Mené en France entre 2015 et 2018 sur 183 patients atteints d'un cancer et recevant des traitements anticancéreux par voie orale, cet essai randomisé évalue l'intérêt d'une intervention menée par téléphone par les infirmiers ou infirmières pour surveiller les toxicités médicamenteuses, l'observance thérapeutique et la qualité de vie des patients

Effectiveness of a nurse-led telephone follow-up in the therapeutic management of patients receiving oral antineoplastic agents: a randomized, multicenter controlled trial (ETICCO study)

Bouleftour, Wafa ; Muron, Thierry ; Guillot, Aline ; Tinquaut, Fabien ; Rivoirard, Romain ; Jacquin, Jean-Philippe ; Saban-Roche, Léa ; Boussoualim, Karima ; Tavernier, Emmanuelle ; Augeul-Meunier, Karine ; Collard, Olivier ; Mery, Benoite ; Pupier, Sidonie ; Oriol, Mathieu ; Bourmaud, Aurélie ; Fournel, Pierre ; Vassal, C.

Purpose : The use of oral cancer drugs (OAD) has increased over the last two decades. The objective of this study was to measure the impact of a nurse-led telephone follow-up in the therapeutic management of patients treated with an OAD regarding toxicity, medication adherence and quality of life. Methods : A randomized, multicenter, controlled trial was conducted. All consecutive over 18-year-old patients, treated in medical oncology, radiotherapy, or hematology departments, receiving OAD for [...]

A partir d'une revue systématique de la littérature (8 essais randomisés incluant 620 patients et 53 aidants), cette étude analyse l'efficacité des interventions destinées à promouvoir l'activité physique chez des patients ayant survécu à un cancer pédiatrique

Physical activity for pediatric cancer survivors: a systematic review of randomized controlled trials

Cheung, Ankie Tan ; Li, William Ho Cheung ; Ho, Laurie Long Kwan ; Ho, Ka Yan ; Chan, Godfrey Chi Fung ; Chung, Joyce Oi Kwan

Purpose : To collate evidence and evaluate the effects of physical activity interventions on physical activity level among pediatric cancer survivors who had completed active cancer treatment. Methods : Relevant published studies were identified in May 2020 via five databases and reference checking. Searches were limited to randomized controlled trials or controlled clinical trials, published in English involving pediatric cancer survivors aged 18 years or below. Interventions were related to [...]

Menée aux Etats-Unis par entretiens auprès de professionnels de santé et de patients ayant survécu à un cancer (55 participants), cette étude qualitative analyse leurs perceptions vis-à-vis de l'utilisation des opioïdes pour prendre en charge la douleur liée à la maladie

Perceptions of prescription opioid medication within the context of cancer survivorship and the opioid epidemic

Tyson, Dinorah Martinez ; Chavez, Melody N. ; Lake, Paige ; Gutierrez, Ana ; Sherry, Peggie ; Rigg, Khary K. ; Marshall, Victoria K. ; Henderson, Heather ; di Ciccone, Barbara Lubrano ; Rajasekhara, Sahana ; Pabbathi, Smitha

Purpose : Prescription opioid medication can be of great benefit for cancer patients and survivors who suffer from cancer-related pain throughout their cancer care trajectory. However, the current opioid epidemic has influenced how such medications are perceived. The purpose of this study was to explore the perceptions of opioid use and misuse in cancer survivorship within the context of the opioid epidemic. Methods : A qualitative study using a semi-structured interview was conducted with a [...]

Mené sur 57 patients présentant des métastases vertébrales douloureuses (durée de suivi médiane : 60 mois), cet essai multicentrique de phase 2 évalue l'efficacité, du point de vue du soulagement de la douleur après 3 mois, d'un traitement par radiothérapie stéréotaxique

Long-term results of dose-intensified fractionated stereotactic body radiotherapy (SBRT) for painful spinal metastases

Guckenberger, Matthias ; Mantel, Frederick ; Sweeney, Reinhart A. ; Hawkins, Maria ; Belderbos, Jose ; Ahmed, Merina ; Andratschke, Nicolaus ; Madani, Indira ; Flentje, Michael

Purpose: To report long-term outcome of fractionated stereotactic body radiotherapy (SBRT) for painful spinal metastases. Material and Methods: This prospective single arm multi-center phase 2 clinical trial enrolled 57 patients with 63 painful, unirradiated spinal metastases between March 2012 and July 2015. Patients were treated 48.5 Gy in 10 SBRT fractions (long life expectancy [Mizumoto score ≤4]) or 35 Gy in 5 SBRT fractions (intermediate life expectancy [Mizumoto score 5-9]). Pain [...]

Menée au Brésil auprès de 103 patients ayant survécu à une greffe de cellules souches hématopoïétiques, cette étude analyse leurs capacités fonctionnelles et pulmonaires ainsi que leur qualité de vie

Functional capacity, pulmonary function, and quality of life in hematopoietic stem cell transplantation survivors

Penna, Giana Berleze ; da Silva, Tassiana Costa ; Aparecida Paz, Alessandra ; Ziegler, Bruna

Objective : Hematopoietic stem cell transplantation (HSCT) is used as a treatment for several diseases. The objective was to evaluate the functional capacity, pulmonary function, and quality of life (QoL) in HSCT survivors. Methods : The patients were submitted to spirometry and six-minute walk test (6MWT) and evaluation of QoL (Functional Assessment of Cancer Therapy Bone Marrow Transplantation—FACT-BMT) and the level of physical activity (Human Activity Profile—HAP) in the post-HSCT [...]

Menée aux Etats-Unis à partir de données portant sur 2 836 adultes ayant survécu à un cancer pédiatrique (âge moyen : 32,2 ans) et sur 343 témoins, cette étude analyse les facteurs associés à la présence de douleurs chroniques et l'effet de ces douleurs sur leurs capacités fonctionnelles et sur leur vie quotidienne

Pain and functional outcomes in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study

Tonning Olsson, Ingrid ; Alberts, Nicole M. ; Li, Chenghong ; Ehrhardt, Matthew J. ; Mulrooney, Daniel A. ; Liu, Wei ; Pappo, Alberto S. ; Bishop, Michael W. ; Anghelescu, Doralina L. ; Srivastava, Deokumar ; Robison, Leslie L. ; Hudson, Melissa M. ; Ness, Kirsten K. ; Krull, Kevin R. ; Brinkman, Tara M.

Background : Although survivors of childhood cancer are at risk of chronic pain, the impact of pain on daily functioning is not well understood. Methods : A total of 2836 survivors (mean age, 32.2 years [SD, 8.5 years]; mean time since diagnosis, 23.7 years [SD, 8.2 years]) and 343 noncancer community controls (mean age, 35.5 years [SD, 10.2 years]) underwent comprehensive medical, neurocognitive, and physical performance assessments, and completed measures of pain, health‐related quality of [...]

Menée en France à partir de données portant sur 1 214 patients atteints d'un mélanome de stade métastatique non résécable (âge médian : 66 ans), cette étude de cohorte prospective analyse l'association entre l'indice de masse corporelle, la survie et la survenue d'événements indésirables induits par les traitements anticancéreux systémiques

Relevance of body mass index as a predictor of systemic therapy outcomes in metastatic melanoma: analysis of the MelBase French cohort data

Di Filippo, Y. ; Dalle, S. ; Mortier, L. ; Dereure, O. ; Dalac, S. ; Dutriaux, C. ; Leccia, M. T. ; Legoupil, D. ; Saiag, P. ; Brunet-Possenti, F. ; Arnnault, J. P. ; Maubec, E. ; Granel-Brocard, F. ; De Quatrebarbes, J. ; Aubin, F. ; Lesimple, T. ; Beylot-Barry, M. ; Stoebner, P. E. ; Dupuy, A. ; Stephan, A. ; Grob, J. J. ; Lefevre, W. ; Oriano, B. ; Allayous, C. ; Lebbe, C. ; Montaudié, H.

Background : The “obesity paradox” suggests that higher body mass index (BMI) is associated with better survival values in metastatic melanoma patients, especially those receiving targeted and immune checkpoint inhibitor therapy. Higher BMI is also associated with higher incidences of treatment-related adverse events. This study assesses whether body mass index is associated with survival outcomes and adverse events in metastatic melanoma patients with systemic therapy. Patients and methods : [...]

Menée en Norvège à partir de données portant sur 5 620 patients atteints d'un cancer du testicule diagnostiqué entre 1980 et 2009, cette étude de cohorte analyse les facteurs associés au risque de second cancer controlatéral métachrone, en lien avec une utilisation d'une chimiothérapie à base de cisplatine (durée médiane de suivi : 18 ans)

Metachronous Contralateral Testicular Cancer in the Cisplatin Era: A Population-Based Cohort Study

Ragnhild Hellesnes ; Tor Åge Myklebust ; Roy M. Bremnes ; Ása Karlsdottir ; Øivind Kvammen ; Helene F. S. Negaard ; Torgrim Tandstad ; Tom Wilsgaard ; Sophie D. Fossa ; Hege S. Haugnes

PURPOSE It is hypothesized that cisplatin-based chemotherapy (CBCT) reduces the occurrence of metachronous contralateral (second) germ cell testicular cancer (TC). However, studies including treatment details are lacking. The aim of this study was to assess the second TC risk, emphasizing the impact of previous TC treatment. PATIENTS AND METHODS Based on the Cancer Registry of Norway, 5,620 men were diagnosed with first TC between 1980 and 2009. Treatment data regarding TC were retrieved from [...]

Menée en Belgique à partir de données portant sur 1 580 aidants de patients atteints d'un cancer, cette étude transversale analyse les facteurs associés à leur détresse psychologique et à leur qualité de vie pendant la période de traitement et de suivi du patient

Caregiver distress and quality of life in primary caregivers of oncology patients in active treatment and follow-up

Decadt, Ine ; Laenen, Annouschka ; Celus, Janne ; Geyskens, Shelly ; Vansteenlandt, Hannah ; Coolbrandt, Annemarie

Objective : As the number of informal caregivers and their caregiving responsibilities increase, this study aims at evaluating caregiver distress, quality of life (QoL) and their predictors in informal caregivers of cancer patients during active treatment and follow-up. Methods : This cross-sectional descriptive study targeted primary caregivers of patients with different cancer diagnoses. Caregiver-reported outcomes were measured by the Caregiver Risk Screen (CRS), Distress Thermometer (DT) [...]

A partir d'une revue systématique de la littérature (18 articles), cette méta-analyse évalue la présence de biais d'attention chez des patients ayant survécu à un cancer et l'association entre ces troubles et une détresse psychique

The role of attentional biases in the context of cancer: A systematic review and meta-analysis

Pradhan, Poorva ; Sharpe, Louise ; Butow, Phyllis

Objective : Little is known about the role of attentional processes in the context of cancer. This systematic review aimed to (1) synthesize the literature on attentional biases in cancer survivors; and (2) assess if these biases are associated with indicators of psychological distress. Method : Studies were identified through a systematic search in PsycINFO, Medline, Scopus, CINAHL, Web of Science and Embase databases. We included studies that examined attentional biases using an accepted [...]

Menée aux Etats-Unis à partir de données portant sur 386 patients atteints d'un cancer de stade avancé et inclus dans un essai randomisé, cette étude analyse l'intérêt d'un outil permettant de mesurer leur détresse psychologique lors du processus de préparation à la fin de vie

Validation of the Death and Dying Distress Scale in Patients with Advanced Cancer

Shapiro, Gilla K. ; Mah, Kenneth ; Li, Madeline ; Zimmermann, Camilla ; Hales, Sarah ; Rodin, Gary

Background : Distress about dying and death is an important clinical and research outcome in advanced cancer. A 15-item Death and Dying Distress Scale (DADDS) measure has undergone preliminary validation, but full validation in a large sample has not previously been reported. We investigated its psychometric characteristics and responsiveness to a therapeutic intervention Methods : This is a secondary analysis of baseline data obtained from a randomized controlled trial of psychotherapeutic [...]

A partir d'une revue de la littérature, cette étude analyse l'intérêt des outils permettant d'évaluer l'image corporelle chez des patientes atteintes d'un cancer du sein

A scoping review of measures used to assess body image in women with breast cancer

Brunet, Jennifer ; Price, Jenson

Objective : The emergence of body image studies in the oncology setting has led to the use of numerous measures to assess dimensions of body image. The present study is a scoping review of the literature on body image in women with breast cancer to describe: (1) measures used to assess body image in women with breast cancer, (2) dimensions the measures used tap into, and (3) gaps and issues needing attention going forward. Methods : Three databases were searched for peer-reviewed original [...]

Menée dans un contexte canadien, cette étude analyse le rapport coût-efficacité d'un traitement contenant de l'olanzapine pour prévenir les nausées et vomissements induits par une chimiothérapie hautement émétisante chez des patients atteints d'un cancer

Cost-effectiveness analysis of olanzapine-containing antiemetic therapy for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in highly emetogenic chemotherapy (HEC) patients

Chow, Ronald ; Chiu, Leonard ; Herrstedt, Jørn ; Aapro, Matti ; Lock, Michael ; DeAngelis, Carlo ; Navari, Rudolph M.

Purpose : Olanzapine-containing regimens have been reported to be effective in preventing CINV following highly emetogenic chemotherapy (HEC), but it is unsure whether it is cost-effective. There has been no cost-effectiveness analysis conducted for olanzapine using costs from the USA. The aim of this study is to determine whether olanzapine-containing antiemetic regimens are cost-effective in patients receiving HEC. Methods : A decision tree model was constructed to evaluate the cost and [...]

A partir d'une revue de la littérature (57 articles), cette étude analyse les besoins et préférences de patients adultes ayant survécu à un cancer concernant l'accès à de l'information nutritionnelle après les traitements anticancéreux

Needs, preferences, and experiences of adult cancer survivors in accessing dietary information post-treatment: A scoping review

Johnston, Elizabeth A. ; van der Pols, Jolieke C. ; Ekberg, Stuart

Introduction : To support provision of healthy lifestyle information tailored to patients’ needs and preferences, this review maps adult cancer survivors’ self‐reported needs, preferences, and experiences accessing dietary information post‐treatment. Methods : A scoping review of research published within the past decade conducted using PRISMA‐ScR guidelines. Seven databases were searched in June 2020. Results : Of 15,973 articles identified, 57 met eligibility criteria. Studies most frequently [...]

A partir d'une revue systématique de la littérature (6 articles, 593 aidants), cette étude analyse les compétences des aidants de patients atteints d'un cancer pour chercher et comprendre l'information médicale

Health literacy in cancer caregivers: a systematic review

Moore, Chloe ; Hassett, Danielle ; Dunne, Simon

Purpose : Cancer caregivers play a vital role in the care and health decision-making of cancer survivors. Consequently, their health literacy levels may be particularly important, as low levels may impede adequate care provision. As such, the current review aimed to systematically examine the literature on health literacy amongst cancer caregivers. Methods : We systematically searched the following databases using controlled vocabulary and free-text terms: PsychINFO, MEDLINE, EMBASE, CINAHL and [...]

Mené sur 995 femmes âgées de 40 à 69 ans et à risque élévé de cancer du sein, cet essai randomisé évalue l'intérêt d'un outil en ligne pour les sensibiliser au risque de cancer du sein, dispenser de l'information sur la chimioprévention et améliorer la communication avec les professionnels de santé sur le recours à la mammographie de dépistage

Effect of personalized breast cancer risk tool on chemoprevention and breast imaging: ENGAGED-2 trial

Wernli, Karen J ; Knerr, Sarah ; Li, Tengfei ; Leppig, Kathleen ; Ehrlich, Kelly ; Farrell, David ; Gao, Hongyuan ; Bowles, Erin J A ; Graham, Amanda L ; Luta, George ; Jayasekera, Jinani ; Mandelblatt, Jeanne S ; Schwartz, Marc D ; O’Neill, Suzanne C

Background : Limited evidence exists about how to communicate breast density-informed breast cancer risk to women at elevated risk to motivate cancer prevention. Methods : We conducted a randomized controlled trial evaluating a web-based intervention incorporating personalized breast cancer risk, information on chemoprevention, and values clarification on chemoprevention uptake vs. active control. Eligible women, aged 40–69 years with normal mammograms and elevated 5-year breast cancer risk, [...]

Menée aux Etats-Unis sur la période 2014-2019, cette étude de cohorte rétrospective analyse l'évolution, depuis la mise en place d'un programme national de transparence financière, de la rétribution financière des oncologues médicaux par l'industrie pharmaceutique

Trends in Industry Payments to Medical Oncologists in the United States Since the Inception of the Open Payments Program, 2014 to 2019

Tarras, Elizabeth S. ; Marshall, Deborah C. ; Rosenzweig, Kenneth ; Korenstein, Deborah ; Chimonas, Susan

Given the potential for undue influence of industry-physician payments on oncology care, it is important to understand how a national transparency program may be associated with financial interactions between industry and medical oncologists.To identify trends in industry payments to medical oncologists from 2014 to 2019 and determine if the implementation of the Open Payments program is associated with changes in the frequency or value of payments or any shift in the nature of [...]

Menée en Australie par enquête auprès de 160 patients atteints d'un cancer de la prostate, cette étude analyse l'intérêt et la possibilité d'utiliser les symptômes auto-déclarés pour mesurer leur santé psychosociale et leur qualité de vie

Measuring psychosocial outcomes of men living with prostate cancer: feasibility of regular assessment of patient-reported outcomes

Ettridge, Kerry ; Wright, Kathleen ; Smith, David ; Chambers, Suzanne ; Corsini, Nadia ; Evans, Susan ; Moretti, Kim ; Roder, David ; Scuffham, Paul ; Miller, Caroline

Objective : To trial collecting patient‐reported outcome measures (PROMs) to assess psychosocial outcomes in men with prostate cancer (PC). Methods : A cross‐sectional postal survey was sent to three groups of 160 men with PC (6, 12 and 24 months post‐initial treatment; ntotal = 480), through the South Australian Prostate Cancer Clinical Outcomes Collaborative (SAPCCOC) registry (2017). Outcomes were as follows: response rate, completeness, general and disease‐specific quality of life, [...]

Menée auprès de 11 761 patients atteints d'un cancer de la tête et du cou, cette étude évalue l'association entre un système de score, évaluant des symptômes déclarés par les patients, et le recours aux services d'urgence ou à une hospitalisation non programmée dans les 14 jours qui suivent l'évaluation

Patient-Reported Symptom Burden as a Predictor of Emergency Department Use and Unplanned Hospitalization in Head and Neck Cancer: A Longitudinal Population-Based Study

Noel, Christopher W. ; Sutradhar, Rinku ; Zhao, Haoyu ; Delibasic, Victoria ; Forner, David ; Irish, Jonathan C. ; Kim, Jonathan ; Husain, Zain ; Mahar, Alyson ; Karam, Irene ; Enepekides, Danny J. ; Chan, Kelvin K. W. ; Singh, Simron ; Hallet, Julie ; Coburn, Natalie G. ; Eskander, Antoine

PURPOSE: To determine the association between patient-reported symptom burden and subsequent emergency department use and unplanned hospitalization (ED/Hosp) in a head and neck cancer (HNC) patient population. METHODS: This was a population-based study of patients diagnosed with HNC who had completed at least one outpatient Edmonton Symptom Assessment System (ESAS) assessment between January 2007 and March 2018 in Ontario, Canada. Logistic regression models were used to determine the [...]