Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Association of COVID-19 mRNA Vaccine With Ipsilateral Axillary Lymph Node Reactivity on Imaging

Adin, Mehmet Emin ; Isufi, Edvin ; Kulon, Michal ; Pucar, Darko

Intramuscular coronavirus 2019 (COVID-19) vaccinations could induce ipsilateral axillary lymph node reactivity that may be falsely attributed to malignant abnormality, prompting unwarranted interventions, or it may be falsely attributed to vaccination rather than cancer, potentially delaying cancer care. We aimed to investigate Moderna and Pfizer COVID-19 vaccine-related nodal reactivity on 18F-flurodeoxyglocose (FDG) positron emission tomographic (PET)/computed tomographic (CT) scans.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Mortality of patients with solid and haematological cancers presenting with symptoms of COVID-19 with vs without detectable SARS-COV-2: a French nationwide prospective cohort study

Assaad, Souad ; Zrounba, Philippe ; Cropet, Claire ; Blay, Jean-Yves ; Oncovid- study Consortium

Background : Over 30 million COVID-19 cases have been diagnosed worldwide from late 2019. Among frail persons, cancer patients are at high risk of death from COVID-19. Methods : The French prospective cohort ONCOVID-19 enrolled patients with solid or haematological tumour, receiving anticancer treatment and presenting with clinical symptoms suggestive of COVID-19. COVID-19 was confirmed through detectable SARS-CoV2 by RT-PCR (repeated twice if negative first) and/or specific CT-scan. The study [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

High levels of anti-SARS-CoV-2 IgG antibodies in previously infected cancer patients after a single dose of BNT 162b2 vaccine

Fong, Dominic ; Mair, Maximilian J. ; Mitterer, Manfred

Dear Editor, As patients with cancer constitute a vulnerable population at higher risk of contracting severe COVID-19, they represent a priority group for SARS-CoV-2 vaccination. However, despite favouring these patients theoretically, cancer patients were excluded from major registration trials on SARS-CoV-2 vaccines Furthermore, two recent reports on the immunogenicity of mRNA vaccines in cancer patients excluded those from the study having previous SARS-CoV-2 exposure We compared IgG [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The impact of COVID-19 on patients with hematological malignancies: the mixed-method analysis of an Israeli national survey

Levy, Ilana ; Sharf, Giora ; Norman, Shlomit ; Tadmor, Tamar

Background : The COVID-19 pandemic required reevaluation of the therapeutic approach and added emotional stress for patients with hematological malignancies at high risk of contracting the virus. We aimed to evaluate how it affected such patients during the second lockdown in Israel. Methods : This national survey included Hebrew-speaking patients with hematological malignancy. This included three tools with 28 items of sociodemographic and medical baseline characteristics, management of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of COVID-19 infection on cancer patients: experience in Latin American country, ACHOCC-19 Study

Ospina, Aylen Vanessa ; Bruges, Ricardo ; Mantilla, William ; Triana, Iván ; Ramos, Pedro ; Aruachan, Sandra ; Quiroga, Alicia ; Munevar, Isabel ; Ortiz, Juan ; Llinás, Néstor ; Pinilla, Paola ; Vargas, Henry ; Idrobo, Henry ; Russi, Andrea ; Kopp, Ray Manneh ; Rivas, Giovanna ; González, Héctor ; Santa, Daniel ; Insuasty, Jesús ; Bernal, Laura ; Otero, Jorge ; Vargas, Carlos ; Pacheco, Javier ; Alcalá, Carmen ; Jiménez, Paola ; Lombana, Milton ; Contreras, Fernando ; Segovia, Javier ; Pino, Luis ; Lobatón, José ; González, Manuel ; Cuello, Javier ; Bogoya, Juliana ; Barrero, Angela ; de Lima Lopes Jr, Gilberto

INTRODUCTION : The ACHOCC-19 study was performed to characterize COVID-19 infection in our oncological population. METHODOLOGY : Analytical cohort study of patients with cancer and COVID-19 infection in Colombia. From April 1 to October 31, 2020. Demographic and clinical variables related to cancer and COVID-19 infection were collected. The primary outcome was 30-day mortality from all causes. The association between the outcome and the prognostic variables was analyzed using logistic [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

“Every day is just kind of weighing my options.” Perspectives of young adult cancer survivors dealing with the uncertainty of the COVID-19 global pandemic

Shay, L. Aubree ; Allicock, Marlyn ; Li, Amanda

Purpose : We explored adolescent and young adult cancer survivor (AYA) experiences with COVID-19 to understand the impact of living through a pandemic, unmet needs, and coping strategies. Methods : AYAs were recruited nationally, completed an online survey, and attended one of six online focus groups. We used qualitative content analysis to analyze focus group data. Results : Thirty-nine AYAs completed the survey, and 24 also participated in the focus groups. In the survey, AYAs responded that [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Seroconversion rates following COVID-19 vaccination amongst patients with cancer

Thakkar, Astha ; Gonzalez-Lugo, Jesus D. ; Goradia, Niyati ; Gali, Radhika ; Shapiro, Lauren C. ; Pradhan, Kith ; Rahman, Shafia ; Kim, So Yeon ; Ko, Brian ; Sica, R. Alejandro ; Kornblum, Noah ; Bachier-Rodriguez, Lizamarie ; McCort, Margaret ; Goel, Sanjay ; Perez-Soler, Roman ; Packer, Stuart ; Sparano, Joseph ; Gartrell, Benjamin ; Makower, Della ; Goldstein, Yitz D. ; Wolgast, Lucia ; Verma, Amit ; Halmos, Balazs

As COVID-19 adversely affects patients with cancer, prophylactic strategies are critically needed. Using a validated antibody assay against SARS-CoV-2 spike protein, we determined a high seroconversion rate (94%) in 200 patients with cancer in New York City that had received full dosing with one of the FDA-approved COVID-19 vaccines. Comparing to solid tumors (98%), a significantly lower rate of seroconversion was observed in patients with hematological malignancies (85%), particularly [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Attitudes and Factors Associated With COVID-19 Vaccine Hesitancy Among Patients With Breast Cancer

Villarreal-Garza, Cynthia ; Vaca-Cartagena, Bryan F. ; Becerril-Gaitan, Andrea ; Ferrigno, Ana S. ; Mesa-Chavez, Fernanda ; Platas, Alejandra ; Platas, Ana

The COVID-19 pandemic has had a substantial effect on cancer care.1 The recent widespread availability of vaccines against SARS-CoV-2 is a promising strategy to prevent COVID-19–associated mortality. However, previous reports have shown a high hesitancy rate to receive a COVID-19 vaccine among oncologic patients.2,3 Because breast cancer is the most commonly diagnosed malignant neoplasm,4 it is imperative to evaluate the specific concerns regarding COVID-19 vaccination among patients with this [...]

Mené au Canada et en Australie sur 229 patients adultes présentant des métastases vertébrales douloureuses (durée médiane de suivi : 6,7 mois), cet essai randomisé de phase II/III évalue l'efficacité, du point de vue de la réduction de la douleur, et la toxicité d'une radiothérapie corporelle stéréotaxique par rapport à une radiothérapie externe conventionnelle

Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial

Sahgal, Arjun ; Myrehaug, Sten D. ; Siva, Shankar ; Masucci, Giuseppina L. ; Maralani, Pejman J. ; Brundage, Michael ; Butler, James ; Chow, Edward ; Fehlings, Michael G. ; Foote, Mathew ; Gabos, Zsolt ; Greenspoon, Jeffrey ; Kerba, Marc ; Lee, Young ; Liu, Mitchell ; Liu, Stanley K. ; Thibault, Isabelle ; Wong, Rebecca K. ; Hum, Maaike ; Ding, Keyue ; Parulekar, Wendy R.

Background : Conventional external beam radiotherapy is the standard palliative treatment for spinal metastases; however, complete response rates for pain are as low as 10–20%. Stereotactic body radiotherapy delivers high-dose, ablative radiotherapy. We aimed to compare complete response rates for pain after stereotactic body radiotherapy or conventional external beam radiotherapy in patients with painful spinal metastasis. Methods : This open-label, multicentre, randomised, controlled, phase [...]

Mené au Canada et en Australie sur 229 patients adultes présentant des métastases vertébrales douloureuses (durée médiane de suivi : 6,7 mois), cet essai randomisé de phase II/III évalue l'efficacité, du point de vue de la réduction de la douleur, et la toxicité d'une radiothérapie corporelle stéréotaxique par rapport à une radiothérapie externe conventionnelle

Spinal stereotactic radiotherapy for painful spinal metastasis

van der Velden, Joanne M. ; van der Linden, Yvette M.

Conventional external beam radiotherapy is the standard of care for patients with cancer who have localised metastatic bone pain. Pain response is reported as a combination of complete (defined as a pain score of 0 on an 11-point scale of 0–10) and partial (defined as a reduction of