Menée en Norvège auprès de 642 femmes ayant réalisé un test de recherche de l'ADN du papillomavirus humain (HPV) sur la période 1990-1992, cette étude analyse le risque de développer des lésions cervicales intraépithéliales de haut grade (CIN3+) au cours des 30 ans de suivi, en fonction du statut HPV initial

Risk of cervical intraepithelial neoplasia grade 3 or higher (CIN3+) among women with HPV-test in 1990–1992, a 30-year follow-up study

Riibe, Marit Østlyngen ; Sørbye, Sveinung Wergeland ; Simonsen, Gunnar Skov ; Sundsfjord, Arnfinn ; Ekgren, Josef ; Maltau, Jan Martin

Background/objective: Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+ in the follow-up period of 30 years. Methods: All women (n = 642) referred to the HPV outpatient clinic at the University Hospital of North Norway (UNN) in 1990–1992, with an HPV test at baseline, were included in a prospective cohort. HPV-testing was performed by [...]

A partir de données 2007-2016 des registres américains des cancers portant sur 86 651 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre l'utilisation d'un traitement de remplacement de la testostérone ou de statines et le risque de développer la maladie, en fonction de l'origine ethnique

Independent and Joint Effects of Testosterone Replacement Therapy and Statins use on the Risk of Prostate Cancer Among White, Black, and Hispanic Men

Lopez, David S. ; Polychronopoulou, Efstathia ; Tsilidis, Konstantinos K. ; Khera, Mohit ; Su, L. Joseph ; Fowke, Jay H. ; Peek, M.K. ; Kuo, Yong-Fang ; Markides, Kyriakos ; Canfield, Steven

The associations of testosterone therapy (TTh) and statins use with prostate cancer remain conflicted. However, the joint effects of TTh and statins use on the incidence of prostate cancer, stage and grade at diagnosis, and prostate cancer-specific mortality (PCSM) have not been studied.We identified White (N = 74,181), Black (N = 9,157), and Hispanic (N = 3,313) men diagnosed with prostate cancer in SEER-Medicare 2007–2016. Prediagnostic prescription of TTh and statins was ascertained for this [...]

Menée en France à partir de données 2010-2019 portant sur 4 322 970 femmes ayant été hospitalisées pendant leur grossesse, cette étude analyse l'association entre une pré-éclampsie ou une éclampsie au cours d'une première grossesse et le risque de cancer

Assessment of All-Cause Cancer Incidence Among Individuals With Preeclampsia or Eclampsia During First Pregnancy

Serrand, Chris ; Mura, Thibault ; Fabbro-Peray, Pascale ; Seni, Gilles ; Mousty, Ève ; Boudemaghe, Thierry ; Gris, Jean-Christophe

Preeclampsia or eclampsia (preeclampsia/eclampsia) during pregnancy induces major physiological changes and may be associated with specific cancer occurrences in later life. The current data regarding the association between preeclampsia/eclampsia and cancer are heterogeneous, and cancer risk after preeclampsia/eclampsia could be different depending on the organ. These uncertainties warrant reexamination of the association between preeclampsia/eclampsia and the risk of cancer overall and by [...]

Menée auprès de 778 828 personnes (durée médiane de suivi : 20 ans), cette étude analyse l'association entre l'indice de masse corporelle, un score métabolique de la pression artérielle moyenne et le risque de cancer du poumon (6 735 cas) ou d'autres cancers liés au tabagisme (13 507 cas)

The inverse association of body mass index with lung cancer: exploring residual confounding, metabolic aberrations and within-person variability in smoking

Wood, Angela M. ; Jonsson, Håkan ; Nagel, Gabriele ; Häggström, Christel ; Manjer, Jonas ; Ulmer, Hanno ; Engeland, Anders ; Zitt, Emanuel ; Jochems, Sylvia H.J. ; Ghaderi, Sara ; Stattin, Pär ; Bjørge, Tone ; Stocks, Tanja

Background: The inverse observational association between body mass index (BMI) and lung cancer risk remains unclear. We assessed whether the association is explained by metabolic aberrations, residual confounding and within-person variability in smoking, and compared against other smoking-related cancers. Methods: We investigated the association between BMI, and its combination with a metabolic score (MS) of mid-blood pressure, glucose and triglycerides, with lung cancer and other [...]