Cet article fait le point sur l'association entre le tabagisme et le risque de cancers liés aux oestrogènes (endomètre, endométrioïde, ovaire et thyroïde)

Cigarette Smoking and Estrogen-Related Cancer

Baron, John A. ; Nichols, Hazel B. ; Anderson, Chelsea ; Safe, Stephen

Cigarette smoking is a known cause of many cancers, yet epidemiological studies have found protective associations with the risk of four "estrogen-related" malignancies: endometrial cancer, endometrioid and clear cell ovarian cancers, and thyroid cancer. This review considers epidemiological and biological aspects of these associations, focusing particularly on estrogen signaling, and contrasts them with those for breast cancer, another estrogen-related malignancy. The observational findings [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank", cette étude analyse l'association entre une obésité infantile et le risque de cancer à long terme (24 localisations)

Causal Association of Childhood Obesity with Cancer Risk in Adulthood: A Mendelian Randomization Study

Fang, Xuexian ; Wang, Xinhui ; Song, Zijun ; Han, Dan ; Yin, Xiangju ; Liu, Bingqing ; Chen, Luyi ; Zhang, Ronghua ; Lian, Fuzhi ; Sui, Xinbing

In observational studies of children and adolescents, higher body weight has been associated with distinct disease outcomes, including cancer, in adulthood. Therefore, we performed a two-sample Mendelian randomization (MR) study to evaluate the causal effect of childhood obesity on long-term cancer risk. Single-nucleotide polymorphisms (SNPs) associated with higher childhood body mass index (BMI) from large-scale genome-wide association studies were used as genetic instruments. Summary-level [...]

Menée à partir de données 1991-2015 de la cohorte "the Nurses’ Health Study II" portant sur 41 272 personnes, cette étude analyse l'association entre la consommation de boissons sucrées ou édulcorées à l'adolescence (13-18 ans) ou à l'âge adulte et le risque de cancer colorectal précoce (109 cas)

Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women

Hur, Jinhee ; Otegbeye, Ebunoluwa ; Joh, Hee-Kyung ; Nimptsch, Katharina ; Ng, Kimmie ; Ogino, Shuji ; Meyerhardt, Jeffrey A ; Chan, Andrew T ; Willett, Walter C ; Wu, Kana ; Giovannucci, Edward ; Cao, Yin

Objective: Sugar-sweetened beverage (SSB) consumption had substantially increased across successive US birth cohorts until 2000, and adolescents and young adults under age 50 years have the highest consumption. However, the link between SSBs and early-onset colorectal cancer (EO-CRC) remains unexamined. Design: In the Nurses’ Health Study II (1991–2015), we prospectively investigated the association of SSB intake in adulthood and adolescence with EO-CRC risk among 95 464 women who had reported [...]

Menée à partir de données portant sur plus d'1 million de femmes (durée de suivi : 8 à 20 ans), cette étude analyse l'association entre la consommation de produits laitiers ou l'apport en calcium (par l'alimentation ou par supplémentation) et le risque de cancer du sein (37 861 cas)

Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies

Wu, You ; Huang, Ruyi ; Wang, Molin ; Bernstein, Leslie ; Bethea, Traci N ; Chen, Chu ; Chen, Yu ; Eliassen, A Heather ; Freedman, Neal D ; Gaudet, Mia M ; Gierach, Gretchen L ; Giles, Graham G ; Krogh, Vittorio ; Larsson, Susanna C ; Liao, Linda M ; McCullough, Marjorie L ; Miller, Anthony B ; Milne, Roger L ; Monroe, Kristine R ; Neuhouser, Marian L ; Palmer, Julie R ; Prizment, Anna ; Reynolds, Peggy ; Robien, Kim ; Rohan, Thomas E ; Sandin, Sven ; Sawada, Norie ; Sieri, Sabina ; Sinha, Rashmi ; Stolzenberg-Solomon, Rachael Z ; Tsugane, Shoichiro ; van den Brandt, Piet A ; Visvanathan, Kala ; Weiderpass, Elisabete ; Wilkens, Lynne R ; Willett, Walter C ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Ziegler, Regina G ; Smith-Warner, Stephanie A

Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes.To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status.We pooled the individual-level data of over 1 million women who were followed for a maximum of 8–20 years across studies. Associations were evaluated for dairy [...]

Menée en Chine entre 2010 et 2014 par questionnaire auprès de 2 648 témoins et 2 554 patients atteints d'un carcinome rhinopharyngé (âge : 20-74 ans), cette étude analyse l'association entre les habitudes alimentaires et le risque de développer la maladie

Dietary patterns and risk of nasopharyngeal carcinoma: a population-based case-control study in southern China

Huang, Tingting ; Ploner, Alexander ; Chang, Ellen T ; Liu, Qing ; Cai, Yonglin ; Zhang, Zhe ; Chen, Guomin ; Huang, Qihong ; Xie, Shanghang ; Cao, Sumei ; Jia, Weihua ; Zheng, Yuming ; Liao, Jian ; Chen, Yufeng ; Lin, Longde ; Ernberg, Ingemar ; Huang, Guangwu ; Zeng, Yi ; Zeng, Yixin ; Adami, Hans-Olov ; Ye, Weimin

Dietary factors, such as consumption of preserved foods, fresh vegetables, and fruits, have been linked to the risk of nasopharyngeal carcinoma (NPC). However, little is known about associations between dietary patterns and the risk of NPC in NPC-endemic areas.We aimed to evaluate whether dietary patterns are associated with NPC risk.We studied 2554 newly diagnosed NPC patients aged 20–74 y living in 3 endemic regions of southern China, and 2648 population-based controls frequency-matched to [...]

Menée aux Etats-Unis à partir de données 1960-1977 portant sur 488 personnes ayant travaillé dans la dernière usine de fabrication de benzidine, cette étude analyse l'association entre l'exposition à la dichlorobenzidine et/ou à la benzidine et le risque de cancer de la vessie (25 cas)

Ongoing risk of bladder cancer among former workers at the last benzidine manufacturing facility in the USA

Millerick-May, Melissa L ; Wang, Ling ; Rice, Carol ; Rosenman, Kenneth D

Objective: To determine whether there is an ongoing risk of developing bladder cancer in a previously studied cohort of workers exposed to both benzidine and dichlorobenzidine or dichlorobenzidine only in the last benzidine manufacturing plant in the USA. Methods: Workers (n=488) were identified from the quarterly 941 forms the employer was required to submit to the Social Security Administration from 1960 to 1977. Exposures were assigned based on dates worked and known [...]

A partir d'une revue systématique de la littérature (13 études), cette méta-analyse évalue l'association entre une exposition environnementale à l'amiante et le risque de cancer du poumon

Environmental exposure to asbestos and the risk of lung cancer: a systematic review and meta-analysis

Kwak, Kyeongmin ; Kang, Dongmug ; Paek, Domyung

Asbestos is a carcinogen associated with lung cancer, but few studies have examined the increased risk of lung cancer due to environmental asbestos exposure. We performed a systematic review and meta-analysis to evaluate the association between environmental asbestos exposure and lung cancer. We searched for articles on non-occupational or environmental asbestos exposure and lung cancer in PubMed, EMBASE, CINAHL and Web of Science databases. Our review included 15 studies, and except studies on [...]

Menée à l'aide des données de 7 études, incluses dans le projet "the Stomach cancer Pooling (StoP) Project", portant sur 2 470 témoins et sur 1 377 patients atteints d'un cancer de l'estomac, cette étude analyse l'association entre une infection par Helicobacter pylori et des facteurs modifiables du mode de vie impliqués dans le risque de cancer gastrique (tabagisme, statut socio-économique, consommation d'alcool et de sel)

Exploring the interactions between Hp infection and other risk factors of gastric cancer: a pooled analysis in the Stomach cancer Pooling (StoP) Project

Collatuzzo, Giulia ; Pelucchi, Claudio ; Negri, Eva ; López-Carrillo, Lizbeth ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Shigueaki Hamada, Gerson ; Hernández-Ramírez, Raúl Ulises ; López-Cervantes, Malaquias ; Malekzadeh, Reza ; Pourfarzi, Farhad ; Mu, Lina ; Zhang, Zuo-Feng ; Lunet, Nuno ; La Vecchia, Carlo ; Boffetta, Paolo

Helicobacter pylori (Hp) is crucial in gastric carcinogenesis, but infection alone is not a sufficient cause, and the interaction between Hp infection and other risk factors has not been adequately studied. We conducted a pooled-analysis of seven case-control studies from the Stomach cancer Pooling (StoP) Project, comprising 1377 cases and 2470 controls, to explore the interaction between Hp infection and tobacco smoking, alcohol drinking, socioeconomic status (SES) and dietary salt intake on [...]

Menée à partir de données 2002-2013 de l'Assurance maladie coréenne portant sur des témoins et sur 11 471 patients utilisant des inhibiteurs de la pompe à protons (durée médiane de suivi : 4,3 ans), cette étude analyse l'association entre cet usage et le risque de cancer de l'estomac

Association between proton pump inhibitor use and gastric cancer: a population-based cohort study using two different types of nationwide databases in Korea

Seo, Seung In ; Park, Chan Hyuk ; You, Seng Chan ; Kim, Jae Young ; Lee, Kyung Joo ; Kim, Jinseob ; Kim, Yerim ; Yoo, Jong Jin ; Seo, Won-Woo ; Lee, Hyung Seok ; Shin, Woon Geon

Objective: The association between proton pump inhibitor (PPI) use and gastric cancer related to Helicobacter pylori eradication has not been fully investigated in geographical regions with high risk of gastric cancer. We aimed to evaluate the association between PPIs and gastric cancer in Korea. Design: This study analysed the original and common data model versions of the Korean National Health Insurance Service database from 2002 to 2013. We compared the incidence rates of gastric cancer [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (12 études, 29 282 patients), cette méta-analyse évalue l'association entre une exposition à la lumière du soleil et le risque de cancer de la prostate

Association between sunlight exposure and risk of prostate cancer: a systematic review and meta-analysis

Yoon, Jong-Gyum ; Kim, Hong-Bae

The prevalence of prostate cancer (PC) is increasing worldwide. An association between sunlight exposure and PC risk has been described by a previously published meta-analysis, although the level of statistical significance was not reached. We have, therefore, performed an updated systematic review and meta-analysis to further elucidate this potential connection.To identify relevant articles, we conducted an in-depth search of 4 electronic databases (PubMed, Embase, the Web of Science and [...]

Menée en Chine à l'aide d'échantillons sanguins collectés auprès de témoins et de 328 hommes atteints d'un cancer de l'estomac, cette étude analyse l'association entre les niveaux sériques d'androgènes, d'oestrogènes ou de globuline de liaison des hormones stéroïdes sexuelles (SHBG) et le risque de développer la maladie

Serum Levels of Androgens, Estrogens, and Sex Hormone Binding Globulin and Risk of Primary Gastric Cancer in Chinese Men: A Nested Case–Control Study

Zhu, Zhikai ; Chen, Yingxi ; Ren, Jiansong ; Dawsey, Sanford M. ; Yin, Jian ; Freedman, Neal D. ; Fan, Jin-Hu ; Taylor, Philip R. ; Liu, Yuanli ; Qiao, You-Lin ; Abnet, Christian C.

Gastric cancer shows a strong male predominance, and sex steroid hormones have been hypothesized to explain this sex disparity. Previous studies examining the associations between sex hormones and sex hormone binding globulin (SHBG) and risk of gastric cancer come primarily from western populations and additional studies in diverse populations will help us better understand the association. We performed a nested case–control study in Linxian Nutrition Intervention Trials cohorts to evaluate the [...]

Menée en Pologne à l'aide du génotypage de 8 016 témoins et 5 472 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre 2 variants du gène PALB2 et le risque de développer la maladie ainsi que la survie spécifique

PALB2 mutations and prostate cancer risk and survival

Wokołorczyk, Dominika ; Kluzniak, Wojciech ; Stempa, Klaudia ; Rusak, Bogna ; Huzarski, Tomasz ; Gronwald, Jacek ; Gliniewicz, Katarzyna ; Kashyap, Aniruddh ; Morawska, Sylwia ; Dębniak, Tadeusz ; Jakubowska, Anna ; Szwiec, Marek ; Domagała, Paweł ; Lubinski, Jan ; Narod, Steven A. ; Akbari, Mohammad R. ; Cybulski, Cezary ; Masojć, Bartłomiej ; Gołąb, Adam ; Gliniewicz, Bartłomiej ; Sikorski, Andrzej ; Słojewski, Marcin ; Świtała, Jerzy ; Borkowski, Tomasz ; Borkowski, Andrzej ; Antczak, Andrzej ; Wojnar, Łukasz ; Przybyła, Jacek ; Sosnowski, Marek ; Małkiewicz, Bartosz ; Zdrojowy, Romuald ; Sikorska-Radek, Paulina ; Matych, Józef ; Wilkosz, Jacek ; Różański, Waldemar ; Kiś, Jacek ; Bar, Krzysztof ; Bryniarski, Piotr ; Paradysz, Andrzej ; Jersak, Konrad ; Niemirowicz, Jerzy ; Słupski, Piotr ; Jarzemski, Piotr ; Skrzypczyk, Michał ; Dobruch, Jakub ; Puszyński, Michał ; Soczawa, Michał ; Kordowski, Mirosław ; Życzkowski, Marcin ; Borówka, Andrzej ; Bagińska, Joanna ; Krajka, Kazimierz ; Stawicka, Małgorzata ; Haus, Olga ; Janiszewska, Hanna ; Stembalska, Agnieszka ; Sąsiadek, Maria Małgorzata ; the Polish Hereditary Prostate Cancer, Consortium

Background: The objective of this study was to establish the contribution of PALB2 mutations to prostate cancer risk and to estimate survival among PALB2 carriers. Methods: We genotyped 5472 unselected men with prostate cancer and 8016 controls for two Polish founder variants of PALB2 (c.509_510delGA and c.172_175delTTGT). In patients with prostate cancer, the survival of carriers of a PALB2 mutation was compared to that of non-carriers. Results: A PALB2 mutation was found in 0.29% of cases and [...]

Menée en Suède à l'aide de données portant sur 333 753 témoins et sur 68 060 patients atteints d'un cancer colorectal, cette étude analyse l'association entre des antécédents familiaux au 1er degré de polypes et le risque de développer la maladie

Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden

Song, Mingyang ; Emilsson, Louise ; Roelstraete, Bjorn ; Ludvigsson, Jonas F

Objective: To assess the risk of colorectal cancer (CRC) in first degree relatives (parents and full siblings) of patients with precursor lesions (polyps) for CRC. Design: Case-control study. Setting: Linkage to the multi-generation register and gastrointestinal ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) histopathology cohort in Sweden. Participants: 68 060 patients with CRC and 333 753 matched controls. Main outcome measures: Multivariable adjusted odds ratios of [...]