A partir d'une revue de la littérature, cette étude fait le point sur la santé sexuelle et la qualité de vie chez des adolescents et jeunes adultes ayant survécu à un cancer (âge : 15-39 ans)

Sexual health among adolescent and young adult cancer survivors: A scoping review from the Children's Oncology Group Adolescent and Young Adult Oncology Discipline Committee

Cherven, Brooke ; Sampson, Amani ; Bober, Sharon L. ; Bingen, Kristin ; Frederick, Natasha ; Freyer, David R. ; Quinn, Gwendolyn P.

Sexual function is a vital aspect of quality of life among adolescent and young adult (AYA) (ages 15-39 years) cancer survivors. Sexual function encompasses physical, psychosocial, and developmental factors that contribute to sexual health, all of which may be negatively impacted by cancer and treatment. However, limited information is available to inform the care of AYA cancer survivors in this regard. This scoping review, conducted by the Children's Oncology Group AYA Oncology Discipline [...]

A partir d'une revue systématique de la littérature (7 essais randomisés), cette étude qualitative analyse l'intérêt de deux types d'interventions non pharmacologiques, utilisant des massages ou des exercices de relaxation, pour soulager les troubles du sommeil chez des patients ayant survécu à un cancer

Randomized control trial evidence for the benefits of massage and relaxation therapy on sleep in cancer survivors—a systematic review

Samuel, Stephen Rajan ; Gururaj, Rachita ; Kumar, K. Vijaya ; Vira, Prina ; Saxena, P. U. Prakash ; Keogh, Justin William Leslie

Purpose : Cancer survivors may experience sleep disturbances during and after their cancer treatments. While pharmacological approaches are commonly used to address sleep disturbances, they may have a number of adverse effects. This review studied the effect of two non-pharmacological interventions (massage and relaxation therapy) on sleep disturbances in cancer survivors. Methods : A search for randomised controlled trials (RCTs) was conducted on PubMed, Scopus, Web of Science, PEDro, and [...]

A partir d'une simulation comportant 216 scénarios, cette étude analyse l'effet de l'exhaustivité des registres des cancers sur les estimations de survie

Exploring the impact of cancer registry completeness on international cancer survival differences: a simulation study

Andersson, Therese M. L. ; Rutherford, Mark J. ; Myklebust, Tor Åge ; Møller, Bjørn ; Soerjomataram, Isabelle ; Arnold, Melina ; Bray, Freddie ; Parkin, D. Max ; Sasieni, Peter ; Bucher, Oliver ; De, Prithwish ; Engholm, Gerda ; Gavin, Anna ; Little, Alana ; Porter, Geoff ; Ramanakumar, Agnihotram V. ; Saint-Jacques, Nathalie ; Walsh, Paul M. ; Woods, Ryan R. ; Lambert, Paul C.

Background : Data from population-based cancer registries are often used to compare cancer survival between countries or regions. The ICBP SURVMARK-2 study is an international partnership aiming to quantify and explore the reasons behind survival differences across high-income countries. However, the magnitude and relevance of differences in cancer survival between countries have been questioned, as it is argued that observed survival variations may be explained, at least in part, by [...]

Menée aux Etats-Unis à l'aide d'une enquête réalisée sur la période 2011-2019 auprès de 1 297 362 adolescents, cette étude analyse les comportements tabagiques (cigarettes et produits tabagiques sans fumée) chez les jeunes, en fonction du sexe et de l'origine ethnique

Trends in Tobacco Use Among Adolescents by Grade, Sex, and Race, 1991-2019

Meza, Rafael ; Jimenez-Mendoza, Evelyn ; Levy, David T.

Use of e-cigarettes increased among adolescents between 2011 and 2019. However, whether these changes are affecting patterns of use of other tobacco products, especially cigarettes, remains unclear.To examine the long-term and recent trends in cigarette smoking and smokeless tobacco product use among US adolescents by grade (8th, 10th, and 12th), sex (male and female), and race (White and Black).In this cross-sectional study, joinpoint regression analyses were performed to characterize trends [...]

Menée à partir des données des registres américains sur la période 1973-2015, cette étude rétrospective analyse les facteurs associés à l'évolution de l'incidence des cancers chez les adolescents et jeunes adultes (âge : 15-39 ans)

Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015

Scott, Alyssa R. ; Stoltzfus, Kelsey C. ; Tchelebi, Leila T. ; Trifiletti, Daniel M. ; Lehrer, Eric J. ; Rao, Pooja ; Bleyer, Archie ; Zaorsky, Nicholas G.

Importance : Previous studies have demonstrated that adolescents and young adults (AYAs) with cancer are a distinct cancer population; however, research on long-term epidemiological trends and characteristics of cancers in AYAs is lacking. Objective : To characterize the epidemiology of cancer in AYAs aged 15 to 39 years with respect to (1) patient demographic characteristics, (2) frequencies of cancer types, and (3) cancer incidence trends over time. Design, Setting, and Participants : This [...]

Menée à partir des données du registre norvégien des cancers portant sur 22 324 patients atteints d'un cancer du poumon diagnostiqué entre 2005 et 2014, cette étude de cohorte analyse l'association entre une utilisation de metformine, avant et après le diagnostic de cancer, et la survie globale et spécifique

Metformin use and lung cancer survival: a population-based study in Norway

Brancher, Suzan ; Støer, Nathalie C. ; Weiderpass, Elisabete ; Damhuis, Ronald A. M. ; Johannesen, Tom B. ; Botteri, Edoardo ; Strand, Trond-Eirik

Background : We assessed associations between metformin use and survival in a nationwide Norwegian cohort of lung cancer (LC) patients. Methods : The study linked 22,324 LC patients from the Cancer Registry of Norway diagnosed 2005–2014 with the Norwegian Prescription Database. We estimated associations of pre- and post-diagnostic metformin use with overall survival (OS) and LC-specific survival (LCSS) using multivariable time-fixed and time-dependent Cox regression. Results : Pre-diagnostic [...]

Menée à partir de données portant sur 20 937 patients atteints d'un cancer du poumon non à petites cellules, cette étude analyse l'association entre l'indice de masse corporelle et la survie globale, en fonction du sexe, de l'appartenance ethnique et du statut tabagique

The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International Lung Cancer Consortium (ILCCO) patients

Jiang, Mei ; Fares, Aline F. ; Shepshelovich, Daniel ; Yang, Ping ; Christiani, David ; Zhang, Jie ; Shiraishi, Kouya ; Ryan, Bríd M. ; Chen, Chu ; Schwartz, Ann G. ; Tardon, Adonina ; Shete, Sanjay ; Schabath, Matthew B. ; Teare, M. Dawn ; Le Marchand, Loic ; Zhang, Zuo-Feng ; Field, John K. ; Brenner, Hermann ; Daio, Nancy ; Xie, Juntao ; Kohno, Takashi ; Harris, Curtis C. ; Wenzlaff, Angela S. ; Fernández-Tardón, Guillermo ; Ye, Yuanqing ; Taylor, Fiona ; Wilkens, Lynne R. ; Davies, Michael ; Liu, Yi ; Barnett, Matt J. ; Goodman, Gary E. ; Morgenstern, Hal ; Holleczek, Bernd ; Thomas, Sera ; Brown, M. Catherine ; Hung, Rayjean J. ; Xu, Wei ; Liu, Geoffrey

Introduction : The relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous.We evaluated the impact of sex, smoking and race on the relationship between BMI andoverall survival (OS) in non-small-cell-lung-cancer (NSCLC). Methods : Data from 16 individual ILCCO studies were pooled to assess interactions between BMIand the following factors on OS: self-reported race, smoking status and sex, usingCox models (adjusted hazard ratios; aHR) with interaction terms and [...]

Menée dans 7 Etats américains, cette étude analyse, chez les patients atteints d'un cancer du poumon, la proportion de non fumeurs et leurs caractéristiques

Proportion of Never Smokers Among Men and Women With Lung Cancer in 7 US States

Siegel, David A. ; Fedewa, Stacey A. ; Henley, S. Jane ; Pollack, Lori A. ; Jemal, Ahmedin

Previous studies reported increases in the proportion of patients in the US and UK with lung cancer who never smoked cigarettes, but these were based on small sample sizes from hospital data rather than population-based cancer registries. Beginning in 2011, the US Centers for Disease Control and Prevention (CDC) National Program of Cancer Registries supported a comparative effectiveness research project to abstract cigarette smoking history from the medical records of patients. Using these [...]

Menée en Allemagne à partir de données portant sur 3 813 patientes atteintes d'un cancer du sein diagnostiqué entre 2002 et 2005 (âge : 50-74 ans) et sur 7 341 témoins, cette étude analyse les facteurs associés à la présence de comorbidités (durée de suivi : 12 ans)

Comorbidity burden in long-term breast cancer survivors compared with a cohort of population-based controls from the MARIE study

Möhl, Annika ; Orban, Ester ; Jung, Audrey Y. ; Behrens, Sabine ; Obi, Nadia ; Chang-Claude, Jenny ; Becher, Heiko

Background : The number of elderly cancer survivors is growing because of increasing survival rates. A high comorbidity burden in the elderly can affect their quality of life and survival. The aim of this study was to examine whether breast cancer survivors and population-based controls have a different comorbidity burden after long-term follow-up. Methods : This study used data from a German breast cancer case-control study, which initially comprised 3813 breast cancer cases aged 50 to 74 [...]

Menée aux Etats-Unis par enquête auprès de 1 026 jeunes patientes atteintes d'un cancer du sein diagnostiqué entre 2006 et 2016 (âge inférieur à 40 ans), cette étude de cohorte prospective analyse leur intérêt vis-à-vis de la préservation de la fertilité et l'état de leurs capacités reproductives 5 ans après le diagnostic de la maladie (152 grossesses, 91 enfants nés vivants)

Pregnancy after breast cancer: Results from a prospective cohort of young women with breast cancer

Poorvu, Philip D. ; Gelber, Shari I. ; Zheng, Yue ; Ruddy, Kathryn J. ; Tamimi, Rulla M. ; Peppercorn, Jeffrey ; Schapira, Lidia ; Borges, Virginia F. ; Come, Steven E. ; Lambertini, Matteo ; Rosenberg, Shoshana M. ; Partridge, Ann H.

Background : Many young women with newly diagnosed breast cancer are interested in future pregnancies. Prospective data regarding fertility interest and reproductive patterns after diagnosis are needed to counsel patients. Methods : The Young Women's Breast Cancer Study is a multicenter, prospective cohort of women who were diagnosed with breast cancer at age ≤40 years between 2006 and 2016. Women complete surveys at baseline, every 6 months for 3 years, then annually. Here, the authors [...]

Menée aux Pays-Bas à partir de données portant sur 320 249 patientes atteintes d'un cancer primitif du sein de stade invasif, cette étude analyse, pour la période 1989-2017, l'évolution des facteurs associés à l'incidence, à la survie et à la mortalité spécifique ainsi que les traitments reçus, en fonction de l'âge, du stade et du sous-type des récepteurs hormonaux

Comprehensive trends in incidence, treatment, survival and mortality of first primary invasive breast cancer stratified by age, stage and receptor subtype in the Netherlands between 1989−2017

van der Meer, Daniël J. ; Kramer, Iris ; van Maaren, Marissa C. ; van Diest, Paul J. ; Linn, Sabine ; Maduro, John H. ; Strobbe, Luc ; Siesling, Sabine ; Schmidt, Marjanka K. ; Voogd, Adri C.

Abstract This study aimed to provide a comprehensive overview of trends in incidence, survival, mortality and treatment of first primary invasive breast cancer (BC), according to age, stage and receptor subtype in the Netherlands between 1989−2017. Data from all women diagnosed with first primary stage I−IV breast cancer (N=320,249) were obtained from the Netherlands Cancer Registry. BC mortality and general population data were retrieved from Statistics Netherlands. Age-standardized incidence [...]

Menée aux Etats-Unis à partir de données portant sur 78 708 patientes atteintes d'un cancer du sein triple négatif diagnostiqué entre 2010 et 2014, cette étude analyse les disparités ethniques dans la mortalité toutes causes confondues à 3 et 5 ans

Racial/Ethnic Disparities in All-Cause Mortality Among Patients Diagnosed with Triple-Negative Breast Cancer

Wang, Fei ; Zheng, Wei ; Bailey, Christina E. ; Mayer, Ingrid A. ; Pietenpol, Jennifer A. ; Shu, Xiao-Ou

It is unclear whether racial/ethnic disparities in triple-negative breast cancer (TNBC) mortality remain after accounting for clinical characteristics, treatment, and access-to-care-related factors. In this study, women with a primary diagnosis of TNBC during 2010-2014 were identified from the National Cancer Database. Hazard ratios (HR) and 95% confidence intervals (CI) for 3- and 5-year all-cause mortality associated with race/ethnicity were estimated using Cox proportional hazards models [...]

Menée à Hong-Kong par enquête auprès de 311 patients ayant survécu à un cancer, cette étude transversale analyse les facteurs associés à la peur de la récidive, à leurs besoins en soins de support et à une utilisation de services psychosociaux

Fear of cancer recurrence, supportive care needs, and the utilization of psychosocial services in cancer survivors: A cross-sectional survey in Hong Kong

Chung, LI Man ; Lin, CHENG Hui

Objective : Fear of cancer recurrence (FCR) is the top-ranked psychological concern in cancer survivors. We examined the prevalence of FCR and the relationships among FCR, supportive care needs, and the utilization of psychosocial services among Chinese cancer survivors. Methods : This cross-sectional, correlational study included 311 cancer survivors within five years of survivorship in Hong Kong. The participants were invited to complete an online survey: the Fear of Progression [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2020 (12 études), cette méta-analyse évalue l'association entre le soutien social et des idées suicidaires chez des patients atteints d'un cancer

Association between social support and suicidal ideation in patients with cancer: A systematic review and meta-analysis

Du, Lin ; Shi, Hai-Yan ; Qian, Yan ; Jin, Xiao-Hong ; Li, Yang ; Yu, Hai-Rong ; Liu, Xiao-Man ; Fu, Xue-Lei ; Chen, Hong-lin

Objective : To quantitatively examine the relationship between social support and suicidal ideation (SI) among patients with cancer and identify the moderators that influence the magnitude of this association. Methods : Publications were searched in PubMed, PsycINFO, EMBASE, Cochrane Library and Chinese National Knowledge Infrastructure from database inception to May, 2020. Correlation coefficients (r) were chosen as the effect size with a random model to evaluate the overall effect size [...]

Menée en Autriche auprès de 846 patients atteints d'un cancer, cette étude transversale analyse la présence d'une douleur et l'association entre cette douleur et des symptômes de stress post-traumatique, de détresse et d'anxiété

Prevalence of pain and its association with symptoms of post-traumatic stress disorder, depression, anxiety and distress in 846 cancer patients: A cross sectional study

Unseld, Matthias ; Zeilinger, Elisabeth L. ; Fellinger, Matthäus ; Lubowitzki, Simone ; Krammer, Katharina ; Nader, Ingo W. ; Hafner, Matthias ; Kitta, Anna ; Adamidis, Feroniki ; Masel, Eva K. ; Preusser, Matthias ; Jäger, Ulrich ; Gaiger, Alexander

Objective : Pain depicts a severe physical symptom but its relationship to mental health problems is not well studied in cancer patients. The aim of this study was to investigate the prevalence of pain and its correlation with symptoms of post‐traumatic stress disorder (PTSD), depression, anxiety and psychological distress in a large sample of cancer patients. Methods : From 2010 to 2019, cancer patients who received outpatient treatment at the Medical University of Vienna were assessed with [...]

Menée en Italie à partir de données portant sur 400 patients atteints d'un cancer du pancréas et devant recevoir un traitement chirurgical en milieu hospitalier, cette étude analyse les facteurs socio-démographiques, cliniques et psycho-sociaux associés à une dépression

Prevalence of depression in a cohort of 400 patients with pancreatic neoplasm attending day-hospital for major surgery. Role on depression of psycho-social functioning and clinical factors

Del Piccolo, Lidia ; Marinelli, Veronica ; Mazzi, Maria Angela ; Danzi, Olivia Purnima ; Bonamini, Deborah ; Secchettin, Erica ; Tuveri, Massimiliano ; Bassi, Claudio ; Rimondini, Michela ; Salvia, Roberto

Objective : 1.To determine the prevalence and type of depressive symptoms at day hospital clinical evaluation, before undergoing major surgery in patients diagnosed with pancreatic neoplasm; 2. To analyze the association between depression and socio-demographic, clinical and psycho-social variables; 3. To understand how coping strategies, perceived social support and self-efficacy might affect depressive symptoms in this cohort of patients. Methods : Secondary data analysis collected during the [...]

Menée aux Etats-Unis par questionnaire auprès de 536 patients âgés atteints d'un cancer de stade avancé (âge moyen : 76,4 ans), cette étude analyse leurs difficultés financières liées aux coûts des traitements anticancéreux, les discussions à ce sujet avec l'oncologue et l'impact de ces difficultés sur la qualité de vie

Assessment of Financial Toxicity Among Older Adults With Advanced Cancer

Arastu, Asad ; Patel, Arpan ; Mohile, Supriya Gupta ; Ciminelli, Joseph ; Kaushik, Ramya ; Wells, Megan ; Culakova, Eva ; Lei, Lianlian ; Xu, Huiwen ; Dougherty, David W. ; Mohamed, Mostafa R. ; Hill, Elaine ; Duberstein, Paul ; Flannery, Marie Anne ; Kamen, Charles Stewart ; Pandya, Chintan ; Berenberg, Jeffrey L. ; Aarne Grossman, Valerie G. ; Liu, Yang ; Loh, Kah Poh

Importance: Financial toxicity (FT), unintended and unanticipated financial burden experienced by cancer patients undergoing cancer care, is associated with negative consequences and increased risk of mortality. Older patients (≥70 years) with cancer are at risk for FT, yet data are limited on FT and whether oncologists discuss FT with their patients. Objective : To examine the prevalence of FT in older adults with advanced cancer, its association with health-related quality of life (HRQoL), [...]

Menée aux Etats-Unis à partir de données portant sur 144 061 campagnes de financement participatif conduites entre 2010 et 2019 pour soutenir la lutte contre le cancer, cette étude transversale analyse l'association entre le niveau socioéconomique du comté et l'efficacité, du point de vue de la somme collectée, de ces campagnes

Association of Neighborhood Deprivation Index With Success in Cancer Care Crowdfunding

Silver, Elisabeth R. ; Truong, Han Q. ; Ostvar, Sassan ; Hur, Chin ; Tatonetti, Nicholas P.

Importance : Financial toxicity resulting from cancer care poses a substantial public health concern, leading some patients to turn to online crowdfunding. However, the practice may exacerbate existing socioeconomic cancer disparities by privileging those with access to interpersonal wealth and digital media literacy. Objective : To test the hypotheses that higher county-level socioeconomic status and the presence (vs absence) of text indicators of beneficiary worth in campaign descriptions are [...]

Menée en Italie dans un contexte de vie réelle, cette étude compare le rapport coût-efficacité de soins palliatifs dispensés précocement à domicile et de soins standard dispensés en milieu hospitalier, pour des patients atteints d'un cancer hématologique de stade avancé ou en phase terminale

Early Palliative Home Care versus Hospital Care for Patients with Hematologic Malignancies: A Cost-Effectiveness Study

Claudio Cartoni, ; Massimo Breccia, ; Johannes Maria Giesinger, ; Erminia Baldacci, ; Ida Carmosino

Background: There is paucity of data on the potential value of early palliative home care for patients with hematologic malignancies. Objective: To compare costs, use of resources, and clinical outcomes between an early palliative home care program and standard hospital care for active-advanced or terminal phase patients. Patients and Methods: In this real-life, nonrandomized comparative study, the allocation of advanced/terminal phase patients to either home or hospital was based on pragmatic [...]