Menée à partir des données 1990-2019 de 3 625 enquêtes réalisées dans 204 pays, cette étude analyse la prévalence du tabagisme et la part des maladies attribuable au tabac, en fonction de l'âge et du sexe

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Reitsma, Marissa B. ; Kendrick, Parkes J. ; Ababneh, Emad ; Abbafati, Cristiana ; Abbasi-Kangevari, Mohsen ; Abdoli, Amir ; Abedi, Aidin ; Abhilash, E. S. ; Abila, Derrick Bary ; Aboyans, Victor ; Abu-Rmeileh, Niveen M. E. ; Adebayo, Oladimeji M. ; Advani, Shailesh M. ; Aghaali, Mohammad ; Ahinkorah, Bright Opoku ; Ahmad, Sohail ; Ahmadi, Keivan ; Ahmed, Haroon ; Aji, Budi ; Akunna, Chisom Joyqueenet ; Al-Aly, Ziyad ; Alanzi, Turki M. ; Alhabib, Khalid F. ; Ali, Liaqat ; Alif, Sheikh Mohammad ; Alipour, Vahid ; Aljunid, Syed Mohamed ; Alla, Francois ; Allebeck, Peter ; Alvis-Guzman, Nelson ; Amin, Tarek Tawfik ; Amini, Saeed ; Amu, Hubert ; Amul, Gianna Gayle Herrera ; Ancuceanu, Robert ; Anderson, Jason A. ; Ansari-Moghaddam, Alireza ; Antonio, Carl Abelardo T. ; Antony, Benny ; Anvari, Davood ; Arabloo, Jalal ; Arian, Nicholas D. ; Arora, Monika ; Asaad, Malke ; Ausloos, Marcel ; Awan, Asma Tahir ; Ayano, Getinet ; Aynalem, Getie Lake ; Azari, Samad ; B, Darshan B. ; Badiye, Ashish D. ; Baig, Atif Amin ; Bakhshaei, Mohammad Hossein ; Banach, Maciej ; Banik, Palash Chandra ; Barker-Collo, Suzanne Lyn ; Bärnighausen, Till Winfried ; Barqawi, Hiba Jawdat ; Basu, Sanjay ; Bayati, Mohsen ; Bazargan-Hejazi, Shahrzad ; Behzadifar, Masoud ; Bekuma, Tariku Tesfaye ; Bennett, Derrick A. ; Bensenor, Isabela M. ; Berfield, Kathleen S. Sachiko ; Bhagavathula, Akshaya Srikanth ; Bhardwaj, Nikha ; Bhardwaj, Pankaj ; Bhattacharyya, Krittika ; Bibi, Sadia ; Bijani, Ali ; Bintoro, Bagas Suryo ; Biondi, Antonio ; Birara, Setognal ; Braithwaite, Dejana ; Brenner, Hermann ; Brunoni, Andre R. ; Burkart, Katrin ; Butt, Zahid A. ; Caetano dos Santos, Florentino Luciano ; Cámera, Luis Alberto ; Car, Josip ; Cárdenas, Rosario ; CARRERAS, Giulia ; Carrero, Juan J. ; Castaldelli-Maia, Joao Mauricio ; Cattaruzza, Maria Sofia Sofia ; Chang, Jung-Chen ; Chen, Simiao ; Chu, Dinh-Toi ; Chung, Sheng-Chia ; Cirillo, Massimo ; Costa, Vera Marisa ; Couto, Rosa A. S. ; Dadras, Omid ; Dai, Xiaochen ; Damasceno, Albertino Antonio Moura ; Damiani, Giovanni ; Dandona, Lalit ; Dandona, Rakhi ; Daneshpajouhnejad, Parnaz ; Darega Gela, Jiregna ; Davletov, Kairat ; Derbew Molla, Meseret ; Dessie, Getenet Ayalew ; Desta, Abebaw Alemayehu ; Dharmaratne, Samath Dhamminda ; Dianatinasab, Mostafa ; Diaz, Daniel ; Do, Hoa Thi ; Douiri, Abdel ; Duncan, Bruce B. ; Duraes, Andre Rodrigues ; Eagan, Arielle Wilder ; Ebrahimi Kalan, Mohammad ; Edvardsson, Kristina ; Elbarazi, Iffat ; El Tantawi, Maha ; Esmaeilnejad, Saman ; Fadhil, Ibtihal ; Faraon, Emerito Jose A. ; Farinha, Carla Sofia e Sa ; Farwati, Medhat ; Farzadfar, Farshad ; Fazlzadeh, Mehdi ; Feigin, Valery L. ; Feldman, Rachel ; Fernandez Prendes, Carlota ; Ferrara, Pietro ; Filip, Irina ; Filippidis, Filippos ; Fischer, Florian ; Flor, Luisa Sorio ; Foigt, Nataliya A. ; Folayan, Morenike Oluwatoyin ; Foroutan, Masoud ; Gad, Mohamed M. ; Gaidhane, Abhay Motiramji ; GALLUS, Silvano ; Geberemariyam, Biniyam Sahiledengle ; Ghafourifard, Mansour ; Ghajar, Alireza ; Ghashghaee, Ahmad ; Giampaoli, Simona ; Gill, Paramjit Singh ; Glozah, Franklin N. ; Gnedovskaya, Elena V. ; Golechha, Mahaveer ; Gopalani, Sameer Vali ; GORINI, Giuseppe ; Goudarzi, Houman ; Goulart, Alessandra C. ; Greaves, Felix ; Guha, Avirup ; Guo, Yuming ; Gupta, Bhawna ; Gupta, Rajat Das ; Gupta, Rajeev ; Gupta, Tarun ; Gupta, Vin ; Hafezi-Nejad, Nima ; Haider, Mohammad Rifat ; Hamadeh, Randah R. ; Hankey, Graeme J. ; Hargono, Arief ; Hartono, Risky Kusuma ; Hassankhani, Hadi ; Hay, Simon I. ; Heidari, Golnaz ; Herteliu, Claudiu ; Hezam, Kamal ; Hird, Thomas R. ; Hole, Michael K. ; Holla, Ramesh ; Hosseinzadeh, Mehdi ; Hostiuc, Sorin ; Househ, Mowafa ; Hsiao, Thomas ; Huang, Junjie ; Iannucci, Vincent C. ; Ibitoye, Segun Emmanuel ; Idrisov, Bulat ; Ilesanmi, Olayinka Stephen ; Ilic, Irena M. ; Ilic, Milena D. ; Inbaraj, Leeberk Raja ; Irvani, Seyed Sina Naghibi ; Islam, Jessica Y. ; Islam, Rakibul M. ; Islam, Sheikh Mohammed Shariful ; Islami, Farhad ; Iso, Hiroyasu ; Itumalla, Ramaiah ; Iwagami, Masao ; Jaafari, Jalil ; Jain, Vardhmaan ; Jakovljevic, Mihajlo ; Jang, Sung-In ; Janjani, Hosna ; Jayaram, Shubha ; Jeemon, Panniyammakal ; Jha, Ravi Prakash ; Jonas, Jost B. ; Joo, Tamas ; Jürisson, Mikk ; Kabir, Ali ; Kabir, Zubair ; Kalankesh, Leila R. ; Kanchan, Tanuj ; Kandel, Himal ; Kapoor, Neeti ; Karimi, Salah Eddin ; Katikireddi, Srinivasa Vittal ; Kebede, Hafte Kahsay ; Kelkay, Bayew ; Kennedy, Ryan David ; Khoja, Abdullah T. ; Khubchandani, Jagdish ; Kim, Gyu Ri ; Kim, Young-Eun ; Kimokoti, Ruth W. ; Kivimäki, Mika ; Kosen, Soewarta ; Koulmane Laxminarayana, Sindhura Lakshmi ; Koyanagi, Ai ; Krishan, Kewal ; Kugbey, Nuworza ; Kumar, G. Anil ; Kumar, Nithin ; Kurmi, Om P. ; Kusuma, Dian ; Lacey, Ben ; Lam, Jennifer O. ; Landires, Iván ; Lasrado, Savita ; Lauriola, Paolo ; Lee, Doo Woong ; Lee, Yo Han ; Leung, Janni ; Li, Shanshan ; Lin, Hualiang ; Linn, Shai ; Liu, Wei ; Lopez, Alan D. ; Lopukhov, Platon D. ; Lorkowski, Stefan ; Lugo, Alessandra ; Majeed, Azeem ; Maleki, Afshin ; Malekzadeh, Reza ; Malta, Deborah Carvalho ; Mamun, Abdullah A. ; Manjunatha, Narayana ; Mansouri, Borhan ; Mansournia, Mohammad Ali ; Martinez-Raga, Jose ; Martini, Santi ; Mathur, Manu Raj ; Medina-Solís, Carlo Eduardo ; Mehata, Suresh ; Mendoza, Walter ; Menezes, Ritesh G. ; Meretoja, Atte ; Meretoja, Tuomo J. ; Miazgowski, Bartosz ; Michalek, Irmina Maria ; Miller, Ted R. ; Mirrakhimov, Erkin M. ; Mirzaei, Hamed ; Mirzaei-Alavijeh, Mehdi ; Misra, Sanjeev ; Moghadaszadeh, Masoud ; Mohammad, Yousef ; Mohammadian-Hafshejani, Abdollah ; Mohammed, Shafiu ; Mokdad, Ali H. ; Monasta, Lorenzo ; Moni, Mohammad Ali ; Moradi, Ghobad ; Moradi-Lakeh, Maziar ; Moradzadeh, Rahmatollah ; Morrison, Shane Douglas ; Mossie, Tilahun Belete ; Mubarik, Sumaira ; Mullany, Erin C. ; Murray, Christopher J. L. ; Naghavi, Mohsen ; Naghshtabrizi, Behshad ; Nair, Sanjeev ; Nalini, Mahdi ; Nangia, Vinay ; Naqvi, Atta Abbas ; Narasimha Swamy, Sreenivas ; Naveed, Muhammad ; Nayak, Smitha ; Nayak, Vinod C. ; Nazari, Javad ; Nduaguba, Sabina O. ; Neupane Kandel, Sandhya ; Nguyen, Cuong Tat ; Nguyen, Huong Lan Thi ; Nguyen, Son Hoang ; Nguyen, Trang Huyen ; Nixon, Molly R. ; Nnaji, Chukwudi A. ; Norrving, Bo ; Noubiap, Jean Jacques ; Nowak, Christoph ; Ogbo, Felix Akpojene ; Oguntade, Ayodipupo Sikiru ; Oh, In-Hwan ; Olagunju, Andrew T. ; Oren, Eyal ; Otstavnov, Nikita ; Otstavnov, Stanislav S. ; Owolabi, Mayowa O. ; P A, Mahesh ; Pakhale, Smita ; Pakshir, Keyvan ; Palladino, Raffaele ; Pan, Liping ; Pana, Adrian ; Panda-Jonas, Songhomitra ; Pandey, Ashok ; Parekh, Utsav ; Park, Eun-Cheol ; Park, Eun-Kee ; Pashazadeh Kan, Fatemeh ; Patton, George C. ; Pawar, Shrikant ; Pestell, Richard G. ; Pinheiro, Marina ; Piradov, Michael A. ; Pirouzpanah, Saeed ; Pokhrel, Khem Narayan ; Polibin, Roman V. ; Prashant, Akila ; Pribadi, Dimas Ria Angga ; Radfar, Amir ; Rahimi-Movaghar, Vafa ; Rahman, Azizur ; Rahman, Mohammad Hifz Ur ; Rahman, Muhammad Aziz ; Rahmani, Amir Masoud ; Rajai, Nazanin ; Ram, Pradhum ; Ranabhat, Chhabi Lal ; Rathi, Priya ; Rawal, Lal ; Renzaho, Andre M. N. ; Reynales-Shigematsu, Luz Myriam ; Rezapour, Aziz ; Riahi, Seyed Mohammad ; Riaz, Mavra A. ; Roever, Leonardo ; Ronfani, Luca ; Roshandel, Gholamreza ; Roy, Ambuj ; Roy, Bedanta ; Sacco, Simona ; Saddik, Basema ; Sahebkar, Amirhossein ; Salehi, Sana ; Salimzadeh, Hamideh ; Samaei, Mehrnoosh ; Samy, Abdallah M. ; Santos, Itamar S. ; Santric-Milicevic, Milena M. ; Sarrafzadegan, Nizal ; Sathian, Brijesh ; Sawhney, Monika ; Saylan, Mete ; Schaub, Michael P. ; Schmidt, Maria Inês ; Schneider, Ione Jayce Ceola ; Schutte, Aletta Elisabeth ; Schwendicke, Falk ; Seidu, Abdul-Aziz ; Senthil Kumar, Nachimuthu ; Sepanlou, Sadaf G. ; Seylani, Allen ; Shafaat, Omid ; Shah, Syed Mahboob ; Shaikh, Masood Ali ; Shalash, Ali S. ; Shannawaz, Mohammed ; Sharafi, Kiomars ; Sheikh, Aziz ; Sheikhbahaei, Sara ; Shigematsu, Mika ; Shiri, Rahman ; Shishani, Kawkab ; Shivakumar, K. M. ; Shivalli, Siddharudha ; Shrestha, Roman ; Siabani, Soraya ; Sidemo, Negussie Boti ; Sigfusdottir, Inga Dora ; Sigurvinsdottir, Rannveig ; Silva, Diego Augusto Santos ; Silva, João Pedro ; Singh, Ambrish ; Singh, Jasvinder A. ; Singh, Virendra ; Sinha, Dhirendra Narain ; Sitas, Freddy ; Skryabin, Valentin Yurievich ; Skryabina, Anna Aleksandrovna ; Soboka, Matiwos ; Soriano, Joan B. ; Soroush, Ali ; Soshnikov, Sergey ; Soyiri, Ireneous N. ; Spurlock, Emma Elizabeth ; Sreeramareddy, Chandrashekhar T. ; Stein, Dan J. ; Steiropoulos, Paschalis ; Stortecky, Stefan ; Straif, Kurt ; Suliankatchi Abdulkader, Rizwan ; Sulo, Gerhard ; Sundström, Johan ; Tabuchi, Takahiro ; Tadakamadla, Santosh Kumar ; Taddele, Biruk Wogayehu ; Tadesse, Eyayou Girma ; Tamiru, Animut Tagele ; Tareke, Minale ; Tareque, Md Ismail ; Tarigan, Ingan Ukur ; Temsah, Mohamad-Hani ; Thankappan, Kavumpurathu Raman ; Thapar, Rekha ; Tichopad, Ales ; Tolani, Musliu Adetola ; Topouzis, Fotis ; Tovani-Palone, Marcos Roberto ; Tran, Bach Xuan ; Tripathy, Jaya Prasad ; Tsegaye, Gebiyaw Wudie ; Tsilimparis, Nikolaos ; Tymeson, Hayley D. ; Ullah, Anayat ; Ullah, Saif ; Unim, Brigid ; Updike, Rachel L. ; Vacante, Marco ; Valdez, Pascual R. ; Vardavas, Constantine ; Varona Pérez, Patricia ; Vasankari, Tommi Juhani ; Venketasubramanian, Narayanaswamy ; Verma, Madhur ; Vetrova, Marina V. ; Vo, Bay ; Vu, Giang Thu ; Waheed, Yasir ; Wang, Yanzhong ; Welding, Kevin ; Werdecker, Andrea ; Whisnant, Joanna L. ; Wickramasinghe, Nuwan Darshana ; Yamagishi, Kazumasa ; Yandrapalli, Srikanth ; Yatsuya, Hiroshi ; Yazdi-Feyzabadi, Vahid ; Yeshaw, Yigizie ; Yimmer, Mohammed Zewdu ; Yonemoto, Naohiro ; Yu, Chuanhua ; Yunusa, Ismaeel ; Yusefzadeh, Hasan ; Zahirian Moghadam, Telma ; Zaman, Muhammed Shahriar ; Zamanian, Maryam ; Zandian, Hamed ; Zar, Heather J. ; Zastrozhin, Mikhail Sergeevich ; Zastrozhina, Anasthasia ; Zavala-Arciniega, Luis ; Zhang, Jianrong ; Zhang, Zhi-Jiang ; Zhong, Chenwen ; Zuniga, Yves Miel H. ; Gakidou, Emmanuela

Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors [...]

Menée à partir des données 1990-2019 de 3 625 enquêtes réalisées dans 204 pays, cette étude analyse la prévalence du tabagisme et la part des maladies attribuable au tabac, en fonction de l'âge et du sexe

Tobacco control: all research, no action

Blum, Alan ; Eke, Ransome

In a sobering Article in The Lancet, the GBD 2019 Tobacco Collaborators 1 refine methods to estimate the increasing toll of tobacco-attributable morbidity and mortality. The authors analysed data on prevalence of smoking tobacco use from 204 countries and territories between 1990 and 2019, based on information from 3625 self-reported nationally representative surveys. Their analysis, the second to focus on tobacco in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), 2 [...]

Menée à l'aide de données de "the International Mismatch Repair Consortium" portant sur 5 585 familles atteintes du syndrome de Lynch dans 22 pays, cette étude analyse la variation de la pénétrance du cancer colorectal chez les porteurs de variants pathogènes selon le sexe et le continent de résidence

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Win, Aung Ko ; Dowty, James G. ; Reece, Jeanette C. ; Lee, Grant ; Templeton, Allyson S. ; Plazzer, John-Paul ; Buchanan, Daniel D. ; Akagi, Kiwamu ; Aksoy, Seçil ; Alonso, Angel ; Alvarez, Karin ; Amor, David J. ; Ankathil, Ravindran ; Aretz, Stefan ; Arnold, Julie L. ; Aronson, Melyssa ; Austin, Rachel ; Backman, Ann-Sofie ; Bajwa-ten Broeke, Sanne W. ; Barca-Tierno, Verónica ; Barwell, Julian ; Bernstein, Inge ; Berthet, Pascaline ; Betz, Beate ; Bignon, Yves-Jean ; Boisjoli, Talya ; Bonadona, Valerie ; Briollais, Laurent ; Brunet, Joan ; Bucksch, Karolin ; Buecher, Bruno ; Buettner, Reinhard ; Burn, John ; Caldes, Trinidad ; Capella, Gabriel ; Caron, Olivier ; Casey, Graham ; Chew, Min H. ; Choi, Yun-Hee ; Church, James ; Clendenning, Mark ; Colas, Chrystelle ; Cops, Elisa J. ; Coupier, Isabelle ; Cruz-Correa, Marcia ; de la Chapelle, Albert ; de Wind, Niels ; Dębniak, Tadeusz ; Della Valle, Adriana ; Delnatte, Capuccine ; Dhooge, Marion ; Dominguez-Valentin, Mev ; Drouet, Youenn ; Duijkers, Floor A. ; Engel, Christoph ; Esperon, Patricia ; Evans, D. Gareth ; Falcón de Vargas, Aída ; Figueiredo, Jane C. ; Foulkes, William ; Fourme, Emmanuelle ; Frebourg, Thierry ; Gallinger, steven ; Garre, Pilar ; Genuardi, Maurizio ; Gerdes, Anne-Marie ; Gima, Lauren M. ; Giraud, Sophie ; Goodwin, Annabel ; Görgens, Heike ; Green, Kate ; Guillem, Jose ; Guillén-Ponce, Carmen ; Guimbaud, Roselyne ; Guindalini, Rodrigo S. C. ; Half, Elizabeth E. ; Hall, Michael J. ; Hampel, Heather ; Hansen, Thomas V. O. ; Heinimann, Karl ; Hes, Frederik J. ; Hill, James ; Ho, Judy W. C. ; Holinski-Feder, Elke ; Hoogerbrugge, Nicoline ; Hüneburg, Robert ; Huntley, Vanessa ; James, Paul A. ; Jensen, Uffe B. ; John, Thomas ; Juhari, Wan K. W. ; Kalady, Matthew ; Kastrinos, Fay ; Kloor, Matthias ; Kohonen-Corish, Maija R. J. ; Krogh, Lotte N. ; Kupfer, Sonia S. ; Ladabaum, Uri ; Lagerstedt-Robinson, Kristina ; Lalloo, Fiona ; Lasset, Christine ; Latchford, Andrew ; Laurent-Puig, Pierre ; Lautrup, Charlotte K. ; Leggett, Barbara A. ; Lejeune, Sophie ; LeMarchand, Loic ; Ligtenberg, Marjolijn ; Lindor, Noralane ; Loeffler, Markus ; Longy, Michel ; Lopez, Francisco ; Lowery, Jan ; Lubinski, Jan ; Lucassen, Anneke M. ; Lynch, Patrick M. ; Malińska, Karolina ; Matsubara, Nagahide ; Mecklin, Jukka-Pekka ; Møller, Pål ; Monahan, Kevin ; Morrison, Patrick J. ; Nattermann, Jacob ; Navarro, Matilde ; Neffa, Florencia ; Neklason, Deborah ; Newcomb, Polly A. ; Ngeow, Joanne ; Nichols, Cassandra ; Nielsen, Maartje ; Nixon, Dawn M. ; Nogues, Catherine ; Okkels, Henrik ; Olschwang, Sylviane ; Pachter, Nicholas ; Pai, Rish K. ; Palmero, Edenir I. ; Pande, Mala ; Parry, Susan ; Patel, Swati G. ; Pearlman, Rachel ; Perne, Claudia ; Pineda, Marta ; Poplawski, Nicola K. ; Pylvanainen, Kirsi ; Qiu, Jay ; Rahner, Nils ; Ramesar, Raj ; Rasmussen, Lene J. ; Redler, Silke ; Reis, Rui M. ; Ricciardiello, Luigi ; Rogoża-Janiszewska, Emilia ; Rosty, Christophe ; Samadder, N. Jewel ; Sampson, Julian R. ; Schackert, Hans K. ; Schmiegel, Wolff ; Schulmann, Karsten ; Schuster, Hélène ; Scott, Rodney ; Senter, Leigha ; Seppälä, Toni T. ; Shtoyerman, Rakefet ; Sijmons, Rolf H. ; Snyder, Carrie ; Solomon, Ilana B. ; Soto, José Luis ; Southey, Melissa C. ; Spigelman, Allan ; Spirandelli, Florencia ; Spurdle, Amanda B. ; Steinke-Lange, Verena ; Stoffel, Elena M. ; Strassburg, Christian P. ; Sunde, Lone ; Susman, Rachel ; Syngal, Sapna ; Tanakaya, Kohji ; Tezcan, Gülçin ; Therkildsen, Christina ; Thibodeau, Steve ; Tomita, Naohiro ; Tucker, Katherine M. ; Tunca, Berrin ; Turchetti, Daniela ; Uhrhammer, Nancy ; Utsunomiya, Joji ; Vaccaro, Carlos ; van Duijnhoven, Fränzel J. B. ; van Wanzeele, Meghan J. ; Vangala, Deepak B. ; Vasen, Hans F. A. ; von Knebel Doeberitz, Magnus ; von Salomé, Jenny ; Wadt, Karin A. W. ; Ward, Robyn L. ; Weitz, Jurgen ; Weitzel, Jeffrey N. ; Williams, Heinric ; Winship, Ingrid ; Wise, Paul E. ; Wods, Julie ; Woods, Michael O. ; Yamaguchi, Tatsuro ; Zachariae, Silke ; Zahary, Mohd N. ; Hopper, John L. ; Haile, Robert W. ; Macrae, Finlay A. ; Möslein, Gabriela ; Jenkins, Mark A.

Background: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative risk (penetrance) of colorectal cancer for all carriers of pathogenic variants in the same gene. We aimed to estimate the variation in the penetrance of colorectal cancer between carriers of pathogenic variants in the same gene by sex and continent of residence. Methods: In this retrospective cohort study, we sourced [...]

Menée à l'aide de données de "the International Mismatch Repair Consortium" portant sur 5 585 familles atteintes du syndrome de Lynch dans 22 pays, cette étude analyse la variation de la pénétrance du cancer colorectal chez les porteurs de variants pathogènes selon le sexe et le continent de résidence

A step closer to a personalised approach for Lynch syndrome

Ballester, Veroushka

Over the past few years, traditional, one-size-fits-all treatment approaches for cancer have been steadily replaced by those that personalise interventions to an individual's unique genetic, molecular, physiological, and environmental profile, seeking to identify effective management and therapeutic strategies for every patient. This change in approach is due, in part, to emerging technologies, such as DNA sequencing and proteomics, that have shown the existence of interindividual variation in [...]

Cette étude analyse l'intérêt des études menées par randomisation mendélienne en comparaison avec les études observationnelles pour fournir des informations sur l'association entre l'obésité et le risque de cancer

The Role of Mendelian Randomization Studies in Deciphering the Effect of Obesity on Cancer

Fang, Zhe ; Song, Mingyang ; Lee, Donghoon ; Giovannucci, Edward L

Associations of obesity have been established for at least 11 cancer sites in observational studies, though some questions remain as to causality, strength of associations, and timing of associations throughout the life course. In recent years, Mendelian randomization (MR) has provided complementary information to traditional approaches, but the validity requires that the genetic instrumental variables be causally related to cancers only mediated by the exposure. We summarize and evaluate [...]

Cette étude analyse l'intérêt des études menées par randomisation mendélienne en comparaison avec les études observationnelles pour fournir des informations sur l'association entre l'obésité et le risque de cancer

Understanding Adiposity at Different Times across the Life Course and Cancer Risk: Is Evidence Sufficient to Act?

Colditz, Graham A

Fang et al. raise several important considerations in understanding adiposity and cancer risk. First, the extensive summary of Mendelian randomization (MR) evidence helps bring together the literature on timing of adiposity in relation to cancer risk at different sites. Second, although 5 years ago the International Agency for Research on Cancer (IARC) evaluation of the cancer preventive effect of absence of excess body fatness concluded that there was sufficient evidence that absence of excess [...]

Cette étude analyse l'intérêt des études menées par randomisation mendélienne en comparaison avec les études observationnelles pour fournir des informations sur l'association entre l'obésité et le risque de cancer

Causality Inference of Obesity and Cancer Risk by Mendelian Randomization Analysis: Are We There yet?

Yao, Song

Strong epidemiological evidence supports an association of excessive body fatness with increased risk of thirteen cancer types. It is estimated that 6% of cancers in adults are attributed to overweight and obesity, placing it as one of the most important cancer risk factors, second only to smoking. However, association does not equate to causality. Body fatness, commonly assessed by body mass index (BMI), is determined by a myriad of genetic and environmental factors. Confounding effects by [...]