Menée aux Etats-Unis sur la période 1985-2014 auprès de plus de 920 000 participants inclus dans l'étude "Cancer Prevention Study II", cette étude analyse, en fonction du statut tabagique, l'association entre l'indice de masse corporelle et la mortalité par cancer du pancréas (7 904 décès)

A Large Cohort Study of Body Mass Index and Pancreatic Cancer by Smoking Status

Jacobs, Eric J. ; Newton, Christina C. ; Stevens, Victoria L. ; Patel, Alpa V. ; Flanders, W. Dana ; Gapstur, Susan M.

Background: Some evidence suggests the association between body mass index (BMI) and pancreatic cancer risk is weaker among current smokers than among never smokers. Methods: We examined the association between BMI and pancreatic cancer mortality among adults who reported smoking status at enrollment into Cancer Prevention Study-II in 1982, including 420,543 never smokers, 282,244 former cigarette smokers, and 219,885 current cigarette smokers. After excluding the first 3 years of follow-up to [...]

Menée en Corée auprès de 202 675 adultes ayant été suivis par endoscopies (durée moyenne de suivi : 4,7 ans), cette étude analyse l'association entre la consommation d'alcool (fréquence et quantité) et le risque de lésions gastriques précancéreuses (69 389 cas)

Low Levels of Alcohol Consumption and Risk of Intestinal Metaplasia: A Cohort Study

Kim, Kyungeun ; Chang, Yoosoo ; Ahn, Jiin ; Yang, Hyo-Joon ; Ryu, Seungho

Background: The impact of alcohol drinking on gastric precancerous lesions remains unclear. We investigated the relationship of alcohol intake with risk of atrophic gastritis (AG) and intestinal metaplasia (IM). Methods: This study included 202,675 Korean adults free from AG and IM on their initial endoscopy who were followed with repeated endoscopic examinations. A parametric proportional hazards model was used to estimate the adjusted HR (aHR) with 95% confidence interval (CI) for incident AG [...]

Menée à l'aide de données d'entretiens réalisés entre 1975 et 1980 auprès de 176 patients atteints d'un mésothéliome et 404 témoins, cette étude analyse l'association entre une exposition professionnelle à différents types ou différentes longueurs de fibres d'amiante (chrysotile, amphibole) et le risque de développer la maladie

Mesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case–control study in the USA, 1975–1980

Wong, Jason Y Y ; Rice, Carol ; Blair, Aaron ; Silverman, Debra T

Objectives: Occupational asbestos exposure is causally linked to mesothelioma. However, whether exposure to only chrysotile asbestos is associated with mesothelioma risk, and the heterogeneity in risk by different fibre types/lengths remains unclear. We investigated whether mesothelioma risk differs among workers exposed to only chrysotile asbestos compared with chrysotile and ≥1 amphibole (ie, amosite, tremolite, anthophyllite and crocidolite) over the working lifetime. Methods: We analysed [...]

Menée à partir des données du registre danois des cancers portant sur 38 375 patientes atteintes d'un cancer du sein (âge : moins de 70 ans), cette étude analyse l'association entre une exposition professionnelle à 4 solvants organiques (méthylchloroforme, trichloréthylène, benzène et toluène) et le risque de développer la maladie

Occupational exposure to specific organic solvents and risk of subtypes of breast cancer in a large population of Danish women, 1964–2016

Pedersen, Julie Elbaek ; Strandberg-Larsen, Katrine ; Andersson, Michael ; Hansen, Johnni

Objective: To explore associations between occupational exposure to four specific organic solvents, respectively, and female breast cancer, including subtypes. Methods: Using the Danish Cancer Registry, we identified 38 375 women under age 70 years with primary breast cancer. Five randomly selected breast-cancer-free controls per case matched on year of birth were retrieved from the Danish Civil Registration System . A nationwide pension fund was used to retrieve full employment history, and [...]

Menée à partir de données des registres nationaux des cancers portant sur 85 132 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre la dose de rayonnements ionisants absorbée par le sein et l'incidence de la maladie dans les régions les plus contaminées par l'accident de Chernobyl en Biélorussie et en Ukraine

Breast cancer incidence in the regions of Belarus and Ukraine most contaminated by the Chernobyl accident: 1978-2016

Zupunski, L. ; Yaumenenka, A. ; Ryzhov, A. ; Veyalkin, I. ; Drozdovitch, V. ; Masiuk, S. ; Ivanova, O. ; Kesminiene, A. ; Pukkala, E. ; Moiseev, P. ; Prysyazhnyuk, A. ; Schuz, J. ; Ostroumova, E.

Even 30 years after the accident, an association between breast cancer incidence and ionizing radiation exposure from Chernobyl fallout remains uncertain. We studied breast cancer incidence in the most contaminated regions of Belarus (Gomel and Mogilev) and Ukraine (Kyiv, Zhytomyr and Chernihiv) before (1978-1986) and after (1987-2016) the accident. Breast cancer cases and female population size data were received from the national cancer registries and the state departments of statistics. The [...]

Menée en Norvège à partir de données des registres des cancers portant sur 359 témoins et sur 181 patients atteints d'un cancer gastrique et menée à l'aide d'échantillons de sang prélevés sur 78 962 personnes, cette étude analyse l'association entre une hypergastrinémie et le risque de développer la maladie, par type histologique

Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: a prospective population-based nested case-control study

Ness-Jensen, Eivind ; Bringeland, Erling Audun ; Mattsson, Fredrik ; Mjønes, Patricia ; Lagergren, Jesper ; Grønbech, Jon Erik ; Waldum, Helge Lyder ; Fossmark, Reidar

The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of this study was therefore to assess if hypergastrinemia was associated with an increased risk of developing gastric adenocarcinoma also in humans. A prospective population-based nested case-control study within the Nord-Trøndelag Health Study (HUNT) cohort, Norway, was used to assess this association. Serum [...]

Menée au Japon auprès de 77 855 personnes ne souffrant pas d'une maladie du foie (durée médiane de suivi : 1 751 jours), cette étude analyse l'association entre les niveaux sériques de bilirubine et la cancérogenèse (5 110 cas)

Negative correlation of high serum bilirubin with cancer development in adults without hepatobiliary disease

Yamamoto, Kazuki ; Ikeya, Takashi ; Okuyama, Shuhei ; Okamoto, Takeshi ; Fukuda, Katsuyuki ; Kobayashi, Daiki

Background and aims: This study aimed to evaluate whether serum bilirubin levels were associated with cancer development in a population without liver disease. Methods: A retrospective longitudinal study was performed by including participants who underwent a health checkup at St. Luke’s International Hospital in Tokyo from 2005 to 2019. We excluded those with liver diseases or prior history of cancer at baseline. All participants were classified into four groups according to their total [...]

Menée à partir de données de la cohorte européenne EPIC portant sur 1 985 patients atteints d'un cancer colorectal et sur 2 220 témoins, cette étude analyse l'association entre la concentration sérique de la forme soluble des récepteurs spécifiques des produits finaux de glycation avancée, leurs polymorphismes à simple nucléotide et le risque de développer la maladie, en fonction du sexe

Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a case-control study nested within a European prospective cohort

Aglago, Elom Kouassivi ; Rinaldi, Sabina ; Freisling, Heinz ; Jiao, Li ; Hughes, David J ; Fedirko, Veronika ; Schalkwijk, Casper G. ; Weiderpass, Elisabete ; Dahm, Christina C. ; Overvad, Kim ; Eriksen, Anne Kirstine ; Kyrø, Cecilie ; Boutron-Ruault, Marie-Christine ; Rothwell, Joseph A ; Severi, Gianluca ; Katzke, Verena ; Kühn, Tilman ; Schulze, Matthias B. ; Aleksandrova, Krasimira ; Masala, Giovanna ; Krogh, Vittorio ; Panico, Salvatore ; Tumino, Rosario ; Naccarati, Alessio ; Bueno-de-Mesquita, Bas ; van Gils, Carla H. ; Sandanger, Torkjel M ; Gram, Inger T. ; Skeie, Guri ; Quirós, J. Ramón ; Jakszyn, Paula ; Sánchez, María-José ; Amiano, Pilar ; Huerta, José María ; Ardanaz, Eva ; Johansson, Ingegerd ; Harlid, Sophia ; Perez-Cornago, Aurora ; Mayén, Ana-Lucia ; Cordova, Reynalda ; Gunter, Marc J. ; Vineis, Paolo ; Cross, Amanda J ; Riboli, Elio ; Jenab, Mazda

Background: Overexpression of the Receptor for Advanced Glycation End-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer (CRC) risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. Methods: To investigate whether sRAGE and related genetic variants are associated with CRC risk, we conducted a nested case-control study in the European Prospective [...]