Menée à partir de données portant sur 106 patients atteints d'un cancer gastrointestinal, cette étude analyse les facteurs associés à des changements rapides dans la qualité de vie 4 semaines après un traitement chirurgical

Factors influencing early postoperative health-related quality of life in patients with alimentary system cancer

Hara, Tsuyoshi ; Kogure, Eisuke ; Kubo, Akira

Purpose : The purpose of this study was to investigate changes in early postoperative health-related quality of life (HRQOL) in patients with gastrointestinal cancer and to examine the factors influencing such changes. Methods : Participants were 106 patients scheduled for elective surgery for gastrointestinal cancer (61 male and 45 females; aged 62.6 ± 12.0 years). HRQOL was evaluated using the Short-Form 36-Item Health Survey version 2 (SF-36) at two time points: 1–2 days prior to surgery [...]

Mené sur 202 patients atteints d'un cancer et recevant un traitement anticancéreux dispensé par voie orale, cet essai randomisé évalue l'intérêt d'une prise en charge pharmacologique et pharmaceutique clinique intensifiée (gestion des médicaments, conseils) pour réduire les effets indésirables liés aux traitements anticancéreux, améliorer la satisfaction des patients vis-à-vis de leur traitement anticancéreux et augmenter leur adhésion

The Randomized AMBORA Trial: Impact of Pharmacological/Pharmaceutical Care on Medication Safety and Patient-Reported Outcomes During Treatment With New Oral Anticancer Agents

Pauline Dürr ; Katja Schlichtig ; Carolin Kelz ; Birgit Deutsch ; Renke Maas ; Michael J. Eckart ; Jochen Wilke ; Harald Wagner ; Kerstin Wolff ; Caroline Preuß ; Valeska Brückl ; Norbert Meidenbauer ; Christian Staerk ; Andreas Mayr ; Rainer Fietkau ; Peter J. Goebell ; Frank Kunath ; Matthias W. Beckmann ; Andreas Mackensen ; Markus F. Neurath ; Marianne Pavel ; Frank Dörje ; Martin F. Fromm

PURPOSE : Oral anticancer drugs (eg, kinase inhibitors) play an important role in cancer therapy. However, considerable challenges regarding medication safety of oral anticancer drugs have been reported. Randomized, controlled, multicenter studies on the impact of intensified clinical pharmacological/pharmaceutical care on patient safety and patient treatment perception are lacking. METHODS : Patients were eligible for the randomized, multicenter AMBORA study, if they were newly started on any [...]

Mené sur 51 patients atteints d'une tumeur thoracique, cet essai prospectif de phase II évalue l'efficacité et la toxicité de faibles doses d'olanzapine combinée au granisétron et à la dexaméthasone pour prévenir et traiter les nausées et vomissements induits par une chimiothérapie à base de carboplatine

Low-Dose Olanzapine Plus Granisetron and Dexamethasone for Carboplatin-Induced Nausea and Vomiting in Patients with Thoracic Malignancies: A Prospective Multicenter Phase II Trial

Sakai, Chizuru ; Shimokawa, Mototsugu ; Iihara, Hirotoshi ; Fujita, Yukiyoshi ; Ikemura, Shinnosuke ; Hirose, Chiemi ; Kotake, Mie ; Funaguchi, Norihiko ; Gomyo, Takenobu ; Imai, Hisao ; Hakamata, Jun ; Kaito, Daizo ; Minato, Koichi ; Arai, Takahiro ; Kawazoe, Hitoshi ; Suzuki, Akio ; Ohno, Yasushi ; Okura, Hiroyuki

Background : Olanzapine is an inexpensive and durable agent for the treatment of chemotherapy‐induced nausea and vomiting and is also superior to neurokinin‐1 receptor antagonists in the control of nausea. This study aimed to investigate the efficacy and safety of a low dose of 5 mg olanzapine plus granisetron and dexamethasone for treatment of carboplatin (CBDCA)‐induced nausea and vomiting in patients with thoracic malignancies. Materials and Methods : We conducted a prospective, open‐label, [...]

A partir des données de la base GLOBOCAN et de données de mortalité de l'Organisation Mondiale de la Santé, cette étude présente une estimation de l'incidence des cancers pour l'année 2020 et de la mortalité spécifique, pour 185 pays et territoires

Cancer statistics for the year 2020: an overview

Ferlay, Jacques ; Colombet, Murielle ; Soerjomataram, Isabelle ; Parkin, Donald M. ; Piñeros, Marion ; Znaor, Ariana ; Bray, Freddie

This paper briefly reviews the data sources and methods used in compiling the International Agency for Research on Cancer (IARC) GLOBOCAN cancer statistics for the year 2020, and summarises the main results. National estimates were calculated based on the best available data on cancer incidence from population-based cancer registries (PBCR) and mortality from the World Health Organization (WHO) mortality database. Cancer incidence and mortality rates for 2020 by sex and age groups were [...]

Menée aux Etats-Unis à partir de données portant sur 50 108 participants (âge moyen : 43,8 ans), cette étude analyse l'association entre la fréquence cardiaque au repos, la santé cardiorespiratoire et la mortalité par cancer (période de suivi : 1974-2002 ; durée moyenne de suivi : 15 ans ; 1 090 décès par cancer)

Resting Heart Rate and Risk of Cancer Mortality

Gutierrez-Martinez, Leidys ; Brellenthin, Angelique G ; Lefferts, Elizabeth C ; Lee, Duck-chul ; Sui, Xuemei ; Lavie, Carl J ; Blair, Steven N.

Background: Increased resting heart rate (RHR) is a predictor of mortality. RHR is influenced by cardiorespiratory fitness (CRF). Little is known about the combined associations of RHR and CRF on cancer mortality. Methods: 50,108 men and women (mean age 43.8 years) were examined between 1974 and 2002 at the Cooper Clinic in Dallas, Texas. RHR was measured by electrocardiogram and categorized as <60, 60-69, 70-79, or >=80 beats/min. CRF was quantified by maximal treadmill test and [...]

Cette étude transversale présente une estimation, jusqu'en 2040, de l'incidence des cancers et de la mortalité associée aux Etats-Unis

Estimated Projection of US Cancer Incidence and Death to 2040

Rahib, Lola ; Wehner, Mackenzie R. ; Matrisian, Lynn M. ; Nead, Kevin T.

Importance : Coping with the current and future burden of cancer requires an in-depth understanding of trends in cancer incidences and deaths. Estimated projections of cancer incidences and deaths will be important to guide future research funding allocations, health care planning, and health policy efforts. Objective : To estimate cancer incidences and deaths in the United States to the year 2040. Design and Setting : This cross-sectional study’s estimated projection analysis used population [...]

Menée en France à partir des données du registre national des cancers de l'enfant sur la période 1990-2014, cette étude analyse les variations saisonnières dans l'incidence des leucémies pédiatriques

Seasonal variations in childhood leukaemia incidence in France, 1990–2014

Bamouni, Sophie ; Hémon, Denis ; Faure, Laure ; Clavel, Jacqueline ; Goujon, Stéphanie

Background : Several studies have addressed the potential seasonality of childhood acute leukaemia (AL) without conclusive results. Using data from the National Registry of Childhood Cancers over 1990–2014 in mainland France, we investigated the seasonal variations in childhood AL taken together, and lymphoblastic (ALL) and myeloid (AML) leukaemia separately. Methods : Assuming constant variations over 1990–2014, we used a Poisson regression model to evaluate variations in standardized [...]

Menée à partir de données portant sur 226 patients atteints d'un cancer colorectal de stade métastatique, cette étude de cohorte évalue l'association entre le statut mutationnel de la tumeur, une perte de muscle, une perte de poids et la survie globale

Muscle Loss is Associated with Overall Survival in Patients with Metastatic Colorectal Cancer Independent of Tumor Mutational Status and Weight Loss

Cand, T. D. Best ; Roeland, E. J. ; Horick, N. K. ; Van Seventer, E. E. ; El-Jawahri, A. ; Cand, A. S. Troschel ; Johnson, P. C. ; Kanter, K. N. ; Fish, M. G. ; Cand, J. P. Marquardt ; Bridge, C. P. ; Temel, J. S. ; Corcoran, R. B. ; Nipp, R. D. ; Fintelmann, F. J.

Background : Survival in patients with metastatic colorectal cancer (mCRC) has been associated with tumor mutational status, muscle loss, and weight loss. We sought to explore the combined effects of these variables on overall survival. Materials and Methods : We performed an observational cohort study, prospectively enrolling patients receiving chemotherapy for mCRC. We retrospectively assessed changes in muscle (using computed tomography) and weight, each dichotomized as >5% or ≤5% loss, at [...]

Menée en Corée par enquête auprès de 433 patients ayant survécu à un cancer, cette étude analyse l'association entre la stigmatisation liée à la maladie et la perte de leur emploi

Association between cancer stigma and job loss among cancer survivors

Shim, Sungkeun ; Kang, Danbee ; Bae, Ka Ryeong ; Lee, WooYong ; Nam, Seokjin ; Sohn, Taesung ; Chang Jeong, Byong ; Sinn, Dong Hyun ; Kweon, Sun Seog ; Shim, Young Mog ; Cho, Juhee

Objective : Previous qualitative studies found cancer stigma was associated with work discrimination and job loss among cancer patients. This study aims to quantify the association between cancer stigma and job loss among cancer survivors. Methods : For this study, we used the data from a face‐to‐face cross sectional survey conducted at 2 cancer hospitals in Seoul and Hwasun in South Korea from October 2017 to March 2018. Cancer stigma was assessed using a validated questionnaire which consists [...]

A partir d'une revue de la littérature (43 études), cette étude analyse les études traitant des enjeux liés au soutien social pour les frères et soeurs d'un enfant atteint d'un cancer

Social Support and Siblings of Children with Cancer: A Scoping Review

Wawrzynski, Sarah E. ; Schaefer, Megan R. ; Schvaneveldt, Nena ; Alderfer, Melissa A.

Objective : Social support is essential in healthy adjustment to life stressors. This scoping review examines how social support has been conceptualized, operationalized, and studied among siblings of children with cancer. Gaps in the current literature are identified, and future research directions are proposed. Methods : A rigorous systematic scoping review framework guided our process. Medline, Embase, CINAHL, PsycINFO, and Scopus were searched for literature regarding social support and [...]

Menée en Chine par questionnaire auprès de 540 patients atteints d'un cancer du poumon, cette étude analyse l'association entre divers facteurs psychosociaux (stratégies pour faire face à la maladie, stratégies de régulation des émotions, soutien social, etc.) et la croissance post-traumatique

Effects of psychosocial factors on posttraumatic growth among lung cancer patients: A structural equation model analysis

Zhang, Huaguo ; Ma, Weiguang ; Wang, Guorong ; Wang, Song ; Jiang, Xiaolian

Objective : The purpose of this study was to investigate how locus of control, coping strategies, emotion regulation strategies and social support affect posttraumatic growth. Methods : A cross-sectional study design was adopted. A convenience sample of 540 patients with lung cancer was recruited from November 2016 to July 2017 at two tertiary grade A hospitals in China. The participants completed a series of questionnaires. Structural equation modelling was used to explore the effects of [...]

Menée en Corée auprès de 184 patients atteints d'un cancer du poumon de stade avancé, cette étude transversale analyse le rôle de la capacité de résilience sur l'association entre la stigmatisation liée à la maladie et le sentiment de bonheur pendant les traitements anticancéreux

The mediating effect of resilience on happiness of advanced lung cancer patients

Cho, Sunwha ; Ryu, Eunjung

Purpose : To identify the perceived level of lung cancer stigma, resilience, and happiness among advanced lung cancer patients during treatment, and to analyze the mediating effect of resilience in the relationship between stigma and happiness. Methods : A cross-sectional study design was used. A total of 184 patients diagnosed with advanced lung cancer were recruited from the National Cancer Center in Korea. Lung cancer stigma, resilience, and happiness were measured using questionnaires. [...]

A partir d'une revue systématique de la littérature (163 articles), cette étude analyse l'utilisation, pendant la radiothérapie, de médecines parallèles et complémentaires pour réduire les effets indésirables et améliorer la qualité de vie des patients atteints d'un cancer

The use of complementary and integrative therapies as adjunct interventions during radiotherapy: a systematic review

Lapen, Kaitlyn ; Cha, Elaine ; Huang, Christina C. ; Rosenberg, David M. ; Rooney, Michael K. ; McArthur, Mark ; Arya, Ritu ; Son, Christina H. ; McCall, Anne R. ; Golden, Daniel W.

Purpose : Literature supporting the efficacy of complementary and integrative medicine (CIM) alongside radiotherapy is fragmented with varying outcomes and levels of evidence. This review summarizes the available evidence on CIM used with radiotherapy in order to inform clinicians. Methods : A systematic literature review identified studies on the use of CIM during radiotherapy. Inclusion required the following criteria: the study was interventional, CIM therapy was for human patients with [...]

Menée aux Etats-Unis, cette étude analyse les disparités ethniques et socioéconomiques dans l'accès, par les patients atteints d'un cancer, à l'information médicale contenue dans leurs dossiers de santé électroniques

Disparities in Electronic Health Record Patient Portal Enrollment Among Oncology Patients

Sinha, Sumi ; Garriga, Meera ; Naik, Nishali ; McSteen, Brian W. ; Odisho, Anobel Y. ; Lin, Amy ; Hong, Julian C.

Care for oncology patients requires multidisciplinary, longitudinal coordination. Patient portals allow patients to access medical information from electronic health records (EHRs) and communicate with clinicians. This can improve treatment coordination and increase active participation in care.1 Unfortunately, disparities in patient portal use across age, race/ethnicity, and socioeconomic status can affect quality of care, especially in oncology.1,2 To identify longitudinal disparities in [...]