Mené sur 173 patients atteints d'un cancer, cet essai randomisé évalue l'intérêt d'une intervention à base de yoga dispensée pendant 8 semaines pour réduire la fatigue et les symptômes de dépression liés à la maladie

Yoga effectively reduces fatigue and symptoms of depression in patients with different types of cancer

Zetzl, Teresa ; Renner, Agnes ; Pittig, Andre ; Jentschke, Elisabeth ; Roch, Carmen ; van Oorschot, Birgitt

Purpose : Examine the effects of an 8-week yoga therapy on fatigue in patients with different types of cancer. Methods : A total of 173 cancer patients suffering from mild to severe fatigue were randomly allocated to yoga intervention (n = 84) (IG) versus waitlist control group (CG) (n = 88). Yoga therapy consisted of eight weekly sessions with 60 min each. The primary outcome was self-reported fatigue symptoms. Secondary outcomes were symptoms of depression and quality of life (QoL). Data were [...]

A partir d'une revue systématique de la littérature (6 articles), cette étude analyse les expériences des patients atteints d'un cancer du pancréas et leur qualité de vie pendant un traitement néoadjuvant

Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol

Cloyd, Jordan M. ; Hyman, Sarah ; Huwig, Tanya ; Monsour, Christina ; Santry, Heena ; Wills, Celia ; Tsung, Allan ; Bridges, John F. P.

Purpose : Neoadjuvant therapy (NT) is increasingly being offered to patients with pancreatic ductal adenocarcinoma (PDAC) prior to surgical resection. However, the experience and quality of life (QOL) of patients undergoing NT are poorly understood. Methods : A systematic review of the Cinahl, Embase, Medline, Pubmed, Scopus, and Web of Science databases was conducted to evaluate the available literature pertaining to the experience and QOL of patient’s undergoing NT for PDAC. Results : Among [...]

Mené sur 40 patientes ayant survécu à un cancer du sein, cet essai randomisé à 3 bras évalue l’intérêt d’une intervention à base d’exercices physiques en aérobie et de relaxation pour soulager leur fatigue

Acute Effects of Aerobic Exercise and Relaxation Training on Fatigue in Breast Cancer Survivors: A Feasibility Trial

Jason Cohen, Wendy A. Rogers, Steven Petruzzello (et al.)

Objective : This three?armed randomized controlled feasibility trial tested the acceptability and acute effects of aerobic exercise and technology?guided mindfulness training (relative to standalone interventions) on cancer?related fatigue among breast cancer survivors (BCS). Methods : BCS recruited from Central Illinois completed pre?and post?testing using established measures and were randomized to one of three groups (combined aerobic exercise with guided?mindfulness relaxation, aerobic [...]

Menée en Norvège par enquête auprès 2 104 patients ayant survécu plus de 5 ans à un cancer pédiatrique diagnostiqué entre 1985 et 2009 (âge moyen lors de l’enquête : 43 ans ; durée moyenne depuis de diagnostic : 17 ans), cette étude analyse les facteurs associés à la survenue d’effets indésirables tardifs liés aux traitements anticancéreux et le recours aux soins

Self-reported late effects and long-term follow-up care among 1889 long-term Norwegian Childhood, Adolescent, and Young Adult Cancer Survivors (the NOR-CAYACS study)

A. V. Mellblom, C. E. Kiserud, C. S. Rueegg, E. Ruud (et al.)

Purpose : The majority of childhood, adolescent, and young adult cancer survivors (CAYACS) are at risk of late effects but may not receive long-term follow-up care for these. Here, we investigated (1) self-reported late effects, (2) long-term follow-up care, and (3) factors associated with receiving follow-up care in a population-based sample of Norwegian long-term CAYACS. Methods : Survivors were identified by the Cancer Registry of Norway. All > 5-year survivors diagnosed between 1985 and [...]

Menée en Australie à partir de données portant sur 43 enfants âgés de moins de 9 ans et ayant survécu à un cancer diagnostiqué entre 2000 et 2015, cette étude analyse l’effet de la maladie sur leur développement physique et psychosocial

The Impact of Cancer on Early Childhood Development: A Linked Data Study

Julia N Morris, David Roder, Deborah Turnbull (et al.)

Objective : This study used retrospective linked population data to investigate the impact of early childhood cancer on developmental outcomes. Methods : Children aged <9?years with a recorded malignant neoplasm were identified in the South Australian Cancer Registry. They were then linked to developmental data recorded in the Australian Early Development Census (AEDC) for the 2009, 2012, and 2015 data collection periods; and assigned five matched controls from the same AEDC year. Results : [...]

Menée en Suède à partir de données portant sur 617 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre une vaccination contre le choléra après le diagnostic et la survie

Association of post-diagnostic use of cholera vaccine with survival outcome in breast cancer patients

Zheng, Guoqiao ; Sundquist, Jan ; Sundquist, Kristina ; Ji, Jianguang

Background : Expensive cancer treatment calls for alternative ways such as drug repurposing to develop effective drugs. The aim of this study was to analyse the effect of post-diagnostic use of cholera vaccine on survival outcome in breast cancer patients. Methods : Cancer diagnosis and cholera vaccination were obtained by linkage of several Swedish national registries. One vaccinated patient was matched with maximum two unvaccinated individuals based on demographic, clinical and socioeconomic [...]

Menée au Canada à partir de données portant sur 425 patientes ayant survécu à un cancer de l'endomètre diagnostiqué entre 2002 et 2006, cette étude de cohorte prospective analyse l'association entre la pratique d'une activité physique, avant et après le diagnostic, la survie sans maladie et la survie globale (durée médiane de suivi : 14,5 mois)

Prospective Cohort Study of Pre- and Postdiagnosis Physical Activity and Endometrial Cancer Survival

Christine M. Friedenreich ; Linda S. Cook ; Qinggang Wang ; Renée L. Kokts-Porietis ; Jessica McNeil ; Charlotte Ryder-Burbidge ; Kerry S. Courneya

PURPOSE : The aim of this study was to evaluate associations between pre- and postdiagnosis physical activity and survival in survivors of endometrial cancer by physical activity domain, intensity, dose (metabolic-equivalent task [MET]-hours/week/year), and change from pre- to postdiagnosis. METHODS : We conducted a prospective cohort study in Alberta, Canada, of 425 women who were diagnosed with histologically confirmed invasive endometrial cancer between 2002 and 2006 and observed to 2019. [...]

Menée à partir des données des registres américains des cancers sur la période 1975-2006 portant sur 102 567 patients atteints d'un carcinome hépatocellulaire, cette étude analyse les taux de suicide et les facteurs associés (70 décès par suicide)

Risk factors associated with suicide among hepatocellular carcinoma patients: A surveillance, epidemiology, and end results analysis

Chen, Chongfa ; Jiang, Yi ; Yang, Fang ; Cai, Qiucheng ; Liu, Jianyong ; Wu, Yushen ; Lin, Huapeng

Background : Throughout the world, hepatocellular carcinoma (HCC) remains the primary type of liver cancer. The suicide risk was higher among patients with HCC than the general population. Hence, the purpose of this study was to confirm the suicide rates, standardized mortality ratios (SMRs), and the potential risk factors associated with suicide among HCC patients. Methods : HCC patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database during 1975–2016. [...]

Menée au Canada à partir de données portant sur 27 295 patients décédés d’un cancer, cette étude de cohorte observationnelle analyse l’évolution de leurs symptômes psychosociaux et leurs besoins en soins à domicile pendant les 6 derniers mois de vie

Trajectory of psychosocial symptoms among home care patients with cancer at end-of-life

Hsien Seow, Tara Stevens, Lisa C. Barbera MD (et al.)

Purpose : Understanding the end?of?life psychosocial needs of cancer patients at home is a knowledge gap. This study describes the trajectory of psychosocial symptoms in the last six months of life among cancer decedents who were receiving home care. Methods : Observational population?based cohort study of cancer decedents who were receiving home care services between 2007 and 2014. Decedents had to have at least 1 home care assessment in the last six months of life for inclusion. Outcomes were [...]

Menée aux Etats-Unis à partir de données portant sur 233 enfants atteints d’une leucémie lymphoïde aiguë et inclus dans un essai de phase III, cette étude analyse les facteurs associés au risque de développer des troubles neurocognitifs

Longitudinal Trajectories of Neurocognitive Functioning in Childhood Acute Lymphoblastic Leukemia

Marita Partanen, PhD, Sean Phipps, PhD, Kathryn Russell (et al.)

Objective : Children with acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits, and examining individual variability is essential to understand these risks. This study evaluated latent longitudinal trajectories and risk factors of neurocognitive outcomes in childhood ALL. Methods : There were 233 participants with ALL who were enrolled on a phase 3, risk-stratified chemotherapy-only clinical trial (NCT00137111) and who completed protocol-directed neurocognitive assessments [...]

Menée aux Etats-Unis par enquête auprès de 505 patientes âgées de moins de 45 ans et de 622 patientes âgées de 55 à 70 ans toutes ayant survécu entre 3 et 8 ans à un cancer du sein, cette étude transversale analyse l'association entre la peur de la récidive et l'utilisation des soins de santé

The Impact of Fear of Cancer Recurrence on Healthcare Utilization Among Long-Term Breast Cancer Survivors Recruited Through ECOG-ACRIN Trials

Vachon, Eric ; Krueger, Ellen ; Champion, Victoria L. ; Haggstrom, David A. ; Cella, David ; Cohee, Andrea A.

Objective : To examine the relationship between fear of cancer recurrence (FCR) and healthcare utilization among long-term breast cancer survivors (BCS). Methods : In a cross-sectional survey study, 505 younger survivors (YS: ≤45 years) and 622 older survivors (OS: 55-70 years) 3-8 years from diagnosis completed a questionnaire assessing demographics, medical history, FCR, and healthcare utilization. Healthcare utilization consisted of breast cancer (BC) and non-BC-related routine and [...]

Menée aux Pays-Bas auprès de 141 patients atteints d'un cancer de la cavité buccale, cette étude de cohorte prospective identifie les facteurs associés au risque de dépression après les traitements anticancéreux (durée de suivi : 5 ans)

Depression and related factors after oral oncological treatment: a 5-year prospective cohort study

Speksnijder, Caroline M. ; Lankhorst, Petra J. M. ; de Bree, Remco ; de Haan, Anton F. J. ; Koole, Ron ; Merkx, Matthias A. W.

Purposes : Being diagnosed with oral cancer is a life-threatening life event. It often induces social, emotional and psychological consequences and may cause depressive disorders. The primary aim of this study was to identify and quantify the personal and clinical characteristics involved in depression for patients who have been treated for oral cavity malignancies, with a 5-year follow-up period after treatment. The secondary aim of this study was to identify the clinical factors that increase [...]

Menée aux Etats-Unis, cette étude analyse l'impact, sur les prescriptions de médicaments anticancéreux et sur les dépenses de santé, d'un programme national de paiement à la performance

Association Between a National Insurer’s Pay-for-Performance Program for Oncology and Changes in Prescribing of Evidence-Based Cancer Drugs and Spending

Justin E. Bekelman ; Atul Gupta ; Ezra Fishman ; David Debono ; Michael J. Fisch ; Ying Liu ; Gosia Sylwestrzak ; John Barron ; Amol S. Navathe

PURPOSE : Cancer drug prescribing by medical oncologists accounts for the greatest variation in practice and the largest portion of spending on cancer care. We evaluated the association between a national commercial insurer’s ongoing pay-for-performance (P4P) program for oncology and changes in the prescribing of evidence-based cancer drugs and spending. METHODS : We conducted an observational difference-in-differences study using administrative claims data covering 6.7% of US adults. We [...]

Cette étude analyse l'évolution, depuis 2006, de l'utilisation des inhibiteurs de tyrosine kinase et les coûts associés, chez les patients atteints d'une leucémie myéloïde chronique

Association of Generic Imatinib Availability and Pricing With Trends in Tyrosine Kinase Inhibitor Use in Patients With Chronic Myelogenous Leukemia

Lyman, Gary H. ; Henk, Henry J.

The increasing price of new cancer therapies over the past 3 decades has contributed considerably to increasing health care expenditures. The life expectancy of patients with chronic myelogenous leukemia (CML) treated with imatinib now approaches that of the general population, increasing the prevalence of survivors with CML receiving treatment.1 Beginning in 2006, a series of second- and third-generation tyrosine kinase inhibitors (TKIs) have been approved and gained widespread use based on [...]

Menée aux Pays-Bas auprès de 58 professionnels de santé, cette étude analyse l'intérêt d'un guide rédigé en langage simple leur permettant de discuter des tests génétiques de prédisposition au cancer du sein avec leurs patientes présentant des capacités limitées pour comprendre l'information médicale

Development of a plain-language guide for discussing breast cancer genetic counseling and testing with patients with limited health literacy

van der Giessen, J. A. M. ; Ausems, M. G. E. M. ; van Riel, E. ; de Jong, A. ; Fransen, M. P. ; van Dulmen, S.

Purpose : Due to limited health literacy and resulting ineffective communication between healthcare professionals and patients, not all eligible patients are offered breast cancer genetic counseling and testing. We aimed to develop a plain-language guide to increase effective communication about genetic counseling and testing with breast cancer patients with limited health literacy. Methods : Together with oncological healthcare professionals, we drafted a list of jargon words frequently used [...]

Menée en Corée à partir de données portant sur 71 patients atteints d’un cancer de stade avancé (âge médian : 65 ans), cette étude analyse le niveau de sévérité de leurs symptômes auto-déclarés et l’association avec leurs besoins en soins palliatifs

Pre-screening of patient-reported symptoms using the Edmonton Symptom Assessment System in outpatient palliative cancer care

Garden Lee, Han Sang Kim, Si Won Lee, Yu Rang Park (et al.)

Objectives : Although early palliative care is associated with a better quality of life and improved outcomes in end?of?life cancer care, the criteria of palliative care referral are still elusive. Methods : We collected patient?reported symptoms using the Edmonton Symptom Assessment System (ESAS) at the baseline, first and second follow?up visits. A total of 71 patients were evaluable, with a median age of 65 years, male (62%) and Eastern Cooperative Oncology Group (ECOG) performance status [...]

A partir de l'analyse de 4 317 citations concernant l'association entre l'exposition aux gaz d'échappement des moteurs diesel et le risque de cancer du poumon (96 publications), cette étude explore la relation entre la source de financement de l'étude et sa conclusion

Determinants of citation in the literature on diesel exhaust exposure and lung cancer: a citation analysis

Duyx, Bram ; Urlings, Miriam J E ; Swaen, Gerard M H ; Bouter, Lex M ; Zeegers, Maurice P

Objectives: Epidemiological research on the association between diesel exhaust exposure and lung cancer risk has some methodological challenges that give rise to different conclusions and intense debates. This raises the question about the role of selective citation and of citation bias in particular. Our aim was to investigate the occurrence and prevalence of selective citation in this field. Design: Citation analysis. Setting: Web of Science Core Collection. Participants: We identified 96 [...]