Menée en Chine auprès de 63 257 participants (durée moyenne de suivi : 17,7 ans), cette étude analyse l'association entre un score évaluant des facteurs associés à un mode de vie sain et le risque de carcinome hépatocellulaire (561 cas)

Composite Score of Healthy Lifestyle Factors and Risk of Hepatocellular Carcinoma: Findings from a Prospective Cohort Study

Luu, Hung N. ; Behari, Jaideep ; Goh, George Boon-Bee ; Wang, Renwei ; Jin, Aizhen ; Thomas, Claire E. ; Clemente, Jose C. ; Odegaard, Andrew O. ; Koh, Woon-Puay ; Yuan, Jian-Min

Background: While the associations between individual lifestyle factors and risk of hepatocellular carcinoma (HCC) have been described previously, their combined impact on HCC risk is unknown. Methods: The association of a composite score of healthy lifestyle factors, including body mass index, alcohol consumption, cigarette smoking, alternative Mediterranean diet, and sleep duration, and HCC risk was examined in the Singapore Chinese Health Study, an ongoing prospective cohort study of 63,257 [...]

Menée à partir de données de la cohorte "the Nurses’ Health Study II" portant sur 27 196 femmes (âge : 25-42 ans), cette étude analyse l'association entre la quantité de produits laitiers consommée pendant l'adolescence et le risque d'adénome colorectal (2 239 cas ; âge moyen au diagnostic : 52,8 ans)

Dairy intake during adolescence and risk of colorectal adenoma later in life

Nimptsch, Katharina ; Lee, Dong Hoon ; Zhang, Xuehong ; Song, Mingyang ; Farvid, Maryam S. ; Rezende, Leandro F. M. ; Cao, Yin ; Chan, Andrew T. ; Fuchs, Charles ; Meyerhardt, Jeffrey ; Nowak, Jonathan A. ; Willett, Walter C. ; Ogino, Shuji ; Giovannucci, Edward ; Pischon, Tobias ; Wu, Kana

Background: Higher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is associated with lower risk of colorectal adenoma, a colorectal cancer precursor. Methods: In 27,196 females from the Nurses’ Health Study 2, aged 25–42 years at recruitment (1989), who had completed a validated high school diet questionnaire in 1998 and undergone at least one [...]

A partir d'une revue systématique de la littérature publiée entre 2014 et 2010 (28 articles), cette étude analyse l'association entre l'apport alimentaire de beta-caroténoïdes et le risque de cancer du sein

Is There an Association between beta-Carotene and Breast Cancer? A Systematic Review on Breast Cancer Risk

Peraita-Costa, Isabel ; Carrillo Garcia, Paula ; Morales-Suárez-Varela, María

It is suspected that diet influences the risk of developing breast cancer. Several beta-carotenoids have been inversely associated with breast cancer risk, but association by type of tumor and participant characteristics remain nuclear. The objective of this review of epidemiological studies is to investigate the relationship between beta-carotenoids and breast cancer. This review covers the 2014-2020 period and was carried out using the PubMed and EMBASE databases. Only epidemiological studies [...]

Menée aux Pays-Bas auprès de 10 941 participants de la "Rotterdam study" (âge médian : 67,4 ans), cette étude analyse l'association entre l'apport en calcium provenant de l'alimentation et de suppléments, les niveaux de calcium dans le sang et le risque de cancer colorectal (427 cas)

Calcium intake, levels and supplementation and effect modification by genetic variation of calcium homeostasis on the risk of colorectal cancer: the Rotterdam study

Araghi, Sadaf Oliai ; Jayakkumaran, Abi ; Mulder, Marlies ; Stricker, Bruno H. ; Ruiter, Rikje ; Kiefte-de Jong, Jessica C.

Objectives: Previous studies showed that high calcium intake may be associated with the reduced colorectal cancer (CRC) risk, but results were inconclusive. In this study, we evaluated whether calcium intake from diet and supplements, as well as the calcium levels itself, were associated with the CRC risk in middle-aged and older individuals. Also, we evaluated whether these associations were modified by genetic variation of calcium homeostasis. Design: This study was embedded in the Rotterdam [...]

Menée à partir de données 2000-2010 de la cohorte "the Health Professionals Follow-Up Study" portant sur 18 123 hommes ayant réalisé au moins une coloscopie, cette étude analyse l'association entre une utilisation d'inhibiteurs de la phosphodiestérase 5 et le risque de lésions dentelées ou d'adénomes colorectaux

Phosphodiesterase 5 inhibitors use and risk of conventional and serrated precursors of colorectal cancer

Zhang, Yiwen ; Lo, Chun-Han ; Giovannucci, Edward L.

Background: Phosphodiesterase 5 (PDE5) inhibitors have been hypothesized to have chemoprotective effects in colorectal cancer (CRC). Current population-based epidemiologic evidence is, however, limited and inconsistent. Methods: Among 18,123 men in the Health Professionals Follow-up Study who had at least one lower gastrointestinal endoscopy, we evaluated the association between PDE5 inhibitors use and risk of conventional adenoma and serrated lesion between 2000 and 2010, adjusted for repeated [...]

Menée à partir de données de registres portant sur 514 537 jeunes femmes vivant au Danemark entre 2006 et 2019 (âge : 17-26 ans ; durée médiane de suivi : 6,9 ans), cette étude évalue l'effet du vaccin anti-papillomavirus humain sur l'incidence des lésions vulvo-vaginales de haut grade

Real-world effectiveness of Human Papillomavirus vaccination against vulvovaginal high-grade precancerous lesions and cancers

Dehlendorff, Christian ; Baandrup, Louise ; Kjaer, Susanne K

Vaccination against human papillomavirus (HPV) has proven to be effective against severe cervical lesions and genital warts, whereas no previous study has provided real-world data on the HPV vaccine effectiveness against high-grade vulvovaginal lesions.A cohort of all women aged 17–26 years, living in Denmark during 2006–2019 was followed in nationwide registers for individual-level information about HPV vaccination and first diagnoses of vulvar and vaginal high-grade intraepithelial lesions or [...]

Menée en Europe par questionnaire auprès de 3 646 femmes participant à un dépistage du col de l'utérus entre 2016 et 2018 (âge : 25-45 ans), cette étude identifie les facteurs associés à un schéma vaccinal anti-HPV complet

Determinants of Human Papillomavirus Vaccine Uptake by Adult Women Attending Cervical Cancer Screening in 9 European Countries

Robles, Claudia ; Bruni, Laia ; Acera, Amelia ; Riera, Joan Carles ; Prats, Laia ; Poljak, Mario ; Mlakar, Jana ; Oštrbenk Valenčak, Anja ; Eriksson, Tiina ; Lehtinen, Matti ; Louvanto, Karolina ; Hortlund, Maria ; Dillner, Joakim ; Faber, Mette T. ; Munk, Christian ; Kjaer, Susanne K. ; Petry, Karl Ulrich ; Denecke, Agnieszka ; Xu, Lan ; Arbyn, Marc ; Cadman, Louise ; Cuzick, Jack ; Dalstein, Veronique ; Clavel, Christine ; de Sanjose, Silvia ; Bosch, F. Xavier

Introduction: Human papillomavirus–vaccinated cohorts, irrespective of age, will likely reduce their subsequent screening requirements, thus opening opportunities for global cost reduction and program sustainability. The determinants of uptake and completion of a 3-dose human papillomavirus vaccination program by adult women in a European context were estimated. Study design: This was an intervention study. Setting/participants: Study participants were women aged 25–45 years, attending [...]

Cette article présente l'estimation de la couverture vaccinale anti-papillomavirus humain à l'échelle mondiale publiée par l'OMS/UNICEF en juillet 2020 selon des données couvrant la période 2010-2019

HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010–2019

Bruni, Laia ; Saura, Anna ; Montoliu, Alexandra ; Brotons, Maria ; Alemany, Laia ; Diallo, Mamadou Saliou ; Afsar, Oya Zeren ; LaMontagne, D. Scott ; Mosina, Liudmila ; Contreras, Marcela ; Velandia-González, Martha ; Pastore, Roberta ; Gacic-Dobo, Marta ; Bloem, Paul

WHO/UNICEF estimates for HPV vaccination coverage from 2010 to 2019 are analyzed against the backdrop of the 90% coverage target for HPV vaccination by 2030 set in the recently approved global strategy for cervical cancer elimination as a public health problem. As of June 2020, 107 (55%) of the 194 WHO Member States have introduced HPV vaccination. The Americas and Europe are by far the WHO regions with the most introductions, 85% and 77% of their countries having already introduced [...]