Menée aux Pays-Bas par questionnaire auprès de 50 patients atteints d'un cancer et recevant un traitement anticancéreux systémique, cette étude analyse leur sensibilité gustative vis-à-vis de 5 compléments nutritionnels adaptés (5 saveurs différentes entraînant des sensations de réchauffement et de refroidissement) en fonction de la présence de troubles du goût ou de l'odorat

Self-reported taste and smell alterations and the liking of oral nutritional supplements with sensory-adapted flavors in cancer patients receiving systemic antitumor treatment

de Haan, Jacco J. ; Renken, Remco J. ; Moshage, Yvette ; Kluifhooft, Daniëlle A. ; Corbier, Camille ; Daly, Louise E. ; Blanchard, Hélène ; Reyners, Anna K. L.

Purpose : Taste and smell alterations (TAs and SAs) are often reported by patients with cancer receiving systemic antitumor therapy and can negatively impact food intake and quality of life. This study aimed to examine the occurrence of TAs and SAs and investigate the impact of TAs on overall liking of oral nutritional supplements (ONS) with warming and cooling sensations. Methods : Patients receiving systemic antitumor therapy completed a questionnaire on sensory alterations and evaluated [...]

Menée au Brésil auprès de 44 patients atteints d'un cancer de la vessie et de 44 patients atteints d'un cancer du rein (âges moyens : 65,9 et 58,6 ans), cette étude transversale analyse l'association entre le statut nutritionnel, la présence d'une fragilité (selon le phénotype de Fried) et la qualité de vie

Influence of nutritional status and frailty phenotype on health-related quality of life of patients with bladder or kidney cancer

dos Reis, Patrícia Fonseca ; de França, Patrícia Sousa ; dos Santos, Mylena Pinto ; Martucci, Renata Brum

Purpose : This research aimed to assess the impact of nutritional status and frailty in the health-related quality of life (HRQoL) of patients with bladder or kidney cancer. Methods : This was a cross-sectional study with individuals aged 20 years or older. Frailty phenotype was defined using the criteria of Fried et al. (2001). Patient-Generated Subjective Global Assessment (PG-SGA) classified nutritional status. The European Organization for Research and Treatment of Cancer Quality of life [...]

Menée en Allemagne par questionnaire auprès de patients atteints d'un cancer de stade avancé, cette étude de cohorte analyse l'évolution de la fatigue et de symptômes de dépression avant et 12 mois après les traitements anticancéreux ainsi que les facteurs facilitant ou entravant une activité physique

Changes in fatigue, barriers, and predictors towards physical activity in advanced cancer patients over a period of 12 months—a comparative study

Frikkel, J. ; Beckmann, M. ; De Lazzari, N. ; Götte, M. ; Kasper, S. ; Hense, J. ; Schuler, M. ; Teufel, M. ; Tewes, M.

Purpose : Physical activity (PA) is recommended to improve advanced cancer patients’ (ACP) physical functioning, fatigue, and quality of life. Yet, little is known about ACPs’ attitude towards PA and its influence on fatigue and depressiveness over a longer period. This prospective, non-interventional cohort study examined ACPs’ fatigue, depression, motivation, and barriers towards PA before and after 12 months of treatment among ACP Methods : Outpatients with incurable cancer receiving [...]

Cette étude présente les recommandations de l'"American Society of Clinical Oncology" concernant la prise en charge d'une dyspnée chez des patients atteints d'un cancer de stade avancé

Management of Dyspnea in Advanced Cancer: ASCO Guideline

David Hui ; Kari Bohlke ; Ting Bao ; Toby C. Campbell ; Patrick J. Coyne ; David C. Currow ; Arjun Gupta ; Aliza L. Leiser ; Masanori Mori ; Stefano Nava ; Lynn F. Reinke ; Eric J. Roeland ; Carole Seigel ; Declan Walsh ; Margaret L. Campbell

PURPOSE : To provide guidance on the clinical management of dyspnea in adult patients with advanced cancer. METHODS : ASCO convened an Expert Panel to review the evidence and formulate recommendations. An Agency for Healthcare Research and Quality (AHRQ) systematic review provided the evidence base for nonpharmacologic and pharmacologic interventions to alleviate dyspnea. The review included randomized controlled trials (RCTs) and observational studies with a concurrent comparison group [...]

Menée aux Etats-Unis par enquête en ligne auprès de 209 patients ayant survécu à un cancer et de leurs 155 partenaires de vie, cette étude analyse les facteurs associés à leurs opinions concernant l'intérêt de l'activité physique et leurs préférences vis-à-vis des programmes encourageant cette pratique

Beliefs and interests in physical activity programs of cancer survivors and their romantic partners

Ulrich, G. R. ; Callan, S. ; Ranby, K. W.

Purpose : Physical activity is associated with improved health outcomes for cancer survivors and their romantic partners, yet it is unclear if joint exercise programs for survivor-partner dyads are acceptable. This study examined demographic, relationship, exercise, and cancer history correlates of survivors’ and their romantic partners’ couples-based exercise beliefs and their preferences for program designs. Methods : All participants (survivors n=209, partners n=155, couples n=143) completed [...]

Menée au Canada par enquête en ligne auprès de 338 professionnels en oncologie, cette étude analyse leurs points de vue et leurs conseils concernant l'activité physique chez des patients atteints d'un cancer et de métastases osseuses

Physical activity recommendations for cancer survivors living with bony metastases: views of oncologic healthcare providers

Adams, J. ; Rauw, J. ; Weller, S. ; Campbell, K. L. ; Pollock, P. ; Goulart, J.

Purpose : The potential of physical activity to improve function and quality of life of an individual with advanced cancer is now established. The purpose of this survey of oncologic healthcare providers (OHPs) is to understand their attitude towards physical activity for individuals living with bony metastases and to assess requirements to confidently provide physical activity recommendations. Methods : A web-based survey administered through Qualtrics™ included questions on participant [...]

Menée en Suisse dans un contexte de vie réelle auprès de 417 patients atteints d'un cancer avec métastases osseuses traitées par des agents thérapeutiques ciblant les os, cette étude transversale analyse la qualité de vie et la douleur liées à la maladie

Quality of life and pain in patients with metastatic bone disease from solid tumors treated with bone-targeted agents– a real-world cross-sectional study from Switzerland (SAKK 95/16)

Ribi, Karin ; Thürlimann, Beat ; Schär, Corinne ; Dietrich, Daniel ; Cathomas, Richard ; Zürrer-Härdi, Ursina ; von Briel, Thomas ; Anchisi, Sandro ; Bohanes, Pierre ; Blum, Veronika ; von Burg, Philippe ; Mannhart, Meinrad ; Caspar, Clemens B. ; von Moos, Roger ; Mark, Michael

Background : Bone-targeted agents (BTAs) are widely used in the management of patients with bone metastases from solid tumors. Knowledge of the impact of their routine care use on patient-reported pain and bone pain-related quality of life (QoL) is limited. Methods : This real world, cross-sectional study enrolled patients over a 3-month period through oncologists across Switzerland. Patients were ≥ 18 years, had solid tumors and at least one bone metastasis, and received routine care for bone [...]

Menée en Espagne à partir de données portant sur 229 patients atteints d'un cancer cutané, non mélanome, dans la zone cervico-faciale, cette étude transversale analyse les facteurs associés à l'évolution de leur qualité de vie, du diagnostic jusqu'à 6 mois après la fin des traitements

Factors related to the evolution of quality of life in patients with cervicofacial non-melanoma skin cancer

García-Montero, Pablo ; de Gálvez-Aranda, María Victoria ; Blázquez-Sánchez, Nuria ; Rivas-Ruíz, Francisco ; Millán-Cayetano, José Francisco ; Harana, Cristina García ; de Troya Martín, Magdalena

Purpose : Non-melanoma skin cancer (NMSC) is the most frequent neoplasm today, worldwide. This type of tumour presents low mortality but causes a major psychosocial impact on the patient. Studies have shown that the patient’s quality of life (as detected by questionnaire scores in this respect) improves as the care process advances. The main aim of the present study is to identify the factors that are related to this favourable evolution. Methods : This descriptive cross-sectional study [...]

Menée aux Etats-Unis auprès de 270 patientes atteintes d'un cancer du sein de stade précoce, cette étude longitudinale analyse les facteurs associés à l'évolution de leur fatigue, entre le diagnostic et jusqu'à 18 mois après la fin des traitements

Do all patients with cancer experience fatigue? a longitudinal study of fatigue trajectories in women with breast cancer

Bower, Julienne E. ; Ganz, Patricia A. ; Irwin, Michael R. ; Cole, Steve W. ; Garet, Deborah ; Petersen, Laura ; Asher, Arash ; Hurvitz, Sara A. ; Crespi, Catherine M.

Background : Fatigue is a common and expected side effect of cancer treatment. However, the majority of studies to date have focused on average levels of fatigue, which may obscure important individual differences in the severity and course of fatigue over time. The current study was designed to identify distinct trajectories of fatigue from diagnosis into survivorship in a longitudinal study of women with early‐stage breast cancer. Methods : Women with stage 0 to stage IIIA breast cancer (270 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2020 (13 études), cette étude analyse l'intérêt d'un entraînement fractionné de haute intensité, pendant ou après les traitements anticancéreux, pour améliorer la qualité de vie et la santé cardiorespiratoire des patientes ayant survécu à un cancer du sein

High-intensity interval training in breast cancer survivors: a systematic review

Tsuji, Katsunori ; Matsuoka, Yutaka J. ; Ochi, Eisuke

Background : To review the settings and outcomes of high-intensity interval training (HIIT) interventions for breast cancer survivors, and to explore the feasibility of prescribing exercise for breast cancer survivors. Methods : A systematic search of electronic databases was conducted for studies published up to May 31, 2020. Eligibility criteria included randomized controlled trials of HIIT intervention in breast cancer survivors. Studies were grouped by whether the intervention was conducted [...]

Menée à partir de données portant sur 661 enfants ayant survécu à une tumeur cérébrale diagnostiquée entre 2002 et 2012 (âge médian lors du suivi : 7,3 ans), cette étude analyse les facteurs associés au risque d'une prise de poids significative, et l'association entre ce surpoids ou cette obésité et la survenue de dysfonctionnements hypothalamiques et hypophysaires

High Prevalence of Weight Gain in Childhood Brain Tumor Survivors and Its Association With Hypothalamic-Pituitary Dysfunction

Jiska van Schaik ; Ichelle M. A. A. van Roessel ; Netteke A. Y. N. Schouten-van Meeteren ; Laura van Iersel ; Sarah C. Clement ; Annemieke M. Boot ; Hedi L. Claahsen-van der Grinten ; Marta Fiocco ; Geert O. Janssens ; Dannis G. van Vuurden ; Erna M. Michiels ; Sen K. S. Han ; Paul A. S. P. van Trotsenburg ; Peter W. P. Vandertop ; Leontien C. M. Kremer ; Hanneke M. van Santen

PURPOSE : Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated in previous cohorts because of inclusion of children with craniopharyngioma. On the contrary, the degree of weight gain may have been underestimated because of exclusion of CBTS who experienced weight gain, but were neither overweight nor obese. Weight gain may be an indicator of underlying [...]

Menée à partir des données des registres canadiens et russes sur la période 1999-2016, cette étude évalue l'évolution de l'incidence du cancer de l'estomac et de la mortalité associée chez les populations circumpolaires

Stomach Cancer Incidence and Mortality Trends among Circumpolar Nations

Simkin, Jonathan ; Nash, Sarah H. ; Barchuk, Anton ; O'Brien, David K ; Erickson, Anders C ; Hanley, Brendan ; Hannah, Heather ; Corriveau, Andre ; Larsen, Inger Kristin ; Skovlund, Charlotte Wessel ; Larønningen, Siri ; Dummer, Trevor JB ; Bruce, Michael G ; Ogilvie, Gina

BACKGROUND: Stomach cancer incidence and mortality rates are declining across circumpolar nations, but the burden may not be distributed equally across sub-populations, including Indigenous peoples. Our objective was to examine stomach cancer incidence and mortality trends across circumpolar populations. METHODS: Cancer incidence and mortality data from 1999-2016 were obtained from the Canadian Cancer Registry, Canadian Vital Statistics, CDC WONDER, NORDCAN, Northwestern Russian cancer [...]

Menée à partir de données coréennes portant sur 14 075 patients atteints d'un cancer de l'estomac traité par gastrectomie entre 2005 et 2017, cette étude évalue l'incidence de fuites gastriques après le traitement et identifie les facteurs de risque associés

Incidence and treatment outcomes of leakage after gastrectomy for gastric cancer: Experience of 14,075 patients from a large volume centre

Roh, Chul Kyu ; Choi, Seohee ; Seo, WonJun ; Cho, Minah ; Kim, Hyoung-Il ; Lee, Sang-Kil ; Lim, JoonSeok ; Hyung, WooJin

Introduction : Leakage is a serious and potentially fatal complication of gastrectomy for gastric cancer. However, comprehensive reports regarding leakage after gastrectomy remain limited. We aimed to evaluate the incidence and treatment outcomes of leakage after gastrectomy for cancer. Methods : We reviewed the prospectively collected data of 14,075 Patients who underwent gastrectomy for gastric cancer between 2005 and 2017. Outcomes included incidence, risk factors of leakage, and leakage [...]

Menée à partir de données portant sur 3 523 individus inclus dans 7 cohortes du "The Cancer Genome Atlas", cette étude analyse la présence et la fréquence de mutations constitutionnelles de 17 gènes impliqués dans l'anémie de Fanconi (maladie génétique prédisposant à des tumeurs solides et à des cancers hématologiques)

Spectrum of Germline Mutations within Fanconi Anemia-Associated Genes across Populations of Varying Ancestry

Chan, Sock Hoai ; Ni, Ying ; Li, Shao-Tzu ; Teo, Jing Xian ; Ishak, Nur Diana Binte ; Lim, Weng Khong ; Ngeow, Joanne

Fanconi anemia (FA) is a rare genetic disorder associated with hematological disorders and solid tumor predisposition. Owing to phenotypic heterogeneity, some patients remain undetected until adulthood, usually following cancer diagnoses. The uneven prevalence of FA cases with different underlying FA gene mutations worldwide suggests variable genetic distribution across populations. Here, we aim to assess the genetic spectrum of FA-associated genes across populations of varying ancestries and [...]

A partir d'une revue systématique de la littérature (27 études), cette méta-analyse évalue l'association entre une obésité ou un surpoids au moment du diagnostic de cancer et la survie sans maladie ou la survie globale, chez des patientes atteintes d'un cancer du sein non métastatique, par sous-type histologique

Association of Obesity with Breast Cancer Outcome in Relation to Cancer Subtypes: A Meta-Analysis

Lohmann, Ana Elisa ; Soldera, Sara V ; Pimentel, Isabel ; Ribnikar, Domen ; Ennis, Marguerite ; Amir, Eitan ; Goodwin, Pamela J

Background : Obesity at breast cancer (BC) diagnosis has been associated with poor outcome, although the magnitude of effect in different BC subtypes is uncertain. We report on the association of obesity/overweight at diagnosis of non-metastatic BC with disease-free (DFS) and overall survival (OS) in the following defined subtypes: hormone receptor positive/HER2 negative (HR+HER2-), HER2 positive (HER2+), and triple negative (TNBC). Methods : We searched MEDLINE, EMBASE and COCHRANE databases [...]

Menée aux Etats-Unis par questionnaire auprès de 80 patients atteints d'une tumeur cérébrale primitive et auprès de 52 aidants, cette étude analyse les facteurs associés à la peur de la récidive

Examining Fear of Cancer Recurrence in Primary Brain Tumor Patients and Their Caregivers Using the Actor-Partner Interdependence Model

Braun, Sarah Ellen ; Aslanzadeh, Farah J ; Thacker, Leroy ; Loughan, Ashlee R

Objective : Fear of cancer recurrence (FCR) is related to psychological distress and poor quality of life in cancer patients and their caregivers. However, no studies have investigated FCR in neuro‐oncology. Given the varied prognosis, treatment, and disease trajectory of brain cancer, FCR may affect patients and their caregivers differently. Methods : Eighty adult primary brain tumor (PBT) patients and 52 caregivers completed questionnaires assessing FCR and psychological distress (depressive [...]

Menée au Japon par questionnaires auprès de 787 membres de la famille de patients décédés d'un cancer (491 répondants), cette étude analyse l'association entre des difficultés financières, avant et après le décès du patient, et des symptômes de dépression ainsi que des difficultés à faire le deuil

Effects of financial status on major depressive disorder and complicated grief among bereaved family members of patients with cancer

Aoyama, Maho ; Sakaguchi, Yukihiro ; Igarashi, Naoko ; Morita, Tatsuya ; Shima, Yasuo ; Miyashita, Mitsunori

Objective : To examine current financial status, changes before and after bereavement, and their effects on possible major depressive disorder (MDD) and complicated grief (CG) among bereaved family members of patients with cancer. Methods : We conducted a nationwide cross‐sectional questionnaire survey on 787 bereaved family members of patients with cancer in 71 palliative care institutions in Japan from May to July 2016. The survey assessed perceived level of concern regarding current [...]

Menée à partir d'une revue systématique de la littérature (7 études), cette étude analyse, dans les pays développés, le rapport coût-efficacité des interventions à base d'activité physique dédiées aux patients ayant survécu à un cancer

Cost-effectiveness of physical activity interventions in cancer survivors of developed countries: a systematic review

Gubler-Gut, Barbara E. ; Pöhlmann, Johannes ; Flatz, Aline ; Schwenkglenks, Matthias ; Rohrmann, Sabine

Purpose : Physical activity has been shown to improve survival and quality of life of cancer patients. Due to differences in patient populations, healthcare settings, and types of intervention, cost-effectiveness analyses of physical activity interventions in cancer survivors are difficult to compare. Available evidence from breast cancer survivor research has shown inconsistent results, and transfer of results to other types of cancer is not straightforward. This paper systematically reviewed [...]

Menée aux Etats-Unis dans un contexte de vie réelle à partir de données portant sur un total de 2 528 patients atteints d'un lymphome diffus à grandes cellules B (âge médian : 72 ans), cette étude rétrospective analyse les stratégies thérapeutiques, l'utilisation des soins médicaux et les coûts associés

Real-World Characteristics, Treatment Patterns, Healthcare Resource Use and Costs of Patients with Diffuse Large B-Cell Lymphoma in the United States

Yang, Xiaoqin ; Laliberté, François ; Germain, Guillaume ; Raut, Monika ; Duh, Mei Sheng ; Sen, Shuvayu S ; Lejeune, Dominique ; Desai, Kaushal ; Armand, Philippe

Background : Diffuse large B‐cell lymphoma (DLBCL) represents the most common subtype of non‐Hodgkin lymphoma in the US, but current real‐world data is limited. This study was conducted to describe real‐world characteristics, treatment patterns, HRU, and healthcare costs of treated DLBCL patients in the US. Materials and Methods : A retrospective study was conducted using the Optum ClinformaticsTM Data Mart database (01/2013‐03/2018). Patients with an ICD‐10‐CM diagnosis for DLBCL after October [...]

Mené au Royaume-Uni entre 2013 et 2018 sur 220 patients atteints d'un cancer de l'oesophage de stade avancé, cet essai randomisé multicentrique de phase III évalue l'efficacité, du point de vue de la survie globale et par rapport aux soins standard, d'une radiothérapie externe pour prévenir la dégradation de la dysphagie et réduire l'utilisation de prothèses oesophagiennes métalliques auto-expansibles

Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial

Adamson, Douglas ; Byrne, Anthony ; Porter, Catharine ; Blazeby, Jane ; Griffiths, Gareth ; Nelson, Annmarie ; Sewell, Bernadette ; Jones, Mari ; Svobodova, Martina ; Fitzsimmons, Deborah ; Nixon, Lisette ; Fitzgibbon, Jim ; Thomas, Stephen ; Millin, Anthony ; Crosby, Tom ; Staffurth, John ; Hurt, Christopher

Background: Patients with advanced oesophageal cancer have a median survival of 3–6 months, and most require intervention for dysphagia. Self-expanding metal stent (SEMS) insertion is the most typical form of palliation in these patients, but dysphagia deterioration and re-intervention are common. This study examined the efficacy of adjuvant external beam radiotherapy (EBRT) compared with usual care alone in preventing dysphagia deterioration and reducing service use after SEMS insertion. [...]

Mené sur 90 patients atteints d'un cancer de la tête et du cou de stade avancé, cet essai de phase III évalue l'intérêt de l'ajout de soins palliatifs précoces à une thérapie standard pour améliorer leur qualité de vie

Effect of Early Palliative Care on Quality of Life of Advanced Head and Neck Cancer Patients: A Phase III Trial

Maruti Patil, Vijay ; Singhai, Pankaj ; Noronha, Vanita ; Bhattacharjee, Atanu ; Deodhar, Jayita ; Salins, Naveen ; Joshi, Amit ; Menon, Nandini Sharrel ; Abhyankar, Anuja ; Khake, Ashwini ; Dhumal, Sachin Babanrao ; Tambe, Rupali ; Muckaden, Mary Ann ; Prabhash, Kumar

Background : Early palliative care (EPC) is an important aspect of cancer management but has never been evaluated in patients with head and neck cancer. Hence, we performed this study to determine whether the addition of EPC to standard therapy leads to an improvement in the quality of life (QOL), decrease in symptom burden and improvement in overall survival. Methods : Adult patients with squamous cell carcinoma of the head and neck region planned for palliative systemic therapy, were [...]

Cette étude analyse l'intérêt d'un modèle basé sur une approche intégrée et pluridisciplinaire pour promouvoir le retour au travail de patients ayant survécu à un cancer

A multidisciplinary working model for promoting return to work of cancer survivors

Cohen, Miri ; Yagil, Dana ; Carel, Rafael

Background : Despite wide recognition of the necessity of an integrative maintenance and return to work (RTW) program for cancer survivors, no such program has been described in the literature. Aims : To examine a working model of an integrative multidisciplinary health care approach for promoting RTW, using the Delphi method. Methods : A working model for promoting cancer survivors’ RTW by oncology health professionals was subjected to two rounds of evaluation by an expert panel in accordance [...]