Menée aux Etats-Unis auprès de patients ayant survécu 10 ans ou plus à un cancer pédiatrique (âge médian au diagnostic : 7 ans ; âge médian lors de l'étude : 30 ans), cette étude analyse les facteurs associés à la présence et à l'évolution de fragilités

Progression of Frailty in Survivors of Childhood Cancer: a St. Jude Lifetime Cohort Report

Delaney, Angela ; Howell, Carrie R ; Krull, Kevin R ; Brinkman, Tara M ; Armstrong, Gregory T ; Chemaitilly, Wassim ; Wilson, Carmen L ; Mulrooney, Daniel A ; Wang, Zhaoming ; Lanctot, Jennifer Q ; Johnson, Ruth E ; Krull, Matthew R ; Partin, Robyn E ; Shelton, Kyla C ; Srivastava, Deo Kumar ; Robison, Leslie L ; Hudson, Melissa M ; Ness, Kirsten K

Background : Some adult survivors of childhood cancers develop frailty at higher rates than expected based on their chronological age. This study examined the incidence of frailty among survivors at ten or more years after diagnosis, frailty prevalence 5 years later, and risk factors for becoming frail. Methods : Frailty was measured at study entry and five years later. Logistic regression tested the associations of several factors with having frailty at five years for all participants and [...]

Menée au Japon à partir de données portant sur 1 896 patients atteints d'un cancer de stade avancé, cette étude de cohorte prospective analyse les facteurs associés à la présence de symptômes rares (myoclonie, transpiration, prurit, hoquet et ténesme)

Prevalence and associated factors of orphan symptoms in advanced cancer patients: a multicenter observational study

Nishijima, Kaoru ; Kizawa, Yoshiyuki ; Yamauchi, Toshihiro ; Odagiri, Takuya ; Ito, Tetsuya ; Kaneishi, Keisuke ; Shimizu, Keiji ; Morita, Tatsuya ; Mori, Masanori

Purpose : The aims of this study were to examine the prevalence of myoclonus, sweating, pruritus, hiccup, and vesical and rectal tenesmus, and to explore associated factors in patients with advanced cancer. Methods : This multicenter prospective cohort study was conducted in 23 inpatient hospices/palliative care units in Japan from January to December 2017. The prevalence and characteristics of each symptom were assessed on admission and in the 3 days before death. We selected factors that [...]

Menée aux Pays-Bas à partir de données portant sur 6 786 patients ayant survécu à un cancer et sur des témoins, cette étude analyse les facteurs associés à leur niveau de fonctionnement cognitif auto-perçu

Self-perceived cognitive functioning and quality of life among cancer survivors: results from the PROFILES registry

Oerlemans, Simone ; Schagen, Sanne B. ; van den Hurk, Corina J. ; Husson, Olga ; Schoormans, Dounya ; van de Poll-Franse, Lonneke V.

Purpose : The aim was to investigate the level of self-perceived cognitive functioning and its associated factors among a large population-based cohort of cancer survivors and their matched controls. Methods : Data were obtained from population-based PROFILES registry cohorts, including colon, rectum, prostate or thyroid cancer, Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia, multiple myeloma (MM), melanoma, or basal cell carcinoma (BCC)/squamous cell carcinoma [...]

A partir d'une revue systématique de la littérature (81 articles), cette synthèse fait le point sur les expériences et la qualité de vie de patients ayant survécu à un cancer colorectal de stade précoce ou de stade avancé

Colorectal cancer survivorship: A systematic review and thematic synthesis of qualitative research

Lim, Chloe Yi Shing ; Laidsaar-Powell, Rebekah Clare ; Young, Jane M. ; Kao, Steven Chuan-Hao ; Zhang, Yuehan ; Butow, Phyllis

Introduction : With rapid changes in treatments for colorectal cancer (CRC), qualitative research into CRC survivorship requires greater synthesis. This paper aims to fill this gap through a systematic review (PROSPERO CRD42019131576) and thematic synthesis of the qualitative literature on survivorship experiences across early‐stage and advanced CRC survivors. Methods : CINAHL, Embase, MEDLINE, PsycINFO and PubMed were searched for qualitative CRC survivorship papers. Titles, abstracts and full [...]

A partir des données GLOBOCAN, cette étude présente, pour l'année 2018, une estimation de l'incidence des cancers pédiatriques (âge : inférieur à 15 ans) et de la mortalité spécifique dans 183 pays

A Systematic Examination of Burden of Childhood Cancers in 183 Countries: Estimates from GLOBOCAN 2018

Sharma, Rajesh

Objective : Childhood cancers are a significant cause of child deaths worldwide. This study examines the burden of 33 childhood cancers in 183 countries. Methods : The estimates of age-, sex- and country-wise incidence and deaths due to 33 childhood cancers (below the age 15) for 183 countries were retrieved from GLOBOCAN 2018. The socioeconomic status of a country was measured by human development index (HDI). Results : Globally, an estimated 200 166 cases and 74 956 deaths were attributed to [...]

Menée à partir de données portant sur 41 109 patients atteints d'un cancer et inclus dans 55 essais de phase II et III entre 1985 et 2012, cette étude analyse les disparités socioéconomiques dans la participation des patients à des essais cliniques et dans la survie

Persistent Disparity: Socioeconomic Deprivation and Cancer Outcomes in Patients Treated in Clinical Trials

Joseph M. Unger ; Anna B. Moseley ; Christabel K. Cheung ; Raymond U. Osarogiagbon ; Banu Symington ; Scott D. Ramsey ; Dawn L. Hershman

PURPOSE : Patients with cancer living in socioeconomically disadvantaged areas have worse cancer outcomes. The association between socioeconomic deprivation and outcomes among patients with cancer participating in clinical trials has not been systematically examined. METHODS : We examined survival outcomes for patients enrolled in phase III and large phase II clinical trials for major cancers conducted by the SWOG Cancer Research Network from 1985 to 2012. Socioeconomic deprivation was measured [...]

Menée auprès de 289 adolescents et jeunes adultes ayant survéu à un cancer pédiatrique, cette étude analyse les facteurs, notamment familiaux, associés à leur utilisation de substances

Family and parent-child relationship correlates of pediatric cancer survivors’ substance use

Tillery, Rachel ; Willard, Victoria W. ; Gordon, Mallorie L. ; Adams, Kristen ; Long, Alanna ; Phipps, Sean

Objective : The primary aims of this research were to examine substance use among adolescent and young adult survivors of pediatric cancer (AYA survivors) and AYA without a history of chronic or life threatening illness (AYA comparisons) and to explore links between demographic, medical, caregiver-AYA, and family system factors with AYA substance use patterns. Methods : Participants included 289 AYA (survivors, n = 171; comparisons = 118; 51% female; Mage = 17.15, SDage = 2.86) and their [...]

Menée auprès de patientes ayant survécu plus de 8 ans (260 cas) ou moins de 5 ans (260 cas) à un cancer de l'ovaire, cette étude analyse chez ces deux groupes la qualité de vie, la survenue d'événements indésirables et l'association entre la qualité de vie et la survie à long terme

Quality of Life and Adverse Events: Prognostic Relationships in Long-Term Ovarian Cancer Survival

Wenzel, Lari ; Osann, Kathryn ; McKinney, Chelsea ; Cella, David ; Fulci, Giulia ; Scroggins, Mary J ; Lankes, Heather A ; Wang, Victoria ; Nephew, Kenneth P ; Maxwell, George L ; Mok, Samuel C ; Conrads, Thomas P ; Miller, Austin ; Mannel, Robert S ; Gray, Heidi J ; Hanjani, Parviz ; Huh, Warner K ; Spirtos, Nick ; Leitao, Mario M ; Glaser, Gretchen ; Sharma, Sudarshan K ; Santin, Alessandro D ; Sperduto, Paul ; Lele, Shashikant B ; Burger, Robert A ; Monk, Bradley J ; Birrer, Michael

BACKGROUND : There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival. METHODS : Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Trial Outcome Index (FACT-O-TOI), including physical, functional and ovarian-specific subscales, was compared between long-term (LTS) (8+ years) and short-term (STS) (<5 years) survivors of GOG 218 at baseline, before cycles 4, 7, 13, 21, and 6 months post-treatment using [...]

Menée à partir des données des registres américains des cancers portant sur 1 294 patients atteints d'un médulloblastome traité par radiothérapie entre 1973 et 2014, cette étude analyse le risque de second cancer

Observed-to-expected incidence ratios of second malignant neoplasms after radiation therapy for medulloblastoma: A surveillance, epidemiology, and end results analysis

Nantavithya, Chonnipa ; Paulino, Arnold C. ; Liao, Kaiping ; Woodhouse, Kristina D. ; McGovern, Susan L. ; Grosshans, David R. ; McAleer, Mary F. ; Khatua, Soumen ; Chintagumpala, Murali M. ; Majd, Nazanin ; Zaky, Wafik ; Yeboa, Debra N.

BACKGROUND : The authors analyzed the incidence and types of second malignant neoplasms (SMNs) in patients treated for medulloblastoma. METHODS : The authors compared the incidence of SMNs after radiotherapy (RT) for medulloblastoma in patients treated in 1973‐2014 with the incidence in the general population with the multiple primary–standardized incidence ratio function of Surveillance, Epidemiology, and End Results 9. Observed‐to‐expected incidence (O/E) ratios and 95% confidence intervals [...]

Menée à partir des données du registre écossais des cancers sur la période 2008-2017, cette étude analyse les disparités ethniques dans l'évolution de l'incidence du cancer du col de l'utérus

Cervical cancer incidence by ethnic group in Scotland from 2008 to 2017: A population-based study

Affar, Saba ; Morrison, David S. ; Campbell, Christine

Background : There is limited information on cervical cancer incidence among different ethnic groups. This study used a name classification system to describe recent patterns of cervical cancer by ethnic group in Scotland. Methods : Data on incident cases of cancer of the cervix and carcinoma in situ diagnosed in Scotland from 2008 to 2017 were extracted from the Scottish Cancer Registry. Onomap was applied to ascribe ethnicity to each patient. Ethnic groups were categorised as White, Black, [...]

Menée aux Etats-Unis par enquête auprès de 13 361 participants sur la période 2013-2018, cette étude analyse les facteurs liés à la présence de difficultés financières déclarées par les patients ayant survécu à un cancer et la détresse psychologique associée

Financial worry and psychological distress among cancer survivors in the United States, 2013—2018

Dee, Edward Christopher ; Nipp, Ryan D. ; Muralidhar, Vinayak ; Yu, Zizi ; Butler, Santino S. ; Mahal, Brandon A. ; Nguyen, Paul L. ; Sanford, Nina N.

Background : A growing proportion of cancer survivors experience financial toxicity. However, the psychological burden of cancer costs and associated mental health outcomes require further investigation. We assessed prevalence and predictors of self-reported financial worry and mental health outcomes among cancer survivors. Patients and methods : Data from the 2013–2018 National Health Interview Survey (NHIS) for adults reporting a cancer diagnosis were used. Multivariable ordinal logistic [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (15 études), cette étude analyse les définitions du concept de résilience chez des patients atteints d'un cancer de stade avancé et recevant des soins palliatifs

Psychological resilience among palliative patients with advanced cancer: A systematic review of definitions and associated factors

Lau, Jerrald ; Khoo, Athena Ming-Gui ; Ho, Andy Hau-Yan ; Tan, Ker-Kan

Objective : The palliative journey can be emotionally stressful for both patients with advanced cancer and their families. Psychological resilience is crucial in aiding with patients' adaptation and post‐traumatic growth. The aim of this systematic review was to critically examine the definitions of psychological resilience and its associated factors in palliative patients with advanced cancer. Methods : Four databases were systematically searched from inception to August 2020. Both qualitative [...]

Menée à partir de données portant sur 327 patientes atteintes d'un cancer du sein de stade I à III et incluses dans un essai randomisé, cette étude analyse l'association entre du soutien social, une fatigue, des douleurs et des symptômes de dépression

Relationship between social support, physical symptoms, and depression in women with breast cancer and pain

Fisher, Hannah M. ; Winger, Joseph G. ; Miller, Shannon N. ; Wright, Arianna N. ; Plumb Vilardaga, Jennifer C. ; Majestic, Catherine ; Kelleher, Sarah A. ; Somers, Tamara J.

Purpose : Fatigue and pain are common among women with breast cancer, and often related to depressive symptoms. Social support may influence levels of fatigue, pain interference, and depressive symptoms. We tested a theory-based, structural model examining the relationship between social support (i.e., emotional and instrumental) and depressive symptoms via fatigue and pain interference in women with breast cancer. Methods : Women (N = 327) with stages I–III breast cancer were enrolled in a [...]

Menée aux Etats-Unis auprès de 193 personnes ayant des antécédents familiaux d'adénocarcinome pancréatique, cette étude rétrospective analyse les facteurs entravant ou facilitant la participation à une surveillance médicale, notamment la communication au sein de la famille concernant le risque de développer la maladie

Cancer surveillance awareness and practice among families at increased risk for pancreatic adenocarcinoma

Everett, Jessica N. ; Burgos, Gabriela ; Chun, Jennifer ; Baptiste, Ariele ; Khanna, Lauren G. ; Oberstein, Paul E. ; Simeone, Diane M.

BACKGROUND : Early detection of pancreatic ductal adenocarcinoma (PDAC) is an important goal for improving survival. Individuals who meet published guidelines for surveillance may be underidentified, and family communication about risk represents a pathway to increasing participation in surveillance. We investigated the uptake of and barriers to surveillance in at‐risk relatives of clinic patients. METHODS : We conducted a retrospective record review of patients with personal or family history [...]