Menée au Royaume-Uni par entretiens auprès de 11 adolescents et jeunes adultes ayant survécu plus de 5 ans à une tumeur cérébrale (âge : 16-30 ans) et auprès de 11 aidants, cette étude analyse leurs besoins en soins de support

Unmet support needs in teenage and young adult childhood brain tumour survivors and their caregivers: “it’s all the aftermath, and then you’re forgotten about”

Nicklin, Emma ; Pointon, Lucy ; Glaser, Adam ; Sarwar, Naseem ; Kwok-Williams, Michelle ; Debono, Miguel ; Velikova, Galina ; Boele, Florien W.

Purpose : Teenage and young adult (TYA) survivors of childhood brain tumours and their family caregivers can experience many late effects of treatment that can hamper the transition to living independent lives. Yet, their long-term supportive care needs are largely unknown. We investigated the supportive care needs of TYA survivors and their caregivers and explored the role and perceived use of support. Methods : Face-to-face semi-structured interviews were conducted with survivors aged 16–30 [...]

Menée aux Pays-Bas à partir des données des registres portant sur des patients atteints d'un cancer gastro-oesophagien de stade avancé (3 077 cas d'adénocarcinome oesophagien, 1 836 cas d'adénocarcinome gastrique, 794 cas de carcinome épidermoïde), cette étude analyse les disparités, selon le sexe des patients, dans le choix des traitements et dans la survie globale

Gender Differences in Treatment Allocation and Survival of Advanced Gastroesophageal Cancer: a Population-Based Study

Dijksterhuis, Willemieke P M ; Kalff, Marianne C ; Wagner, Anna D ; Verhoeven, Rob H A ; Lemmens, Valery E P P ; van Oijen, Martijn G H ; Gisbertz, Suzanne S ; van Berge Henegouwen, Mark I ; van Laarhoven, Hanneke W M

Background : Biological sex and gender have been reported to impact incidence and overall survival (OS) of curatively treated gastroesophageal cancer. The aim of this study was to compare palliative treatment allocation and OS between women and men with advanced gastroesophageal cancer. Methods : Patients with an unresectable (cT4b) or metastatic (cM1) esophageal (including cardia) adenocarcinoma (EAC) or squamous cell carcinoma (ESCC), or gastric adenocarcinoma (GAC) diagnosed in 2015-2018 [...]

Menée à partir de données portant sur 1 762 adultes ayant survécu à un cancer pédiatrique, cette étude transversale analyse l'association entre le nombre de copies de gènes de l'ADN mitochondrial mesuré dans les leucocytes du sang périphérique et la présence d'une sarcopénie

The Association of Mitochondrial Copy Number with Sarcopenia in Adult Survivors of Childhood Cancer

McCastlain, Kelly ; Howell, Carrie R ; Welsh, Catherine E ; Wang, Zhaoming ; Wilson, Carmen L ; Mulder, Heather L ; Easton, John ; Mertens, Ann C ; Zhang, Jinghui ; Yasui, Yutaka ; Hudson, Melissa M ; Robison, Leslie L ; Kundu, Mondira ; Ness, Kirsten K

Background : Adult childhood cancer survivors are at risk for frailty, including low muscle mass and weakness (sarcopenia). Using peripheral blood (PB) mitochondrial DNA copy number (mtDNAcn) as a proxy for functional mitochondria, this study describes cross-sectional associations between mtDNAcn and sarcopenia among survivors. Methods : Among 1,762 adult childhood cancer survivors (51.6% male; median age = 29.4 [IQR = 23.3-36.8] years), with a median of 20.6 years from diagnosis (IQR = [...]

Menée en Espagne par enquêtes, l'une en janvier 2020 (avant la crise sanitaire liée au COVID-19) et l'autre en août 2020, cette étude analyse les comportements des individus concernant l'observation de symptômes potentiellement liés au cancer et la consultation de leur médecin

Anticipated help-seeking for cancer symptoms before and after the coronavirus pandemic: results from the Onco-barometer population survey in Spain

Petrova, Dafina ; Pollan, Marina ; Rodriguez-Barranco, Miguel ; Garrido, Dunia ; Borràs, Josep M. ; Sánchez, María-José

Background : The patient interval—the time patients wait before consulting their physician after noticing cancer symptoms—contributes to diagnostic delays. We compared anticipated help-seeking times for cancer symptoms and perceived barriers to help-seeking before and after the coronavirus pandemic. Methods : Two waves (pre-Coronavirus: February 2020, N = 3269; and post-Coronavirus: August 2020, N = 1500) of the Spanish Onco-barometer population survey were compared. The international ABC [...]

Menée en Suède à partir des données des registres portant sur 1 692 enfants atteints d'une leucémie lymphoïde aiguë ou d'une leucémie myéloïde aiguë (âge : 1-14 ans), cette étude de cohorte analyse l'association entre le nombre de frères et soeurs présents dans le foyer et la survie

Number of siblings and survival from childhood leukaemia: a national register-based cohort study from Sweden

Mogensen, Hanna ; Modig, Karin ; Talbäck, Mats ; Erdmann, Friederike ; Heyman, Mats ; Feychting, Maria ; Tettamanti, Giorgio

Background : Previous studies suggest worse leukaemia survival for children with siblings, but the evidence is sparse, inconsistent and does not consider clinical factors. We explored the associations between number of siblings in the household, birth order and survival from childhood acute lymphoid leukaemia (ALL) and acute myeloid leukaemia (AML). Methods : In this nationwide register-based study we included all children aged 1–14, diagnosed with ALL and AML between 1991–mid-2015 in Sweden [...]

Menée par enquête téléphonique aux Etats-Unis, cette étude analyse les pratiques de surveillance médicale des patients ayant survécu à un cancer colorectal, selon leur orientation sexuelle

Follow-up surveillance among colorectal cancer survivors of different sexual orientations

Boehmer, Ulrike ; Potter, Jennifer ; Clark, Melissa A. ; Winter, Michael ; Berklein, Flora ; Ceballos, Rachel M. ; Hartshorn, Kevan ; Ozonoff, Al

Purpose : The purpose of this study was to examine receipt of follow-up surveillance among sexual minority and heterosexual survivors and identify survivor-, physician-, and practice-level characteristics associated with follow-up surveillance. Methods : An average of 3 years after their stage I–III colorectal cancer diagnosis, we recruited survivors from four cancer registries. A questionnaire, which queried about sexual orientation and other eligibility criteria, was mailed to all cancer [...]

Menée dans 204 pays et territoires, cette étude analyse l'évolution, sur la période 1990-2019, des facteurs liés au risque de cancer de la trachée, des bronches et du poumon, ainsi que des années de vie perdues ajustées sur l'incapacité et de la mortalité associées

Burden of tracheal, bronchus and lung cancer and its attributable risk factors in 204 countries and territories, 1990-2019

Safiri, Saeid ; Sohrabi, Mohammad-Reza ; Carson-Chahhoud, Kristin ; Bettampadi, Deepti ; Taghizadieh, Ali ; Almasi-Hashiani, Amir ; Ashrafi-Asgarabad, Ahad ; Sepidarkish, Mahdi ; Eagen, Arielle ; Mansournia, Mohammad-Ali ; Kolahi, Ali-Asghar

Introduction : Understanding trends in the annual incidence, mortality and disability adjusted life years (DALYs) for tracheal, bronchus and lung (TBL) cancers globally is important to enable appropriate targeting of resources for prevention, clinical practice improvement, and research. The aim of this study was to determine the global, regional and national burden of TBL cancer in 204 countries and territories from 1990 to 2019 by age, sex and socio-demographic index (SDI). Methods : Estimates [...]

Menée en Allemagne à partir de données portant sur 2 141 patients atteints d'un cancer, cette étude analyse la présence de pensées et d'intentions suicidaires et leur association avec des troubles psychiques

Thoughts of death and suicidality among patients with cancer: examining subtypes and their association with mental disorders

Vehling, S ; Mehnert-Theuerkauf, A ; Glaesmer, H ; Bokemeyer, C ; Oechsle, K ; Härter, M ; Koch, U

Objective : Cancer is associated with an increased risk for completed suicide. We explored subtypes of thoughts of death, death wishes, suicidal ideation and behavior and their association with mental disorders and demographic and disease‐related characteristics. Methods : We studied 2,141 cancer patients with the standardized Composite International Diagnostic Interview‐Oncology (CIDI‐O). Assessment included 4‐week‐prevalences of thoughts of death, wish to die, suicidal ideation, suicide [...]

Menée aux Etats-Unis à partir de données portant sur 1 730 patients atteints d'un cancer de l'oesophage, cette étude analyse l'impact de leurs symptômes d'anxiété sur la durée du séjour hospitalier après une oesophagectomie

Concurrent Diagnosis of Anxiety Increases Postoperative Length of Stay Among Patients Receiving Esophagectomy for Esophageal Cancer

Coffey, Max R. ; Bachman, Katelynn C. ; Worrell, Stephanie G. ; Argote-Greene, Luis M. ; Linden, Philip A. ; Towe, Christopher W.

Objective : Psychiatric comorbidities disproportionately affect patients with cancer. While identified risk factors for prolonged length of stay (LOS) after esophagectomy are primarily medical comorbidities, the impact of psychiatric comorbidities on perioperative outcomes is unclear. We hypothesized that psychiatric comorbidities would prolong LOS in patients with esophageal cancer. Methods : The 2016 National Inpatient Sample (NIS) was used to identify patients with esophageal cancer [...]

Menée aux Etats-Unis par questionnaire auprès de 1 802 patients ayant survécu à un cancer du testicule, cette étude analyse les facteurs associés à une utilisation de médicaments pour traiter des symptômes d'anxiété et/ou de dépression

Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study

ArdeshirRouhaniFard, Shirin ; Dinh, Paul C ; Monahan, Patrick O ; Fosså, Sophie D. ; Huddart, Robert ; Fung, Chunkit ; Song, Yiqing ; Feldman, Darren R. ; Hamilton, Robert J ; Vaughn, David J ; Martin, Neil E ; Kollmannsberger, Christian ; Einhorn, Lawrence ; Kroenke, Kurt ; Travis, Lois B.

Background: This study examined sociodemographic factors, cisplatin-related adverse health outcomes (AHOs), and cumulative burden of morbidity (CBMPt) scores associated with medication use for anxiety and/or depression in testicular cancer survivors (TCS). Methods: A total of 1,802 TCS who completed cisplatin-based chemotherapy {greater than or equal to}12 months previously completed questionnaires regarding sociodemographic features and cisplatin-related AHOs (hearing impairment, tinnitus, [...]

A partir d'une revue systématique de la littérature (8 articles), cette étude analyse les caractéristiques des outils permettant de mesurer la qualité de vie, l'anxiété et la dépression chez des patients atteints d'un cancer du testicule

Quality of Life, Anxiety and Depression Patient-Reported Outcome Measures in Testicular Cancer: A Systematic Review

Dincer, Amine Nur ; Brunckhorst, Oliver ; Genel, Oktay ; Dasgupta, Prokar ; FEBU, FLS, Urol ; FKC ; Muneer, Asif ; Ahmed, Kamran

Objectives : Several patient‐reported outcome measures (PROMs) are available for the assessment of quality of life (QoL), anxiety and depression for testicular cancer (TCa); however, these PROMs have uncertain validation of their psychometric properties for TCa‐only cohorts. This systematic review aims to critically analyse and evaluate the psychometric properties of these QoL, anxiety and depression PROMs. Methods : PubMed, EMBASE and PsycInfo were searched by two independent reviewers from [...]

Menée au Royaume-Uni par questionnaire auprès de 250 femmes présentant une suspicion de cancer de l'endomètre (âge : 50-59 ans), cette étude observationnelle analyse les facteurs associés à leur niveau de stress et d'anxiété

Anxiety and stress in women with suspected endometrial cancer: Survey and paired observational study

Diana, Marcus ; Alex, King ; Joseph, Yazbek ; Cathy, Hughes ; Sadaf, Ghaem-Maghami

Objective : To determine the anxiety and stress levels of women with suspected endometrial cancer and factors affecting this. Methods : Prospective survey and paired observational study of consecutive women with suspected endometrial cancer in a rapid access gynaecology clinic. Structured questionnaire including a GAD‐7 anxiety test and a modified stress thermometer. Patients ranked their perception of a cancer diagnosis on 0‐5 Likert scale (0 = confident not cancer and 5 = cancer). Patients [...]

A partir d'une revue systématique de la littérature (86 articles), cette étude analyse l'intérêt des outils permettant de mesurer l'impact financier de la maladie chez des adolescents et jeunes adultes atteints d'un cancer et chez leurs aidants

Systematic review of financial burden assessment in cancer: Evaluation of measures and utility among adolescents and young adults and caregivers

Salsman, John M. ; Danhauer, Suzanne C. ; Moore, Justin B. ; Ip, Edward H. ; McLouth, Laurie E. ; Nightingale, Chandylen L. ; Cheung, Christabel K. ; Bingen, Kristin M. ; Tucker-Seeley, Reginald D. ; Little-Greene, Denisha ; Howard, Dianna S. ; Reeve, Bryce B.

The cost of cancer care is rising and represents a stressor that has significant and lasting effects on quality of life for many patients and caregivers. Adolescents and young adults (AYAs) with cancer are particularly vulnerable. Financial burden measures exist but have varying evidence for their validity and reliability. The goal of this systematic review is to summarize and evaluate measures of financial burden in cancer and describe their potential utility among AYAs and their caregivers. [...]

Menée aux Etats-Unis dans les centres de lutte contre le cancer, cette étude analyse l'information disponible pour les patients atteints d'un cancer concernant les prix des soins, et notamment le prix des actes chirurgicaux

Analysis of Price Transparency for Oncologic Surgery Among National Cancer Institute–Designated Cancer Centers in 2020

Xiao, Roy ; Miller, Lauren E. ; Workman, Alan D. ; Bartholomew, Ryan A. ; Xu, Lucy J. ; Rathi, Vinay K.

In January 2019, the Centers for Medicare and Medicaid Services (CMS) began legally requiring hospitals to publish chargemasters online to promote price transparency. Hospital chargemasters list gross charges for all items and services, which are the undiscounted prices hospitals bill patients who are uninsured, self pay, or have out-of-network insurance. Understanding the cost of care is important for patients with cancer, who often suffer considerable financial burdens. However, a recent [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d'une interdiction éventuelle de l'utilisation des cabines de bronzage pour les adolescents (âgé : 14-17 ans) pour prévenir le risque de mélanome

To ban or not to ban tanning bed use for minors: A cost-effectiveness analysis from multiple US perspectives for invasive melanoma

Eskander, Antoine ; Marqueen, Kathryn E. ; Edwards, Heather A. ; Joshua, Anthony M. ; Petrella, Teresa M. ; de Almeida, John R. ; Goldstein, David P. ; Ferket, Bart S.

Background : Tanning bed use is common among US adolescents, but is associated with increased melanoma risk. The decision to ban tanning bed use by adolescents should be made in consideration of the potential health benefits and costs. Methods : The US population aged 14 to 17 years was modeled by microsimulation, which compared ban versus no ban strategies. Lifetime quality-adjusted life years (QALYs) and costs were estimated from a health care sector perspective and two societal perspectives: [...]

A partir d'une revue systématique de la littérature publiée entre 2003 et 2019 (19 études), cette étude analyse l'intérêt des formations dispensées en ligne et destinées à améliorer les compétences en communication des professionnels de santé travaillant en oncologie et dans le domaine des soins palliatifs

Effectiveness of online communication skills training for cancer and palliative care health professionals: A systematic review

Berg, Melissa ; Ngune, Irene ; Schofield, Penelope ; Grech, Lisa ; Juraskova, Ilona ; Strasser, Michelle ; Butt, Zoe ; Halkett, Georgia

Objective : To determine the reported effect of online communication skills training (CST) on health professional (HP) communication skills and patient care outcomes in cancer and palliative care. Methods : Primary research published in English between January 2003 and April 2019 was identified in bibliographic databases including Medline, Embase and Proquest (Prospero: CRD42018088681). An integrated mixed‐method approach included studies describing a CST intervention and its effect, for cancer [...]

Mené en Australie par entretiens auprès de 790, 746 et 712 femmes sans antécédent familial ou personnel de cancer (âge : 48-50 ans), cet essai randomisé évalue l'intérêt d'une intervention présentant des informations sur le surdiagnostic et le surtraitement pour améliorer leurs connaissances et éclairer leur décision concernant le dépistage du cancer du sein

Informing Women About Overdetection in Breast Cancer Screening: Two-year Outcomes from a Randomized Trial

Hersch, Jolyn ; Barratt, Alexandra ; McGeechan, Kevin ; Jansen, Jesse ; Houssami, Nehmat ; Dhillon, Haryana ; Jacklyn, Gemma ; Irwig MBBCh, Les ; McCaffery, Kirsten

Background : Supporting well-informed decisions about breast cancer screening requires communicating that inconsequential disease may be detected, leading to overdiagnosis and overtreatment. Having previously shown that telling women about overdetection improved informed choice, we investigated effects on screening knowledge and participation over 2 years. Methods : We conducted a community-based, parallel-group, randomised controlled trial in Australia. Participants were women aged 48–50 [...]

Menée à partir de données portant sur 227 patients atteints d'un cancer de stade avancé et hospitalisés dans des unités de soins palliatifs, cette étude prospective identifie les facteurs neuro-comportementaux et cognitifs associés à la présence d'un délire

Does Delirium Phenomenology in Persons with Advanced Cancer follow a Specific Pattern?

Maria Caterina Pallotti ; Jesus Lopez-Fidalgo ; Carlos Centeno ; Daniela Celin ; Guido Biasco ; Maddalena Giovannini ; Marco Maltoni ; Antonio Noguera

Objective: Recognizing delirium phenomenology (DP) aids the early diagnosis of this syndrome and improves quality of life in patients with advanced cancer. The aim of this study was to identify the neurobehavioral and cognitive patterns of delirium-related symptoms in persons with advanced cancer. Methods: We conducted an observational comparative prospective study on delirium in patients with advanced cancer in different palliative care settings, assessing the presentation/evolution of DP with [...]