Menée aux Etats-Unis par questionnaire auprès de 95 708 participants de l'essai "Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial" (âge : 55-74 ans ; durée de suivi : 848 534 personnes-années), cette étude analyse l'association entre la charge acide d'origine alimentaire évaluée par 2 indices (la production nette d'acide endogène : NEAP ; la charge acide rénale potentielle : PRAL) et le risque de cancer du pancréas (337 cas)

Dietary acid load and the risk of pancreatic cancer: a prospective cohort study

Shi, Li-Wei ; Wu, Yi-Lin ; Hu, Jie-Jun ; Yang, Peng-Fei ; Sun, Wei-Ping ; Gao, Jian ; Wang, Kang ; Peng, Yang ; Wu, Jing-Jing ; Zhong, Guo-Chao

Background: Modern Western diets are rich in acidogenic foods. Human and in vitro studies suggest a potential link between dietary acid load and cancer risk. However, no epidemiological studies have investigated the association of dietary acid load with the risk of pancreatic cancer. Therefore, we conducted a prospective cohort study to fill this gap. Methods: A population-based cohort of 95708 American adults was identified. Potential renal acid load (PRAL) and net endogenous acid production [...]

Menée en Chine auprès de 63 257 personnes âgées de 45 à 74 ans (durée moyenne de suivi : 17,6 ans), cette étude analyse l'association entre l'apport alimentaire en vitamine B12 et le risque de cancer du poumon (2 001 cas)

The association between dietary vitamin B12 and lung cancer risk: findings from a prospective cohort study

Luu, Hung N. ; Wang, Renwei ; Jin, Aizhen ; Koh, Woon-Puay ; Yuan, Jian-Min

Background: Since previous epidemiological studies reported inconsistent associations between dietary vitamin B12 intake and lung cancer risk, more studies are warranted to clarify this association in different populations. Methods: The association between dietary B12 intake and lung cancer risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63 257 Singaporean Chinese men and women, 45–74 years of age at enrollment during 1993–1998 and were followed [...]

Menée à partir de données de santé sur la période 1990-2017 dans 195 pays, cette étude estime le degré d'exposition et la part des cancers attribuable à 13 agents cancérogènes en milieu professionnel (arsenic, amiante, benzène, béryllium, cadmium, chrome, gaz d'échappement des moteurs diesel, formaldéhyde, nickel, hydrocarbures aromatiques polycycliques, silice, acide sulfurique et trichloréthylène)

Association of 13 Occupational Carcinogens in Patients With Cancer, Individually and Collectively, 1990-2017

Li, Na ; Zhai, Zhen ; Zheng, Yi ; Lin, Shuai ; Deng, Yujiao ; Xiang, Grace ; Yao, Jia ; Xiang, Dong ; Wang, Shuqian ; Yang, Pengtao ; Yang, Si ; Xu, Peng ; Wu, Ying ; Hu, Jingjing ; Dai, Zhijun ; Wang, Meng

Occupational exposure to carcinogens has been shown to pose a serious disease burden at the global, regional, and national levels. Based on epidemiologic studies and clinical observations, working environment appears to have important effects on the occurrence of human malignant tumors; however, to date, no systematic articles have been published that specifically investigated cancer burden due to occupational exposure in an individual and collective manner.To estimate the degree of exposure [...]

Menée en Australie à partir de données portant sur 839 332 femmes, cette étude analyse l'association entre une hystérectomie pour des indications bénignes et le risque de cancer mammaire, colorectal, rénal et thyroïdien, selon l'âge au moment de la chirurgie et en fonction de la conservation des ovaires ou non

Hysterectomy and risk of breast, colorectal, thyroid and kidney cancer - an Australian data linkage study

Wilson, Louise F ; Tuesley, Karen M ; Webb, Penelope M. ; Dixon-Suen, Suzanne C. ; Stewart, Louise M ; Jordan, Susan J.

Background: This study aimed to investigate the associations between hysterectomy for benign indications and risk of breast, colorectal, kidney and thyroid cancer; and to explore whether these associations are modified by removal of ovaries at the time of surgery or age at surgery. Methods: We conducted a retrospective cohort study of the female population of Western Australia (n=839,332) linking data from electoral, hospital, births, deaths and cancer records. We used Cox regression to [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (26 études, 239 302 patients), cette méta-analyse évalue l'association entre une exposition à la lumière du soleil et le risque de lymphomes

Sunlight exposure in association with risk of lymphoid malignancy: a meta-analysis of observational studies

Kim, Hong-Bae ; Kim, Jung-Ha

Purpose: Several observational studies have shown contradictory results regarding the association between sunlight exposure and the risk of malignant lymphoma. Thus, we aimed to systematically determine the association between sunlight exposure and lymphoid malignancy risk through a meta-analysis. Methods: A thorough search of four electronic databases (PubMed, Embase, Web of Science, and Scopus) was performed to identify eligible studies until 13 August 2020. A random-effects model was used to [...]

Menée à partir de données 2005-2014 de registres suédois portant sur 7 116 femmes souffrant d'hypertension (durée médiane de suivi : 24-46 mois), cette étude analyse l'association entre le type de bêta-bloquants utilisé (non sélectifs ou sélectifs bêta-1), la dose quotidienne et le risque de cancer du sein

Beta-blockers use and risk of breast cancer in women with hypertension

Zheng, Guoqiao ; Sundquist, Jan ; Sundquist, Kristina ; Ji, Jianguang

Background: The risk of breast cancer among hypertensive patients who use beta-blockers has attracted attention. However, the evidence is inconsistent and investigation of the dose-specific associations for subtypes of beta-blockers are limited. Methods: By incorporating Swedish national registers, breast cancer risk was estimated in women with hypertension who used nonselective beta-blockers and beta-1 selective blockers compared with propensity score-matched non-users. The cumulative defined [...]

Menée aux Etats-Unis entre 2003 et 2008 auprès de 670 patientes atteintes d'un cancer épithélial de l'ovaire et 1 551 témoins, cette étude analyse l'association entre la prise de poids pendant la grossesse et le risque de développer la maladie

Gestational weight gain and risk of epithelial ovarian cancer

Fu, Zhuxuan ; Kelley, Joseph L. ; Odunsi, Kunle ; Edwards, Robert P. ; Moysich, Kirsten ; Modugno, Francesmary

Objective: To examine the association between (GWG) and epithelial ovarian cancer (EOC). Methods: We compared GWG between 670 incident EOC cases and 1,551 community controls from a population-based, case–control study conducted in Pennsylvania, Ohio, and New York from 2003 to 2008. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) associated with GWG adjusting for potential confounders. To explore the potential effect of [...]

Menée à partir des données de 12 études portant sur 11 590 témoins et sur 8 192 patients atteints d'un cancer colorectal, cette méta-analyse évalue l'association entre le polymorphisme à simple nucléotide rs9929218 et le risque de développer la maladie

Variation rs9929218 and risk of the colorectal Cancer and adenomas: A meta-analysis

Wang, Huiyan ; Gu, Dongying ; Yu, Miao ; Hu, Yanjun ; Chen, Zhe ; Huo, Xinying ; Yu, Tao ; Chen, Jinfei ; Zheng, Yang

Backgrounds: Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the risk of colorectal cancer, colorectal adenoma, or both. These studies, however, reported inconsistent associations. Methods: To derive a more accurate approximation of the connection, we carried out a meta-analysis of 12 published pieces of research including 11,590 controls [...]

Menée à partir de données 1995-2011 portant sur 490 605 participants (âge : 50-71 ans), cette étude analyse l'association entre un reflux gastro-oesophagien et le risque d'adénocarcinome de l'oesophage (931 cas), de carcinome épidermoïde de l'oesophage (301 cas) ou de carcinome épidermoïde du larynx (876 cas)

Gastroesophageal reflux disease: A risk factor for laryngeal squamous cell carcinoma and esophageal squamous cell carcinoma in the NIH-AARP Diet and Health Study cohort

Wang, Shao-Ming ; Freedman, Neal D. ; Katki, Hormuzd A. ; Matthews, Charles ; Graubard, Barry I. ; Kahle, Lisa L. ; Abnet, Christian C.

Background: Prior studies have suggested that gastroesophageal reflux disease (GERD) may be associated with risk of squamous cancers of the larynx and esophagus; however, most of these studies have had methodological limitations or insufficient control for potential confounders. Methods: We prospectively examined the association between GERD and esophageal adenocarcinoma (EADC), esophageal squamous cell carcinoma (ESCC), and laryngeal squamous cell carcinoma (LSCC) in 490,605 participants of [...]