Menée sur 88 patients atteints d'un cancer gastrointestinal, cette étude analyse l'effet de massages thérapeutiques pour soulager leur fatigue induite par la chimiothérapie

The effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients

Alizadeh, Javad ; Yeganeh, Mohammad Reza ; Pouralizadeh, Moluk ; Roushan, Zahra Atrkar ; Gharib, Cyrus ; Khoshamouz, Sara

Introduction : Gastrointestinal cancer patients undergoing chemotherapy usually suffer from fatigue, which may affect different aspects of their lives. Objective : The current study aimed to investigate the effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients. Method : In this quasi-experimental study, 88 gastrointestinal cancer patients were randomly allocated into two groups of intervention and control. Patients received the chemotherapy for 3 h. The [...]

Menée à partir des données des registres américains des cancers portant sur 1 214 patients âgés ayant survécu à un cancer (sein, prostate, côlon-rectum), cette étude analyse leur fatigue avant et après le diagnostic de la maladie

Trajectories of fatigue in a population-based sample of older adult breast, prostate, and colorectal cancer survivors: an analysis using the SEER-MHOS data resource

Byrne, Morgan ; Leiser, Jaclyn ; Mitchell, Sandra A. ; Kent, Erin E. ; Siembida, Elizabeth J. ; Somers, Tamara ; Arem, Hannah

Purpose : Fatigue is one of the most common and distressing symptoms experienced by cancer survivors. Understanding fatigue trajectories from pre- to post-diagnosis could inform fatigue prevention and management strategies. Methods : We used the Surveillance, Epidemiology and End Results Medicare Health Outcomes Survey (SEER-MHOS) linked data resource to characterize fatigue trajectories and their predictors 1214 older adult survivors of breast, colorectal, or prostate cancer. Fatigue was [...]

Menée aux Etats-Unis à partir de données portant sur 214 505 participants dont 6 259 patients ayant survécu à un cancer, cette étude analyse leur utilisation de cannabis

Prevalence of cannabis use among individuals with a history of cancer in the United States

Cousins, Matthew M. ; Jannausch, Mary L. ; Coughlin, Lara N. ; Jagsi, Reshma ; Ilgen, Mark A.

Background : Patients with cancer have played a key role in advocating for legal access to cannabis, but little is known about links between cancer and cannabis use or cannabis-related beliefs. The authors used data from a national survey to study these relationships. Methods : Nationally representative data collected by the National Survey on Drug Use and Health from 2015 to 2019 were acquired. Patterns of cannabis use and cancer history were examined and tested within age group subpopulations [...]

Menée auprès de 100 patients atteints d'un cancer traité par chimiothérapie ou immunothérapie, cette étude analyse les altérations du goût, les troubles de la déglutition et l'inconfort au niveau de la cavité buccale en lien avec les traitements anticancéreux

Taste alterations and oral discomfort in patients receiving chemotherapy

Larsen, Anne Kathrine ; Thomsen, Christine ; Sanden, Mathilde ; Skadhauge, Lotte Boa ; Anker, Camilla Bundgaard ; Mortensen, Marie Nerup ; Bredie, Wender L. P.

Purpose : Taste alterations (TA) and oral discomfort in cancer patients are neglected side effects of the disease and treatments. They contribute to poor appetite, decrease food intake and affect quality of life, leading to adverse outcomes such as malnutrition and depression. The study aimed to explore TAs in relation to other oral conditions causing discomfort in cancer patients. Additionally, the correlation between patients’ acidity of saliva and experienced TAs and oral discomfort was [...]

Menée aux Etats-Unis à partir de données portant sur 5 044 témoins et sur 25 583 patients ayant survécu à un cancer diagnostiqué pendant l'enfance, cette étude analyse la présence de dysfonctionnements neuromusculaires associés aux traitements anticancéreux

Longitudinal evaluation of neuromuscular dysfunction in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Rodwin, Rozalyn L. ; Chen, Yan ; Yasui, Yutaka ; Leisenring, Wendy M. ; Gibson, Todd M. ; Nathan, Paul C. ; Howell, Rebecca M. ; Krull, Kevin R. ; Mohrmann, Caroline ; Hayashi, Robert J. ; Chow, Eric J ; Oeffinger, Kevin C. ; Armstrong, Gregory T. ; Ness, Kirsten K. ; Kadan-Lottick, Nina S

Background: Children treated for cancer are at risk for neuromuscular dysfunction, but data are limited regarding prevalence, longitudinal patterns, and long-term impact. Methods: Longitudinal surveys from 25,583 childhood cancer survivors {greater than or equal to}5 years from diagnosis and 5,044 siblings from the Childhood Cancer Survivor Study were used to estimate the prevalence and cumulative incidence of neuromuscular dysfunction. Multivariable models adjusted for age, sex, race, and [...]

Menée en Allemagne auprès de 1 026 patients atteints d'un cancer, cette étude analyse l'intérêt d'un outil permettant d'identifier les facteurs associés aux troubles du sommeil et à la sévérité d'une insomnie

Assessment of sleep problems with the Insomnia Severity Index (ISI) and the sleep item of the Patient Health Questionnaire (PHQ-9) in cancer patients

Schulte, Thomas ; Hofmeister, Dirk ; Mehnert-Theuerkauf, Anja ; Hartung, Tim ; Hinz, Andreas

Objective : The objectives of this study were to examine sleep problems in cancer patients, to test the psychometric properties of the Insomnia Sleep Index (ISI) in comparison with the sleep item of the Patient Health Questionnaire-9 (PHQ-9), and to analyze disrupting factors which might cause the sleep problems. Methods : A sample of 1026 mixed-site cancer patients in treatment at a German oncological rehabilitation clinic was examined. Results : The reliability of the ISI was very good [...]

Mené sur 30 patients atteints d'un cancer de stade IV, cet essai randomisé évalue l'intérêt du cannabis thérapeutique pour soulager la douleur et réduire l'utilisation des opioïdes

A randomized trial of medical cannabis in patients with stage IV cancers to assess feasibility, dose requirements, impact on pain and opioid use, safety, and overall patient satisfaction

Zylla, Dylan M. ; Eklund, Justin ; Gilmore, Grace ; Gavenda, Alissa ; Guggisberg, Jordan ; VazquezBenitez, Gabriela ; Pawloski, Pamala A. ; Arneson, Tom ; Richter, Sara ; Birnbaum, Angela K. ; Dahmer, Stephen ; Tracy, Matthew ; Dudek, Arkadiusz

Purpose : The prevalence of medical cannabis (MC) use in patients with cancer is growing, but questions about safety, efficacy, and dosing remain. Conducting randomized, controlled trials (RCTs) using state-sponsored MC programs is novel and could provide data needed to guide patients and providers. Methods : A pilot RCT of patients with stage IV cancer requiring opioids was conducted. Thirty patients were randomized 1:1 to early cannabis (EC, n = 15) versus delayed start cannabis (DC, n = 15). [...]

Mené sur 100 patients atteints d'un cancer du poumon à petites cellules traité par chimiothérapie à base de sels de platine, cet essai randomisé évalue l'intérêt d'une intervention de musicothérapie en 6 étapes pour améliorer la qualité du sommeil, soulager la douleur et les symptômes d'anxiété

The efficacy of music therapy to relieve pain, anxiety, and promote sleep quality, in patients with small cell lung cancer receiving platinum-based chemotherapy

Tang, Haoke ; Chen, Liping ; Wang, Yichun ; Zhang, Yongchang ; Yang, Nong ; Yang, Ning

Purpose : Chemotherapy induces a range of physical and psychological symptoms, including pain, sleep disorders, fatigue, and anxiety. We aimed to assess the efficacy of six-step music therapy in relieving pain and anxiety and improving sleep quality in lung cancer patients receiving platinum-based chemotherapy. Methods : Between March 2013 and October 2015, we enrolled a total of 100 patients who were diagnosed with small cell lung cancer and scheduled for platinum-based chemotherapy. Patients [...]

Menée aux Etats-Unis sur la période 1959-2017 à partir de données portant sur une cohorte d'astronautes, cette étude analyse l'évolution de l'incidence des cancers et la mortalité spécifique dans cette population

Cancer incidence and mortality in the USA Astronaut Corps, 1959–2017

Reynolds, Robert ; Little, Mark P ; Day, Steven ; Charvat, Jacqueline ; Blattnig, Steven ; Huff, Janice ; Patel, Zarana S

Objectives : Cancer incidence and mortality are important outcomes in the surveillance of long-term astronaut health. We compare cancer incidence rates, cancer-specific mortality rates, and cancer case-fatality ratios in US astronauts with those in the US general population. Methods : We use standardised incidence ratios (SIRs) and standardised mortality ratios (SMRs) to index the incidence and mortality of various cancers against rates in the US general population, from the US astronaut cohort [...]

Menée à partir des données des registres américains des cancers portant sur 1 733 906 patients atteints d'un cancer, cette étude de cohorte rétrospective analyse l'association entre le statut marital, le stade au diagnostic et la survie spécifique

Assessment of Modifiable Factors for the Association of Marital Status With Cancer-Specific Survival

Chen, Zi-Hang ; Yang, Kai-Bin ; Zhang, Yuan-zhe ; Wu, Chen-Fei ; Wen, Dan-Wan ; Lv, Jia-Wei ; Zhu, Guang-Li ; Du, Xiao-Jing ; Chen, Lei ; Zhou, Guan-Qun ; Liu, Qing ; Sun, Ying ; Ma, Jun ; Xu, Cheng ; Lin, Li

Importance : Married patients with cancer have better cancer-specific survival than unmarried patients. Increasing the early diagnosis and definitive treatment of cancer among unmarried patients may reduce the survival gap. Objectives : To evaluate the extent to which marriage is associated with cancer-specific survival, stage at diagnosis, and treatment among patients with 9 common solid cancers and to recommend methods for reducing the survival gap. Design, Setting, and Participants : This [...]

Menée aux Etats-Unis par enquête sur la période 2003-2014 auprès de 32 238 participants, cette étude analyse l'association entre une polypharmacie et les interactions médicamenteuses chez les patients ayant survécu à un cancer (1 899 cas)

Polypharmacy and medication use by cancer history in a nationally representative group of adults in the USA, 2003–2014

Hsu, Christine D. ; Nichols, Hazel B. ; Lund, Jennifer L.

Purpose : This study examines polypharmacy and prescription drug use patterns in cancer survivors, a growing population at risk for cancer sequelae and side effects from treatment, which can arise months or even years following diagnosis. Survivors may experience greater medication burden than the general population, increasing concerns for polypharmacy and subsequent risks of drug interactions and non-adherence. Methods : Using the National Health and Nutrition Examination Survey (NHANES) data [...]

Menée à partir des données des registres américains des cancers sur la période 2000-2015, cette étude analyse l'impact, sur la survie, du statut socioéconomique et de l'origine ethnique chez des patients atteints d'un myélome multiple

Differences in survival among multiple myeloma patients in the United States SEER population by neighborhood socioeconomic status and race/ethnicity

Castañeda-Avila, Maira A. ; Jesdale, Bill M. ; Beccia, Ariel ; Bey, Ganga S. ; Epstein, Mara M.

Purpose : We examined the combined influences of race/ethnicity and neighborhood socioeconomic status (SES) on long-term survival among patients with multiple myeloma (MM). Methods : Data from the 2000–2015 NCI Surveillance, Epidemiology, and End Results Program (SEER-18) were used. Census tract-level SES index was assessed in tertiles (low, medium, high SES). Competing-risk modeling was used to estimate sub-hazard ratios (SHR) and 95% confidence intervals (CIs) for SES tertile adjusted for sex [...]

Menée aux Etats-Unis à partir de données portant sur 1 891 patientes afro-américaines ayant survécu à un cancer du sein, cette étude de cohorte prospective analyse l'association entre des mesures de l'adiposité (indice de masse corporelle, distribution de la graisse corporelle, composition corporelle, etc.) et la mortalité spécifique ou toutes causes confondues

Association of Body Mass Index, Central Obesity, and Body Composition With Mortality Among Black Breast Cancer Survivors

Bandera, Elisa V. ; Qin, Bo ; Lin, Yong ; Zeinomar, Nur ; Xu, Baichen ; Chanumolu, Dhanya ; Llanos, Adana A. M. ; Omene, Coral O. ; Pawlish, Karen S. ; Ambrosone, Christine B. ; Demissie, Kitaw ; Hong, Chi-Chen

Importance : Obesity disproportionately affects Black women, who also have a higher risk of death after a breast cancer diagnosis compared with women of other racial/ethnic groups. However, few studies have evaluated the association of measures of adiposity with mortality among Black breast cancer survivors. Objective : To assess the association of measures of adiposity with survival after a breast cancer diagnosis among Black women. Design, Setting, and Participants : This prospective [...]

Menée sur la période 1978-2016, cette étude analyse l'évolution, en France et aux Etats-Unis, de l'association entre la fertilité et le risque de cancer du sein, en fonction de groupes d'âge (inférieur à 50 ans, 50-64 ans et supérieur ou égal à 65 ans)

Effects of fertility on breast cancer incidence trends: comparing France and US

Bellanger, Martine ; Lima, Sarah M. ; Cowppli-Bony, Anne ; Molinié, Florence ; Terry, Mary Beth

Purpose : Breast cancer incidence rates are now higher in France than most other European countries as well as the United States (US). Increasing breast cancer incidence rates globally have often been attributed to declining fertility rates. Methods : We compared temporal trends in breast cancer incidence in France and the US, and examined the extent temporal trends in national fertility rates can explain the temporal trends in breast cancer incidence. This study of temporal trends used [...]

Menée aux Etats-Unis à partir de données portant sur 29 233 patientes atteintes d'un cancer, cette étude analyse, en fonction de l'origine ethnique, la prévalence de variants constitutionnels de 12 gènes de susceptibilité à la maladie

Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States

Domchek, Susan M. ; Yao, Song ; Chen, Fei ; Hu, Chunling ; Hart, Steven N. ; Goldgar, David E. ; Nathanson, Katherine L. ; Ambrosone, Christine B. ; Haiman, Christopher A. ; Couch, Fergus J. ; Polley, Eric C. ; Palmer, Julie R. ; CARRIERS Consortium

Importance : The prevalence of germline pathogenic variants (PVs) in cancer susceptibility genes in US Black women compared with non-Hispanic White women with breast cancer is poorly described. Objective : To determine whether US Black and non-Hispanic White women with breast cancer have a different prevalence of PVs in 12 cancer susceptibility genes. Design, Setting, and Participants : Multicenter, population-based studies in the Cancer Risk Estimates Related to Susceptibility (CARRIERS) [...]

Menée en Angleterre à partir de données portant sur 243 patientes atteintes d'un cancer du col de l'utérus (âge médian : 49 ans), cette étude analyse l'association entre des indicateurs socioéconomiques liés à la pauvreté et la récidive de la maladie ou la mortalité

The impact of socioeconomic deprivation on mortality in cervical cancer patients in Cornwall (England)

Donkers, Hannah ; McGrane, John ; Eleuteri, Antonio ; Giamougiannis, Panagiotis ; Bekkers, Ruud ; Galaal, Khadra

Objectives : To assess the association between risk factors, including socioeconomic deprivation, and mortality, recurrence and chemo- or radiation toxicity in cervical cancer patients. Methods : Retrospective study of cervical cancer patients diagnosed between January 2007 and July 2018. Patient characteristics and mortality data, including recurrence, were assessed, together with socioeconomic deprivation measures evaluated using the English Indices of Multiple Deprivation. Markov multi-state [...]

Menée aux Etats-Unis auprès de 44 aidants familiaux d'enfants atteints d'un cancer, cette étude transversale analyse les facteurs associés à leur détresse psychologique pendant la première année des traitements anticancéreux

Family rules, routines, and caregiver distress during the first year of pediatric cancer treatment

Bates, Carolyn R. ; Pallotto, Isabella K. ; Moore, Rachel M. ; Fornander, Mirae J. ; Covitz, Lynne M. ; Dreyer Gillette, Meredith L.

Objective : A new diagnosis of pediatric cancer may disrupt family functioning. The current study aimed to describe changes in family rules and routines during the first year of pediatric cancer treatment, and to explore associations with demographics, illness factors, and caregiver distress. Methods : This exploratory mixed-methods, cross-sectional study examined 44 primary caregivers of youth in treatment for a new cancer diagnosis in 2019 and 2020, before the onset of the COVID-19 pandemic. [...]

Menée aux Etats-Unis auprès de 112 aidants familiaux de patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre leurs capacités de résilience, leur aptitude à prendre des décisions et leur détresse psychologique

Resilience, preparedness, and distress among family caregivers of patients with advanced cancer

Dionne-Odom, J. Nicholas ; Azuero, Andres ; Taylor, Richard A. ; Wells, Rachel D. ; Hendricks, Bailey A. ; Bechthold, Avery C. ; Reed, Rhiannon D. ; Harrell, Erin R. ; Dosse, Chinara K. ; Engler, Sally ; McKie, Peggy ; Ejem, Deborah ; Bakitas, Marie A. ; Rosenberg, Abby R.

Objective : Resilience has been proposed as a primary factor in how many family caregivers of patients with advanced cancer are able to resist psychological strain and perform effectively in the role while bearing a high load of caregiving tasks. To evaluate this hypothesis, we examined whether self-perceived resilience is associated with distress (anxiety and depressive symptoms), caregiver preparedness, and readiness for surrogate decision-making among a racially diverse sample of family [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2021, cette étude identifie les facteurs associés au comportement social des adolescents et jeunes adultes atteints d'un cancer

Determinants of social functioning among adolescents and young adults with cancer: a systematic review

Schilstra, Clarissa E. ; Fardell, Joanna E. ; Burns, Mary A. ; Ellis, Sarah J. ; Anazodo, Antoinette C. ; Trahair, Toby N. ; Sansom-Daly, Ursula M.

Objectives : Survivors of adolescent and young adult (AYA) cancer report deficits in social functioning relative to healthy peers. Identifying factors related to their social functioning is critical to improve their long-term social outcomes. This review addressed: (1) How is social functioning defined and measured among studies of AYAs who have had cancer? (2) What factors have quantitatively/qualitatively are associated with/predictors of social functioning? And (3) What associated [...]

Menée à partir de données portant sur 2 211 patients atteints d'un cancer du système nerveux périphérique, cette étude de cohorte analyse leurs fonctions cognitives, avant et après le diagnostic de la maladie

Change in cognition before and after non-central nervous system cancer diagnosis: A population-based cohort study

van der Willik, Kimberly D. ; Jóźwiak, Katarzyna ; Hauptmann, Michael ; van de Velde, Edolie E.D. ; Compter, Annette ; Ruiter, Rikje ; Stricker, Bruno H. ; Ikram, M. Arfan ; Schagen, Sanne B.

Objective : Clinical studies showing that non-central nervous system cancer patients can develop cognitive impairment have primarily focused on patients with specific cancer types and intensive treatments. To better understand the course of cognitive function in the general population of cancer patients, we assessed cognitive trajectories of patients before and after cancer diagnosis in a population-based setting. Methods : Between 1989 and 2014, 2211 participants from the population-based [...]

Menée au Royaume-Uni à partir de données portant sur 8 438 patientes ayant survécu à un cancer du sein, cette étude de cohorte transversale analyse l'association entre des morbidités et une dépression

Associations between multimorbidity and depression among breast cancer survivors within the UK Biobank cohort: a cross-sectional study

Foster, Murray ; Niedzwiedz, Claire L.

Background : Advances in the early detection of cancer and its treatment have resulted in an increasing number of people living with and beyond breast cancer. Multimorbidity is also becoming more common in this population as more people live longer with breast cancer and experience late effects of cancer treatment. Breast cancer survivors have heightened risk of depression, but to what extent multimorbidity affects the mental health of this population is less clear. This study aims to [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2020, cette étude fait le point sur les coûts associés aux traitements et soins des patientes atteintes d'un cancer du sein dans les pays à faible et moyen revenu

Economic Evaluations of Breast Cancer Care in Low- and Middle-Income Countries: A Scoping Review

Erfani, Parsa ; Bhangdia, Kayleigh ; Stauber, Catherine ; Mugunga, Jean Claude ; Pace, Lydia E. ; Fadelu, Temidayo

Background : Understanding the cost of delivering breast cancer (BC) care in low- and middle-income countries (LMICs) is critical to guide effective care delivery strategies. This scoping review summarizes the scope of literature on the costs of BC care in LMICs and characterizes the methodological approaches of these economic evaluations. Materials and Methods : A systematic literature search was performed in five databases and gray literature up to March 2020. Studies were screened to [...]

Menée au Canada à partir de données portant sur 7 122 adolescents et jeunes adultes décédés d'un cancer entre 2000 et 2017, cette étude de cohorte analyse les facteurs associés à l'intensité des soins de fin de vie et à l'utilisation des soins palliatifs

Impact of Palliative Care Involvement on End-of-Life Care Patterns Among Adolescents and Young Adults With Cancer: A Population-Based Cohort Study

Alisha Kassam ; Abha Gupta ; Adam Rapoport ; Amirrtha Srikanthan ; Rinku Sutradhar ; Jin Luo ; Kimberley Widger ; Joanne Wolfe ; Craig Earle ; Sumit Gupta

PURPOSE : Evidence suggests that adolescents and young adults (AYAs) with cancer (defined as age 15-39 years) receive high-intensity (HI) medical care at the end-of-life (EOL). Previous population-level studies are limited and lack information on the impact of palliative care (PC) provision. We evaluated prevalence and predictors of HI-EOL care in AYAs with cancer in Ontario, Canada. A secondary aim was to evaluate the impact of PC physicians on the intensity of EOL care in AYAs. METHODS : A [...]

Menée aux Etats-Unis, cette étude analyse les relations financières entre les oncologues médicaux participant aux comités d'élaboration des recommandations de pratique clinique (54 médecins) et l'industrie pharmaceutique

Personal Payments from Pharmaceutical Companies to Authors of Oncology Clinical Practice Guidelines

Mitchell, Aaron P. ; Mishra, Akriti ; Dey, Pranam ; Curry, Michael A. ; Trivedi, Niti U. ; Haddadin, Michael ; Rahman, Mohammed W. ; Winn, Aaron N. ; Dusetzina, Stacie B. ; Bach, Peter B.

Background : Oncologists who author clinical practice guidelines frequently have financial relationships with the pharmaceutical industry. It is unknown whether participation on clinical practice guideline committees is associated with differences in the amounts of industry money received. Materials and Methods : We conducted a nested case-control study from August 2013 to December 2018. We manually abstracted membership records of National Comprehensive Cancer Network (NCCN) Guidelines [...]