Nota Bene Cancer
Nota Bene Cancer est un bulletin hebdomadaire de veille bibliographique. En libre accès, Nota Bene Cancer permet à ses abonnés de gagner du temps pour se tenir informé de l’actualité scientifique et médicale dans les divers domaines de la recherche sur les cancers.
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Pour retrouver les publications signalées par Nota Bene Cancer (archives indexées à partir du n°127 du 1" mars 2012) :
Sommaire du n° 490 du 21 mai 2021
Lutte contre les cancers
Qualité de vie, soins de support (1)
Mené sur 22 patients atteints d'un cancer, cet essai randomisé analyse l'effet de patchs à la nicotine sur l'amélioration de leurs déficiences cognitives induites par la chimiothérapie
Subjective cognition and mood in persistent chemotherapy-related cognitive impairment
Mené sur 22 patients atteints d'un cancer, cet essai randomisé analyse l'effet de patchs à la nicotine sur l'amélioration de leurs déficiences cognitives induites par la chimiothérapie
Subjective cognition and mood in persistent chemotherapy-related cognitive impairment
Vega, Jennifer N. ; Albert, Kimberly M. ; Mayer, Ingrid A. ; Taylor, Warren D. ; Newhouse, Paul A.
Purpose : Persistent chemotherapy-related cognitive impairment (CRCI) is commonly reported following cancer treatment and negatively affects quality of life. While past research has focused on potential pathophysiological mechanisms underlying this relationship, the role of psychological factors, such as mood, stress, and anxiety, in the development of persistent CRCI has received less attention. As an additional analysis of data from a trial investigating the effects of transdermal nicotine [...]
Observation (8)
A partir des données des registres américains des cancers portant sur la période 2000-2018, cette étude analyse l'évolution de la mortalité par cancer primitif du foie, du stade au diagnostic, des traitements reçus et de la survie globale
The Mortality and Overall Survival Trends of Primary Liver Cancer in the United States
A partir des données des registres américains des cancers portant sur la période 2000-2018, cette étude analyse l'évolution de la mortalité par cancer primitif du foie, du stade au diagnostic, des traitements reçus et de la survie globale
The Mortality and Overall Survival Trends of Primary Liver Cancer in the United States
Lee, Yi-Te ; Wang, Jasmine J ; Luu, Michael ; Noureddin, Mazen ; Kosari, Kambiz ; Agopian, Vatche G ; Rich, Nicole E ; Lu, Shelly C ; Tseng, Hsian-Rong ; Nissen, Nicholas N ; Singal, Amit G ; Yang, Ju Dong
Background : Recent trends of hepatocellular carcinoma (HCC) mortality and outcome remain unknown in the United States (US). We investigated the recent trends of primary liver cancer (excluding intrahepatic cholangiocarcinoma) mortality and HCC stage, treatment, and overall survival (OS) in the US. Methods : US Cancer Mortality database was analyzed to investigate the trend of primary liver cancer mortality. We analyzed the SEER 18 database to assess the temporal trend of tumor size, stage, [...]
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of COVID-19 on the management of patients with thoracic cancers in a tertiary referral center
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of COVID-19 on the management of patients with thoracic cancers in a tertiary referral center
Basse, Clémence ; Daniel, Catherine ; Livartowski, Alain ; Beaucaire-Danel, Sophie ; Girard, Nicolas
Introduction : Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has spread worldwide in 2020 leading the World Health Organization to declare a pandemic. Patients with thoracic cancers have been reported at higher risk to develop severe disease, and die from COVID-19. In this setting, clinical practice recommendations for the management of patients were published. We report here how these guidelines were implemented in a routine practice setting. Methods : We retrospectively collected [...]
Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy
Bertuzzi, Alexia F. ; Ciccarelli, Michele ; Marrari, Andrea ; Gennaro, Nicolò ; Dipasquale, Andrea ; Giordano, Laura ; Cariboni, Umberto ; Quagliuolo, Vittorio Lorenzo ; Alloisio, Marco ; Santoro, Armando
Background : The impact of active cancer in COVID-19 patients is poorly defined; however, most studies showed a poorer outcome in cancer patients compared to the general population. Methods : We analysed clinical data from 557 consecutive COVID-19 patients. Uni-multivariable analysis was performed to identify prognostic factors of COVID-19 survival; propensity score matching was used to estimate the impact of cancer. Results : Of 557 consecutive COVID-19 patients, 46 had active cancer (8%). [...]
Colorectal Cancer Care and Patient’s Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Colorectal Cancer Care and Patient’s Perceptions Before and During COVID-19: Implications for Subsequent SARS-CoV-2 Infection Waves
Derksen, Jeroen W G ; May, Anne M ; van de Poll-Franse, Lonneke V ; de Rooij, Belle H ; Hafkenscheid, Dorothee A ; Verkooijen, Helena M ; Koopman, Miriam ; Vink, Geraldine R ; PLCRC study group
Changes in colorectal cancer (CRC) care planning due to the coronavirus disease 2019 (COVID-19) pandemic and associated health-related quality of life (HRQoL) and well-being of patients with CRC are unknown. We report changes in CRC care and patient-reported outcomes (PROs) including HRQoL, distress, and loneliness during the first wave of SARS-CoV-2.In April 2020, 4,984 patients included in the nationwide Prospective Dutch Colorectal Cancer cohort were invited to complete a COVID-19-specific [...]
Economic impact of avoidable cancer deaths caused by diagnostic delay during the COVID-19 pandemic: a national population-based modelling study in...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Economic impact of avoidable cancer deaths caused by diagnostic delay during the COVID-19 pandemic: a national population-based modelling study in England, UK
Gheorghe, Adrian ; Maringe, Camille ; Spice, James ; Purushotham, Arnie ; Chalkidou, Kalipso ; Rachet, Bernard ; Sullivan, Richard ; Aggarwal, Ajay
Introduction : Delays in cancer diagnosis arose from the commencement of non-pharmaceutical interventions (NPI) introduced in the UK in March 2020 in response to the COVID-19 pandemic. Our earlier work predicted this will lead to approximately 3620 avoidable deaths for four major tumour types (breast, bowel, lung, and oesophageal cancer) in the next 5 years. Here, using national population-based modelling, we estimate the health and economic losses resulting from these avoidable cancer deaths. [...]
Impact of Cancer History on Outcomes Among Hospitalized Patients with COVID-19
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of Cancer History on Outcomes Among Hospitalized Patients with COVID-19
Klein, Isaac A. ; Rosenberg, Shoshana M. ; Reynolds, Kerry L. ; Zubiri, Leyre ; Rosovsky, Rachel ; Piper-Vallillo, Andrew J. ; Gao, Xin ; Boland, Genevieve ; Bardia, Aditya ; Gaither, Rachel ; Freeman, Hannah ; Kirkner, Gregory J. ; Rhee, Chanu ; Klompas, Michael ; Baker, Meghan A. ; Wadleigh, Martha ; Winer, Eric P. ; Kotton, Camille N. ; Partridge, Ann H.
Background: Early reports suggested increased mortality from COVID-19 in patients with cancer but lacked rigorous comparisons to patients without cancer. We investigated whether a current cancer diagnosis or cancer history is an independent risk factor for death in hospitalized patients with COVID-19. Patients and Methods: We identified patients with a history of cancer admitted to two large hospitals between March 13, 2020, and May 10, 2020, with laboratory-confirmed COVID-19 and matched them [...]
COVID-19 Vaccines in Patients With Cancer—A Welcome Addition, but There Is Need for Optimization
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
COVID-19 Vaccines in Patients With Cancer—A Welcome Addition, but There Is Need for Optimization
Korompoki, Eleni ; Gavriatopoulou, Maria ; Kontoyiannis, Dimitrios P.
The urgency of the COVID-19 pandemic led to the scientific triumph of rapid vaccine development against SARS-CoV-2 within less than a year, a period much faster to traditional vaccine development, which spans decades. That impressive speed is credited to a novel approach to vaccine development, with vaccines encoding genetic information in the form of messenger RNA (mRNA) and inducing the body to produce neutralizing antibodies against the SARS-CoV-2 spike protein, the attachment protein for [...]
Coordination and optimization of PET/CT and COVID-19 vaccination; Lessons learned in the early stages of mass vaccination
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Coordination and optimization of PET/CT and COVID-19 vaccination; Lessons learned in the early stages of mass vaccination
McIntosh, Lacey J. ; Rosen, Max P. ; Mittal, Kriti ; Whalen, Giles F. ; Bathini, Venu G. ; Ali, Tasneem ; Edmiston, Kathryn L. ; Walsh, William V. ; Gerber, Jonathan M.
As the world embarks on mass vaccination for COVID-19, we are beginning to encounter unintended dilemmas in imaging oncology patients; particularly with regards to FDG PET/CT. In some cases, vaccine-related lymphadenopathy and FDG uptake on PET/CT can mimic cancer and lead to confounding imaging results. These cases with findings overlapping with cancer pose a significant dilemma for diagnostic purposes, follow-up, and management leading to possible treatment delays, unnecessary repeat imaging [...]
COVID-19 and the multidisciplinary care of patients with lung cancer: an evidence-based review and commentary
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
COVID-19 and the multidisciplinary care of patients with lung cancer: an evidence-based review and commentary
Round, Thomas ; L’Esperance, Veline ; Bayly, Joanne ; Brain, Kate ; Dallas, Lorraine ; Edwards, John G. ; Haswell, Thomas ; Hiley, Crispin ; Lovell, Natasha ; McAdam, Julia ; McCutchan, Grace ; Nair, Arjun ; Newsom-Davis, Thomas ; Sage, Elizabeth K. ; Navani, Neal
Delivering lung cancer care during the COVID-19 pandemic has posed significant and ongoing challenges. There is a lack of published COVID-19 and lung cancer evidence-based reviews, including for the whole patient pathway. We searched for COVID-19 and lung cancer publications and brought together a multidisciplinary group of stakeholders to review and comment on the evidence and challenges. A rapid review of the literature was undertaken up to 28 October 2020, producing 144 papers, with 113 full [...]
Differential impact of COVID-19 on cancer diagnostic services based on body regions - A public facility-based study in Hong Kong
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Differential impact of COVID-19 on cancer diagnostic services based on body regions - A public facility-based study in Hong Kong
Vardhanabhuti, Varut ; Ng, Kei Shing
Purpose: A reduction in cancer services during the COVID-19 pandemic has impacted cancer diagnosis. The purpose of this study is to quantitatively determine the impact on cancer diagnostic service in public facilities across Hong Kong. Quantifying the temporal changes in the number of cancer diagnosis before, during and after the outbreak, is useful to establish the scale of the problem and to assess if there has been an adequate level of response. Methods and Materials: Retrospective cohort [...]
Temporal Trends in Inpatient Oncology Census Before and During the COVID-19 Pandemic and Rates of Nosocomial COVID-19 Among Patients with Cancer at...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Temporal Trends in Inpatient Oncology Census Before and During the COVID-19 Pandemic and Rates of Nosocomial COVID-19 Among Patients with Cancer at a Large Academic Center
Zubiri, Leyre ; Rosovsky, Rachel P. ; Mooradian, Meghan J. ; Piper-Vallillo, A.J. ; Gainor, Justin F. ; Sullivan, Ryan J. ; Marte, Daniel ; Boland, Genevieve M. ; Gao, Xin ; Hochberg, Ephraim P. ; Ryan, David P. ; McEwen, Corey ; Mai, Minh ; Sharova, Tanya ; Soumerai, Tara E. ; Bardia, Aditya ; Reynolds, Kerry L.
Background: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted health care systems. However, to date, the trend of hospitalizations in the oncology patient population has not been studied, and the frequency of nosocomial spread to patients with cancer is not well understood. The objectives of this study were to evaluate the impact of COVID-19 on inpatient oncology census and determine the nosocomial rate of COVID-19 in patients with cancer admitted at a large academic [...]
Menée aux Etats-Unis sur la période 1999-2018, cette étude compare l'évolution de la mortalité par cancers liés à l'obésité à celle de la mortalité par maladie cardiaque
Comparison of 20-Year Obesity-Associated Cancer Mortality Trends With Heart Disease Mortality Trends in the US
Menée aux Etats-Unis sur la période 1999-2018, cette étude compare l'évolution de la mortalité par cancers liés à l'obésité à celle de la mortalité par maladie cardiaque
Comparison of 20-Year Obesity-Associated Cancer Mortality Trends With Heart Disease Mortality Trends in the US
Avery, Christy L. ; Howard, Annie Green ; Nichols, Hazel B.
Importance : Heart disease and cancer are the 2 major diseases associated with mortality risk in the United States. Four decades of improvements in heart disease mortality slowed after 2011; this slowing has been associated with the obesity epidemic. The same pattern has not been observed for total cancer mortality. However, trends in total cancer mortality may obscure patterns specific to obesity-associated cancers. Objective : To investigate whether trends in obesity-associated cancer [...]
Menée au Canada à l'aide de données portant sur 82 037 patients âgés d'au moins 70 ans et ayant subi une résection pour un cancer diagnostiqué entre 2007 et 2017 (63,5 % de femmes), cette étude analyse la mortalité par cancer (16 900 décès, 49,6 %) et la mortalité toutes causes confondues (34 044 décès)
All-Cause and Cancer-Specific Death of Older Adults Following Surgery for Cancer
Menée au Canada à l'aide de données portant sur 82 037 patients âgés d'au moins 70 ans et ayant subi une résection pour un cancer diagnostiqué entre 2007 et 2017 (63,5 % de femmes), cette étude analyse la mortalité par cancer (16 900 décès, 49,6 %) et la mortalité toutes causes confondues (34 044 décès)
All-Cause and Cancer-Specific Death of Older Adults Following Surgery for Cancer
Chesney, Tyler R. ; Coburn, Natalie ; Mahar, Alyson L. ; Davis, Laura E. ; Zuk, Victoria ; Zhao, Haoyu ; Hsu, Amy T. ; Wright, Frances ; Haas, Barbara ; Hallet, Julie ; Recovery After Surgical Therapy for Older Adults Research–Cancer Group
Cancer care has inherent complexities in older adults, including balancing risks of cancer and noncancer death. A poor understanding of cause-specific outcomes may lead to overtreatment and undertreatment.To examine all-cause and cancer-specific death throughout 5 years for older adults after cancer resection.This population-based cohort study was conducted in Ontario, Canada, using the administrative databases stored at ICES (formerly the Institute for Clinical Evaluative Sciences). All adults [...]
Menée à partir des donnés des registres américains des cancers portant sur 19 257 patients atteints d'un adénocarcinome de l'oesophage et sur 15 162 patients atteints d'un carcinome épidermoïde oesophagien diagnostiqué entre 1992 et 2016, cette étude analyse les disparités ethniques dans l'évolution de la mortalité spécifique et dans le stade de la maladie au diagnostic
Trends in Esophageal Cancer Mortality and Stage at Diagnosis by Race and Ethnicity in the United States
Menée à partir des donnés des registres américains des cancers portant sur 19 257 patients atteints d'un adénocarcinome de l'oesophage et sur 15 162 patients atteints d'un carcinome épidermoïde oesophagien diagnostiqué entre 1992 et 2016, cette étude analyse les disparités ethniques dans l'évolution de la mortalité spécifique et dans le stade de la maladie au diagnostic
Trends in Esophageal Cancer Mortality and Stage at Diagnosis by Race and Ethnicity in the United States
Corona, Edgar ; Yang, Liu ; Esrailian, Eric ; Ghassemi, Kevin A. ; Conklin, Jeffrey L. ; May, Folasade P.
Introduction : Esophageal cancer (EC) is an aggressive malignancy with poor prognosis. Mortality and disease stage at diagnosis are important indicators of improvements in cancer prevention and control. We examined United States trends in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) mortality and stage at diagnosis by race and ethnicity. Methods : We used Surveillance, Epidemiology, and End Results (SEER) data to identify individuals with histologically [...]
Menée aux Etats-Unis à partir de données portant sur 1 461 patientes atteintes d'un cancer épithélial invasif de l'ovaire, cette étude de cohorte analyse l'association entre la pratique d'une activité physique de loisir, avant et après le diagnostic, et la survie
Pre- and post-diagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Menée aux Etats-Unis à partir de données portant sur 1 461 patientes atteintes d'un cancer épithélial invasif de l'ovaire, cette étude de cohorte analyse l'association entre la pratique d'une activité physique de loisir, avant et après le diagnostic, et la survie
Pre- and post-diagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang, Tianyi ; Townsend, Mary K. ; Eliassen, A. Heather ; Terry, Kathryn L. ; Song, Mingyang ; Irwin, Melinda L. ; Tworoger, Shelley S.
Little is known about the influence of pre- and post-diagnosis physical activity on ovarian cancer survival. We investigated this association in two large cohorts, the Nurses’ Health Study (NHS) and NHSII. Analyses included 1461 women with confirmed invasive, epithelial ovarian cancer and data on physical activity. Cox regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for ovarian cancer-specific mortality. Ovarian cancer-specific mortality was not [...]
Menée à une échelle internationale sur la période 1988-2012, cette étude analyse l'évolution des disparités géographiques dans l'incidence de l'ostéosarcome
International Trends in Incidence of Osteosarcoma (1988 - 2012)
Menée à une échelle internationale sur la période 1988-2012, cette étude analyse l'évolution des disparités géographiques dans l'incidence de l'ostéosarcome
International Trends in Incidence of Osteosarcoma (1988 - 2012)
Rojas, Gabriela A. ; Hubbard, Aubrey K. ; Diessner, Brandon J. ; Ribeiro, Karina B. ; Spector, Logan G.
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. The etiology of OS is largely unknown but may be informed by comparisons of incidence and trends between geographic regions. Using the Cancer Incidence in Five Continents (CI5) data from 1988-2012, we present OS age-standardized incidence rates (ASRs; cases/million) and average annual percent change (AAPC) and 95% confidence intervals (CI) by geographic region among the age groups 0-9, 10-19, 20-29, 30-59, [...]
Menée à partir de données 2010-2016 des registres américains des cancers portant sur 23 123 patientes atteintes d'un cancer du sein triple négatif, cette étude analyse les disparités ethniques dans les traitements et la mortalité spécifique
Evaluation of Racial/Ethnic Differences in Treatment and Mortality Among Women With Triple-Negative Breast Cancer
Menée à partir de données 2010-2016 des registres américains des cancers portant sur 23 123 patientes atteintes d'un cancer du sein triple négatif, cette étude analyse les disparités ethniques dans les traitements et la mortalité spécifique
Evaluation of Racial/Ethnic Differences in Treatment and Mortality Among Women With Triple-Negative Breast Cancer
Cho, Beomyoung ; Han, Yunan ; Lian, Min ; Colditz, Graham A. ; Weber, Jason D. ; Ma, Cynthia ; Liu, Ying
To our knowledge, there is no consensus regarding differences in treatment and mortality between non-Hispanic African American and non-Hispanic White women with triple-negative breast cancer (TNBC). Little is known about whether racial disparities vary by sociodemographic, clinical, and neighborhood factors.To examine the differences in clinical treatment and outcomes between African American and White women in a nationally representative cohort of patients with TNBC and further examine the [...]
Approches psycho-sociales (2)
Menée au Danemark à partir de données portant sur 5 774 partenaires de vie de patients atteints d'un cancer du pancréas diagnostiqué entre 2000 et 2016, cette étude de cohorte analyse leurs difficultés psychologiques et leurs symptômes de dépression, d'anxiété et d'insomnie
The psychological symptom burden in partners of pancreatic cancer patients: a population-based cohort study
Menée au Danemark à partir de données portant sur 5 774 partenaires de vie de patients atteints d'un cancer du pancréas diagnostiqué entre 2000 et 2016, cette étude de cohorte analyse leurs difficultés psychologiques et leurs symptômes de dépression, d'anxiété et d'insomnie
The psychological symptom burden in partners of pancreatic cancer patients: a population-based cohort study
Dengsø, Kristine Elberg ; Thomsen, Thordis ; Andersen, Elisabeth Wreford ; Hansen, Carsten Palnæs ; Christensen, Bo Marcel ; Hillingsø, Jens ; Dalton, Susanne Oksbjerg
Purpose : Pancreatic cancer (PC) has high morbidity and mortality and is stressful for patients and their partners. We investigated the psychological symptom burden in partners of PC patients. Methods : We followed 5774 partners of PC patients diagnosed from 2000 to 2016 up for first redeemed prescriptions of antidepressants or hospital admission, anxiolytics, and hypnotics as proxies for clinical depression, anxiety, and insomnia and compared them with 59,099 partners of cancer-free spouses. [...]
A partir d'une revue de la littérature (68 articles), cette méta-synthèse qualitative fait le point sur les problématiques associées à l'image corporelle, l'estime de soi et la perception de la virilité chez des patients atteints d'un cancer de la prostate
Body image, self-esteem, and sense of masculinity in patients with prostate cancer: a qualitative meta-synthesis
A partir d'une revue de la littérature (68 articles), cette méta-synthèse qualitative fait le point sur les problématiques associées à l'image corporelle, l'estime de soi et la perception de la virilité chez des patients atteints d'un cancer de la prostate
Body image, self-esteem, and sense of masculinity in patients with prostate cancer: a qualitative meta-synthesis
Bowie, Jessica ; Brunckhorst, Oliver ; Stewart, Robert ; Dasgupta, Prokar ; Ahmed, Kamran
Purpose : Body image, self-esteem, and masculinity are three interconnected constructs in men with prostate cancer, with profound effects on quality of life. This meta-synthesis aimed to evaluate all known qualitative studies published studying the effect of prostate cancer on these constructs. Methods : A systematic review utilising PubMed, Embase, MEDLINE, and PsycINFO databases up to May 2020 was conducted in line with PRISMA and ENTREQ guidelines. All qualitative studies of men’s [...]
Analyses économiques et systèmes de soins (2)
Menée aux Etats-Unis dans un contexte de vie réelle à partir de données portant sur 367 patients atteints d'un cancer, cette étude de cohorte prospective non randomisée évalue l'intérêt d'un programme d'hospitalisation à domicile et son impact sur les hospitalisations non programmées et leur durée, sur les visites dans des services d'urgence et les coûts associés
Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial
Menée aux Etats-Unis dans un contexte de vie réelle à partir de données portant sur 367 patients atteints d'un cancer, cette étude de cohorte prospective non randomisée évalue l'intérêt d'un programme d'hospitalisation à domicile et son impact sur les hospitalisations non programmées et leur durée, sur les visites dans des services d'urgence et les coûts associés
Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial
Kathi Mooney ; Karen Titchener ; Benjamin Haaland ; Lorinda A. Coombs ; Brock O'Neil ; Richard Nelson ; Jordan P. McPherson ; Anne C. Kirchhoff ; Anna C. Beck ; John H. Ward
PURPOSE : Patients with cancer experience high rates of morbidity and unplanned health care utilization and may benefit from new models of care. We evaluated an adult oncology hospital at home program's rate of unplanned hospitalizations and health care costs and secondarily, emergency department (ED) use, length of hospital stays, and intensive care unit (ICU) admissions during the 30 days after enrollment. METHODS : We conducted a prospective, nonrandomized, real-world cohort comparison of [...]
Menée dans un contexte américain à partir de données portant sur 487 patients atteints d'un carcinome épidermoïde de la tête et du cou de stade métastatique, réfractaire ou récidivant, cette étude compare le rapport coût-efficacité du nivolumab et du pembrolizumab, après l'échec de traitements à base de sels de platine
Nivolumab vs Pembrolizumab for Treatment of US Patients With Platinum-Refractory Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A N...
Menée dans un contexte américain à partir de données portant sur 487 patients atteints d'un carcinome épidermoïde de la tête et du cou de stade métastatique, réfractaire ou récidivant, cette étude compare le rapport coût-efficacité du nivolumab et du pembrolizumab, après l'échec de traitements à base de sels de platine
Nivolumab vs Pembrolizumab for Treatment of US Patients With Platinum-Refractory Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Network Meta-analysis and Cost-effectiveness Analysis
Pei, Rui ; Shi, Yin ; Lv, Shuhe ; Dai, Tingting ; Zhang, Fengyu ; Liu, Shao ; Wu, Bin
Importance : Nivolumab and pembrolizumab are approved for treating platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). Physicians and patients are uncertain which drug is preferable, rendering a cost-effectiveness comparison between them necessary. Objective :To evaluate the cost-effectiveness of nivolumab vs pembrolizumab in treating platinum-refractory R/M HNSCC. Design, Setting, and Participants: Both the network meta-analysis and cost-effectiveness [...]
