Menée aux Etats-Unis à partir de données collectées grâce au système PROMIS et portant sur 572 patients adolescents et jeunes adultes ayant survécu à un cancer (âge : 15-39 ans), cette étude analyse les facteurs associés aux disparités dans la qualité de vie

Measuring health-related quality of life in adolescent and young adult (AYA) cancer survivors with the NIH PROMIS : Comparing adolescent, emerging adult, and young adult survivor perspectives

Siembida, Elizabeth J. ; Reeve, Bryce B. ; Zebrack, Brad J. ; Snyder, Mallory A. ; Salsman, John M.

Objective : Our knowledge of symptom burden and functioning among adolescent and young adult (AYA; diagnosed ages 15‐39) cancer survivors has been hindered by variability in health‐related quality of life (HRQOL) measurement associated with developmental and disease heterogeneity among AYAs. We aimed to examine the variability in domain‐specific aspects of HRQOL as a function of cancer type and developmental stage to clarify commonalities and differences using the NIH Patient‐Reported Outcome [...]

Mené sur 161 patients ayant survécu à un cancer de la prostate, cet essai randomisé évalue l'intérêt à long terme d'une intervention de réadaptation menée sur une période de 6 mois par des infirmiers et des physiothérapistes et destinée à réduire les effets indésirables liés à la radiothérapie (durée de suivi : 3 ans)

Long-term follow-up 3 years after a randomized rehabilitation study among radiated prostate cancer survivors

Dieperink, Karin B. ; Hansen, Steinbjørn ; Wagner, Lis ; Minet, Lisbeth R. ; Hansen, Olfred

Purpose : In the Rehabilitation of Prostate Cancer (RePCa) study, the intervention reduced early adverse effects in prostate cancer 6 months after radiotherapy. This 3-year follow-up study assesses late adverse effects, evaluates rehabilitative long-term effects and identifies patients who benefit the most. Design : RePCa was a randomized clinical trial with multidisciplinary rehabilitation (n = 79) or usual care (n = 82). The intervention during the first 6 months consisted of consultations by [...]

Menée aux Pays-Bas à partir de données portant sur 646 patients atteints d'un cancer colorectal, cette étude analyse l'association entre la composition corporelle (masse musculaire squelettique, tissu adipeux viscéral, tissu adipeux sous-cutané, etc.) et la fatigue durant les 2 années qui suivent le diagnostic

Body composition and its association with fatigue in the first 2 years after colorectal cancer diagnosis

van Baar, H. ; Bours, M. J. L. ; Beijer, S. ; van Zutphen, M. ; van Duijnhoven, F. J. B. ; Kok, D. E. ; Wesselink, E. ; de Wilt, J. H. W. ; Kampman, E. ; Winkels, R. M.

Purpose : Persistent fatigue among colorectal cancer (CRC) patients might be associated with unfavorable body composition, but data are sparse and inconsistent. We studied how skeletal muscle index (SMI), skeletal muscle radiodensity (SMR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) at diagnosis are associated with fatigue up to 24 months post-diagnosis in stage I–III CRC patients. Methods : SMI, SMR, VAT, and SAT were assessed among 646 CRC patients using [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2019 (11 études, 1 067 patients), cette méta-analyse évalue l'efficacité des interventions destinées à prendre en charge les différents aspects de la fatigue (aspect cognitif, physique) chez des patientes atteintes d'un cancer du sein

Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review

Vannorsdall, Tracy D. ; Straub, Ermiece ; Saba, Christina ; Blackwood, Mallory ; Zhang, Jingyi ; Stearns, Keren ; Smith, Karen Lisa

Purpose : This meta-analysis sought to determine whether exercise, psychological, or alternative forms of interventions differentially improve cognitive, physical, and general dimensions of cancer-related fatigue (CRF) in women with a history of breast cancer. Methods : Databases (PubMed, PsychINFO, EMBASE, and Cochrane Library) were systematically reviewed from inception through March 2019, with data extracted from randomized controlled trials of fatigue interventions using multidimensional [...]

Menée à une échelle internationale, cette étude quantifie la part des maladies non transmissibles, dont le cancer, attribuable à des facteurs infectieux et évalue, selon les zones géographiques, les années de vies perdues ajustées sur l'incapacité et induites par ces différentes maladies infectieuses

Burden of non-communicable diseases from infectious causes in 2017: a modelling study

Coates, Matthew M. ; Kintu, Alexander ; Gupta, Neil ; Wroe, Emily B. ; Adler, Alma J. ; Kwan, Gene F. ; Park, Paul H. ; Rajbhandari, Ruma ; Byrne, Anthony L. ; Casey, Daniel C. ; Bukhman, Gene

Background : Non-communicable diseases (NCDs) cause a large burden of disease globally. Some infectious diseases cause an increased risk of developing specific NCDs. Although the NCD burden from some infectious causes has been quantified, in this study, we aimed to more comprehensively quantify the global burden of NCDs from infectious causes. Methods : In this modelling study, we identified NCDs with established infectious risk factors and infectious diseases with long-term non-communicable [...]

Menée aux Etats-Unis à partir de données portant sur 80 275 patients atteints d'un cancer de stade IV, cette étude analyse les facteurs associés à une utilisation de traitements agressifs, notamment de traitements chirurgicaux, et évalue l'impact de ces traitements sur la mortalité en milieu hospitalier

Increased in-hospital mortality and emergent cases in patients with stage IV cancer

Majdinasab, Elleana J. ; Puckett, Yana ; Pei, Kevin Y.

Background : Cancer patients in the USA are still being treated with aggressive, life-prolonging interventions. Palliative care services remain vastly underutilized despite surges in both quality and quantity of programs. We evaluated surgical outcomes of metastatic cancer patients to question whether palliative care may be a better option. Study design : We queried the 2014 National Surgical Quality Improvement Program database (NSQIP) for patients with a diagnosis of malignancy (ICD 9 Codes [...]

Menée en Autriche à partir de données portant sur 672 patients atteints d'un cancer traité par inhibiteurs de points de contrôle immunitaire, cette étude rétrospective analyse les facteurs associés au risque de thromboembolie veineuse et artérielle ainsi que la mortalité associée

Incidence, risk factors and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy

Moik, Florian ; Chan, Wei-Shin Evelyn ; Wiedemann, Sarah ; Hoeller, Christoph ; Tuchmann, Felix ; Aretin, Marie-Bernadette ; Fuereder, Thorsten ; Zöchbauer-Müller, Sabine ; Preusser, Matthias ; Pabinger, Ingrid ; Ay, Cihan

The risk of venous and arterial thromboembolism (VTE/ATE) associated with immune checkpoint inhibitors is currently unclear, and clinical trials evaluating these agents in patients with cancer did not provide information. Our aim was to quantify risk of VTE/ATE in a cohort of patients treated with immune checkpoint inhibitors, explore clinical impact, and investigate potential clinical risk factors. Patients treated with an immune checkpoint inhibitor at the Medical University of Vienna from [...]

Menée à partir des données du registre belge des cancers portant sur 109 591 patients atteints d'un cancer diagnostiqué sur la période 2006-2013, cette étude de cohorte analyse les disparités socioéconomiques et démographiques dans la survie

Social inequalities in cancer survival in Belgium: A population-based cohort study

Rosskamp, Michael ; Verbeeck, Julie ; Sass, Victoria ; Gadeyne, Sylvie ; Verdoodt, Freija ; De Schutter, Harlinde

Background: Socioeconomic status is an important factor in cancer survival, however results are heterogeneous and linked to characteristics of the study population and health care system. This population-based cohort study evaluates the association between individual-level socioeconomic and -demographic factors and cancer survival for the first time in Belgium. Methods: From the Belgian Cancer Registry, we identified 109 591 patients diagnosed between 2006-2013 with one of eight common cancer [...]

Menée en Suède à partir de données portant sur 371 673 parents atteints d'un cancer diagnostiqué sur la période 1973-2014, cette étude analyse l'association entre le décès de leur enfant (mort naturelle, non naturelle, par cancer ou autre cause) et la mortalité

Death of a Child and Mortality after Cancer: a Nationwide Cohort Study in Sweden

Wang, Yujie ; Wei, Dang ; Chen, Hua ; Chen, Bao-An ; Li, Jiong ; László, Krisztina D

Background: The death of a child is a traumatic life event that may influence mortality in patients with cancer. Only a few studies investigated this association and their findings have been mixed. We analyzed whether the death of a child is associated with mortality in cancer patients. Methods: We conducted a cohort study of 371,673 parents who were diagnosed with cancer in Sweden during 1973-2014 by linking several population-based registers. We analyzed the association between the death of a [...]

Menée à partir des données 2010-2015 des registres américains des cancers portant sur 239 211 patientes atteintes d'un cancer du sein (âge médian : 60 ans), cette étude de cohorte analyse les disparités ethniques dans l'incidence de la maladie par sous-type moléculaire

Variation in Breast Cancer Subtype Incidence and Distribution by Race/Ethnicity in the United States From 2010 to 2015

Kong, Xiangyi ; Liu, Zhiqiang ; Cheng, Ran ; Sun, Li ; Huang, Shaolong ; Fang, Yi ; Wang, Jing

Importance : Breast cancer is the most commonly diagnosed cancer and the leading cause of death in women worldwide. Yet the racial/ethnic disparity in incidences and distributions of breast cancer remains largely unknown. Objective : To examine the racial/ethnic patterns associated with the incidence of the subtypes of breast cancer and distribution of patients across clinicopathological variables. Design, Setting, and Participants : This population-based cohort study analyzed data from the [...]

Menée aux Etats-Unis, cette étude analyse les modalités d'utilisation de tests prédictifs basés sur la méthylation du promoteur du gène MGMT pour les patients atteints d'un glioblastome récemment diagnostiqué, et souligne les disparités socioéconomiques dans l'accès à ces tests

Socioeconomic Disparities Associated With MGMT Promoter Methylation Testing for Patients With Glioblastoma

Lamba, Nayan ; Chukwueke, Ugonma N. ; Smith, Timothy R. ; Ligon, Keith L. ; Aizer, Ayal ; Reardon, David A. ; Iorgulescu, J. Bryan

Silencing of the DNA-repair MGMT gene via promoter methylation is presently the only clinically relevant predictive biomarker for patients with glioblastoma and, increasingly, a critical eligibility criterion for clinical trial participation. Consequently, National Comprehensive Cancer Network guidelines recommend testing all newly diagnosed glioblastomas. Promoter methylation status of MGMT is particularly important for clinical decision-making for patients who are elderly or frail, who are [...]

Menée à partir de données de 153 pays portant sur 4 351 patients atteints d'un rétinoblastome, cette étude de cohorte internationale analyse les facteurs associés à leurs déplacements au-delà des frontières de leur pays pour accéder aux traitements et soins anticancéreux

International travel to obtain medical treatment for primary retinoblastoma: a global cohort study

Bowman, RJC ; Foster, A ; Stacey, A ; Keren-Froim, N ; Bascaran, C ; Kivelä, T T ; Munier, F ; Fabian, ID

Early diagnosis and treatment of retinoblastoma (Rb), the most common intraocular malignancy, can save both the child’s life and vision. However, access to services and hence chances for survival and preserving the eye and its vision vary widely across the globe. Some families have to, or make a choice to, leave their home country to seek planned medical treatment abroad. We aimed to investigate how frequently this cross border travel occurs and the factors associated with it. A total of 278 Rb [...]

Menée au Royaume-Uni par entetiens auprès de 32 professionnels de santé, cette étude qualitative analyse leurs expériences concernant l'apport en soins psychologiques à des parents atteints d'un cancer, en fin de vie et ayant des enfants à charge (âge : inférieur à 18 ans)

Providing care to parents dying from cancer with dependent children: Health and social care professionals’ experience

Hanna, Jeffrey R. ; McCaughan, Eilis ; Beck, Esther R. ; Semple, Cherith J.

Objective : Parents often feel ill-equipped to prepare their dependent children (<18 years old) for the death of a parent, necessitating support from professionals. The aim of this study is to explore health and social care professionals’ (HSCPs) experiences and perceptions of providing supportive care to parents regarding their children, when a parent is dying from cancer. Methods : Semi-structured qualitative interviews were conducted with 32 HSCPs, including nurses, allied health [...]

Menée au Canada auprès de 502 enfants atteints d'un cancer (âge : 8-18 ans) et recevant une greffe de cellules souches hématopoïétiques, cette étude analyse les facteurs associés aux sentiments d'inquiétude ou de frayeur auto-déclarés

Feeling scared or worried self-report in children receiving cancer treatments using the Symptom Screening in Pediatrics Tool (SSPedi)

Hyslop, Shannon ; Tomlinson, Deborah ; Baggott, Christina ; Dix, David ; Gibson, Paul ; Johnston, Donna L. ; Orsey, Andrea D. ; Portwine, Carol ; Price, Vicky ; Vanan, Magimairajan ; Kuczynski, Susan ; Spiegler, Brenda ; Tomlinson, George A. ; Dupuis, L. Lee ; Sung, Lillian

Introduction : The objectives of this study were to describe reports of bother for feeling scared or worried among children with cancer and pediatric hematopoietic stem cell transplant (HSCT) recipients, and to identify factors associated with it. Methods : We included children receiving cancer treatments who were 8–18 years of age. Three patient types were enrolled: inpatients receiving active cancer treatment, outpatients receiving maintenance acute lymphoblastic leukemia chemotherapy, and [...]

Menée en Allemagne sur la période 2001-2014, cette étude analyse la présence de troubles psychiques chez des patients atteints d'un cancer récemment diagnostiqué et les facteurs associés à leur utilisation de services et de soins psychosociaux

Mental disorders and utilization of mental health services in newly diagnosed cancer patients: an analysis of German health insurance claims data

Salm, Sandra ; Blaschke, Katja ; Ihle, Peter ; Schubert, Ingrid ; Dresen, Antje ; Pfaff, Holger ; Scholten, Nadine

Objective : People with cancer are often confronted not only with the burdens of medical treatment but also with psychological strain, which can lead to mental disorders (MD). To date, the prevalence of MD in newly diagnosed cancer patients and their utilization of mental health services (MHS) are mainly estimated through data of primary studies than considering healthcare-related claims data. Methods : Statutory health insurance claims data of the AOK/KV Hesse from 2011 to 2014 was analyzed. [...]

Cette étude analyse les facteurs cognitifs et sociaux associés à la peur de la récidive chez des jeunes adultes ayant survécu à un cancer pédiatrique

Fear of Cancer Recurrence in Childhood Cancer Survivors: A Developmental Perspective from Infancy to Young Adulthood

Tutelman, Perri R. ; Heathcote, Lauren C.

Aims : Fear of cancer recurrence (FCR) is among the most prevalent and distressing concerns reported by cancer survivors. While younger age is the most consistent predictor of elevated FCR, research to date has focused almost exclusively on adult cancer survivors. This is despite the fact that children with cancer are more likely to survive compared to adults, and will become regular, lifelong users of the medical system to mitigate the effects of toxic treatment. The early experience of cancer [...]

Menée au Royaume-Uni à partir de données portant sur 356 patientes ayant survécu à un cancer du sein et sur 252 témoins, cette étude analyse leur santé psychique (troubles cognitifs, anxité, etc.) et leur qualité de vie (troubles sexuels, fatigue, douleur, évitement social, etc.)

Quality of life and mental health in breast cancer survivors compared with non-cancer controls: a study of patient-reported outcomes in the United Kingdom

Carreira, Helena ; Williams, Rachael ; Dempsey, Harley ; Stanway, Susannah ; Smeeth, Liam ; Bhaskaran, Krishnan

Purpose : There is limited high-quality evidence on quality of life, anxiety, and depressive symptoms in breast cancer survivors and women with no history of cancer. We aimed to address this by comparing patient-reported outcomes between breast cancer survivors and women with no history of breast cancer. Methods : Breast cancer survivors and women with no prior cancer were selected from the UK Clinical Practice Research Datalink GOLD primary care database, which includes population-based [...]

Menée à Taïwan par entretiens auprès de 20 enfants ayant survécu à une tumeur cérébrale (âge : 8-15 ans), cette étude qualitative analyse leurs expériences et leur bien-être psychologique en lien avec leur participation à un programme de formation musicale

Pediatric brain tumor survivors’ lived experience of engaging in a musical training program which promoted their psychological well-being: a qualitative study

Cheung, Ankie Tan ; Li, William Ho Cheung ; Ho, Laurie Long Kwan ; Xia, Wei ; Chan, Godfrey Chi Fung ; Chung, Joyce Oi Kwan

Purpose :Musical training has been found to promote psychological well-being and quality of life among pediatric brain tumor survivors. Yet, the essential elements of musical training that influence its efficacy remain unknown. This study aimed to examine the lived experience of engaging in the musical training program from the perspectives of pediatric brain tumor survivors, their parents, and interveners. Methods : We employed a descriptive phenomenological approach. Twenty pediatric brain [...]

Menée aux Etats-Unis par entretiens téléphoniques auprès de 1 425 participants, cette étude analyse les disparités socioéconomiques dans leurs représentations négatives du cancer

Negative Cancer Beliefs: Socioeconomic Differences from the Awareness and Beliefs about Cancer Survey

Sarma, Elizabeth A. ; Quaife, Samantha L. ; Rendle, Katharine A. ; Kobrin, Sarah C.

Objective : Socioeconomic gaps in cancer mortality may be driven partially by poorer uptake of early detection behaviors among lower socioeconomic status (SES) groups. Lower SES groups may hold both fewer positive and more negative cancer beliefs that discourage these behaviors. We examined SES differences in positive and negative cancer beliefs in US adults. Methods : We conducted telephone interviews with a population‐representative sample, aged 50+, using the Awareness and Beliefs about [...]

Mené aux Etats-Unis sur 26 patients atteints d'une tumeur hématologique de stade avancé, cet essai pilote évalue l'interêt et la faisabilité d'une intervention de soins palliatifs dispensée par des infirmiers

Primary Palliative Care for Patients with Advanced Hematologic Malignancies: A Pilot Trial of the SHARE Intervention

Judith M. Resick, Caroline Sefcik, Robert M. Arnold, Thomas W. LeBlanc, Marie Bakitas, Margaret Quinn Rosenzweig, Thomas J. Smith (et al.)

Objective: Develop and pilot-test a nurse-led primary palliative care intervention for patients with advanced hematologic malignancies. Background: Nurse-led primary palliative care interventions may improve outpatient palliative care provision for patients with advanced hematologic malignancies. Methods: This two-phase, single-arm pilot study involved patients with recurrent or resistant hematologic malignancies, their caregivers, and oncology clinicians at two US-based urban, [...]

Menée en Australie, cette étude identifie les facteurs organisationnels permettant d'implémenter, dans les services d'oncologie et les soins de routine, des interventions de nature psychologique destinées à détecter et prendre en charge les symptomes de dépression et d'anxiété chez les patients atteints d'un cancer

What factors influence organisational readiness for change? Implementation of the Australian clinical pathway for the screening, assessment and management of anxiety and depression in adult cancer patients (ADAPT CP)

Geerligs, L. ; Shepherd, H. L. ; Butow, P. ; Shaw, J. ; Masya, L. ; Cuddy, J. ; Andrews, Gavin ; Baychek, Kate ; Beale, Philip ; Allison, Karen ; Clayton, Josephine ; Coll, Joseph ; Cuddy, Jessica ; Girgis, Afaf ; Grimison, Peter ; Hack, Tom ; Kelly, Brian ; Kirsten, Laura ; Lindsay, Toni ; Lovell, Melanie ; Luckett, Tim ; Murphy, Michael ; Newby, Jill ; Orr, Frances ; Pearce, Alison ; Piro, Don ; Shaw, Tim ; Stubbs, John ; Viney, Rosalie ; White, Fiona ; Yim, Jackie ; Rankin, N. M. ; The, Adapt Program Group

Aims : Translation of evidence-based psycho-oncology interventions into routine care can significantly improve patient outcomes, yet effective implementation remains challenging due to numerous real-world barriers. A key factor that may influence implementation is organisational readiness for change. This mixed method study sought to identify factors associated with organisational readiness for implementing the Australian clinical pathway for the screening, assessment and management of anxiety [...]