Mené sur 508 patients atteints d'un cancer (colorectal, mammaire, gynécologique), cet essai de phase III évalue l'intérêt d'un outil en ligne pour améliorer la prise en charge de leurs symptômes auto-déclarés, l'utilisation des soins de santé, leur sentiment d'auto-efficacité et leur qualité de vie pendant la chimiothérapie

Phase III Randomized Controlled Trial of eRAPID: eHealth Intervention During Chemotherapy

Kate Absolom ; Lorraine Warrington ; Eleanor Hudson ; Jenny Hewison ; Carolyn Morris ; Patricia Holch ; Robert Carter ; Andrea Gibson ; Marie Holmes ; Beverly Clayton ; Zoe Rogers ; Lucy McParland ; Mark Conner ; Liz Glidewell ; Barbara Woroncow ; Bryony Dawkins ; Sarah Dickinson ; Claire Hulme ; Julia Brown ; Galina Velikova

PURPOSE : Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID) is an online eHealth system for patients to self-report symptoms during cancer treatment. It provides automated severity-dependent patient advice guiding self-management or medical contact and displays the reports in electronic patient records. This trial evaluated the impact of eRAPID on symptom control, healthcare use, patient self-efficacy, and quality of life (QOL) in a patient population [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'efficacité de l'olanzapine pour prévenir et traiter les nausées et vomissements induits par une chimiothérapie moyennement ou hautement émétisante chez des patients atteints d'un cancer

Olanzapine for the prophylaxis and rescue of chemotherapy-induced nausea and vomiting: a systematic review, meta-analysis, cumulative meta-analysis and fragility assessment of the literature

Chow, Ronald ; Herrstedt, Jørn ; Aapro, Matti ; Chiu, Leonard ; Lam, Henry ; Prsic, Elizabeth ; Lock, Michael ; DeAngelis, Carlo ; Navari, Rudolph M.

Introduction : The aim of this study is to rigorously review the efficacy and safety of olanzapine in defined hematology oncology settings including (1) the setting of highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) settings (2) at 5 mg and 10 mg doses, and (3) for response rates for use in the acute, delayed, and overall settings post-MEC and HEC. Methods : Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched through April 23, [...]

Menée auprès de 250 patients atteints d'un cancer de stade avancé, cette étude de cohorte analyse l'intérêt d'un outil pour évaluer la sévérité et la fréquence des symptômes au niveau de la cavité buccale

Oral symptoms in patients with advanced cancer: an observational study using a novel oral symptom assessment scale

Davies, Andrew ; Buchanan, Alison ; Todd, Jennifer ; Gregory, Amanda ; Batsari, Kabir Mohammed

Purpose : The aim of this study was to utilise a novel oral assessment tool (the Oral Symptom Assessment Scale/OSAS) to investigate oral symptoms in a cohort of advanced cancer patients receiving specialist palliative care. Methods : Participants were asked to complete the OSAS, which asks about the presence of 20 oral symptoms in the previous week (and, if present, about the frequency, the severity, and the amount of distress caused by the symptoms). Patients were also asked to complete the [...]

Menée aux Etats-Unis à partir de données portant sur 1 554 patients atteints d'un cancer et recevant des opioïdes pour soulager la douleur liée à la maladie, cette étude analyse les facteurs associés à une utilisation non médicale d'opioïdes, et la fréquence de ces comportements

Frequency of and Factors Associated With Nonmedical Opioid Use Behavior Among Patients With Cancer Receiving Opioids for Cancer Pain

Yennurajalingam, Sriram ; Arthur, Joseph ; Reddy, Suresh ; Edwards, Tonya ; Lu, Zhanni ; Rozman de Moraes, Aline ; Wilson, Susamma M. ; Erdogan, Elif ; Joy, Manju P. ; Ethridge, Shirley Darlene ; Kuriakose, Leela ; Malik, Jimi S. ; Najera, John M. ; Rashid, Saima ; Qian, Yu ; Kubiak, Michal J. ; Nguyen, Kristy ; PharmD ; Wu, Jimin ; Hui, David ; Bruera, Eduardo

Importance : One of the main aims of research on nonmedical opioid use (NMOU) is to reduce the frequency of NMOU behaviors through interventions such as universal screening, reduced opioid exposure, and more intense follow-up of patients with elevated risk. The absence of data on the frequency of NMOU behavior is the major barrier to conducting research on NMOU. Objective : To determine the overall frequency of and the independent predictors for NMOU behavior. Design, Setting, and Participants: [...]

Mené sur 70 enfants et jeunes adultes atteints d'une leucémie lymphoblastique aiguë à cellules B réfractaire ou récidivante, cet essai évalue l'efficacité d'une administration de tocilizumab adaptée au risque de syndrome sévère de libération de cytokines après immunothérapie à base de lymphocytes CAR-T ciblant CD19

Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Stephan Kadauke ; Regina M. Myers ; Yimei Li ; Richard Aplenc ; Diane Baniewicz ; David M. Barrett ; Allison Barz Leahy ; Colleen Callahan ; Joseph G. Dolan ; Julie C. Fitzgerald ; Whitney Gladney ; Simon F. Lacey ; Hongyan Liu ; Shannon L. Maude ; Regina McGuire ; Laura S. Motley ; David T. Teachey ; Gerald B. Wertheim ; Lisa Wray ; Amanda M. DiNofia ; Stephan A. Grupp

PURPOSE : To prospectively evaluate the effectiveness of risk-adapted preemptive tocilizumab (PT) administration in preventing severe cytokine release syndrome (CRS) after CTL019, a CD19 chimeric antigen receptor T-cell therapy. METHODS : Children and young adults with CD19-positive relapsed or refractory B-cell acute lymphoblastic leukemia were assigned to high- (≥ 40%) or low- (< 40%) tumor burden cohorts (HTBC or LTBC) based on a bone marrow aspirate or biopsy before infusion. HTBC patients [...]

Mené sur 328 patients atteints d'un cancer oesogastrique de stade métastatique, cet essai de phase III évalue l'intérêt, du point de vue de l'amélioration de la survie globale, de leur intégration précoce (dès la phase intiale des traitements anticancéreux) dans une démarche de soins de support pluridisciplinaires

Early Interdisciplinary Supportive Care in Patients With Previously Untreated Metastatic Esophagogastric Cancer: A Phase III Randomized Controlled Trial

Zhihao Lu ; Yu Fang ; Chang Liu ; Xiaotian Zhang ; Xiaowei Xin ; Yi He ; Yanshuo Cao ; Xi Jiao ; Tianqi Sun ; Ying Pang ; Yanli Wang ; Jun Zhou ; Changsong Qi ; Jifang Gong ; Xicheng Wang ; Jian Li ; Lili Tang ; Lin Shen

PURPOSE : Effective interventions to improve prognosis in metastatic esophagogastric cancer (EGC) are urgently needed. We assessed the effect of the early integration of interdisciplinary supportive care for patients with metastatic EGC on overall survival (OS). PATIENTS AND METHODS : An open-label, phase III, randomized, controlled trial was conducted at Peking University Cancer Hospital & Institute. Patients with previously untreated metastatic EGC were enrolled. Patients were randomly [...]

A partir d'une revue systématique de la littérature, cette étude analyse l'efficacité de prescriptions d'exercices physiques pour améliorer la qualité de vie pendant les traitements et réduire les morbidités ainsi que la mortalité chez des patients atteints d'un adénocarcinome canalaire du pancréas

Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

O’Connor, Dominic ; Brown, Malcolm ; Eatock, Martin ; Turkington, Richard C. ; Prue, Gillian

Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy before surgery or adjuvant therapy afterward, inherently exposing them to toxicity. As such, optimizing physical function through exercise during treatment remains imperative to optimize quality of life either before surgery or during rehabilitation. However, current [...]

Menée aux Etats-Unis à partir des données d'une enquête portant sur 17 179 adultes non fumeurs (ayant fumé moins de 100 cigarettes dans leur vie), cette étude analyse leur consommation actuelle et passée de tabac et/ou de nicotine

Tobacco and nicotine use among US adult “never smokers” in Wave 4 (2016-2018) of the Population Assessment of Tobacco and Health Study

Klemperer, Elias M ; Hughes, John R ; Callas, Peter W ; West, Julia C ; Villanti, Andrea C

A common criterion for being labeled a “never smoker” is having smoked <100 lifetime cigarettes. This category is often used as an unexposed reference group to estimate the relative harm from cigarettes. We examined the amount of current and past cigarette and non-cigarette tobacco/nicotine use among adults who met this “never smoker” criterion.We analyzed cross-sectional data from 17,179 adult “never smokers” (i.e., reported <100 lifetime cigarettes) in Wave 4 (2016 to 2018) of the [...]

A partir d'une revue systématique de la littérature (26 études), cette étude analyse l'association entre des facteurs métaboliques et liés au mode de vie et le risque de neuropathie périphérique induite par la chimiothérapie chez des patients atteints d'un cancer traité par taxanes et sels de platine

Metabolic and lifestyle risk factors for chemotherapy-induced peripheral neuropathy in taxane and platinum-treated patients: a systematic review

Timmins, Hannah C. ; Mizrahi, David ; Li, Tiffany ; Kiernan, Matthew C. ; Goldstein, David ; Park, Susanna B.

Purpose : Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common dose-limiting toxicity of cancer treatment causing functional impairment and impacting quality of life. Effective prevention and treatment of CIPN are lacking, and CIPN risk factors remain ill-defined. Metabolic syndrome and associated conditions have emerged as potential risk factors, due to their high prevalence and independent association with nerve dysfunction. This systematic review aimed to investigate the [...]

Menée aux Etats-Unis à partir de données portant sur 72 409 patients atteints d'un cancer du poumon à petites cellules de stade limité (âge médian : 67 ans), cette étude analyse l'association entre l'origine ethnique, des facteurs socio-économiques, les traitements reçus et la survie globale

Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer

Zhou, Kexun ; Shi, Huashan ; Chen, Ruqin ; Cochuyt, Jordan J. ; Hodge, David O. ; Manochakian, Rami ; Zhao, Yujie ; Ailawadhi, Sikander ; Lou, Yanyan

Importance : It has been established that disparities in race and socioeconomic status are associated with outcomes of non–small cell lung cancer. However, it remains unknown whether this extends to stage I, II, or III small cell lung cancer (SCLC), or limited-stage SCLC (L-SCLC). Objective: To investigate the associations of race, socioeconomic factors, and treatment characteristics with survival among patients with L-SCLC Design, Setting, and Participants : Demographic information for [...]

Menée aux Etats-Unis auprès de 410 patients atteints d'un cancer localisé de la prostate récemment diagnostiqué et bénéficiant d'une surveillance active, cette étude de cohorte analyse l'association entre l'adhésion à un régime de type méditerranéen, le risque de progression de la maladie et la survie sans progression, en fonction de la présence d'un diabète et d'une utilisation de statines (durée médiane de suivi : 36 mois)

Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort

Gregg, Justin R. ; Zhang, Xiaotao ; Chapin, Brian F. ; Ward, John F. ; Kim, Jeri ; Davis, John W. ; Daniel, Carrie R.

BACKGROUND : The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti‐inflammatory, antilipidemic, and chemopreventive properties. This study prospectively investigated adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors. METHODS : Men with newly diagnosed PCa on an AS protocol (n = 410) completed a baseline food frequency questionnaire, [...]

Menée à partir des données des registres américains des cancers, cette étude analyse les facteurs associés à l'évolution, sur la période 2000-2017, de l'incidence du glioblastome chez les personnes âgées

Recent incidence trend of elderly patients with glioblastoma in the United States, 2000–2017

Chen, Boran ; Chen, Chaoyue ; Zhang, Yang ; Xu, Jianguo

Background : The incidence of glioblastoma increases significantly with age. With the growing and aging population, there is a lack of comprehensive analysis of recent glioblastoma incidence trend in the United States. This study aims to provide in-depth description of the patterns of incidence trends and to examine the age-period-cohort effects to the trends of glioblastoma specific to elderly patients. Methods : The incidence rates were age-adjusted and reported per 100,000 population. We [...]

Menée aux Etats-Unis par enquête réalisée entre 2010 et 2018 auprès de 2 646 patients ayant survécu à un cancer diagnostiqué à l'adolescence ou au début de l'âge adulte, cette étude analyse la présence de dysfonctionnements cognitifs et d'une détresse psychologique

Psychological distress and cognition among long-term survivors of adolescent and young adult cancer in the USA

Dewar, Elena O. ; Ahn, Chul ; Eraj, Salman ; Mahal, Brandon A. ; Sanford, Nina N.

Background : Patients diagnosed with cancer as adolescent and young adult (AYA) are at risk for a range of long-term psychosocial sequelae, which have been poorly studied. We sought to characterize the prevalence of cognitive dysfunction and psychological distress among long-term AYA cancer survivors. Methods : Using data from the National Health Interview Survey between 2010 and 2018, multivariable logistic regression analyses defined the association between AYA cancer diagnosis and cognitive [...]

Menée à partir de données portant sur 781 patients adultes ayant survécu à une greffe de cellules souches hématopoïétiques et inclus dans un essai clinique (durée de suivi après la greffe : 3 à 18 ans), cette étude transversale analyse l'effet du soutien social sur l'adhésion aux soins, la détresse psychologique et sur les comorbidités

Social support as a moderator of healthcare adherence and distress in long-term hematopoietic cell transplantation survivors

Nørskov, Kristina Holmegaard ; Yi, Jean C. ; Crouch, Marie-Laure ; Fiscalini, Allison Stover ; Flowers, Mary E. D. ; Syrjala, Karen L.

Background : Treatment with hematopoietic cell transplantation (HCT) has potentially severe effects on physical and psychosocial functioning. Poor social support has been linked with physical morbidity and mortality as well as psychological distress in HCT survivors. This study tested a theory-driven hypothesis that social support buffers adverse effects of health stressors of comorbidities and graft-versus-host disease (cGVHD) on distress and adherence to recommended healthcare among long-term [...]

Menée aux Etats-Unis auprès de 314 aidants familiaux d'enfants atteints d'un cancer (âge : inférieur ou égal à 17 ans), cette étude analyse l'association entre divers facteurs (démographiques, intra et inter-personnels, psychosociaux, etc.) et leur capacité de résilience à la fin des traitements anticancéreux

Longitudinal Predictors of Caregiver Resilience Outcomes at the End of Childhood Cancer Treatment

Barakat, Lamia P. ; Madden, Rebecca E. ; Vega, Gabriela ; Askins, Martha ; Kazak, Anne E.

Objective : Caregiver resilience in the context of childhood cancer treatment has been described using cross‐sectional and retrospective studies, but little is known about prospective predictors of resilience outcomes. We examined associations of demographics, cancer‐related variables, and intrapersonal and interpersonal factors at diagnosis (family psychosocial risk, perceived social support, health care self‐efficacy) and psychosocial services provided during treatment with caregiver [...]

Menée en Irlande par enquête auprès de patients ayant survécu à un cancer de la tête et du cou, cette étude analyse les facteurs associés à leur capacité à trouver et à comprendre l'information médicale, et l'effet de cette compétence sur leurs comportements d'auto-prise en charge, sur leur qualité de vie et sur leur peur de la récidive (395 répondants)

Health literacy impacts self-management, quality of life and fear of recurrence in head and neck cancer survivors

Clarke, Nicholas ; Dunne, Simon ; Coffey, Laura ; Sharp, Linda ; Desmond, Deirdre ; O’Conner, Jean ; O’Sullivan, Eleanor ; Timon, Conrad ; Cullen, Claire ; Gallagher, Pamela

Purpose : Little is known about whether health literacy is associated with affects certain key outcomes in head and neck cancer (HNC) survivors. We investigated (i) the socio-demographic and clinical profile of health literacy and (ii) associations among between health literacy and self-management behaviours, health-related quality of life (HRQL) and fear of recurrence (FoR) in HNC survivors. Methods : A population-based survey was conducted in Ireland. Health literacy was assessed using a [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d'une radiothérapie prostatique, dispensée en complément d'une thérapie anti-androgénique, chez des patients atteints d'un cancer métastatique de la prostate hormonosensible et de faible volume tumoral

Cost-effectiveness of Prostate Radiation Therapy for Men With Newly Diagnosed Low-Burden Metastatic Prostate Cancer

Lester-Coll, Nataniel H. ; Ades, Steven ; Yu, James B. ; Atherly, Adam ; Wallace, H. James, III ; Sprague, Brian L.

Importance : Prostate radiation therapy (PRT) is a treatment option in men with low-volume metastatic prostate cancer based on the results of the Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy Arm H (STAMPEDE-H) trial. However, the cost-effectiveness of this treatment remains unaddressed. Objective : To assess the cost-effectiveness of PRT when added to androgen deprivation therapy (ADT) for men with low-volume metastatic hormone-sensitive prostate [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité d'un doublet à base d'encorafénib et de cétuximab et d'une chimiothérapie standard pour traiter les patients atteints d'un cancer colorectal de stade métastatique présentant un variant du gène BRAF

Evaluation of the Cost-effectiveness of Doublet Therapy in Metastatic BRAF Variant Colorectal Cancer

Patel, Kishan K. ; Stein, Stacey ; Lacy, Jill ; O’Hara, Mark ; Huntington, Scott F.

Importance : The BEACON trial showed that combination therapy with encorafenib (BRAF inhibitor) and cetuximab (EGFR inhibitor) was associated with prolonged overall survival compared with standard chemotherapy in patients with metastatic BRAF variant colorectal cancer. However, the cost-effectiveness of using these agents in this clinical setting is unknown. Objective : To create a cost-effectiveness model to compare doublet therapy (encorafenib plus cetuximab) with standard chemotherapy [...]