Menée en Norvège auprès de 12 242 femmes présentant une lésion bénigne ou une hyperplasie du sein et auprès de 2 379 patientes atteintes d'un carcinome mammaire in situ, cette étude analyse l'association entre des facteurs de risque modifiables (activité physique, indice de masse corporelle, consommation d'alcool, tabagisme, traitements hormonaux) et le développement du cancer du sein chez les femmes présentant une lésion précancéreuse

Can breast cancer be stopped? Modifiable risk factors of breast cancer among women with a prior benign or premalignant lesion

Lilleborge, Marie ; Falk, Ragnhild S ; Sørlie, Therese ; Ursin, Giske ; Hofvind, Solveig

Physical inactivity, high postmenopausal body mass index, alcohol consumption and use of menopausal hormone therapy are established risk factors for breast cancer. Less is known about whether these factors influence the risk of progression of benign and premalignant breast lesions to invasive breast cancer. This registry-based cohort study was based on women with a precancerous lesion who were followed for breast cancer. The cohort consisted of 11,270 women with a benign lesion, 972 women with [...]

Menée à partir de données 1993-2009 portant sur 101 695 participants de l'essai "the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial" (durée moyenne de suivi : 8,9 ans), cette étude analyse l'association entre un apport alimentaire en vitamine K et le risque de cancer du pancréas (361 cas)

Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101695 American Adults

Yu, Dao-Wu ; Li, Qu-Jin ; Cheng, Long ; Yang, Peng-Fei ; Sun, Wei-Ping ; Peng, Yang ; Hu, Jie-Jun ; Wu, Jing-Jing ; Gong, Jian-Ping ; Zhong, Guo-Chao

No epidemiological studies have been conducted to assess the association of dietary vitamin K intake with the risk of pancreatic cancer. We used prospective data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial between 1993 and 2009 to fill this gap. A total of 101695 subjects were identified. Dietary intakes of phylloquinone (vitamin K1), menaquinones (vitamin K2), and dihydrophylloquinone (dihydrovitamin K1) were assessed with a food frequency questionnaire. Cox [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2020, cette méta-analyse évalue l'association entre la consommation globale de fruits ou de légumes et le risque de cancer du sein

Fruit and vegetable consumption and incident breast cancer: a systematic review and meta-analysis of prospective studies

Farvid, Maryam S. ; Barnett, Junaidah B. ; Spence, Nicholas D.

Background: We conducted a systematic review and meta-analysis of prospective studies to clarify the relation of fruit and vegetable consumption with incident breast cancer. Methods: We searched systematically PubMed and EMBASE databases up to November 2020 to include prospective studies that reported the association of fruit and vegetable consumption with incident breast cancer. The pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated for the highest versus the lowest [...]

Menée aux Etats-Unis auprès de 48 835 femmes ménopausées (âge : 50-79 ans), cette étude randomisée analyse l'effet d'une alimentation pauvre en graisses sur la mortalité par cancer du sein, en fonction de composantes du syndrome métabolique (tour de taille élevé, pression artérielle élevée, antécédents d'hypercholestérolémie et antécédents de diabète)

Low-fat dietary pattern and breast cancer mortality by metabolic syndrome components: a secondary analysis of the Women’s Health Initiative (WHI) randomised trial

Pan, Kathy ; Aragaki, Aaron K. ; Neuhouser, Marian L. ; Simon, Michael S. ; Luo, Juhua ; Caan, Bette ; Snetselaar, Linda ; Mortimer, Joanne E. ; Manson, JoAnn E. ; Kroenke, Candyce ; Lane, Dorothy ; Reding, Kerryn ; Rohan, Thomas E. ; Chlebowski, Rowan T.

Background: In the Women’s Health Initiative (WHI) dietary modification (DM) randomised trial, the low-fat dietary intervention reduced deaths from breast cancer (P = 0.02). Extending these findings, secondary analysis examined dietary intervention influence on breast cancer mortality by metabolic syndrome (MS) components. Methods: In total, 48,835 postmenopausal women with no prior breast cancer were randomised to a low-fat dietary intervention or comparison groups. Four MS components were [...]

Menée à partir de données portant sur des participants de l'essai "the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial" (durée de suivi : 13 ans), cette étude analyse l'association entre une utilisation d'aspirine ou d'ibuprofène et le risque d'adénome distal (1 221 cas), d'adénome récurrent (862 cas) et de cancer colorectal (2 826 cas)

Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial

Chudy-Onwugaje, Kenechukwu ; Huang, Wen-Yi ; Su, L. Joseph ; Purdue, Mark P. ; Johnson, Christine C. ; Wang, Lingxiao ; Katki, Hormuzd A. ; Barry, Kathryn Hughes ; Berndt, Sonja I.

BACKGROUND: Studying the differential impact of aspirin and other nonsteroidal anti-inflammatory drugs across the stages of colorectal neoplasia from early adenoma to cancer is critical for understanding the benefits of these widely used drugs. METHODS: With 13 years of follow-up, the authors prospectively evaluated the association between aspirin and ibuprofen use and incident distal adenoma (1221 cases), recurrent adenoma (862 cases), and incident colorectal cancer (CRC; 2826 cases) among men [...]

Menée aux Etats-Unis en 2017-2018 auprès de 1 196 parents d'enfants âgés de 9 à 17 ans, cette étude analyse l'effet de différentes vidéos présentées par un pédiatre sur la défiance et le comportement des parents vis-à-vis de la vaccination de leurs enfants contre le papillomavirus humain

Easing Human Papillomavirus Vaccine Hesitancy: A Communication Experiment With U.S. Parents

Shah, Parth D. ; Calo, William A. ; Gilkey, Melissa B. ; Margolis, Marjorie A. ; Dailey, Susan Alton ; Todd, Karen G. ; Brewer, Noel T.

Introduction: The Announcement Approach using presumptive announcements increases human papillomavirus vaccine uptake. This study seeks to understand the impact of the final Announcement Approach steps—easing parents’ vaccine concerns and then encouraging them to get human papillomavirus vaccine for their children—on parents’ human papillomavirus vaccine hesitancy and confidence in the vaccine's benefits. Methods: In 2017–2018, investigators recruited an online national sample of 1,196 U.S. [...]

Menée aux Etats-Unis entre 2014 et 2020 à l'aide du séquençage de l'ADN de 290 311 échantillons tumoraux provenant de patients atteints d'un carcinome épidermoïde de stade avancé (col de l'utérus, tête et cou, anus, vulve, vagin ou pénis), cette étude analyse la prévalence des types de papillomavirus humain à haut risque non couverts par le vaccin nonavalent, en fonction de l'origine ethnique

Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry

Williams, Erik A. ; Newberg, Justin ; Williams, Kevin Jon ; Montesion, Meagan ; Alexander, Brian M. ; Lin, Douglas I. ; Elvin, Julia A.

High-risk human papillomavirus (hrHPV) causes squamous cell carcinoma (SCC) at a variety of sites, including cervix, head and neck, anus, vulva, vagina, and penis. The 9-valent HPV vaccine is highly effective at preventing carcinomas at these sites related to the specific HPV types it covers. Among women with hrHPV detected in routine cervical swabs, however, the distribution of hrHPV types is known to differ by racial/ethnic group, with East and West Africans1 and North Americans of African [...]

Menée à partir de données d'incidence 1990-2012 de la base internationale "CI5plus", cette étude présente une projection de l'évolution de l'incidence des cancers attribuables au papillomavirus humain dans le monde jusqu'en 2030

Worldwide trend in human papillomavirus–attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030

Wu, Jie ; Xiao, Fenqiang ; Zheng, Yang ; Lin, Yushi ; Wang, Hong-Liang

BACKGROUND: There is a paucity of global comparative trend analyses of all human papillomavirus (HPV)–attributable cancers. In addition, most analyses by international sources only describe past trends; few studies have projected the future trend of HPV-attributable cancers. METHODS: Data were used from the Cancer Incidence in Five Continents (CI5plus) database that contains annual incidence by cancer site, age, and sex, as well as corresponding populations. Age-standardized HPV-attributable [...]

Menée aux Pays-Bas par questionnaire et à l'aide de prélèvements vaginaux collectés auprès de 2 027 jeunes filles, cette étude analyse l'efficacité, 4 ans après la vaccination contre le papillomavirus humain, de deux doses du vaccin bivalent préconisé par le programme national depuis 2014

Vaccine effectiveness following routine immunization with bivalent HPV vaccine: Protection against incident genital HPV infections from a reduced-dosing schedule

Hoes, Joske ; King, Audrey J ; Schurink-van ‘t Klooster, Tessa M ; Berkhof, prof Johannes ; Bogaards, Johannes A ; de Melker, Hester E

In the Netherlands, the bivalent HPV vaccine (2vHPV) has been offered to preadolescent girls via the National Immunization Program (NIP) in a two-dose (2D) schedule since 2014. The current study estimates vaccine effectiveness (VE) against HPV infections up to four years post-vaccination among girls eligible for routine 2D immunization.A cohort study (HAVANA2) was used in which participants annually filled out an online questionnaire and provided a vaginal self-sample for determination of HPV [...]