Menée notamment à l'aide des données 2018 d'incidence et de mortalité des cancers issues du "Global Cancer Observatory", cette étude analyse l'association entre la consommation de viandes transformées, la consommation d'alcool et le risque de carcinome rénal

Association of Processed Meats and Alcohol Consumption with Renal Cell Carcinoma: A Worldwide Population-Based Study

Ziouziou, Imad ; Shariat, Shahrokh F. ; Ajdi, Farida ; Khabbal, Youssef

The link between diet and renal cell carcinoma (RCC) is still unclear. The purpose of this study was to evaluate the association of diet with RCC?s incidence and mortality rates worldwide. We conducted an ecological study including 170 countries, whose data on age-standardized (AS) incidence and mortality rates of RCC, dietary factors, and potentially confounding factors such as obesity, insufficient physical activity, tobacco smoking, hypertension, diabetes, and human development index (HDI) [...]

Menée en Espagne auprès de 1 738 patientes atteintes d'un cancer du sein récemment diagnostiqué et 1 910 témoins (âge moyen : 54,9 ans), cette étude multicentrique analyse l'association entre une exposition professionnelle à la chaleur et le risque de développer la maladie

Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study

Hinchliffe, Alice ; Kogevinas, Manolis ; Pérez-Gómez, Beatriz ; Ardanaz, Eva ; Amiano, Pilar ; Marcos-Delgado, Alba ; Castaño-Vinyals, Gemma ; Llorca, Javier ; Moreno, Víctor ; Alguacil, Juan ; Fernández-Tardón, Guillermo ; Salas-Trejo, Dolores ; Marcos-Gragera, Rafael ; Aragonés, Nuria ; Guevara, Marcela ; Gil, Leire ; Martin, Vicente ; Benavente, Yolanda ; Gómez-Acebo, Inés ; Santibáñez, Miguel ; Ángel Alba, Miguel ; García, Ana M ; Pollan, Marina ; Turner, Michelle C

Background: Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited. Methods: We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (P greater [...]

Menée en Chine auprès de cohortes incluant au total 11 684 témoins et 3 010 patients atteints d'un carcinome urothélial des voies excrétrices supérieures, cette étude analyse l'association entre une exposition conjointe aux acides aristolochiques et à l'arsenic et le risque de développer la maladie

Additive effects of arsenic and aristolochic acid in chemical carcinogenesis of upper urinary tract urothelium

Chen, Chung-Hsin ; Grollman, Arthur P ; Huang, Chao-Yuan ; Shun, Chia-Tung ; Sidorenko, Viktoriya S ; Hashimoto, Keiji ; Moriya, Masaaki ; Turesky, Robert J. ; Yun, Byeong Hwa ; Tsai, Karen ; Wu, Stephanie ; Chuang, Po-Ya ; Tang, Chao-Hsiun ; Yang, Wen-Horng ; Tsai, Tzong-Shin ; Tsai, Yuh-Shyan ; Dickman, Kathleen G ; Pu, Yeong-Shiau

Background: Aristolochic acids (AA) and arsenic are chemical carcinogens associated with urothelial carcinogenesis. Here we investigate the combined effects of AA and arsenic towards the risk of developing upper tract urothelial carcinoma (UTUC). Methods: Hospital-based (n=89) and population-based (2,921 cases, 11,684 controls) Taiwanese UTUC cohorts were used to investigate the association between exposure to AA and/or arsenic and the risk of developing UTUC. In the hospital cohort, AA [...]

Menée à partir de données d'une cohorte portant sur 6 786 patients atteints d'une hépatite B chronique (âge moyen : 46,2 ans ; 63,5 % d'hommes ; durée moyenne de suivi : 132 mois), cette étude analyse l'association entre une stéatose hépatique et le risque de cirrhose (564 cas) ou de carcinome hépatocellulaire (281 cas)

Association between fatty liver and cirrhosis, hepatocellular carcinoma, and HBsAg seroclearance in chronic hepatitis B

Li, Jie ; Yang, Hwai-I ; Yeh, Ming-Lun ; Le, Michael H ; Le, An K ; Yeo, Yee Hui ; Dai, Chia-Yen ; Barnett, Scott ; Zhang, Jian Q ; Huang, Jee-Fu ; Trinh, Huy N ; Wong, Christopher ; Wong, Clifford ; Hoang, Joseph K ; Cheung, Ramsey ; Yu, Ming-Lung ; Nguyen, Mindie H

Chronic hepatitis B (CHB) and fatty liver (FL) are common, natural history data on concurrent FL and CHB (FL-CHB) are limited. This study aimed to evaluate the effect of FL on cirrhosis, hepatocellular carcinoma (HCC), and HBsAg seroclearance incidence in CHB patients.In a retrospective cohort study of 6,786 adult CHB patients, we used propensity score matching (PSM) to balance the FL-CHB and non-FL CHB groups. Kaplan-Meier methods were used to compare cumulative cirrhosis, HCC, and HBsAg [...]

Menée au Canada à l'aide de données du registre des cancers et menée auprès de 33 711 personnes prises en charge pour un syndrome d'apnée du sommeil (âge médian : 50 ans ; 58 % d'hommes ; durée médiane de suivi : 7 ans), cette étude analyse l'association entre la sévérité de l'apnée obstructive du sommeil et le risque de cancer (2 498 cas)

Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study

Kendzerska, Tetyana ; Povitz, Marcus ; Leung, Richard S. ; Boulos, Mark I. ; McIsaac, Daniel I ; Murray, Brian J. ; Bryson, Gregory L ; Talarico, Robert ; Hilton, John F. ; Malhotra, Atul ; Gershon, Andrea S

Background: To examine the association between the severity of obstructive sleep apnea (OSA) and nocturnal hypoxemia with incident cancer. Methods: A multicenter retrospective clinical cohort study using linked clinical and provincial health administrative data on consecutive adults who underwent a diagnostic sleep study between 1994 and 2017 in four academic hospitals (Canada) who were free of cancer at baseline. Cancer status was derived from the Ontario Cancer Registry. Cox cause-specific [...]

Menée à partir de données de 7 études portant sur 4 296 patientes atteintes d'un cancer de l'ovaire et sur 12 048 témoins, cette étude analyse la part des cancers attribuable aux facteurs de risque, qu'ils soient modifiables ou non, en fonction de l'origine ethnique

Racial differences in population attributable risk for epithelial ovarian cancer in the OCWAA Consortium

Peres, Lauren C ; Bethea, Traci N ; Camacho, Tareq F ; Bandera, Elisa V ; Beeghly-Fadiel, Alicia ; Chyn, Deanna L ; Harris, Holly R ; Joslin, Charlotte E ; Moorman, Patricia G ; Myers, Evan ; Ochs-Balcom, Heather M ; Rosenow, Will ; Setiawan, V Wendy ; Wu, Anna H ; Rosenberg, Lynn ; Schildkraut, Joellen M

The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women.We used data from four case-control studies and three case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of ten known or suspected EOC risk factors using [...]

Menée à l'aide de données 2009-2017 de l'Assurance maladie coréenne portant sur 9,5 millions de personnes de plus de 20 ans (durée moyenne de suivi : 8,3 ans), cette étude analyse l'association entre le niveau sérique de cholestérol HDL et le risque de cancer hématologique (15 864 cas)

Association between high-density lipoprotein cholesterol level and risk of hematologic malignancy

Jeong, Su-Min ; Choi, Taewoong ; Kim, Dahye ; Han, Kyungdo ; Kim, Seok Jin ; Rhee, Sang Youl ; Giovannucci, Edward L. ; Shin, Dong Wook

This study investigated the relationships between HDL-C and major types of blood cancers. Competing risks regression was used to examine the hazard ratios of hematologic malignancies in 9,596,145 individuals (≥20 years) using data from the Korean National Health Insurance Service (2009–2017). The incidence of the following hematologic cancers was determined based on the International Classification of Diseases 10th revision: Multiple Myeloma (MM), Hodgkin Lymphoma (HL), Non-Hodgkin Lymphoma [...]

Menée à partir du séquençage profond de 46 gènes d'échantillons cutanés prélevés sur 127 personnes en bonne santé, cette étude met en évidence l'effet de l'âge sur l'acquisition et la sélection de mutations somatiques liées à l'exposition solaire et contribuant au développement de cancers cutanés

The effect of age on the acquisition and selection of cancer driver mutations in sun-exposed normal skin

Hernando, B. ; Dietzen, M. ; Parra, G. ; Gil-Barrachina, M. ; Pitarch, G. ; Mahiques, L. ; Valcuende-Cavero, F. ; McGranahan, N. ; Martinez-Cadenas, C.

Background : The accumulation of somatic mutations contributes to ageing and cancer. Sunlight is the principal aetiological factor associated with skin cancer development. However, genetic and phenotypic factors also contribute to skin cancer risk. This study aimed at exploring the role of photoaging, as well as other well-known epidemiological risk factors, in the accumulation of somatic mutations in cancer-free human epidermis. Material and Methods : We deeply sequenced 46 genes in normal [...]