Menée aux Etats-Unis à partir de données portant sur 6 864 employés de 2 sites industriels, cette étude analyse l'association entre une exposition au chloroprène ou au chlorure de vinyle et le risque de décès par cancer du poumon ou du foie

Mortality Patterns Among Industrial Workers Exposed to Chloroprene and Other Substances: Extended Follow-Up

Marsh, Gary M. ; Kruchten, Adam ; Buchanich, Jeanine M.

Objectives: To update the U.S. portion of an historical cohort mortality study of workers with potential exposure to chloroprene (CD) and vinyl chloride (VC) with focus on lung and liver cancer. Methods: Subjects were 6,864 workers from two sites with vital status determined through 2017 for 99% of subjects and cause of death for 97.2% of deaths. Historical exposures to CD and VC were estimated quantitatively. We performed external and internal mortality comparisons. Results: External [...]

Menée en Italie à l'aide de données 2011-2015 portant sur des statistiques nationales et à l'aide de données de mortalité de l'OMS, cette étude estime la part des décès par cancer attribuable à 7 types d'infection (Helicobacter pylori, virus de l'hépatite B et C, papillomavirus humain, Epstein–Barr, herpèsvirus type 8, virus lymphotrope à cellules T de type 1)

Estimates of Cancer Mortality Attributable to Carcinogenic Infections in Italy

Ferrara, Pietro ; Conti, Sara ; Agüero, Fernando ; Albano, Luciana ; Masuet-Aumatell, Cristina ; Ramon-Torrell, Josep Maria ; Mantovani, Lorenzo Giovanni

Several infectious agents are ascertained causes of cancer, but the burden of cancer mortality attributable to carcinogenic infections in Italy is still unknown. To tackle this issue, we calculated the rate and regional distribution of cancer deaths due to infections sustained by seven pathogens ranked as group 1 carcinogenic agents in humans by the International Agency for Research on Cancer. Population attributable fractions related to these agents were applied to annual statistics of cancer [...]

Menée à l'aide de données de la "UK Biobank" portant sur 451 186 participants et à l'aide d'un génotypage communautaire (âge moyen : 56,8 ans ; durée médiane de suivi : 8,9 ans ; 54,3 % de femmes), cette étude analyse, en fonction du sexe, l'association entre une hémochromatose et le risque de cancer du foie chez les porteurs du variant pathogène homozygote HFE p.C282Y

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy

Atkins, Janice L. ; Pilling, Luke C. ; Masoli, Jane A. H. ; Kuo, Chia-Ling ; Shearman, Jeremy D. ; Adams, Paul C. ; Melzer, David

Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but risks are unclear in mostly undiagnosed p.C282Y homozygotes identified in community genotyping.To estimate the incidence of primary hepatic carcinoma and death by HFE variant status.Cohort study of 451 186 UK Biobank participants of European ancestry (aged 40-70 years), [...]

Menée à partir de données des cohortes "the Nurses’ Health Studies" portant sur 1 919 patientes atteintes d'un cancer du sein et sur 1 695 témoins (âge moyen : 54 ans), cette étude analyse l'association entre le taux sérique de caroténoïdes et le risque de développer la maladie, en fonction de prédispositions génétiques évaluées par un score

Circulating carotenoids and breast cancer among high-risk individuals

Peng, Cheng ; Gao, Chi ; Lu, Donghao ; Rosner, Bernard A ; Zeleznik, Oana ; Hankinson, Susan E ; Kraft, Peter ; Eliassen, A Heather ; Tamimi, Rulla M

Carotenoids represent 1 of few modifiable factors to reduce breast cancer risk. Elucidation of interactions between circulating carotenoids and genetic predispositions or mammographic density (MD) may help inform more effective primary preventive strategies in high-risk populations.We tested whether women at high risk for breast cancer due to genetic predispositions or high MD would experience meaningful and greater risk reduction from higher circulating levels of carotenoids in a nested [...]