Menée aux Pays-Bas à partir de données de registres et à l'aide des données d'une cohorte de 120 852 participants âgés de 55 à 69 ans (durée de suivi : 20,3 ans), cette étude analyse l'association entre la consommation d'alcool, le tabagisme et le risque de métastases d'origine inconnue

Alcohol consumption, cigarette smoking and Cancer of Unknown Primary (CUP) risk: results from the Netherlands Cohort Study

Hermans, Karlijn E.P.E. ; van den Brandt, Piet A. ; Loef, Caroline ; Jansen, Rob L. H. ; Schouten, Leo J.

Cancer of Unknown Primary (CUP) is a metastasised malignancy with no identifiable primary tumour origin. Despite the frequent occurrence and bleak prognosis of CUP, research into its aetiology is scarce. This study investigates alcohol consumption, tobacco smoking and CUP risk. We used data from the Netherlands Cohort Study, a cohort that includes 120,852 participants aged 55-69 years, who completed a self-administered questionnaire on cancer risk factors at baseline. Cancer follow-up was [...]

Menée au Japon auprès de 37 823 femmes et 26 025 hommes (âge : 40-79 ans ; durée médiane de suivi : 13,3 ans), cette étude analyse l'association entre la consommation de thé et le risque de cancer gastrique (1 494 cas)

Association of tea consumption and the risk of gastric cancer in Japanese adults: the Japan Collaborative Cohort Study

Sheerah, Haytham ; Keyang, Liu ; Eshak, Ehab Salah ; Cui, Renzhe ; Shirai, Kokoro ; Muraki, Isao ; Iso, Hiroyasu ; Tamakoshi, Akiko

Objective: To examine the possible relationship between tea consumption and risk of gastric cancer (GC) among Japanese men and women included in a large Japanese population-based study titled the Japan Collaborative Cohort (JACC) Study. Design: Prospective cohort study. Setting: A population-based cohort included subjects who were recruited from 24 areas of JACC Study, in which data regarding the incidence of cancer were available. Participants: 63 848 participants (26 025 men and 37 823 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2019 (8 études), cette méta-analyse évalue l'association entre une consommation de thé et le risque de cancer de l'endomètre

Tea Consumption and the Risk of Endometrial Cancer: An Updated Meta-Analysis

Zhang, Liqi ; Ma, Junyan ; Lin, Kaiqing ; Lv, Yifei ; Wang, Huihua ; Lin, Jun

Although the relationship between tea consumption and the risk of endometrial cancer has been previously analyzed in certain studies, the resulting information is still conflicting, and a previous meta-analysis yielded inconsistent results. Therefore, here, we aimed to perform an updated meta-analysis of studies on this subject in order to elucidate this relationship. We searched the literature on the PubMed, Web of Science, Scopus, and Chinese National Knowledge Infrastructure databases for [...]

Menée au Texas sur la période 2010-2014 auprès de 6 302 265 personnes âgées d'au moins 20 ans et résidant à proximité d'une raffinerie de pétrole, cette étude analyse le risque de développer un cancer (vessie, sein, côlon, poumon, lymphome ou prostate) en fonction de la distance de la raffinerie

Proximity to Oil Refineries and Risk of Cancer: A Population-Based Analysis

Williams, Stephen B ; Shan, Yong ; Jazzar, Usama ; Kerr, Preston S ; Okereke, Ikenna ; Klimberg, V Suzanne ; Tyler, Douglas S ; Putluri, Nagireddy ; Lopez, David S ; Prochaska, John D ; Elferink, Cornelis ; Baillargeon, Jacques G ; Kuo, Yong-Fang ; Mehta, Hemalkumar B

The association between proximity to oil refineries and cancer rate is largely unknown. We sought to compare the rate of cancer (bladder, breast, colon, lung, lymphoma, and prostate) according to proximity to an oil refinery in the State of Texas.A total of 6,302,265 persons aged ≥20 years resided within 30 miles from an oil refinery from 2010-2014. We used multilevel zero-inflated Poisson regression models to examine the association between proximity to an oil refinery and cancer rate.We [...]

Menée à partir des données de 2 cohortes américaines portant sur 1 175 patients atteints d'un cancer colorectal, cette étude analyse l'association entre 24 facteurs de risque et 4 sous-types moléculaires de la maladie, en fonction du sexe

Risk factors and incidence of colorectal cancer according to major molecular subtypes

Wang, Liang ; He, Xiaosheng ; Ugai, Tomotaka ; Haruki, Koichiro ; Lo, Chun-Han ; Hang, Dong ; Akimoto, Naohiko ; Fujiyoshi, Kenji ; Wang, Molin ; Fuchs, Charles S ; Meyerhardt, Jeffrey A ; Zhang, Xuehong ; Wu, Kana ; Chan, Andrew T ; Giovannucci, Edward L ; Ogino, Shuji ; Song, Mingyang

Colorectal cancer (CRC) is a heterogeneous disease that can develop via three major pathways, including the conventional, serrated, and alternate pathways. We aimed to examine whether the risk factor profiles differ according to pathway-related molecular subtypes.We examined the association of 24 risk factors with four CRC molecular subtypes based on a combinatorial status of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), BRAF and KRAS mutations by collecting data [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 316 phénotypes et à partir de données d'études d'association sur le génome entier portant sur 12 488 patients atteints d'un gliome et sur 18 169 témoins, cette étude analyse les facteurs génétiques associés au risque de développer la maladie

Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study

Saunders, Charlie N. ; Cornish, Alex J. ; Kinnersley, Ben ; Law, Philip J. ; Houlston, Richard S. ; Claus, Elizabeth B. ; Il’yasova, Dora ; Schildkraut, Joellen ; Barnholtz-Sloan, Jill S. ; Olson, Sara H. ; Bernstein, Jonine L. ; Lai, Rose K. ; Chanock, Stephen ; Rajaraman, Preetha ; Johansen, Christoffer ; Jenkins, Robert B. ; Melin, Beatrice S. ; Wrensch, Margaret R. ; Sanson, Marc ; Bondy, Melissa L. ; Collaborators,

Background: The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma risk factors. Methods: We performed an MR-PheWAS analysing 316 phenotypes, proxied by 8387 genetic variants, and summary genetic data from a GWAS of 12,488 glioma cases and 18,169 controls. Causal effects were estimated under a random-effects inverse-variance-weighted (IVW-RE) [...]

Menée à partir de données de la cohorte européenne EPIC portant sur 273 patientes atteintes d'un cancer de la thyroïde et sur 512 témoins, cette étude analyse l'association entre la concentration sanguine de 36 polyphénols et le risque de développer la maladie, par sous-type

Blood polyphenol concentrations and differentiated thyroid carcinoma in women from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raul ; Luján-Barroso, Leila ; Achaintre, David ; Franceschi, Silvia ; Kyrø, Cecilie ; Overvad, Kim ; Tjønneland, Anne ; Truong, Thérèse ; Lécuyer, Lucie ; Boutron-Ruault, Marie-Christine ; Katzke, Verena ; Johnson, Theron S ; Schulze, Matthias B ; Trichopoulou, Antonia ; Peppa, Eleni ; La Vechia, Carlo ; Masala, Giovanna ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Ricceri, Fulvio ; Skeie, Guri ; Quiros, J Ramon ; Rodriguez-Barranco, Miguel ; Amiano, Pilar ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Almquist, Martin ; Hennings, Joakim ; Vermeulen, Roel ; Wareham, Nicholas J ; Tong, Tammy Y N ; Aune, Dagfinn ; Byrnes, Graham ; Weiderpass, Elisabete ; Scalbert, Augustin ; Rinaldi, Sabina ; Agudo, Antonio

Polyphenols are natural compounds with anticarcinogenic properties in cellular and animal models, but epidemiological evidence determining the associations of these compounds with thyroid cancer (TC) is lacking.The aim of this study was to evaluate the relations between blood concentrations of 36 polyphenols and TC risk in EPIC (the European Prospective Investigation into Cancer and Nutrition).A nested case–control study was conducted on 273 female cases (210 papillary, 45 follicular, and 18 [...]