Cette étude fait le point sur la carcinogenèse pulmonaire et sur les mécanismes oncogènes du vapotage

Vaping and Lung Cancer - A Review of Current Data and Recommendations

Bracken-Clarke, Dara ; Kapoor, Dhruv ; Baird, Anne Marie ; Buchanan, Paul James ; Gately, Kathy ; Cuffe, Sinead ; Finn, Stephen P.

Objectives: Lung cancer is the most common cause of cancer mortality worldwide and, while tobacco smoke remains the primary cause, there is increasing concern that vaping and E-cigarette use may also increase lung cancer risk. This review concentrates on the current data, scholarship and active foci of research regarding potential cancer risk and oncogenic mechanisms of vaping and lung cancer. Materials and methods: We performed a literature review of current and historical publications on lung [...]

Menée à l'aide de données portant sur 1 961 Thaïlandais (âge : 35-54 ans ; durée de suivi : plus de 30 ans), cette étude analyse l'association entre la trajectoire de consommation d'alcool et la mortalité par cancer (89 décès)

Associations between alcohol consumption trajectory and deaths due to cancer, cardiovascular diseases and all-cause mortality: a 30-year follow-up cohort study in Thailand

Jankhotkaew, Jintana ; Bundhamcharoen, Kanitta ; Suphanchaimat, Rapeepong ; Waleewong, Orratai ; Chaiyasong, Surasak ; Markchang, Kamolphat ; Wongworachate, Chadthapong ; Vathesatogkit, Prin ; Sritara, Piyamitr

Objectives: This study examined the association between alcohol consumption trajectory and deaths due to cancer, cardiovascular diseases (CVDs) and all-cause mortality in Thailand. Design: Data were obtained from a Thai prospective cohort study with more than 30 years of follow-up (n=1961). Setting: All participants resided in Bangkok and its vicinity. Participants: Employees from the Electricity Generating Authority of Thailand aged between 35 and 54 years old were randomly selected. Main [...]

Menée au Japon par questionnaire auprès de 49 173 femmes et 42 773 hommes âgés de 45 à 74 ans (durée de suivi : 15 ans), cette étude analyse l'association entre l'apport en fibres alimentaires et le risque de cancer gastrique (2 228 cas)

Dietary fiber intake and risk of gastric cancer: The Japan Public Health Center-based prospective study

Katagiri, Ryoko ; Goto, Atsushi ; Shimazu, Taichi ; Yamaji, Taiki ; Sawada, Norie ; Iwasaki, Motoki ; Inoue, Manami ; Tsugane, Shoichiro ; for the Japan Public Health Center-based Prospective Study Group

Evidence of the association between dietary fiber intake and gastric cancer (GC) risk from prospective studies is limited. We examined the association between dietary fiber intake and GC risk in a large prospective study. A total of 91 946 eligible Japanese aged 45 to 74 years (42 773 men and 49 173 women) participated in a population-based cohort study (Japan Public Health Center-based prospective study). From a validated food frequency questionnaire with 138 food items, total and food [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2020 (15 études observationnelles, 5 121 patients), cette méta-analyse évalue l'association entre la quantité de produits laitiers consommés et le risque de cancer du foie

Dairy Consumption and Liver Cancer Risk: A Systematic Review and Dose–Response Meta-Analysis of Observational Studies

Zhao, Qihong ; He, Yue ; Wang, Kexin ; Wang, Chen ; Wu, Hanhan ; Gao, Lei ; Hu, Anla ; Yang, Wanshui ; Wang, Sufang

The relationship of dairy consumption and liver cancer risk is still controversial. We conducted a meta-analysis of published cohort and case-control studies to summarize the epidemiologic evidence on the relationship between dairy products consumption and the risk of liver cancer. The literatures were screened from PubMed, EMBASE, and Cochrane Library before May 2020. A total of seven cohort studies and eight case-control studies (5,121 cases) were included. The summary relative risks (RRs) [...]

Menée à partir de données des cohortes "the Nurses’ Health Studys" portant sur 96 746 femmes ayant enregistré régulièrement leurs tours de taille et de hanches (durée de suivi : 24-30 ans), cette étude analyse l'association entre l'obésité abdominale et le risque de cancer du sein (6 129 cas), en fonction du statut ménopausique

Central adiposity and subsequent risk of breast cancer by menopause status

Houghton, Serena C ; Eliassen, Heather ; Tamimi, Rulla M ; Willett, Walter C ; Rosner, Bernard A ; Hankinson, Susan E

Increased body mass index (BMI) is associated with higher postmenopausal breast cancer risk and lower premenopausal breast cancer risk. Less is known about the central adiposity-breast cancer risk association, particularly for tumor subtypes.We used prospective waist (WC) and hip circumference (HC) measures in the Nurses’ Health Studies. We examined associations of WC, HC and waist-to-hip ratio (WHR) with breast cancer independent of BMI, by menopausal status. Cox proportional hazards models [...]

Menée au Mexique auprès de 394 patientes atteintes d'un cancer du sein et de 404 témoins, cette étude analyse l'association entre la concentration urinaire de bisphénol A libre et le risque de développer la maladie

Exposure to bisphenol A and breast cancer risk in northern Mexican women

López-Carrillo, Lizbeth ; Mérida-Ortega, Ángel ; Gómez-Ruiz, Humberto ; Hernández-Garciadiego, Lucia ; Gamboa-Loira, Brenda

Objective: To evaluate the association between BC and urinary concentrations of free-bisphenol A (BPA-F), the biological form of BPA, among women residing in Northern Mexico. Methods: The population under study comprised 394 histologically confirmed BC cases and 404 age-matched controls. Women were interviewed face to face about their sociodemographic and reproductive characteristics. BPA-F was determined by high-pressure liquid chromatography equipped with a fluorescence detector (HPLC/FLD). [...]

Menée à l'aide des données 1975-2014 de 4 registres nationaux danois portant sur 144 patients pédiatriques atteints d'un rétinoblastome (diagnostiqué avant l'âge de 5 ans), cette étude analyse l'effet d'expositions professionnelles des parents sur le risque pour l'enfant de développer la maladie

Parental Occupation and Risk of Childhood Retinoblastoma in Denmark

Omidakhsh, Negar ; Hansen, Johnni ; Ritz, Beate ; Coleman, Anne L. ; McKean-Cowdin, Roberta ; Olsen, Jorn ; Heck, Julia E.

Objective: Retinoblastoma is the most common primary intraocular tumor affecting children. We examine the role of parental occupational exposures and risk of retinoblastoma among offspring. Methods: Our population-based case-control study linked data from four nationwide Danish registries and included all cases of retinoblastoma diagnosed in Danish children (<5 years, n = 144) between 1975–2014. We focused on two biologically relevant time periods: 90 days preconception to conception for [...]

Menée au Canada à partir des données 2015 d'incidence des carcinomes basocellulaires ou épidermoïdes de la peau, cette étude estime la part de ces cancers attribuable aux rayonnements ultraviolets (UV) et aux comportements à risque vis-à-vis des UV

The current burden of non-melanoma skin cancer attributable to ultraviolet radiation and related risk behaviours in Canada

O’Sullivan, Dylan E. ; Brenner, Darren R. ; Villeneuve, Paul J. ; Walter, Stephen D. ; Demers, Paul A. ; Friedenreich, Christine M. ; King, Will D. ; the Com, PARe Study Team

Purpose: Ultraviolet radiation (UVR) is an established cause of non-melanoma skin cancer (NMSC)—basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The aim of this study was to estimate the current burden of BCC and SCC associated with UVR and modifiable UVR behaviours (sunburn, sunbathing, and indoor tanning) in Canada in 2015. Methods: The current burden of BCC and SCC associated with UVR was estimated by comparing 2015 incidence rates with rates of less exposed body sites (trunk [...]

Menée à partir de données de registres portant sur 146 104 femmes vivant au Danemark entre 1995 et 2017 (âge : 20-45 ans ; durée médiane de suivi : 10,1 ans), cette étude analyse l'association entre une utilisation de médicaments traitant l'hypofertilité et le risque de cancer de l'endomètre (119 cas)

Endometrial cancer risk after fertility treatment: a population-based cohort study

Guleria, Sonia ; Jensen, Allan ; Albieri, Vanna ; Nøhr, Bugge ; Frederiksen, Kirsten ; Kjær, Susanne K.

Purpose: Using data from a large population-based cohort of women with fertility problems in Denmark, we examined the association between use of fertility drugs and endometrial cancer incidence. Methods: Women aged 20–45 years living in Denmark during 1 January 1995–31 December 2017 and diagnosed with fertility problems (i.e., subfertile women) were identified from the Danish Infertility Cohort. Information on use of fertility drugs, endometrial cancer, covariates and vital status was obtained [...]

Menée à partir des données 2008-2013 de la base Medicare et des registres américains des cancers portant sur 348 319 personnes, cette étude analyse l'association entre une utilisation d'opioïdes prescrits par ordonnance et l'incidence des cancers, par localisation

The association of prescription opioid use with incident cancer: A surveillance, epidemiology, and end results-medicare population-based case-control study

Havidich, Jeana E. ; Weiss, Julie E. ; Onega, Tracy L. ; Low, Ying H. ; Goodrich, Martha E. ; Davis, Mathew A. ; Sites, Brian D.

Background: Cancer is the second leading cause of death globally, and researchers seek to identify modifiable risk factors Over the past several decades, there has been ongoing debate whether opioids are associated with cancer development, metastasis, or recurrence. Basic science, clinical, and observational studies have produced conflicting results. The authors examined the association between prescription opioids and incident cancers using the Surveillance, Epidemiology, and End Results [...]

Menée à partir de données de la "UK Biobank" portant sur 386 101 personnes (âge : 37-73 ans ; 54,5% de femmes), cette étude analyse l'association entre l'obésité générale et abdominale (mesurées respectivement par l'indice de masse corporelle et le tour de taille) et l'incidence des cancers ainsi que la mortalité spécifique, en fonction du sexe et de la localisation

Combined association of general and central obesity with incidence and mortality of cancers in 22 sites

Parra-Soto, Solange ; Petermann-Rocha, Fanny ; Boonpor, Jirapitcha ; Gray, Stuart R ; Pell, Jill P ; Celis-Morales, Carlos ; Ho, Frederick K

Body mass index (BMI) and waist circumference (WC) are measures of general and central obesity, respectively, and both have been shown to be associated with cancer. However, there is insufficient evidence of their combined association with the risk of cancer.This study aimed to investigate the associations of combinations of BMI and WC with cancer at 22 sites.A total of 386,101 (54.5% women) UK Biobank participants aged from 37 to 73 y were included. The outcomes were incidence of and mortality [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2020 (36 études, 14 496 patients), cette méta-analyse évalue l'association entre des antécédents de diabète sucré et le risque de cancer de l'ovaire

Diabetes mellitus and the risk of ovarian cancer: a systematic review and meta-analysis of cohort and case–control studies

Wang, Lihai ; Zhong, Lei ; Xu, Bin ; Chen, Min ; Huang, Hongxiao

Objective: Emerging evidence from observational studies (cohort and case–control studies) suggests that a history of diabetes mellitus (DM) has been linked to increased risk of ovarian cancer (OC), but the association between them remains inconclusive. The aim of this systematic review and meta-analysis of observational studies was to clarify this association. Design: Systematic review and meta-analysis. Methods: We searched PubMed, Embase and the Cochrane library databases published from the [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 26 397 patients atteints d'un cancer colorectal et sur 41 481 témoins, cette étude analyse l'association entre les taux sanguins de bilirubine ou la présence de calculs biliaires et le risque de développer la maladie

Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis

Culliford, Richard ; Cornish, Alex J. ; Law, Philip J. ; Farrington, Susan M. ; Palin, Kimmo ; Jenkins, Mark A. ; Casey, Graham ; Hoffmeister, Michael ; Brenner, Hermann ; Chang-Claude, Jenny ; Kirac, Iva ; Maughan, Tim ; Brezina, Stefanie ; Gsur, Andrea ; Cheadle, Jeremy P. ; Aaltonen, Lauri A. ; Dunlop, Malcom G. ; Houlston, Richard S.

Background: Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of developing colorectal cancer (CRC) have been inconsistent. To address possible confounding and reverse causation, we examine the relationship between these potential risk factors and CRC using Mendelian randomisation (MR). Methods: We used two-sample MR to examine the relationship between genetic liability to gallstone disease and circulating levels of bilirubin [...]

Menée auprès de 144 599 femmes ménopausées (âge : 50-79 ans ; durée moyenne de suivi : 15,9 ans), cette étude estime le risque de carcinome rénal (583 cas) chez les femmes ayant eu recours à une hystérectomie, une ovariectomie et/ou recevant un traitement hormonal substitutif

Hysterectomy, oophorectomy and risk of renal cell carcinoma

Luo, Juhua ; Rohan, Thomas E. ; Neuhouser, Marian L. ; Liu, Nianjun ; Saquib, Nazmus ; Li, Yueyao ; Shadyab, Aladdin H. ; Qi, Lihong ; Wallace, Robert B ; Hendryx, Michael

Background: Female hormones may play roles during renal cell carcinoma (RCC) carcinogenesis. The aims of this study were to investigate associations between hysterectomy, oophorectomy and risk of RCC, and to assess whether the associations were modified by exogenous estrogen, commonly used among women who have undergone hysterectomy. Methods: Postmenopausal women (n= 144,599) aged 50-79 years at enrollment (1993-1998) in the Women's Health Initiative were followed for a mean of 15.9 years. [...]

Menée en Asie de l'Est à partir de données de l'Assurance maladie portant sur plus de 3,3 millions de femmes ayant réalisé 2 examens de dépistage entre 2009 et 2012 et âgées d'au moins 40 ans, cette étude analyse l'association entre une évolution de la densité mammaire et le risque de cancer du sein

Association between changes in mammographic density category and the risk of breast cancer: A nationwide cohort study in East-Asian women

Kim, Soyeoun ; Park, Boyoung

Breast density is strongly associated with breast cancer risk; however, studies on the association between density changes and breast cancer risk have controversial results. The aim of this study was to determine the association between breast density changes and breast cancer risk in East-Asian women. We included 3,301,279 women aged ≥40 years screened for breast cancer twice during 2009–2010 and 2011–2012. Data were obtained from the National Health Insurance Service (NHIS) database. Breast [...]