Menée notamment à l'aide d'enquêtes et de données 2017 sur l'incidence du cancer en France, cette étude estime la part des cancers attribuable à une exposition professionnelle à dix agents cancérigènes (amiante, benzène, chrome VI, gaz d'échappement des moteurs diesel, formaldéhyde, composés du nickel, hydrocarbures aromatiques polycycliques, poussière de silice, trichloréthylène, poussière de bois) et à deux situations à risque (peintres et travailleurs du caoutchouc)

Estimated number of cancers attributable to occupational exposures in France in 2017: an update using a new method for improved estimates

Marant Micallef, Claire ; Charvat, Hadrien ; Houot, Marie-Tülin ; Vignat, Jérôme ; Straif, Kurt ; Paul, Adèle ; El Yamani, Mounia ; Pilorget, Corinne ; Soerjomataram, Isabelle

Background: Over the last 50 years, occupational exposure to carcinogenic agents has been widely regulated in France. Objective: Report population-attributable fraction (PAF) and number of attributable cancer cases linked to occupational exposure in France based on an updated method to estimate lifetime occupational exposure prevalence. Methods: Population-level prevalence of lifetime exposure to ten carcinogenic agents (asbestos, benzene, chromium VI, diesel engine exhaust, formaldehyde, [...]

Menée en Suisse à partir de données portant sur 4 351 383 personnes, cette étude identifie les expositions professionnelles associées à la mortalité par cancer du poumon entre 1990 et 2014

Lung Cancer Mortality in the Swiss Working Population: The Effect of Occupational and Non-Occupational Factors

Bovio, Nicolas ; Wild, Pascal ; Canu, Irina Guseva ; for the Swiss National Cohort

Objective: To assess the effect of occupational exposures on lung cancer mortality in Switzerland after adjustment for non-occupational lung carcinogens. Methods: Using data on 4’351’383 Swiss residents, we used negative binomial regression to assess the effect occupation on lung cancer mortality between 1990 and 2014, accounting for socio-demographic factors, predicted probabilities of smoking and measured environmental radon exposure. Results: After adjustment, male machine operators and [...]

Menée aux Etats-Unis auprès de 1 008 participants de l'étude "VIRUSCAN" (âge médian : 68 ans ; durée de suivi : 4 ans), cette étude analyse l'association entre une infection par le polyomavirus de Merkel et le risque de carcinome d'origine kératinocytaire

Association between human polyomaviruses and keratinocyte carcinomas: A prospective cohort study

Amorrortu, Rossybelle P. ; Zhao, Yayi ; Messina, Jane L. ; Schell, Michael J. ; Fenske, Neil A. ; Cherpelis, Basil S ; Sondak, Vernon K. ; Giuiliano, Anna R. ; Pawlita, Michael ; McKay-Chopin, Sandrine ; Gheit, Tarik ; Waterboer, Tim ; Tommasino, Massimo ; Rollison, Dana E.

Background: A positive association between Merkel cell polyomavirus (MCPyV) infection and cutaneous squamous cell carcinoma (cuSCC) has been observed in at least one previous case-control study. To evaluate this association in a prospective context, we investigated infections with human polyomaviruses (HPyV), including MCPyV, as predictors of keratinocyte carcinomas (KC), including cuSCC and basal cell carcinoma (BCC), among a cohort of immunocompetent individuals enrolled in the Viruses in [...]

Menée à l'aide des données de 3 études canadiennes portant sur 1 827 témoins et sur 609 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre des facteurs de risque modifiables ou non modifiables et le risque de développer la maladie avant l'âge de 50 ans

Examining the etiology of early-onset breast cancer in the Canadian Partnership for Tomorrow’s Health (CanPath)

Pader, Joy ; Basmadjian, Robert B. ; O’Sullivan, Dylan E. ; Mealey, Nicole E. ; Ruan, Yibing ; Friedenreich, Christine ; Murphy, Rachel ; Wang, Edwin ; Quan, May Lynn ; Brenner, Darren R.

Purpose: Breast cancer incidence among younger women (under age 50) has increased over the past 25 years, yet little is known about the etiology among this age group. The objective of this study was to investigate relationships between modifiable and non-modifiable risk factors and early-onset breast cancer among three prospective Canadian cohorts. Methods: A matched case–control study was conducted using data from Alberta’s Tomorrow Project, BC Generations Project, and the Ontario Health [...]

Menée à partir des données d'une étude japonaise portant sur 44 158 hommes et 47 940 femmes (durée moyenne de suivi : 19 ans), cette étude analyse l'association entre l'indice de masse corporelle, la taille ou les variations du poids et l'incidence du cancer du poumon (2 152 cas)

Body mass index, height, weight change, and subsequent lung cancer risk: the Japan Public Health Center-based Prospective Study

Abe, Sarah K ; Narita, Saki ; Saito, Eiko ; Sawada, Norie ; Shimazu, Taichi ; Goto, Atsushi ; Yamaji, Taiki ; Iwasaki, Motoki ; Inoue, Manami ; Tsugane, Shoichiro

Background: BMI is inversely associated with lung cancer risk, while residual confounding by smoking or weight change is controversial. Evidence on height and lung cancer is scarce. Methods: We investigated the associations between anthropometrics, body mass index (BMI) and height, and incidence of lung cancer among 92,098 study subjects (44,158 men and 47,940 women) in the Japan Public Health Center-based Prospective Study. Cox proportional hazards regression was performed with adjustment for [...]

Menée à partir de données 1998-2014 de la cohorte "the Nurses’ Health Study" portant sur 77 541 participantes (durée de suivi : 14 ans), cette étude analyse l'association entre la perte osseuse parodontale et le risque de cancer du sein (5 110 cas)

Periodontal disease and breast cancer risk: Results from the Nurses' Health Study

Farhat, Zeinab ; Cadeau, Claire ; Eliassen, A. Heather ; Freudenheim, Jo L.

Background: While periodontal disease has been linked to increased cancer risk, studies regarding an association with breast cancer are limited. Methods: We examined the relationship between self-reported diagnosis of periodontal bone loss and incidence of breast cancer in a large, prospective cohort study, the Nurses' Health Study (1998-2014). We calculated hazard ratios using Cox proportional hazard modeling, adjusting for risk factors common to both periodontal disease and breast cancer. [...]