Risk and influencing factors for subsequent primary lung cancer after treatment of breast cancer: a systematic review and two meta-analyses based on four million cases

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2020, une première méta-analyse compare à la population générale le risque de développer un cancer du poumon chez des patientes atteintes d'un cancer du sein (15 études, 1,2 millions de patientes) et une seconde identifie des facteurs associés au risque de cancer du poumon après un traitement pour un cancer du sein (22 études, 3 millions de patientes)

Résumé en anglais

Purpose: To compare the risk of developing lung cancer between breast cancer patients and the general population and explore the risk factors for the development of primary lung cancer after treatment for breast cancer.

Methods: The PubMed, EMBASE and Web of Science databases were searched from the establishment date to October 11, 2020. Two separate meta-analyses were performed: one focused on studies reporting the risk of subsequent lung cancer after breast cancer and one focused on studies exploring the risk factors for subsequent lung cancer in breast cancer patients. The standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were combined to compare the risk of developing lung cancer between breast cancer patients and the general population. The relative risks (RRs) or odds ratios (ORs) with 95% CIs were combined to assess the association of clinicopathological parameters with the risk of developing lung cancer after breast cancer. All statistical analyses were conducted by STATA 12.0.

Results: A total of 15 studies involving 1,161,979 patients were eventually included in the first meta-analysis, and the pooled results indicated that female patients with breast cancer showed a significantly higher risk of developing subsequent lung cancer (SIR=1.25, P