Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)

Menée en France auprès de 201 patients atteints d'un cancer digestif, cette étude prospective analyse l'intérêt de mesurer la force d'agrippement pour mesurer ou prédire le risque de dynapénie (perte de force musculaire) et de vulnérabilité nutritionnelle

Résumé en anglais

Background : The FIGHTDIGO study determined the feasibility and acceptability of handgrip strength (HGS) measurement in digestive cancer outpatients.

Purpose : To assess the relationship between muscle strength and markers of functional and nutritional status in this population.

Design : In this prospective study, a total of 201 patients were followed during 6 months and were asked to perform HGS measurement at each hospitalization. Anthropometric measurements, laboratory tests, and performance status (PS) evaluation were collected. The modified Glasgow Prognostic Score (mGPS) was calculated using CRP and albumin levels. Severe malnutrition was defined as body mass index (BMI) < 18 kg/m2 in patients > 70 years old, and BMI < 16 kg/m2 in those < 70 years old. Dynapenia was defined as HGS < 30 kg (men) and < 20 kg (women). Mixed logistic regressions and mixed linear regressions were performed to study factors associated with dynapenia and HGS value, respectively.

Results : A total of 879 HGS measurements were analyzed. Dynapenia occurred in 177 measurements (20.1%). BMI and HGS were significantly associated in univariate analysis (p = 0.001). In multivariate analysis, mGPS score (