Menée à partir des données d'une étude espagnole portant sur 1 278 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre la trajectoire de consommation d'alcool tout au long de la vie et le développement de la maladie

Trajectories of alcohol consumption during life and the risk of developing breast cancer

Donat-Vargas, Carolina ; Guerrero-Zotano, Ángel ; Casas, Ana ; Baena-Cañada, José Manuel ; Lope, Virginia ; Antolín, Silvia ; Garcia-Saenz, José Ángel ; Bermejo, Begoña ; Muñoz, Montserrat ; Ramos, Manuel ; de Juan, Ana ; Jara Sánchez, Carlos ; Sanchez-Rovira, Pedro ; Antón, Antonio ; Brunet, Joan ; Gavilá, Joaquín ; Salvador, Javier ; Arriola Arellano, Esperanza ; Bezares, Susana ; Fernández de Larrea-Baz, Nerea ; Pérez-Gómez, Beatriz ; Martin, Miguel ; Pollan, Marina

Background: Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC). Methods: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify [...]

Menée à partir des données de 3 études portant au total sur 237 505 participants (durée de suivi : 6 216 378 personnes-années), cette étude analyse l'association entre la consommation d'alcool et le risque de gliome, en fonction du sexe

Alcohol intake and risk of glioma: results from three prospective cohort studies

Cote, David J. ; Samanic, Claudine M. ; Smith, Timothy R. ; Wang, Molin ; Smith-Warner, Stephanie A. ; Stampfer, Meir J. ; Egan, Kathleen M.

Purpose: The association between alcohol intake and glioma remains unclear. We evaluated the association between alcohol intake and incidence of glioma in three large, prospective cohort studies with repeated alcohol assessments. Methods: We harnessed data from three studies with repeat alcohol assessment to compute hazard ratios (HR) and 95% confidence intervals (CI) for glioma by overall alcohol intake and intake from specific beverages using Cox proportional hazards regression, adjusted for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2020, cette méta-analyse évalue l'association entre la consommation de viande rouge ou transformée et le risque de cancer

Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies

Farvid, Maryam S. ; Sidahmed, Elkhansa ; Spence, Nicholas D. ; Mante Angua, Kingsly ; Rosner, Bernard A. ; Barnett, Junaidah B.

Red meat and processed meat consumption has been hypothesized to increase risk of cancer, but the evidence is inconsistent. We performed a systematic review and meta-analysis of prospective studies to summarize the evidence of associations between consumption of red meat (unprocessed), processed meat, and total red and processed meat with the incidence of various cancer types. We searched in MEDLINE and EMBASE databases through December 2020. Using a random-effect meta-analysis, we calculated [...]

Menée aux Pays-Bas à partir de données 1999-2016 de 2 registres nationaux portant sur plus de 11 millions de personnes, cette étude analyse l'association entre la profession, une exposition professionnelle aux agents pathogènes gastro-intestinaux connus et le risque de cancer du côlon (44 778 cas)

Occupational exposure and risk of colon cancer: a nationwide registry study with emphasis on occupational exposure to zoonotic gastrointestinal pathogens

Duijster, Janneke ; Mughini-Gras, Lapo ; Neefjes, Jacques ; Franz, Eelco

Objectives: While colon cancer (CC) risk is associated with several lifestyle-related factors, including physical inactivity, smoking and diet, the contribution of occupation to CC morbidity remains largely unclear. Growing evidence indicates that gastrointestinal infections like salmonellosis could contribute to CC development. We performed a nationwide registry study to assess potential associations between occupation (history) and CC, including also those occupations with known increased [...]

Menée auprès de 166 patients suivis par coloscopie de surveillance après une résection de polypes colorectaux (durée médiane de suivi : 17-45 mois), cette étude analyse l'association entre le type de résection des polypes et le risque de néoplasie métachrone

Recurrence of Colorectal Neoplastic Polyps After Incomplete Resection

Background: Incomplete resection of neoplastic polyps is considered an important reason for the development of colorectal cancer. However, there are no data on the natural history of polyps that were incompletely removed. Objective: To examine the risk for metachronous neoplasia during surveillance colonoscopy after documented incomplete polyp resection. Design: Observational cohort study of patients who participated in the CARE (Complete Adenoma REsection) study (2009 to 2012). Setting: 2 [...]

Menée aux Etats-Unis auprès de 43 500 femmes, cette étude analyse l'association entre une exposition résidentielle à la lumière nocturne artificielle et le risque de cancer du sein, en fonction de l'origine ethnique

The Association between Outdoor Artificial Light at Night and Breast Cancer Risk in Black and White Women in the Southern Community Cohort Study

Qian Xiao ; Gretchen L. Gierach ; Cici Bauer ; William J. Blot ; Peter James ; Rena R. Jones

Black women in the United States are more likely to develop breast cancer at a younger age and to be diagnosed with more aggressive subtypes and more advanced stage disease, both contributing to higher rates of breast cancer mortality among Black women. Light at night (LAN) has been proposed as a breast cancer risk factor because it inhibits nighttime production of melatonin, a hormone that may modulate biological pathways involved in breast cancer carcinogenesis. Several epidemiologic studies [...]

Menée au Canada entre 2003 et 2018 auprès de 110 709 témoins et 36 903 patients nécessitant un cathéter sus-pubien (âge médian : 62 ans ; durée médiane de suivi : 8,8 ans ; 52 % de femmes), cette étude analyse l'association entre ce cathétérisme et le risque de cancer de la vessie (697 cas), ainsi que la mortalité spécifique (165 décès)

Association between chronic bladder catheterisation and bladder cancer incidence and mortality: a population-based retrospective cohort study in Ontario, Canada

Hird, Amanda E ; Saskin, Refik ; Liu, Ying ; Lee, Yuna ; Ajib, Khaled ; Matta, Rano ; Kodama, Ronald ; Carr, Lesley ; Kulkarni, Girish S ; Herschorn, Sender ; Narod, Steven A ; Nam, Robert K

Objectives: To compare the risk of bladder cancer and bladder cancer mortality among patients with chronic bladder catheterisation (indwelling or intermittent) to patients from the general population. Design: Retrospective cohort study.Setting Population-based study in Ontario, Canada between 2003 and 2018. Participants: Adult patients 18–90 years of age with chronic bladder catheterisation were hard matched to patients from the general population without a history of bladder catheterisation. [...]

Menée au Danemark à l'aide de données de registres et menée entre 2004 et 2015 auprès de 101 765 personnes (âge médian : 58 ans ; durée médiane de suivi : 9 ans ; 55 % de femmes), cette étude analyse l'association entre le niveau plasmatique d'amylase pancréatique et le risque de cancer du pancréas (442 cas)

Low and high pancreatic amylase is associated with pancreatic cancer and chronic pancreatitis

Hansen, Signe E. J. ; Langsted, Anne ; Varbo, Anette ; Madsen, Christian M. ; Tybjærg-Hansen, Anne ; Nordestgaard, Børge G.

Incidences of pancreatic cancer and acute and chronic pancreatitis are rising globally, and often no curative treatment is available at the time of diagnosis. We tested the hypothesis that low and high plasma concentrations of pancreatic amylase are associated with increased risk of pancreatic cancer, acute pancreatitis, and chronic pancreatitis in the general population. We included 101,765 individuals (55% women) aged 20–100 years from the Copenhagen General Population Study with baseline [...]

Menée en Suède à partir de données de registres portant sur 318 653 participants ayant réalisé des biopsies gastriques entre 1979 et 2011, cette étude analyse l'association entre l'état de la muqueuse gastrique et le risque de cancer du pancréas (3 540 cas)

Gastric mucosal abnormality and risk of pancreatic cancer: a population-based gastric biopsy cohort study in Sweden

Yu, Jingru ; Song, Huan ; Ekheden, Isabella ; Löhr, Matthias ; Ploner, Alexander ; Ye, Weimin

Background: It remains open whether gastric precancerous lesions are associated with an elevated risk of pancreatic cancer. Our aim was to investigate the association between gastric mucosal status and pancreatic cancer risk. Methods: Patients with gastric biopsies (normal, minor changes, superficial gastritis, and atrophic gastritis/intestinal metaplasia/dysplasia [AG/IM/Dys]) from the Swedish histopathology registers during 1979-2011 were included. Cross linkages with several nationwide [...]

Menée aux Etats-Unis auprès de 14 507 mères ayant reçu des soins prénataux entre 1959 et 1966 (durée de suivi : 738 048 personnes-années), cette étude analyse l'association entre une obésité maternelle, une prise de poids pendant la grossesse ou le poids à la naissance et le risque de cancer colorectal de leur enfant à l'âge adulte (68 cas)

Maternal obesity, pregnancy weight gain, and birth weight and risk of colorectal cancer

Murphy, Caitlin C ; Cirillo, Piera M ; Krigbaum, Nickilou Y ; Singal, Amit G ; Lee, MinJae ; Zaki, Timothy ; Burstein, Ezra ; Cohn, Barbara A

Objective: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Obesity is a well-established risk factor for CRC, and fetal or developmental origins of obesity may underlie its effect on cancer in adulthood. We examined associations of maternal obesity, pregnancy weight gain, and birth weight and CRC in adult offspring. Design: The Child Health and Development Studies is a prospective cohort of women receiving prenatal care between 1959 and 1966 in Oakland, California [...]