for these unmet needs. Methods : PubMed, PsycINFO and CINAHL were searched for publications (January 2011 to March 2021) focusing on unmet needs of patients with rare cancer. Two reviewers independently [...]

Mené sur 78 patients ayant survécu à un cancer (âge moyen : 55 ans), cet essai randomisé évalue la faisabilité et l'intérêt d'un programme d'activité physique combinant yoga, streching et exercices aérobiques, pour améliorer la qualité de vie

Feasibility of a yoga, aerobic and stretching-toning exercise program for adult cancer survivors: the STAYFit trial

Gothe, Neha P. ; Erlenbach, Emily

Background : The use of yoga as a mind–body practice has become increasingly popular among clinical populations and older adults who use this practice to manage age and chronic disease-related symptoms. Although yoga continues to gain popularity among practitioners and researchers, pilot studies that examine its feasibility and acceptability, especially among cancer survivors, are limited. Feasibility studies play a critical role in determining whether the target population is likely to engage [...]

Menée à partir de données portant sur 232 patients ayant survécu à un cancer pédiatrique (âge médian : 3,5 ans ; durée médiane depuis le diagnostic : 23,6 ans), cette étude analyse l'association entre la sévérité de crises convulsives, l'état des fonctions neurocognitives et la qualité de vie

Seizures' impact on cognition and quality of life in childhood cancer survivors

Phillips, Nicholas S. ; Khan, Raja B. ; Li, Chenghong ; Mirzaei Salehabadi, Sedigheh ; Brinkman, Tara M. ; Srivastava, Deokumar ; Robison, Leslie L. ; Hudson, Melissa M. ; Krull, Kevin R. ; Sadighi, Zsila S.

Background : The objective of this study was to determine the impact of seizure-related factors on neurocognitive, health-related quality of life (HRQOL), and social outcomes in survivors of childhood cancer. Methods : Survivors of childhood cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; median time since diagnosis, 23.6 years) completed neurocognitive testing and questionnaires. The presence, severity, resolution, and treatment history of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (27 articles), cette méta-analyse évalue l'effet des traitements curatifs sur la forme physique des patients atteints d'un cancer de l'oesophage (capacité à pratiquer une activité physique, force musculaire, etc.)

Impact of curative treatment on the physical fitness of patients with esophageal cancer: A systematic review and meta-analysis

Reijneveld, Elja A. E. ; Bor, Petra ; Dronkers, Jaap J. ; Argudo, Nuria ; Ruurda, Jelle P. ; Veenhof, Cindy

Background : Esophageal cancer and curative treatment have a significant impact on the physical fitness of patients. Knowledge about the course of physical fitness during neoadjuvant therapy and esophagectomy is helpful to determine the needs for interventions during and after curative treatment. This study aims to review the current evidence on the impact of curative treatment on the physical fitness of patients with esophageal cancer. Methods : A systematic literature search of PubMed, [...]

A partir d'une revue de la littérature, cette étude analyse l'association entre des facteurs liés au mode de vie (activité physique, alimentation, tabagisme, consommation d'alcool, etc.) et la qualité de vie chez des patientes atteintes d'un cancer du sein de stade précoce et recevant un traitement endocrinien adjuvant

Lifestyle and quality of life in patients with early-stage breast cancer receiving adjuvant endocrine therapy

Purpose of review : A comprehensive approach to survivorship care for women with early-stage, hormone-receptor positive breast cancer should systematically include the proactive assessment and adequate management of endocrine therapy-associated symptoms, in order to assure optimal balance between preserving quality of life (QOL) and maximizing treatment adherence. We reviewed the recent literature focused on lifestyle factors, including physical activity, diet and nutrition, weight management, [...]

Menée en Chine par questionnaire auprès de 461 patientes atteintes d'un cancer du sein traité par chirurgie, cette étude transversale analyse leurs besoins en soins de support et identifie les facteurs associés

Emotional, informational and instrumental support needs in patients with breast cancer who have undergone surgery: a cross-sectional study

Cai, Tingting ; Huang, Qingmei ; Yuan, Changrong

Objectives : This study evaluated emotional, informational and instrumental support needs in patients with breast cancer who had undergone surgery, then identified the variables associated with those needs. Design : This was a cross-sectional survey study.Setting Questionnaires were distributed in tertiary hospitals in China between January 2018 and July 2020. Participants : We recruited 477 eligible patients with breast cancer via convenience sampling. Due to exclusions for response errors, [...]

Menée auprès de 580 patientes ateintes d'un cancer du sein de stade I à IIIC et de 363 témoins, cette étude analyse l'association entre diverses pratiques d'activité physique, avant, pendant et après la chimiothérapie, et les fonctions cognitives des patients

Physical Activity Patterns and Relationships With Cognitive Function in Patients With Breast Cancer Before, During, and After Chemotherapy in a Prospective, Nationwide Study

Elizabeth A. Salerno ; Eva Culakova ; Amber S. Kleckner ; Charles E. Heckler ; Po-Ju Lin ; Charles E. Matthews ; Alison Conlin ; Lora Weiselberg ; Jerry Mitchell ; Karen M. Mustian ; Michelle C. Janelsins

PURPOSE : Physical activity (PA) is a promising intervention for cancer-related cognitive decline, yet research assessing its use during chemotherapy is limited. This study evaluated patterns of PA before, during, and after chemotherapy in patients with breast cancer and the association between PA and cognitive function. METHODS : In a nationwide, prospective cohort study, we assessed PA (Aerobics Center Longitudinal Study PA measure) and perceived and objectively measured cognitive functioning [...]

Menée en Allemagne à partir de données portant sur 4 505 patients pédiatriques ayant survécu 5 ans à un cancer diagnostiqué avant l'âge de 15 ans, cette étude analyse les causes de décès

Mortality Risk among 5-Year Survivors of Childhood Cancer in Germany - Results from the CVSS Study

Merzenich, Hiltrud ; Baaken, Dan ; Schneider, Astrid ; Neu, Marie A. ; Wingerter, Arthur ; Faber, Jörg ; Wild, Philipp S. ; Spix, Claudia

The growing population of long-term childhood cancer survivors is at increased risk for severe, therapy-related late effects and premature mortality. The CVSS study (Cardiac and Vascular late Sequelae in long-term Survivors of childhood cancer) is a cohort of patients from Germany diagnosed with a neoplasia prior to 15 years of age in the time period 1980-1990. Late mortality was evaluated in a total of 4505 individuals who survived 5 years or more after the initial diagnosis (5-year [...]

Menée à partir des données 2007-2017 du registre californien des cancers portant sur 4 807 enfants, adolescents et jeunes adultes atteints d'un lymphome hodgkinien (âge : inférieur ou égal à 40 ans), cette étude identifie les facteurs sociodémographiques et les facteurs liés aux traitements associés à la survie globale et à la survie spécifique (durée médiane de suivi : 4,4 ans)

Initial cancer treatment and survival in children, adolescents, and young adults with Hodgkin lymphoma: A population-based study

Kahn, Justine M. ; Maguire, Frances B. ; Li, Qian ; Abrahão, Renata ; Flerlage, Jamie E. ; Alvarez, Elysia ; Keegan, Theresa H. M.

Background : Hodgkin lymphoma (HL) is a treatable tumor affecting children, adolescents and young adults (AYAs; 15-39 years old). Population-based studies report worse survival for non-White children and AYAs but have limited data on individual therapeutic exposures. This study examined overall and HL-specific survival in a population-based cohort of patients while adjusting for sociodemographic factors and treatment. Methods : Data for 4807 patients younger than 40 years with HL (2007-2017) [...]

Menée en Angleterre sur la période 2005-2013, cette étude analyse l'association entre la présence de comorbidités et le délai avant diagnostic de la maladie, chez des patients atteints d'un lymphome folliculaire ou d'un lymphome diffus à grandes cellules B (30 078 et 15 551 patients)

Investigating the inequalities in route to diagnosis amongst patients with diffuse large B-cell or follicular lymphoma in England

Smith, Matthew J. ; Fernandez, Miguel Angel Luque ; Belot, Aurélien ; Quartagno, Matteo ; Bonaventure, Audrey ; Majano, Sara Benitez ; Rachet, Bernard ; Njagi, Edmund Njeru

Introduction : Diagnostic delay is associated with lower chances of cancer survival. Underlying comorbidities are known to affect the timely diagnosis of cancer. Diffuse large B-cell (DLBCL) and follicular lymphomas (FL) are primarily diagnosed amongst older patients, who are more likely to have comorbidities. Characteristics of clinical commissioning groups (CCG) are also known to impact diagnostic delay. We assess the association between comorbidities and diagnostic delay amongst patients [...]

Menée aux Etats-Unis à partir de données portant sur 343 089 patients atteints d'un cancer métastatique de la prostate résistant à la castration, cette étude analyse l'évolution de la prévalence de la maladie sur la période 2010-2017

Increasing prevalence of metastatic castration-resistant prostate cancer in a managed care population in the United States

Wallace, Katrine L. ; Landsteiner, Adrienne ; Bunner, Scott H. ; Engel-Nitz, Nicole M. ; Luckenbaugh, Amy N.

Purpose : Numerous treatment breakthroughs for patients with metastatic castration-resistant prostate cancer (mCRPC) have been demonstrated in clinical trials in the past 15 years. However, real-world evidence on the changing epidemiology and longevity of this population has not been demonstrated. This study assessed prevalence trends for mCRPC over eight years in a large managed care population. Methods : In a claims database, adult male patients were included with ≥ 1 claim for prostate [...]

Menée en Allemagne à partir de données portant sur 3 239 patients atteints d'un cancer colorectal et âgés de plus de 65 ans, cette étude analyse l'association entre une polypharmacie et la survie (durée de suivi : 5 ans ; 1 070 décès dont 615 par cancer)

Association of polypharmacy with colorectal cancer survival among older patients

Chen, Li-Ju ; Nguyen, Thi Ngoc Mai ; Chang-Claude, Jenny ; Hoffmeister, Michael ; Brenner, Hermann ; Schottker, Ben

Background : In geriatric oncology, polypharmacy is often assessed during a comprehensive geriatric assessment. Previous studies about its association with survival among colorectal cancer (CRC) patients were inconclusive and had high risk for indication bias. Patients and Methods : A cohort study was conducted with 3,239 CRC patients, aged ≥65 years, who were recruited in Germany between 2003 and 2016 while being hospitalized for CRC surgery. We defined polypharmacy as concurrent use of 5 or [...]

Menée à partir des données des registres américains des cancers, cette étude présente l'évolution, sur la période 2008-2017, de l'incidence du cancer du cerveau et d'autres tumeurs du système nerveux central et de la survie

Brain and other central nervous system tumor statistics, 2021

Miller, Kimberly D. ; Ostrom, Quinn T. ; Kruchko, Carol ; Patil, Nirav ; Tihan, Tarik ; Cioffi, Gino ; Fuchs, Hannah E. ; Waite, Kristin A. ; Jemal, Ahmedin ; Siegel, Rebecca L. ; Barnholtz-Sloan, Jill S.

Brain and other central nervous system (CNS) tumors are among the most fatal cancers and account for substantial morbidity and mortality in the United States. Population-based data from the Central Brain Tumor Registry of the United States (a combined data set of the National Program of Cancer Registries [NPCR] and Surveillance, Epidemiology, and End Results [SEER] registries), NPCR, National Vital Statistics System and SEER program were analyzed to assess the contemporary burden of malignant [...]

A partir des données des registres américains des cancers sur la période 1975-2017 et menée à partir d'une revue systématique de la littérature, cette étude analyse, en fonction du sexe, les disparités dans l'incidence et la prévalence du cancer de la thyroïde

Evaluation of Gender Inequity in Thyroid Cancer Diagnosis: Differences by Sex in US Thyroid Cancer Incidence Compared With a Meta-analysis of Subclinical Thyroid Cancer Rates at Autopsy

LeClair, Karissa ; Bell, Katy J. L. ; Furuya-Kanamori, Luis ; Doi, Suhail A. ; Francis, David O. ; Davies, Louise

Importance : Thyroid cancer is more common in women than in men, but the associated causes of these differences are not fully understood. Objective : To compare sex-specific thyroid cancer rates in the US to the prevalence of subclinical thyroid cancer at autopsy. Data Sources : Data on thyroid cancer incidence and mortality by sex among US adults (≥18 years) were extracted from the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program (SEER) data for 1975 to 2017. [...]

Menée à partir des données des registres américains des cancers portant sur 59 580 patients atteints d'un adénocarcinome de l'estomac sur la période 1975-2016, cette étude analyse les facteurs associés au risque de suicide et à la mortalité spécifique

Risk factors for suicide mortality and cancer-specific mortality among patients with gastric adenocarcinoma: A SEER based study

Elshanbary, Alaa Ahmed ; Zaazouee, Mohamed Sayed ; Hasan, Sara Mohamed ; Abdel-Aziz, Walid

Objective : This study aims to investigate the risk factors for suicide in patients with gastric adenocarcinoma (GAC) to recognize patients at higher risk who require special mental health care. Methods : Patients' data were collected from the Surveillance, Epidemiology, and End Results database from 1975 to 2016. The relationships among categorical variables were assessed using Person's chi-square test. Standardized mortality ratio was used to compare ratios of suicide and other causes of [...]

Menée au Canada auprès de 157 aidants d'un patient décédé d'un cancer de stade avancé, cette étude analyse l'association entre la préparation à la fin de vie, les symptômes et l'âge du patient, et la détresse psychique de l'aidant lors du processus de deuil

Caregiver bereavement outcomes in advanced cancer: associations with quality of death and patient age

Mah, Kenneth ; Swami, Nadia ; Pope, Ashley ; Earle, Craig C. ; Krzyzanowska, Monika K. ; Nissim, Rinat ; Hales, Sarah ; Rodin, Gary ; Hannon, Breffni ; Zimmermann, Camilla

Purpose : We investigated relationships between domains of quality of dying and death in patients with advanced cancer and their caregivers’ bereavement outcomes and the moderating effect of patient age at death. Methods : Bereaved caregivers of deceased patients with advanced cancer who had participated in an early palliative care trial completed measures of grief (Texas Revised Inventory of Grief [TRIG]), complicated grief (Prolonged Grief Inventory [PG-13]), and depression (Center for [...]

Menée à partir des données portant sur 345 patients décédés d'une tumeur solide de stade IV, cette étude analyse l'évolution de leurs symptômes physiques et de leur détresse psychologique durant leur dernière année de vie

Trajectories of physical symptom burden and psychological distress during the last year of life in patients with a solid metastatic cancer

Shafiq, Mahham ; Malhotra, Rahul ; Teo, Irene ; Ozdemir, Semra ; Kanesvaran, Ravindran ; Malhotra, Chetna ; COMPASS Study Group

Objective : To delineate the trajectories of physical symptoms and psychological distress among patients with a solid metastatic cancer during the last year of life. Methods : We used data of 345 decedents from a prospective cohort of 600 patients with a Stage IV solid cancer. Using group-based trajectory modelling, we assessed (a) demographic (age, gender, education, cancer site) predictors of trajectory membership, (b) shift in trajectories associated with planned and unplanned [...]

A partir d'une revue systématique de la littérature publiée entre 1999 et 2020 (73 articles), cette étude analyse l'association entre les divers symptômes de patients ayant survécu à un cancer et leur situation professionnelle

Investigating how cancer-related symptoms influence work outcomes among cancer survivors: a systematic review

Tan, Chia Jie ; Yip, Samantha Yin Ching ; Chan, Raymond Javan ; Chew, Lita ; Chan, Alexandre

Purpose : The purpose of this study is to investigate how different cancer-related symptoms influence work outcomes among cancer survivors. Methods : A literature search was performed in PubMed, EMBASE, CINAHL, PsycINFO, and Scopus to identify studies published between 1st January 1999 and 30th October 2020 that investigated the impact of specific cancer-related symptoms on work outcomes among cancer survivors who have completed primary antineoplastic treatment. Study findings were extracted [...]

Mené sur 247 femmes ayant survécu à un cancer du sein diagnostiqué avant l'âge de 50 ans et présentant des symptômes importants de dépression (âge médian : 46 ans), cet essai randomisé évalue l'intérêt, pour réduire les symptômes vasomoteurs ainsi que les symptômes de dépression et de fatigue, de 2 interventions comportementales, l'une à base de méditation en pleine conscience, l'autre pédagogique pour apprendre à gérer l'après-cancer

Targeting Depressive Symptoms in Younger Breast Cancer Survivors: The Pathways to Wellness Randomized Controlled Trial of Mindfulness Meditation and Survivorship Education

Julienne E. Bower ; Ann H. Partridge ; Antonio C. Wolff ; Elissa D. Thorner ; Michael R. Irwin ; Hadine Joffe ; Laura Petersen ; Catherine M. Crespi ; Patricia A. Ganz

PURPOSE : Younger women are at risk for depression and related symptoms following breast cancer. The Pathways to Wellness study, a randomized, multi-institution, three-arm trial, tested the efficacy of two behavioral interventions for younger breast cancer survivors with elevated depressive symptoms: mindful awareness practices (MAPs) and survivorship education (SE) (Clincaltrials.gov identifier: NCT03025139). METHODS : Women diagnosed with breast cancer at or before 50 years of age who had [...]

A partir d'une revue de la littérature publiée entre mars et août 2020 (39 études), cette méta-analyse évalue l'association entre l'annonce d'un diagnostic de cancer du sein et des symptômes psychiques (détresse, anxiété, stress post-traumatique, dépression)

The mental health impacts of receiving a breast cancer diagnosis: A meta-analysis

Fortin, Justine ; Leblanc, Mélissandre ; Elgbeili, Guillaume ; Cordova, Matthew J. ; Marin, Marie-France ; Brunet, Alain

Background : Receiving a breast cancer diagnosis can be a turning point with negative impacts on mental health, treatment and prognosis. This meta-analysis sought to determine the nature and prevalence of clinically significant psychological distress-related symptoms in the wake of a breast cancer diagnosis. Methods : Ten databases were searched between March and August 2020. Thirty-nine quantitative studies were meta-analysed. Results : The prevalence of clinically significant symptoms was 39% [...]

Menée en France par enquête auprès de 146 patients ayant survécu à un cancer de la thyroïde diagnostiqué en 2010 (82,9 % de femmes ; âge moyen : 42 ans), cette étude analyse leur situation professionnelle 5 ans après le diagnostic de la maladie et leurs difficultés lors de la reprise du travail

Returning to work by thyroid cancer survivors 5 years after diagnosis: the VICAN survey

Creff, G. ; Jegoux, F. ; Bendiane, M. K. ; Babin, E. ; Licaj, I.

Purpose : Return to work (RTW) following cancer diagnosis is a challenge for both the patient and society. As thyroid cancer (TC) incidence is increasing, this study aims to assess difficulties in returning to work and income changes in TC survivors 5 years post-diagnosis. Methods : This study belongs to the national VICAN survey conducted in France among TC patients diagnosed between January and June 2010. Data were collected through phone interviews, medical surveys and from the national [...]

Menée aux Etats-Unis par enquête auprès de patients atteints d'un cancer et âgés de moins de 65 ans, cette étude rétrospective transversale analyse, dans le cadre de la loi sur la protection des patients et les soins abordables ("Obamacare"), les dépenses de santé et les facteurs associés au risque de perte d'assurance

Associations of Insurance Churn and Catastrophic Health Expenditures With Implementation of the Affordable Care Act Among Nonelderly Patients With Cancer in the United States

Albright, Benjamin B. ; Chino, Fumiko ; Chino, Junzo P. ; Havrilesky, Laura J. ; Aviki, Emeline M. ; Moss, Haley A.

Health insurance coverage is dynamic in the United States, potentially changing from month to month. The Patient Protection and Affordable Care Act (ACA) aimed to stabilize markets and reduce financial burden, particularly among those with preexisting conditions.To describe the risks of insurance churn (ie, gain, loss, or change in coverage) and catastrophic health expenditures among nonelderly patients with cancer in the United States, assessing for changes associated with ACA [...]

Menée au Royaume-Uni, à partir de données portant sur 1 225 patients atteints d'un cancer d'origine primitive inconnue et orientés vers un service régional d'oncologie pour y être traités par une équipe pluridisciplinaire spécialisée dans cette pathologie, cette étude analyse, sur une période de 10 ans, les facteurs démographiques, cliniques et pathologiques associés à la survie

Characterisation and outcomes of patients referred to a regional cancer of unknown primary team: a 10-year analysis

Stares, Mark ; Purshouse, Karin ; Knowles, Gillian ; Haigh, Rachel ; Irvine, Jenny ; Gatenby, Aoife ; Patton, Rebekah ; McGinty, Jo ; Christie, Alan ; MacLennan, Marjory ; Barrie, Colin ; Clive, Sally

Background : In the United Kingdom, national guidance published in 2010 recommended the establishment of specialist teams to improve clinical pathways for patients presenting with malignancies of undefined primary origin (MUO) and cancer of unknown primary (CUP). This study sought to define outcomes of patients referred to a regional MUO/CUP service. Methods : Data were collected prospectively on all patients (n = 1225) referred to a regional CUP team over a 10-year period. Patient [...]

Menée en Italie sur la période 2001-2018, cette étude rétrospective analyse les coûts associés aux hospitalisations des patients atteints d'un mésothéliome malin

Hospitalisation costs of malignant mesothelioma: results from the Italian hospital discharge registry (2001–2018)

Ferrante, Pierpaolo

Objectives :This paper aims to establish hospitalisation costs of mesothelioma in Italy and to evaluate hospital-related trends associated with the 1992 asbestos ban. Design : This is a retrospective population-based study of Italian hospitalisations treating pleura, peritoneum and pericardium mesothelioma in the period 2001–2018. Settings : Public and private Italian hospitals reached by the Ministry of Health (coverage close to 100%). Participants :157 221 admissions with primary or [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d'un traitement de première ligne combinant durvalumab, étoposide et sels de platine, chez des patients atteints d'un cancer du poumon à petites cellules de stade étendu

First-line durvalumab in addition to etoposide and platinum for extensive-stage small cell lung cancer: a United States-based cost-effectiveness analysis

Lin, Shen ; Luo, Shaohong ; Gu, Dian ; Li, Meiyue ; Rao, Xin ; Wang, Changlian ; Huang, Pinfang ; Xu, Xiongwei ; Weng, Xiuhua

Background : The latest published CASPIAN trial demonstrated that adding durvalumab to etoposide and platinum (EP) improved survival dramatically for patients with extensive-stage small cell lung cancer (ES-SCLC). Considering the high cost of durvalumab, this study evaluated the cost-effectiveness of durvalumab plus EP (DEP) in the first-line setting for treatment-naïve ES-SCLC patients from the US payer perspective. Methods : We developed a three-state Markov model to simulate the disease [...]

Menée aux Etats-Unis, cette étude de cohorte analyse les coûts associés au dépistage du cancer du sein chez des femmes âgées de 40 à 64 ans disposant d'une assurance maladie privée

Trends in Breast Cancer Screening Costs Among Privately Insured Women Aged 40 to 64 Years

Richman, Ilana B. ; Long, Jessica B. ; Kunst, Natalia ; Kyanko, Kelly ; Xu, Xiao ; Busch, Susan ; Gross, Cary P.

Over the past decade, screening mammography in the US has undergone notable technological change, as digital breast tomosynthesis (DBT) has replaced 2-dimensional (2D) mammography. Although DBT is more expensive than 2D mammography, DBT may generate downstream savings by reducing the number of women called back for additional imaging. The goal of this cohort study was to characterize changes in breast cancer screening costs as DBT has been adopted at both the patient and population levels.

Menée à l'aide d'un modèle de microsimulation, cette étude évalue l'association entre l'extension de l'accès aux traitements et aux techniques d'imagerie et les disparités mondiales en matière de survie à 5 ans chez les patientes atteintes d'un cancer du sein

The impact of scaling up access to treatment and imaging modalities on global disparities in breast cancer survival: a simulation-based analysis

Ward, Zachary J. ; Atun, Rifat ; Hricak, Hedvig ; Asante, Kwanele ; McGinty, Geraldine ; Sutton, Elizabeth J. ; Norton, Larry ; Scott, Andrew M. ; Shulman, Lawrence N.

Background : Female breast cancer is the most commonly diagnosed cancer in the world, with wide variations in reported survival by country. Women in low-income and middle-income countries (LMICs) in particular face several barriers to breast cancer services, including diagnostics and treatment. We aimed to estimate the potential impact of scaling up the availability of treatment and imaging modalities on breast cancer survival globally, together with improvements in quality of care. Methods : [...]

Mené au Royaume-Uni sur 234 adultes vivant dans des zones socioéconomiquement défavorisées, cet essai randomisé évalue le rapport coût-efficacité d'une intervention destinée à sensibiliser les personnes aux symptômes liés au cancer et à les encourager à consulter

Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK

Moriarty, Yvonne ; Lau, Mandy ; Sewell, Bernadette ; Trubey, Rob ; Quinn-Scoggins, Harriet ; Owen, Sioned ; Padgett, Louise ; Kolovou, Vasiliki ; Hepburn, Julie ; Buckle, Peter ; Playle, Rebecca ; Townson, Julia ; Robling, Michael ; Gilbert, Stephanie ; Dimitropoulou, Polyxeni ; Edwards, Adrian ; Mitchell, Caroline ; Matthews, Maura ; Smits, Stephanie ; Wood, Fiona ; Neal, Richard D. ; Brain, Kate ; Jones, Mari ; Farr, Angela ; A. BACus study team

Background : Cancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation. Methods : This is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. [...]