Menée aux Etats-Unis à partir de données portant sur 112 patients atteints d'un cancer gastro-intestinal de stade avancé, cette étude prospective analyse l'association entre les symptômes et la qualité de vie déclarés par les patients, la réponse aux traitements anticancéreux, l'utilisation des soins et la survie

Associations of baseline patient-reported outcomes with treatment outcomes in advanced gastrointestinal cancer

Van Seventer, Emily E. ; Fish, Madeleine G. ; Fosbenner, Kathryn ; Kanter, Katie ; Mojtahed, Amirkasra ; Allen, Jill N. ; Blaszkowsky, Lawrence ; Clark, Jeffrey W. ; Dubois, Jon ; Franses, Joseph W. ; Giantonio, Bruce J. ; Goyal, Lipika ; Klempner, Samuel J. ; Roeland, Eric J. ; Ryan, David P. ; Weekes, Colin D. ; Mulvey, Therese ; El-Jawahri, Areej ; Horick, Nora ; Corcoran, Ryan B. ; Parikh, Aparna R. ; Nipp, Ryan D.

Background : Patient‐reported outcomes (PROs) assessing quality of life (QOL) and symptom burden correlate with clinical outcomes in patients with cancer. However, to the authors' knowledge, data regarding associations between PROs and treatment response are lacking. Methods : The authors prospectively approached consecutive patients with advanced gastrointestinal cancer who were initiating a new treatment. Prior to treatment, patients reported their QOL (Functional Assessment of Cancer [...]

Menée aux Etats-Unis par questionnaire auprès de 154 aidants familiaux d'enfants atteints d'un cancer (âge : 0-18 ans) et auprès de 52 patients pédiatriques (âge : 7-18 ans), cette étude analyse l'association entre des facteurs familiaux (fonctionnement familial, qualité de vie et détresse psychique des aidants, etc...) et la qualité de vie des enfants à la fin des traitements anticancéreux

Family Factors and Health-related Quality of Life within Six Months of Completion of Childhood Cancer Treatment

Al Ghriwati, Nour ; Stevens, Evelyn ; Velázquez-Martin, Blanca ; Hocking, Matthew C. ; Schwartz, Lisa A. ; Barakat, Lamia P.

Objective : The transition from active cancer treatment to survivorship represents a period of uncertainty for youth and their families, but factors associated with adaptation during this period are understudied. We evaluated associations among cancer and treatment‐related variables, family factors (family functioning, caregiver health‐related quality of life [HRQL], and caregiver distress), and patient HRQL after treatment completion. We assessed the indirect effects of neurocognitive [...]

A partir d'une revue systématique de la littérature publiée entre 2009 et 2019 (7 articles), cette étude analyse les effets de l'art thérapie sur les symptômes d'anxiété et de dépression et sur la qualité de vie des patients atteints d'un cancer

The effects of art therapy on anxiety, depression, and quality of life in adults with cancer: a systematic literature review

Bosman, J. T. ; Bood, Z. M. ; Scherer-Rath, M. ; Dörr, H. ; Christophe, N. ; Sprangers, M. A. G. ; van Laarhoven, H. W. M.

Purpose : While there is increasing evidence for the effectiveness of psychosocial support programs for cancer patients, little attention has been paid to creativity or art as a way of addressing their psychological problems and improving quality of life. This review provides an overview of interventional studies that investigate the effects of art therapy interventions on anxiety, depression, and quality of life in adults with cancer. Methods : We conducted a literature review with a [...]

A partir d'une revue de la littérature (45 articles, dont 21 essais randomisés), cette étude présente des recommandations pour la pratique clinique concernant la prise en charge d'une mucite buccale chez des patients pédiatriques atteints d'un cancer

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

Miranda-Silva, Wanessa ; Gomes-Silva, Wagner ; Zadik, Yehuda ; Yarom, Noam ; Al-Azri, Abdul Rahman ; Hong, Catherine H. L. ; Ariyawardana, Anura ; Saunders, Deborah P. ; Correa, M. Elvira ; Arany, Praveen R. ; Bowen, Joanne ; Cheng, Karis Kin Fong ; Tissing, Wim J. E. ; Bossi, Paolo ; Elad, Sharon ; On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral, Oncology

Objective : The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population. Methods : This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored [...]

A partir d'une revue systématique de la littérature (5 essais randomisés, 722 participants), cette méta-analyse évalue l'intérêt des interventions personnalisées nutritionnelles et/ou promouvant l'activité physique auprès d'adultes participant au dépistage du cancer colorectal ou du cancer du sein

Effectiveness of diet and physical activity interventions amongst adults attending colorectal and breast cancer screening: a systematic review and meta-analysis

Orange, Samuel T. ; Hicks, Kirsty M. ; Saxton, John M.

Purpose : To estimate the effectiveness of tailored physical activity and dietary interventions amongst adults attending colorectal and breast cancer screening. Methods : Five literature databases were systematically searched to identify randomised controlled trials (RCTs) of tailored physical activity and/or dietary interventions with follow-up support initiated through colorectal and breast cancer screening programmes. Outcomes included markers of body fatness, physical activity, and dietary [...]

Mené sur 150 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cet essai de phase III à trois bras évalue l'intérêt, du point de vue de l'amélioration de la qualité de vie et de la survie, de l'ajout de l'homéopathie au traitement anticancéreux

Homeopathic Treatment as an Add-On Therapy May Improve Quality of Life and Prolong Survival in Patients with Non-Small Cell Lung Cancer: A Prospective, Randomized, Placebo-Controlled, Double-Blind, Three-Arm, Multicenter Study

Frass, Michael ; Lechleitner, Peter ; Gründling, Christa ; Pirker, Claudia ; Grasmuk-Siegl, Erwin ; Domayer, Julian ; Hochmair, Maximilian ; Gaertner, Katharina ; Duscheck, Cornelia ; Muchitsch, Ilse ; Marosi, Christine ; Schumacher, Michael ; Zöchbauer-Müller, Sabine ; Manchanda, Raj K. ; Schrott, Andrea ; Burghuber, Otto

Background : Patients with advanced non‐small cell lung cancer (NSCLC) have limited treatment options. Alongside conventional anticancer treatment, additive homeopathy might help to alleviate side effects of conventional therapy. The aim of the present study was to investigate whether additive homeopathy might influence quality of life (QoL) and survival in patients with NSCLC. Methods : In this prospective, randomized, placebo‐controlled, double‐blind, three‐arm, multicenter, phase III study, [...]

Menée aux Pays-Bas auprès de 340 patients atteints d'un cancer colorectal, cette étude de cohorte prospective analyse l'évolution, au cours des deux années suivant le diagnostic, d'une neuropathie périphérique induite par la chimiothérapie et son impact sur la qualité de vie

The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients

Bonhof, Cynthia S. ; van de Poll-Franse, Lonneke V. ; Wasowicz, Dareczka K. ; Beerepoot, Laurens V. ; Vreugdenhil, Gerard ; Mols, Floortje

Purpose : To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods : All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) [...]

Menée au Royaume-Uni à partir de données portant sur 4 796 patientes atteintes d'un cancer du sein traité par mastectomie, cette étude analyse, 18 mois après la chirurgie, leur satisfaction vis-à-vis des propositions de reconstruction mammaire immédiate (1 889 patientes sans proposition de reconstruction mammaire, 1 489 refus de la proposition, 1 489 cas de reconstruction)

Patients’ satisfaction with the reconstructive options provided to them measured 18 months after mastectomy surgery for breast cancer

Jeevan, Ranjeet ; Browne, John P. ; Gulliver-Clarke, Carmel ; Pereira, Jerome ; Caddy, Christopher M. ; van der Meulen, Jan H. P. ; Cromwell, David A.

Introduction : Mastectomy patients’ satisfaction with reconstructive options has not been examined. Methods : A national study measured 18‐month satisfaction with reconstructive options and collected case‐mix and reconstructive offer and uptake data on breast cancer patients having mastectomy with or without immediate reconstruction (IR) in England between January 2008 and March 2009. Multivariable logistic regression examined the relationship between satisfaction, age, IR offer and uptake, and [...]

Mené sur 146 patients atteints d'un cancer du rhinopharynx, cet essai randomisé évalue l'intérêt d'exercices physiques de résistance pendant la chimioradiothérapie pour réduire les effets indésirables des traitements ainsi que la fatigue liée à la maladie et améliorer la qualité de vie

Effects of resistance exercise on complications, cancer-related fatigue and quality of life in nasopharyngeal carcinoma patients undergoing chemoradiotherapy: A randomised controlled trial

Hu, Qinglei ; Zhao, Dongju

Background : Chemotherapy of nasopharyngeal carcinoma (NPC) can lead to significant side effects and complications. Exercises during chemoradiotherapy have potential to reduce complications and fatigue and improve quality of life. The aim of the randomised clinical study was to investigate the benefits of resistance exercise during chemoradiotherapy in NPC patients. Methods : A total of 146 patients were randomised to perform resistance or relaxation exercises during chemoradiotherapy. [...]

Menée aux Etats-Unis à partir de données portant sur 37 personnes transgenres atteintes d'un cancer, cette étude rétrospective analyse leurs caractéristiques cliniques, leurs expériences vis-à-vis des traitements reçus et la survie

Clinical Characteristics, Experiences, and Outcomes of Transgender Patients With Cancer

Burns, Zackory T. ; Bitterman, Danielle S. ; Perni, Subha ; Boyle, Patrick J. ; Guss, Carly E. ; Haas-Kogan, Daphne A. ; Liu, Kevin X.

Importance : More than 1 million people in the US identify as transgender; however, few studies have examined the experiences and outcomes of transgender patients with cancer. Objective : To examine clinical characteristics, experiences, and outcomes of transgender patients with cancer. Design, Setting, and Participants :This retrospective case series assessed transgender patients with at least 1 cancer diagnosis who were evaluated at Dana-Farber Cancer Institute or Brigham and Women’s Hospital [...]

Menée en Corée par enquête auprès de 19 019 participants dont 1 023 patients ayant survécu à un cancer, cette étude analyse la présence d'une obésité et/ou d'une sarcopénie et analyse l'association entre ces facteurs et le risque à 10 ans de développer une maladie cardiovasculaire

Sarcopenic obesity and 10-year cardiovascular disease risk scores in cancer survivors and non-cancer participants using a nationwide survey

Lee, Kayoung

Objective : To evaluate the associations of combinations of sarcopenia and adiposity phenotypes with 10‐year cardiovascular disease (CVD) risk scores in cancer survivors and non‐cancer participants. Methods : In 19,019 individuals including 1023 cancer survivors free of CVD who were aged ≥30 years from the Korea National Health and Nutrition Examination Survey, combination groups of sarcopenia, obesity and abdominal obesity based on handgrip strength, BMI and waist circumference, respectively, [...]

Menée aux Etats-Unis par enquête réalisée sur la période 2015-2018 auprès de 69 249 étudiants, cette étude analyse, en fonction de la zone de résidence (urbaine ou rurale), les facteurs d'exposition au tabagisme passif au domicile et en voiture

Secondhand Smoke Exposure at Home and/or in a Vehicle: Differences Between Urban and Non-Urban Adolescents in the United States, from 2015 to 2018

Mantey, Dale S ; Omega-Njemnobi, Onyinye ; Barroso, Cristina S

Secondhand smoke exposure during adolescence is linked to increased risk for cigarette smoking susceptibility and initiation. Non-urban youth may encounter a disproportionate number social and environmental risk factors for secondhand smoke exposure. Research is needed to explore geographic disparities in secondhand smoke exposure. Four years of National Youth Tobacco Survey (2015-2018) data were pooled. Participants were 69,249 middle and high school students. Multivariable logistic regression [...]

Menée au Brésil à partir de données portant sur 62 patients atteints d'un cancer traité par radiothérapie en 2008-2009, cette étude analyse l'effet d'un changement de poids pendant les traitements sur la survie à long terme (durée de suivi : 10 ans)

Weight loss, phase angle, and survival in cancer patients undergoing radiotherapy: a prospective study with 10-year follow-up

Paixão, Elemarcia M. S. ; Gonzalez, Maria Cristina ; Nakano, Eduardo Y. ; Ito, Marina K. ; Pizato, Nathalia

Background/Objectives : Cancer patients undergoing radiotherapy (RT) frequently experience weight loss and changes in body composition, which negatively affect their nutritional status, lead to a poor clinical prognosis, and reduce survival rates. This study aimed to evaluate whether changes in body weight, phase angle, and standardized phase angle are associated with longer survival in cancer patients undergoing RT. Methods : This prospective cohort study included 62 cancer patients who [...]

Menée aux Pays-Bas par questionnaire auprès de 98 patients atteints d'une tumeur solide (taux de réponse : 88 %), cette étude rétrospective analyse leurs opinions et leurs attitudes vis-à-vis de la vaccination contre la grippe, pour eux-mêmes et les membres de leur foyer

Cocoon vaccination for influenza in patients with a solid tumor: a retrospective study

Rensink, M. J. ; van Laarhoven, H. W. M. ; Holleman, F.

Purpose : Oncological patients are susceptible to various severe viral infections, including influenza. Vaccinating oncological patients and their household contacts (“cocoon vaccination”) may protect these patients from contracting influenza. To understand the potential of cocoon vaccination in oncological patients, this study assesses the influenza vaccination status of oncological patients and their household contacts and their considerations regarding the vaccination. Methods : In this [...]

Menée aux Etats-Unis, cette étude estime, pour l'année 2017, les années potentielles de vie perdues prématurément à cause du cancer

Premature Years of Life Lost Due to Cancer in the United States in 2017

Song, Minkyo ; Hildesheim, Allan ; Shiels, Meredith S.

Background: Burden of cancer mortality is often measured by death counts or mortality rates, but potential years of life lost (PYLL) and PYLL per death may be more useful to estimate the impact of cancer-related deaths occurring at younger ages. Methods: We used U.S. national death certificate data. A total of 45 categories of common cancers were grouped for cancer-specific calculations of PYLL and PYLL per death. PYLL was defined as the sum of the total years of life lost prior to age 75 [...]

Menée aux Etats-Unis sur la période 2008-2013 auprès de 175 489 patients atteints d'un cancer, cette étude analyse, en fonction du statut tabagique au diagnostic, l'effet du sevrage sur la mortalité liée à la maladie

Smoking cessation potential among newly diagnosed cancer patients: a population-based study of the ten most common cancers in Massachusetts, USA, 2008-2013

Stang, Andreas ; Knowlton, Richard ; Rekowski, Jan ; Gershman, Susan T. ; Galea, Sandro

Purpose: In cancer patients, cigarette smoking is causally linked with increased mortality. We examined the relationship between smoking status at the time of diagnosis and cancer mortality to help estimate the scope of smoking cessation services required to meet the needs of cancer patients. Methods: We studied the ten most common cancers in Massachusetts, 2008-2013 including 175,489 incident cases and used smoking status at the time of diagnosis to provide smoking prevalence. We calculated [...]

Menée aux Etats-Unis sur la période 2016-2018, cette étude analyse les disparités géographiques, selon les Etats, dans les taux de dépistage annuel du cancer de poumon par tomographie numérique thoracique à faible dose de rayonnements chez les personnes âgées, fumeuses ou anciennes fumeuses

State Variation in Low-Dose CT Scanning for Lung Cancer Screening in the United States

Fedewa, Stacey A ; Kazerooni, Ella A ; Studts, Jamie L ; Smith, Robert ; Bandi, Priti ; Sauer, Ann Goding ; Cotter, Megan ; Sineshaw, Helmneh M ; Jemal, Ahmedin ; Silvestri, Gerard A

Background : Annual lung cancer screening (LCS) with low dose chest computed tomography in older current and former smokers (ie,, eligible adults) has been recommended since 2013. Uptake has been slow and variable across the United States (US). We estimated the LCS rate and growth at the national and state level between 2016–2018. Methods : The American College of Radiology’s Lung Cancer Screening Registry (LCSR) was used to capture screening events. Population-based surveys, US Census, and [...]

Menée à partir des données de la cohorte "Women's Health Initiative" portant sur 12 076 patientes atteintes d'un cancer du sein après la ménopause, cette étude analyse l'association entre des troubles cardiométaboliques, la survie, la mortalité par maladie cardiovasculaire, par cancer et toutes causes confondues (durée médiane de suivi : 10 ans ; 3 607 décès dont 1 546 décès par cancer)

Cardiometabolic risk factors and survival after cancer in the Women's Health Initiative

Simon, Michael S. ; Hastert, Theresa A. ; Barac, Ana ; Banack, Hailey R. ; Caan, Bette J. ; Chlebowski, Rowan T. ; Foraker, Randi ; Hovsepyan, Gayane ; Liu, Simin ; Luo, Juhua ; Manson, JoAnn E. ; Neuhouser, Marian L. ; Okwuosa, Tochukwu M. ; Pan, Kathy ; Qi, Lihong ; Ruterbusch, Julie J. ; Shadyab, Aladdin H. ; Thomson, Cynthia A. ; Wactawski-Wende, Jean ; Waheed, Nida ; Beebe-Dimmer, Jennifer L.

Background : Cardiometabolic abnormalities are a leading cause of death among women, including women with cancer. Methods : This study examined the association between prediagnosis cardiovascular health and total and cause-specific mortality among 12,076 postmenopausal women who developed local- or regional-stage invasive cancer in the Women's Health Initiative (WHI). Cardiovascular risk factors included waist circumference, hypertension, high cholesterol, and type 2 diabetes. Obesity-related [...]

Menée en Suède à partir de données portant sur des enfants de patients ayant survécu à une tumeur du système nerveux central pendant l'enfance ou l'adolescence (âge lors du diagnostic : inférieur à 20 ans), cette étude analyse les facteurs associés au risque de maladie somatique pendant l'enfance (maladie maligne, infectieuse ou parasitaire)

Risk of somatic diseases in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden

Huang, Wuqing ; Sundquist, Kristina ; Sundquist, Jan ; Ji, Jianguang

With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared with population controls. Children of survivors with CNS tumor below age of 20 were identified between 1973 and 2014 by combining the several Swedish registers. Five children without parental CNS tumor were matched randomly to generate the [...]

Menée aux Etats-Unis à partir de données collectées auprès de 129 dyades constituées du patient ayant survécu à un cancer pédiatrique et de son aidant, cette étude transversale analyse l'association entre la santé psychique des aidants (symptômes de stress post-traumatique, symptômes dépressifs) et l'utilisation, par les patients, de substances psychoactives (alcool, tabac, cannabis)

A cross-sectional examination of caregiver mental health and childhood cancer survivors’ tobacco, alcohol, and marijuana use

Fischer, Caitlin M. ; Hamilton, Ann S. ; Slaughter, Rhona I. ; Milam, Joel

Purpose : As childhood cancer survivors (CCS) age, they face numerous long-term consequences, or late effects, from their cancer treatments. Late effects may be mitigated by health-promoting behaviors, including the avoidance of substance use. CCS with greater depression symptomology have reported greater substance use, but whether their habits are associated with the mental health of their caregivers is unknown. The aim of this study was to examine caregiver psychosocial correlates of CCS [...]

Menée aux Etats-Unis par questionnaire auprès de 273 patientes ayant survécu à un cancer gynécologique ou à un cancer du sein, cette étude analyse leur utilisation des médias sociaux et l'association entre cette utilisation, leur détresse psychologique et leur qualité de vie

Patterns of social media use and associations with psychosocial outcomes among breast and gynecologic cancer survivors

Tolby, Leah T. ; Hofmeister, Elisa N. ; Fisher, Sophie ; Chao, Sabrina ; Benedict, Catherine ; Kurian, Allison W. ; Berek, Jonathan S. ; Schapira, Lidia ; Palesh, Oxana G.

Purpose : We sought to characterize the use of social media (SM) among breast and gynecologic cancer survivors, as well as associations between patterns of SM use and psychosocial outcomes. Methods : Two hundred seventy-three breast and gynecologic cancer survivors recruited at the Stanford Women’s Cancer Center completed the study. Participants completed questionnaires to measure quality of life (FACT-G), functional social support (Duke-UNC FSSQ), distress (PHQ-4), decision regret (DRS), and [...]

Menée en Suède à partir de données portant sur 10 996 patients atteints d'un cancer de la prostate récemment diagnostiqué et sur 20 482 hommes subissant une biopsie de la prostate pour une suspicion de cancer, cette étude analyse la présence de troubles psychiatriques et de maladies cardiovasculaires pendant la période précédant le diagnostic ou la biopsie

Psychiatric disorders and cardiovascular diseases during the diagnostic workup of suspected prostate cancer

Shen, Qing ; Ma, Yuanjun ; Jöud, Anna ; Schelin, Maria E C ; Fall, Katja ; Andrén, Ove ; Fang, Fang

Background : It is unknown whether the rate of psychiatric disorders and cardiovascular disease is increased during the diagnostic workup of suspected prostate cancer. Methods : We designed a population-based cohort study including 579,992 men living during 2005–2014 in Skåne Sweden according to the Swedish Total Population Register and the Skåne Healthcare Register (SHR). We used the Swedish Cancer Register and the SHR to identify all men with a new diagnosis of prostate cancer (N = 10,996) [...]

Menée aux Etats-Unis à partir de données portant sur 1 029 patientes atteintes d'un cancer du sein diagnostiqué entre 2014 et 2016, cette étude analyse les disparités ethniques dans les facteurs associés à une détresse psychologique (facteurs émotionnels, familiaux, physiques, spirituels, etc.) et analyse l'impact de ces facteurs de stress sur l'accès aux soins

Patient-reported causes of distress predict disparities in time to evaluation and time to treatment after breast cancer diagnosis

Fayanju, Oluwadamilola M. ; Ren, Yi ; Stashko, Ilona ; Power, Steve ; Thornton, Madeline J. ; Marcom, P. Kelly ; Hyslop, Terry ; Hwang, E. Shelley

Background : We examined whether the National Comprehensive Cancer Network distress thermometer (DT), a patient‐reported outcome measure, could be used to identify levels and causes of distress associated with racial/ethnic disparities in time to care among patients with breast cancer. Methods : We identified women aged ≥18 years with stage 0‐IV breast cancer who were diagnosed in a single health system between January 2014 and July 2016. The baseline visit was defined as the first [...]

Menée aux Etats-Unis auprès de 390 femmes effectuant une mammographie de dépistage, cette étude analyse les facteurs, notamment le niveau d'éducation, associés à un sentiment de fatalisme vis-à-vis du cancer

The relationship between cancer fatalism and education

Keller, Kristin G. ; Toriola, Adetunji T. ; Schneider, Joanne Kraenzle

Purpose : Fatalism is defined by feelings of pessimism, hopelessness, and powerlessness regarding cancer outcomes. Early researchers reported associations between race and cancer fatalism. Yet current evidence suggests that social determinants of health are better predictors of cancer fatalism than race. Therefore, the aim of this study was to examine the association between age, race, education, and cancer fatalism. Methods : Three hundred ninety (n = 390) women who attended a screening [...]

Menée aux Etats-Unis, cette étude rétrospective analyse les coûts associés à l'autorisation par la FDA en 2018 d'anticancéreux (46 autorisations, 17 nouveaux anticancéreux, 29 nouvelles indications thérapeutiques) et estime le nombre de patients éligibles à ces traitements

Potential Cost Implications for All US Food and Drug Administration Oncology Drug Approvals in 2018

DeMartino, Patrick C. ; Miljković, Miloš D. ; Prasad, Vinay

Importance The growth of cancer drug spending in the US has outpaced spending in nearly all other sectors, and an increasing proportion of the drug development pipeline is devoted to oncology. In 2018, there was a record number of drugs entering the US market. Objective To estimate the number of patients with cancer who are eligible for the newly approved drug-indication pairs, and project potential spending and use of the approvals in the US. Design, Setting, Participants This is a [...]

Menée en Israël et dans 5 pays européens (Pays-Bas, Allemagne, Autriche, Belgique, Suisse), cette étude analyse les coûts restant à la charge des patients atteints d'un cancer (âge : supérieur à 50 ans) durant leur dernière année de vie

Out-of-pocket spending of deceased cancer patients in five European countries and Israel

Tur-Sinai, Aviad ; Urban, Damien ; Bentur, Netta

Objective : Cancer imposes a substantial economic burden on society, health and social care systems, patients and their families. This study aims to examine the out‐of‐pocket spending of cancer patients in their last year of life, in six countries with health insurance system hat have a defined benefits package. Methods : Data from SHARE and SHARE End‐of‐Life surveys among people aged +50 were analysed. Family members of deceased persons were interviewed in order to learn about the [...]

Menée par questionnaires auprès de 340 dyades constituées de la patiente ayant survécu à un cancer du sein et de son aidant, cette étude analyse l'association entre les compétences de l'aidant pour trouver de l’information médicale et la santé psychique de la patiente (dépression et anxiété)

Is the health literacy of informal caregivers associated with the psychological outcomes of breast cancer survivors?

Høeg, Beverley Lim ; Frederiksen, Marie Hoffmann ; Andersen, Elisabeth Anne Wreford ; Saltbæk, Lena ; Friberg, Anne Sofie ; Karlsen, Randi Valbjørn ; Johansen, Christoffer ; Dalton, Susanne Oksbjerg ; Horsbøl, Trine Allerslev ; Bidstrup, Pernille Envold

Purpose : To investigate whether health literacy (HL) among informal caregivers of breast cancer (BC) survivors is associated with patient psychological outcomes. Methods : We used data (n = 340 pairs) from baseline questionnaires administered in the MyHealth trial investigating nurse-led BC follow-up. All BC survivors and their invited caregivers were included immediately after completion of primary treatment. We performed multivariate regression analyses to examine the association between [...]

Menée aux Etats-Unis à partir de données portant sur 112 patients atteints d'un cancer du pancréas diagnostiqué précocement (âge médian : 46 ans), cette étude rétrospective analyse les facteurs associés à l'utilisation de soins palliatifs et décrit les caractéristiques des soins de fin de vie (hospitalisations, lieu du décès, durée entre la dernière chimiothérapie et le décès, etc.)

Early-onset pancreatic cancer: an institutional series evaluating end-of-life care

Kadakia, Kunal C. ; Trufan, Sally J. ; Jagosky, Megan H. ; Worrilow, William M. ; Harrison, Bradley W. ; Broyhill, Katherine L. ; Hwang, Jimmy J. ; Musselwhite, Laura W. ; Aktas, Aynur ; Walsh, Declan ; Salem, Mohamed E.

Purpose : Little is known about the use of palliative and hospice care and their impact on healthcare utilization near the end of life (EOL) in early-onset pancreatic cancer (EOPC). Methods : Patients with EOPC (≤ 50 years) were identified using the institutional tumor registry for years 2011–2018, and demographic, clinical, and rates of referral to palliative and hospice services were obtained retrospectively. Predictors of healthcare utilization, defined as use of ≥ 1 emergency department [...]

Menée en Espagne à partir de données portant sur 324 patients atteints d'un cancer de stade avancé (âge moyen : 69 ans), cette étude de cohorte prospective analyse la présence de dilemnes de nature éthique pendant la fin de vie (conflits d'informations, attentes irréalistes quant aux résultats des essais cliniques, demandes d'euthanasie ou de suicide médicalement assisté, etc.)

Prevalence of ethical dilemmas in advanced cancer patients (secondary analysis of the PALCOM study)

Tuca, Albert ; Viladot, Margarita ; Barrera, Carmen ; Chicote, Manoli ; Casablancas, Irene ; Cruz, Claudia ; Font, Elena ; Marco-Hernández, Javier ; Padrosa, Joan ; Pascual, Anais ; Codorniu, Núria ; Román, Begoña

Purpose : The main aim of this study was to determine the prevalence of ethical dilemmas in the end-of-life process in advanced cancer patients. Methods : We carried out a multicenter, cross-sectional, observational, prospective study in a cohort of cancer patients whose life expectancy was ≤ 6 months. We recorded sociodemographic characteristics, diagnosis of cancer, symptom burden, cognitive and functional status, emotional impact, and sociofamilial risk factors. The main outcome measure was [...]

Mené sur 240 patients atteints d'un cancer, cet essai randomisé évalue l'intérêt d'un outil d'aide à la décision pour améliorer la communication avec le médecin au sujet de l'utilisation de médecines complémentaires et alternatives pendant la chimiothérapie

Use of decision aid to improve informed decision-making and communication with physicians on the use of oral complementary and alternative medicine (CAM) among cancer patients on chemotherapy treatment: a randomised controlled trial

Chong, Wan-Qin ; Mogro, Maria Jannet ; Arsad, Asrie ; Tai, Bee-Choo ; Lee, Soo-Chin

Purpose : Complementary and alternative medicine (CAM) is often used by cancer patients and is concerning as concomitant oral CAM and chemotherapy use may result in adverse interactions and toxicities. We hypothesise that a decision aid (DA) may promote informed and rational use of oral CAM during chemotherapy, and increase patients’ discussion with their oncologists on CAM use. Methods : We randomised 240 patients initiating chemotherapy to receive DA or none. Questionnaires were administered [...]