Concepts of extracellular matrix remodelling in tumour progression and metastasis

Cet article analyse les mécanismes par lesquels les tumeurs et les cellules stromales associées modifient la matrice extracellulaire et favorisent la croissance tumorale ainsi que la migration des cellules cancéreuses

Résumé en anglais

Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.