A partir d'une revue systématique de la littérature publiée jusqu'en février 2020 (25 études, 5 474 patients), cette méta-analyse évalue l'association entre une consommation de volaille ou de poisson et le risque de cancer du pancréas

Poultry and Fish Intake and Pancreatic Cancer Risk: A Systematic Review and Meta-Analysis

Gao, Yu ; Ma, Yunfei ; Yu, Mingwei ; Li, Guangda ; Chen, Yuhan ; Li, Xiaoxiao ; Chen, Xinjie ; Xie, Ying ; Wang, Xiaomin

Although several epidemiological studies have investigated associations between poultry and fish consumption and pancreatic cancer (PC) risk, these findings have been inconsistent. The present study aimed to perform a meta-analysis to comprehensively evaluate these associations. We retrieved Eligible cohort studies and case-control studies published before February 2020 from the Medline, EMBASE, and Cochrane Library and applied a random or fixed effects model to calculate the pooled relative [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" portant sur plus de 400 000 personnes, cette étude analyse l'association entre la 25-hydroxyvitamine D et le risque de cancer, puis compare ces résultats avec les études antérieures

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

Ong, Jue-Sheng ; Dixon-Suen, Suzanne C. ; Han, Xikun ; An, Jiyuan ; Fitzgerald, Rebecca ; Buas, Matt ; Gammon, Marilie D. ; Corley, Douglas A. ; Shaheen, Nicholas J. ; Hardie, Laura J. ; Bird, Nigel C. ; Reid, Brian J. ; Chow, Wong-Ho ; Risch, Harvey A. ; Ye, Weimin ; Liu, Geoffrey ; Romero, Yvonne ; Bernstein, Leslie ; Wu, Anna H. ; Whiteman, David E. ; Vaughan, Thomas ; Agee, M. ; Alipanahi, B. ; Auton, A. ; Bell, R. K. ; Bryc, K. ; Elson, S. L. ; Fontanillas, P. ; Furlotte, N. A. ; Hinds, D. A. ; Huber, K. E. ; Kleinman, A. ; Litterman, N. K. ; McIntyre, M. H. ; Mountain, J. L. ; Noblin, E. S. ; Northover, C. A. M. ; Pitts, S. J. ; Sathirapongsasuti, J. Fah ; Sazonova, O. V. ; Shelton, J. F. ; Shringarpure, S. ; Tian, C. ; Tung, J. Y. ; Vacic, V. ; Wilson, C. H. ; Liyanage, Upekha ; Dusingize, Jean-Cluade ; Schumacher, Johannes ; Gockel, Ines ; Böhmer, Anne ; Jankowski, Janusz ; Palles, Claire ; O’Mara, Tracy ; Spurdle, Amanda ; Law, Matthew H. ; Iles, Mark M. ; Pharoah, Paul ; Berchuck, Andrew ; Zheng, Wei ; Thrift, Aaron P. ; Olsen, Catherine ; Neale, Rachel E. ; Gharahkhani, Puya ; Webb, Penelope M. ; MacGregor, Stuart ; Esophageal Cancer, Consortium ; Me Research, Team

Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR [...]

Menée à partir de données des registres américains des cancers portant sur 20 142 patientes atteintes d'un cancer rectal diagnostiqué entre 1973 et 2015 (âge médian : 65 ans), cette étude analyse l'association entre un traitement par radiothérapie et le risque de cancer gynécologique

Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms

Guan, Xu ; Wei, Ran ; Yang, Runkun ; Lu, Zhao ; Liu, Enrui ; Zhao, Zhixun ; Chen, Haipeng ; Yang, Ming ; Liu, Zheng ; Jiang, Zheng ; Wang, Xishan

Radiotherapy is a common treatment for rectal cancer, yet the risk of second gynecological malignant neoplasms (SGMNs) in patients with rectal cancer undergoing radiotherapy have not been adequately studied.To investigate the association between radiotherapy and the risk of individual types of SGMN in patients with rectal cancer and assess survival outcomes.A large population-based cohort study was designed to identify the risk of SGMNs in patients with rectal cancer diagnosed from January 1973 [...]

Menée à partir de données portant sur 209 185 femmes (durée moyenne de suivi : 14,5 ans), cette étude analyse l'association entre une utilisation de talc sur la zone génitale et le risque de cancer utérin (3 272 cas)

Genital powder use and risk of uterine cancer: A pooled analysis of prospective studies

O'Brien, Katie M. ; Tworoger, Shelley S. ; Harris, Holly R. ; Trabert, Britton ; Weinberg, Clarice R. ; Fortner, Renée T. ; D'Aloisio, Aimee A. ; Kaunitz, Andrew M. ; Wentzensen, Nicolas ; Sandler, Dale P.

When powder is applied to the genital area, it has the potential to reach internal reproductive organs and promote carcinogenesis by irritating and inflaming exposed tissues. While many studies have considered the association between genital powder use and ovarian cancer risk, the relationship between genital powder use and uterine cancer is less well-studied. We pooled data from four large, prospective cohorts (the Nurses' Health Study, the Nurses' Health Study II, the Sister Study, and the [...]

Menée entre 2013 et 2018 par enquête auprès de 345 témoins et 163 patients atteints d'un cancer de l'oropharynx lié au papillomavirus humain (HPV), cette étude analyse l'association entre des pratiques de sexe oral (intensité, moment, nombre de partenaires) et le risque de développer la maladie

Timing, number, and type of sexual partners associated with risk of oropharyngeal cancer

Drake, Virginia E. ; Fakhry, Carole ; Windon, Melina J. ; Stewart, C. Matthew ; Akst, Lee ; Hillel, Alexander ; Chien, Wade ; Ha, Patrick ; Miles, Brett ; Gourin, Christine G. ; Mandal, Rajarsi ; Mydlarz, Wojciech K. ; Rooper, Lisa ; Troy, Tanya ; Yavvari, Siddhartha ; Waterboer, Tim ; Brenner, Nicole ; Eisele, David W. ; D’Souza, Gypsyamber

Background: Case-control studies from the early 2000s demonstrated that human papillomavirus–related oropharyngeal cancer (HPV-OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk factors (sexual debut behaviors, exposure intensity, and relationship dynamics) and serological markers on odds of HPV-OPC. Methods: HPV-OPC patients and frequency-matched controls were enrolled in a multicenter study from 2013 to 2018. Participants [...]

Menée à l'aide du génotypage de 4 702 témoins, 810 patients atteints d'un cancer du rein et de 1 413 patients atteints d'un cancer de la vessie, cette étude analyse la prévalence de 2 mutations de PALB2 chez les patients atteints d'un cancer

Recurrent PALB2 mutations and the risk of cancers of bladder or kidney in Polish population

Złowocka-Perłowska, Elżbieta ; Dębniak, Tadeusz ; Słojewski, Marcin ; Lemiński, Artur ; Soczawa, Michał ; van de Wetering, Thierry ; Trubicka, Joanna ; Kluzniak, Wojciech ; Wokołorczyk, Dominika ; Cybulski, Cezary ; Lubinski, Jan

Introduction: The role of PALB2 in carcinogenesis remains to be clarified. Our main goal was to determine the prevalence of PALB2 (509_510delGA and 172_175delTTGT) mutations in bladder and kidney cancer patients from Polish population. Materials and methods: 1413 patients with bladder and 810 cases with kidney cancer and 4702 controls were genotyped for two PALB2 variants: 509_510delGA and 172_175delTTGT. Results: Two mutations of PALB2 gene were detected in 5 of 1413 (0.35%) unselected bladder [...]

Menée à l'aide d'échantillons de sang collecté auprès de 1 246 participants inclus dans un essai randomisé, cette étude analyse l'association entre les taux sériques de l'oxystérol 27-hydroxycholestérol (27-OHC) et le risque de néoplasies colorectales (polypes ou adénomes)

Circulating 27-hydroxycholesterol and risk of colorectal adenomas and serrated polyps

Passarelli, Michael N. ; Thompson, Bonne M. ; McDonald, Jeffrey G. ; Snover, Dale C ; Palys, Thomas J. ; Rees, Judy R ; Barry, Elizabeth L. ; Baron, John A.

The oxysterol 27-hydroxycholesterol (27-OHC) is an endogenous selective estrogen receptor modulator implicated in breast cancer etiology. It is unknown whether circulating 27-OHC is associated with colorectal neoplasia risk. Circulating 27-OHC was measured using liquid chromatography/mass spectrometry in fasting plasma collected at baseline from participants of the Vitamin D/Calcium Polyp Prevention Study, a completed randomized clinical trial. Participants were between 45 and 75 years old, [...]