Menée à partir des données d'une étude portant sur 31 805 femmes ménopausées, cette étude analyse l'association entre l'indice de masse corporelle, la pratique d'une activité physique de loisir d'intensité modérée à vigoureuse et le risque de cancer pouvant être lié à l'obésité (sein, endomètre et côlon)

Joint associations of physical activity and body mass index with the risk of established excess body fatness-related cancers among postmenopausal women

Maliniak, Maret L. ; Gapstur, Susan M. ; McCullough, Lauren E. ; Rees-Punia, Erika ; Gaudet, Mia M. ; Um, Caroline Y. ; Guinter, Mark A. ; Flanders, W. Dana ; Patel, Alpa V.

Purpose: Excess body fatness and physical activity independently influence the risk of several types of cancer. However, few studies have examined whether physical activity mitigates the excess risk associated with higher body mass index (BMI). Methods: We examined the individual and joint associations between BMI (kg/m2) and leisure-time moderate-to-vigorous physical activity (MVPA, MET-hours/week) with the risk of three established excess body fatness-related cancers (breast, colon, and [...]

Menée au Japon sur la période 2018-2020 auprès de 61 patients atteints d'un cancer de l'œsophage et 62 témoins (50% d'hommes), cette étude analyse l'association entre plusieurs types de bactéries infectieuses présentes dans la plaque dentaire ou la salive et le risque de développer la maladie

Oral infectious bacteria in dental plaque and saliva as risk factors in patients with esophageal cancer

Nakajima, Yasuaki ; Kawasaki, Machiko ; Ikeda, Yuichi ; Ikeda, Eri ; Takahashi, Momoko ; Tanaka, Daiki ; Arakawa, Shinichi ; Izumi, Yuichi ; Miyake, Satoshi

Background: High levels of periodontopathic bacteria as well as Streptococcus anginosus were detected in cancer tissue from patients with esophageal cancer. An association between oral infectious bacteria and esophageal cancer has been reported. Methods: Characteristics of the oral microbiota and periodontal conditions were studied as clinicopathologic factors in patients with esophageal cancer. The study included 61 patients with esophageal cancer and 62 matched individuals without any [...]

Menée aux Etats-Unis à l'aide de données portant sur 330 patients atteints d'un mélanome cutané et sur des témoins (âge médian : 51 ans ; 39% d'hommes), cette étude analyse l'association entre l'utilisation de cabines de bronzage et le risque de développer plusieurs mélanomes

Indoor tanning exposure in association with multiple primary melanoma

Karapetyan, Lilit ; Yang, Xi ; Wang, Hong ; Sander, Cindy A. ; Moyer, Ashley ; Wilson, Melissa ; Karunamurthy, Arivarasan ; Kirkwood, John M.

Background: Patients with primary cutaneous melanoma are at increased risk for subsequent new primary melanomas. Indoor tanning is a recognized risk factor for melanoma. This study was aimed at determining the association between indoor tanning and the occurrence of multiple primary melanoma. Methods: This was a retrospective case-control study of cases with multiple primary melanoma and sex-matched controls with single primary melanoma retrieved at a 1:2 ratio from the Biological Sample and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2020 (22 études, 9 630 435 patients), cette méta-analyse évalue, en fonction d'un diagnostic antérieur de cancer, l'incidence de la maladie d'Alzheimer chez les personnes âgées

Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis

Ospina-Romero, Monica ; Glymour, M. Maria ; Hayes-Larson, Eleanor ; Mayeda, Elizabeth Rose ; Graff, Rebecca E. ; Brenowitz, Willa D. ; Ackley, Sarah F. ; Witte, John S. ; Kobayashi, Lindsay C.

Observational studies consistently report inverse associations between cancer and Alzheimer disease (AD). Shared inverse etiological mechanisms might explain this phenomenon, but a systematic evaluation of methodological biases in existing studies is needed.To systematically review and meta-analyze evidence on the association between cancer and subsequent AD, systematically identify potential methodological biases in studies, and estimate the influence of these biases on the estimated pooled [...]

Menée en Inde à l'aide d'un questionnaire et de données d'imagerie portant sur 1 170 patients atteints d'un cancer de la vésicule biliaire et sur 2 525 témoins, et menée à partir de données génétiques d'une étude d'association sur le génome entier de 27 174 patients souffrant de calculs biliaires et 736 838 témoins supplémentaires, cette étude analyse l'association entre des antécédents de calculs biliaires et le risque de cancer de la vésicule biliaire

The role of gallstones in gallbladder cancer in India: a Mendelian randomization study

Mhatre, Sharayu ; Richmond, Rebecca C ; Chatterjee, Nilanjan ; Rajaraman, Preetha ; Wang, Zhaoming ; Zhang, Haoyu ; Badwe, Rajendra ; Goel, Mahesh ; Patkar, Shraddha ; Shrikhande, Shailesh V ; Patil, Prachi S ; Davey Smith, George ; Relton, Caroline L. ; Dikshit, Rajesh P

Background: Past history of gallstones is associated with increased risk of gallbladder cancer (GBC) in observational studies. We conducted complementary observational and Mendelian Randomization (MR) analyses to determine whether history of gallstones is causally related to development of GBC in an Indian population. Methods: To investigate associations between history of gallstones and GBC, we used questionnaire and imaging data from a GBC case-control study conducted at Tata Memorial [...]