Menée en Australie auprès de 9 435 participants ayant survécu à un premier cancer (durée médiane de suivi : 7 ans), cette étude analyse l'association entre la consommation d'alcool depuis l'âge de 20 ans et le risque de cancer métachrone (1 512 cas)

Pre-diagnosis alcohol intake and metachronous cancer risk in cancer survivors: a prospective cohort study

Jayasekara, Harindra ; Hodge, Allison M. ; Haydon, Andrew ; Room, Robin ; Hopper, John L. ; English, Dallas R. ; Smith-Warner, Stephanie A. ; Giles, Graham G. ; Milne, Roger L. ; MacInnis, Robert J.

Alcohol consumption is a known cause of cancer, but its role in the etiology of second primary (metachronous) cancer is uncertain. Associations between alcohol intake up until study enrollment (pre-diagnosis) and risk of metachronous cancer were examined in 9,435 participants in the Melbourne Collaborative Cohort Study who were diagnosed with their first invasive cancer after enrollment (1990-94). Follow-up was from date of first invasive cancer until diagnosis of metachronous cancer, death or [...]

Menée à l'aide de données 1991-2000 de la cohorte européenne EPIC portant sur 389 220 participants (âge médian au recrutement : 52 ans), cette étude analyse l'association entre la consommation de jus de fruits ou de boissons gazeuses et le risque de carcinome rénal (888 cas) ainsi que la mortalité associée (356 décès)

Soft drink and juice consumption and renal cell carcinoma incidence and mortality in the European Prospective Investigation into Cancer and Nutrition

Heath, Alicia K. ; Clasen, Joanna L ; Jayanth, Nick P ; Jenab, Mazda ; Tjonneland, Anne ; Petersen, Kristina E.N. ; Overvad, Kim ; Srour, Bernard ; Katzke , Verena ; Bergmann, Manuela M. ; Schulze, Matthias B. ; Masala, Giovanna ; Krogh, Vittorio ; Tumino, Rosario ; Catalano, Alberto ; Pasanisi, Fabrizio ; Brustad, Magritt ; Olsen, Karina Standahl ; Skeie, Guri ; Luján-Barroso, Leila ; Rodriguez-Barranco, Miguel ; Amiano, Pilar ; Santiuste, Carmen ; Barricarte Gurrea, Aurelio ; Axelson, Håkan ; Ramne, Stina ; Ljungberg, Börje ; Watts, Eleanor L. ; Huybrechts, Inge ; Weiderpass, Elisabete ; Riboli, Elio ; Muller, David C.

Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of RCC. We investigated the associations of soft drink and juice consumption with RCC incidence and mortality in the European Prospective Investigation into [...]

Menée à partir de données des cohortes "the Nurses’ Health Studys" portant sur 196 161 femmes (durée médiane de suivi : 20,8 ans), cette étude analyse l'association entre l'apport en acides aminés à chaîne ramifiée (isoleucine, leucine, valine) et le risque de cancer du sein invasif (10 046 cas)

Dietary Intake of Branched Chain Amino Acids and Breast Cancer Risk in the NHS and NHS II Prospective Cohorts

Tobias, Deirdre ; Chai, Boyang ; Tamimi, Rulla M ; Manson, JoAnn E ; Hu, Frank B ; Willett, Walter C ; Eliassen, A Heather

Branched-chain amino acids (BCAAs) are essential amino acids common throughout the US diet. While circulating BCAAs have been implicated in insulin resistance and some obesity-related cancers, the relationship between dietary intake of BCAAs and incident breast cancer is unknown. We sought to evaluate the association between long-term dietary intakes of BCAAs and invasive breast cancer risk.Our analyses included 196,161 women from the Nurses’ Health Study and Nurses’ Health Study II [...]

Menée à partir des données 2004-2006 de l'étude multicentrique française CERENAT portant sur 1 192 témoins et sur 596 patients atteints d'une tumeur du système nerveux central, cette étude analyse l'association entre une exposition professionnelle aux pesticides et le risque de développer la maladie

Occupational exposure to pesticides and central nervous system tumors: results from the CERENAT case–control study

Baldi, Isabelle ; De Graaf, Lucie ; Bouvier, Ghislaine ; Gruber, Anne ; Loiseau, Hugues ; Meryet-Figuiere, Matthieu ; Rousseau, Sarah ; Fabbro-Peray, Pascale ; Lebailly, Pierre

Background: The etiology of the central nervous system (CNS) tumors remains largely unknown. The role of pesticide exposure has been suggested by several epidemiological studies, but with no definitive conclusion. Objective: To analyze associations between occupational pesticide exposure and primary CNS tumors in adults in the CERENAT study. Methods: CERENAT is a multicenter case–control study conducted in France in 2004–2006. Data about occupational pesticide uses—in and outside [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données génétiques portant sur 85 467 patients au total, cette étude analyse l'association entre une prédisposition génétique à une maladie parodontale et le risque de cancer colorectal, de cancer du poumon ou du pancréas

Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer

Corlin, Laura ; Ruan, Mengyuan ; Tsilidis, Konstantinos K ; Bouras, Emmanouil ; Yu, Yau-Hua ; Stolzenberg-Solomon, Rachael ; Klein, Alison P ; Risch, Harvey A ; Amos, Christopher I ; Sakoda, Lori C ; Vodicka, Pavel ; Rish, Pai K ; Beck, James ; Platz, Elizabeth A ; Michaud, Dominique S

Observational studies indicate that periodontal disease may increase the risk of colorectal, lung, and pancreatic cancers. Using a two-sample Mendelian randomization (MR) analysis, we assessed whether a genetic predisposition index for periodontal disease was associated with colorectal, lung, or pancreatic cancer risks.Our primary instrument included single nucleotide polymorphisms (SNPs) with strong genome-wide association study evidence for associations with chronic, aggressive, and/or severe [...]

Menée au Canada à partir de données de santé 1998-2017 portant sur 907 902 adultes, cette étude analyse l'association entre une utilisation de médicaments antihypertenseurs et le risque de cancer de la peau (carcinome kératinocytaire ou mélanome) chez les personnes âgées de 66 ans et plus, en fonction de la classe médicamenteuse

Association between antihypertensive medications and risk of skin cancer in people older than 65 years: a population-based study

Drucker, Aaron M. ; Hollestein, Loes ; Na, Yingbo ; Weinstock, Martin A. ; Li, Wen-Qing ; Abdel-Qadir, Husam ; Chan, An-Wen

BACKGROUND: The risk of skin cancer associated with antihypertensive medication use is unclear, although thiazides have been implicated in regulatory safety warnings. We aimed to assess whether use of thiazides and other antihypertensives is associated with increased rates of keratinocyte carcinoma and melanoma. METHODS: We conducted a population-based inception cohort study using linked administrative health data from Ontario, 1998–2017. We matched adults aged ≥ 66 years with a first [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" ou de la "FinnGen" portant au total sur 544 460 participants, cette étude analyse l'association entre des variants génétiques liés à la concentration sérique en folate, en vitamine B6 ou en vitamine B12 et le risque de cancer digestif (oesophage, estomac, colon-rectum, pancréas)

Genetically predicted circulating B vitamins in relation to digestive system cancers

Yuan, Shuai ; Carter, Paul ; Vithayathil, Mathew ; Kar, Siddhartha ; Mason, Amy M. ; Burgess, Stephen ; Larsson, Susanna C.

Background: Folate, vitamin B6 and vitamin B12 have been associated with digestive system cancers. We conducted a two-sample Mendelian randomisation study to assess the causality of these associations. Methods: Two, one and 14 independent single nucleotide polymorphisms associated with serum folate, vitamin B6 and vitamin B12 at the genome-wide significance threshold were selected as genetic instruments. Summary-level data for the associations of the vitamin-associated genetic variants with [...]

Menée à partir des données d'une étude chinoise portant sur 69 296 participantes (âge : 40-70 ans ; durée moyenne de suivi : 17,5 ans), cette étude analyse l'association entre l'obésité globale, la répartition de la masse graisseuse corporelle à différents moments de la vie et le risque de cancer du foie (241 cas)

Dose-response association between adiposity and liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

Li, Zhuo-Ying ; Li, Hong-Lan ; Ji, Xiao-Wei ; Shen, Qiu-Ming ; Wang, Jing ; Tan, Yu-Ting ; Xiang, Yong-Bing

Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), adult weight gain, and annual [...]

Menée à l'aide de données portant sur 251 335 participants issus de 2 cohortes américaines, cette étude analyse l'association entre la consommation de viande rouge et le risque de cancer du pancréas (1 884 cas), puis évalue l'influence de certains facteurs génétiques sur cette association, en fonction de l'origine ethnique

Red meat consumption, cooking mutagens, NAT1/2 genotypes, and pancreatic cancer risk in two racially diverse prospective cohorts

Huang, Brian Z. ; Wang, Songren ; Bogumil, David ; Wilkens, Lynne R. ; Wu, Lang ; Blot, William J. ; Zheng, Wei ; Shu, Xiao-Ou ; Pandol, Stephen J. ; Le Marchand, Loic ; Setiawan, Veronica Wendy

There is limited evidence on the association between red meat consumption and pancreatic cancer among racial/ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary, and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort-specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études d'association sur le génome entier portant, entre autres, sur 29 266 patients atteints d'un cancer du poumon, cette étude analyse l'association entre des polymorphismes à simple nucléotide liés à une consommation de cannabis et le risque de développer la maladie

Cannabis use, pulmonary function, and lung cancer susceptibility: A Mendelian randomization study

Baumeister, Sebastian-Edgar ; Baurecht, Hansjörg ; Nolde, Michael ; Alayash, Zoheir ; Gläser, Sven ; Johansson, Mattias ; Amos, Christopher I. ; Johnson, Emma C. ; Hung, Rayjean J.

Introduction: Because of widespread use, understanding the pulmonary effects of cannabis use is important but its role independent from tobacco smoking is yet to be elucidated. We used Mendelian randomization (MR) to assess the effect of genetic liability to lifetime cannabis use and cannabis use disorder on pulmonary function and lung cancer. Methods: We used four single nucleotide polymorphisms (SNPs) associated with lifetime cannabis use (p value <5x10-8) from a genome-wide association study [...]

Menée auprès de 187 patients atteints d'un adénocarcinome pulmonaire (âge : 28-89 ans ; 72,7 % de femmes), cette étude identifie des variants constitutionnels pathogènes associés à la survenue précoce de la maladie

Germline mutations and age at onset of lung adenocarcinoma

Reckamp, Karen L. ; Behrendt, Carolyn E. ; Slavin, Thomas P. ; Gray, Stacy W. ; Castillo, Danielle K. ; Koczywas, Marianna ; Cristea, Mihaela C. ; Babski, Kirsten M. ; Stearns, Donna ; Marcum, Catherine A. ; Rodriguez, Yenni P. ; Hass, Amie J. ; Vecchio, Mary M. ; Mora, Pamela ; Cervantes, Aleck E. ; Sand, Sharon R. ; Mejia, Rosa M. ; Tsou, Terrence C. ; Salgia, Ravi ; Weitzel, Jeffrey N.

Background: To identify additional at-risk groups for lung cancer screening, which targets persons with a long history of smoking and thereby misses younger or nonsmoking cases, the authors evaluated germline pathogenic variants (PVs) in patients with lung adenocarcinoma for an association with an accelerated onset. Methods: The authors assembled a retrospective cohort (1999-2018) of oncogenetic clinic patients with lung adenocarcinoma. Eligibility required a family history of cancer, data on [...]

Menée en Chine entre 2016 et 2019 auprès de 320 patients atteints d'un cancer colorectal récemment diagnostiqué, cette étude estime, par catégorie d'âges (plus ou moins de 50 ans), la fréquence des cancers colorectaux liés au phénotype méthylateur CIMP, puis analyse l'association entre un CIMP élevé et des caractéristiques clinicopathologiques

Association between risk factors, molecular features and CpG island methylator phenotype colorectal cancer among different age groups in a Taiwanese cohort

Chen, Kuo-Hsing ; Lin, Liang-In ; Yuan, Chang-Tsu ; Tseng, Li-Hui ; Chao, Yu-Liang ; Liang, Yi-Hsin ; Liang, Jin-Tung ; Lin, Been-Ren ; Cheng, Ann-Lii ; Yeh, Kun-Huei

Background: CpG island methylator phenotype (CIMP) represents a carcinogenesis pathway of colorectal cancer (CRC) and the association between CIMP CRC, molecular features and risk factors in East Asian population is less studied. Methods: We prospectively enrolled newly diagnosed CRC patients at the National Taiwan University Hospital. Clinicopathological data and risk factors for CRC were collected during interview. The tumour samples were subjected to CIMP, RAS/BRAF mutation and [...]

Menée à l'aide de données portant sur 10 934 femmes ménopausées ayant eu un premier cancer du sein diagnostiqué entre 1995 et 2011 (durée médiane de suivi : 6,8 ans), cette étude identifie des facteurs de risque de cancer du sein controlatéral (436 cas)

Risk factors for contralateral breast cancer in postmenopausal breast cancer survivors in the NIH-AARP Diet and Health Study

Ramin, Cody ; Mullooly, Maeve ; Schonfeld, Sara J. ; Advani, Pragati G. ; Bodelon, Clara ; Gierach, Gretchen L. ; de González, Amy Berrington

Purpose: The role of established breast cancer risk factors and clinical characteristics of the first breast cancer in the development of contralateral breast cancer (CBC) among postmenopausal women is unclear. Methods: We identified 10,934 postmenopausal women diagnosed with a first primary breast cancer between 1995 and 2011 in the NIH-AARP Diet and Health Study. CBC was defined as a second primary breast cancer diagnosed in the contralateral breast ≥ 3 months after the first breast cancer. [...]

Menée à partir de données de la "UK Biobank" portant sur 163 859 femmes (durée moyenne de suivi : 7,1 ans), cette étude analyse l'association entre la concentration sérique de différentes hormones endogènes et le risque de cancer du sein (3 524 cas), en fonction du statut ménopausique

Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank

Tin Tin, Sandar ; Reeves, Gillian K. ; Key, Timothy J.

Background: Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. Methods: UK Biobank was used. Hormone concentrations were measured in serum collected in 2006–2010, and in a repeat subsample (N ~ 5000) in 2012–13. Incident cancers were identified through data linkage. Cox regression models were used, and hazard ratios (HRs) corrected for regression dilution bias. Results: Among 30,565 pre-menopausal and 133,294 [...]