Menée aux Etats-Unis à partir des données d'une cohorte multi-ethnique incluant 55 068 personnes, cette étude analyse l'association entre la charge ou l'index glycémique de l'alimentation et le risque de cancer du poumon (947 cas)

Investigating the associations of glycemic load and glycemic index with lung cancer risk in the Southern Community Cohort Study

Shu, Xiang ; Yu, Danxia ; Shu, Xiao-Ou ; Munro, Heather M. ; Zheng, Wei ; Blot, William J.

Purpose: Diets with a high glycemic load (GL) or glycemic index (GI) may increase cancer risk. Findings from prior studies on the relationship between GL, GI, and lung cancer risk are inconsistent. We investigated this relationship in a large prospective cohort. Methods: We analyzed data from the Southern Community Cohort Study, a prospective cohort that includes diverse racial groups predominantly low-income adults aged 40–79 in 12 southeastern states of the USA. We estimated dietary GL and GI [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études d'association sur le génome entier portant sur 29 266 patients atteints d'un cancer du poumon et sur 56 450 témoins, cette étude analyse l'association entre l'indice de masse corporelle et le risque de développer la maladie, en fonction du statut tabagique

Causal Relationships between Body Mass Index, Smoking, and Lung Cancer: Univariable and Multivariable Mendelian Randomization

Zhou, Wen ; Liu, Geoffrey ; Hung, Rayjean J. ; Haycock, Philip C. ; Aldrich, Melinda C. ; Andrew, Angeline S. ; Arnold, Susanne M. ; Bickeböller, Heike ; Bojesen, Stig E. ; Brennan, Paul ; Brunnström, Hans ; Melander, Olle ; Caporaso, Neil E. ; Landi, Maria Teresa ; Chen, Chu ; Goodman, Gary E. ; Christiani, David C. ; Cox, Angela ; Field, John K. ; Johansson, Mikael ; Kiemeney, Lambertus A. ; Lam, Stephen ; Lazarus, Philip ; Le Marchand, Loic ; Rennert, Gad ; Risch, Angela ; Schabath, Matthew B. ; Shete, Sanjay S. ; Tardon, Adonina ; Zienolddiny, Shanbeh ; Shen, Hongbing ; Amos, Christopher I.

At the time of cancer diagnosis, body mass index (BMI) is inversely correlated with lung cancer risk, which may reflect reverse causality and confounding due to smoking behavior. We used two-sample univariable and multivariable Mendelian randomization (MR) to estimate causal relationships of BMI and smoking behaviors on lung cancer and histological subtypes, based on an aggregated genome wide association studies (GWASs) analysis of lung cancer in 29 266 cases and 56 450 controls. We observed a [...]

A partir de données danoises portant sur 14 986 adultes atteints d'une leucémie diagnostiquée entre 1989 et 2014 et sur 51 624 témoins, cette étude évalue l'association entre une exposition à la pollution atmosphérique (PM2.5, noir de carbone, dioxyde d'azote et ozone) et le risque de développer une leucémie en fonction de la durée moyenne d'exposition (plus de 1, 5 ou 10 ans)

Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

Puett, Robin C. ; Poulsen, Aslak Harbo ; Taj, Tahir ; Ketzel, Matthias ; Geels, Camilla ; Brandt, Jørgen ; Christensen, Jesper H. ; Sørensen, Mette ; Roswall, Nina ; Hvidtfeldt, Ulla ; Raaschou-Nielsen, Ole

Background : Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods : Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2020 (15 études), cette méta-analyse évalue l'association entre le niveau d'exposition aux particules fines (PM2.5 et PM10) et l'incidence du cancer du sein ainsi que la mortalité associée

Relationship between particulate matter exposure and female breast cancer incidence and mortality: a systematic review and meta-analysis

Guo, Qing ; Wang, Xi ; Gao, Yue ; Zhou, Jun ; Huang, Chenyin ; Zhang, Zhengdong ; Chu, Haiyan

Objectives: The associations of PM with the risk and prognosis of breast cancer have not been determined. This systematic review aimed to provide an updated understanding of the relationship between PM exposure level and breast cancer incidence and mortality. Methods: Articles from Web of Science and PubMed databases were methodically inspected until March 8, 2020. In final, 15 studies were kept for analysis, which provided necessary information to estimate the impact of PM on breast cancer [...]

Menée à partir des données de 18 études portant au total sur 7 562 patients atteints d'un cancer de l'estomac et sur 19 033 témoins, cette étude analyse l'association entre la taille à l'âge adulte et le risque de développer la maladie

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Giraldi, Luca ; Stojanovic, Jovana ; Arzani, Dario ; Persiani, Roberto ; Hu, Jinfu ; Johnson, Kenneth C. ; Zhang, Zuo-Feng ; Ferraroni, Monica ; Palli, Domenico ; Yu, Guo-Pei ; La Vecchia, Carlo ; Pelucchi, Claudio ; Lunet, Nuno ; Ferro, Ana ; Malekzadeh, Reza ; Muscat, Joshua ; Zaridze, David ; Maximovich, Dmitry ; Aragonés, Nuria ; Martin, Vicente ; Vioque, Jesús ; Navarrete-Muñoz, Eva M. ; Pakseresht, Mohammadreza ; Negri, Eva ; Rota, Matteo ; Pourfarzi, Farhad ; Mu, Lina ; Kurtz, Robert C. ; Lagiou, Areti ; Lagiou, Pagona ; Pastorino, Roberta ; Boccia, Stefania

Background: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. Methods: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was [...]

Menée en Corée à l'aide de données portant sur plus de 2,2 millions d'individus âgés de 20 à 39 ans (âge moyen : 32,7 ans ; durée de suivi : 12 ans), cette étude analyse l'association entre une variation du poids et le risque de carcinome hépatocellulaire chez les jeunes adultes (3 000 cas), en fonction du sexe

Association of weight change in young adulthood with subsequent risk of hepatocellular carcinoma: a national cohort study

Kim, Kyuwoong ; Choi, Seulggie ; Lee, Gyeongsil ; Son, Joung Sik ; Kim, Kyae Hyung ; Park, Sang Min

Risk of hepatocellular carcinoma (HCC) in young adults might be clinically overlooked for future HCC risk. Thus, we examined the association between weight change and future risk of developing HCC in young adults. We collected a nationwide and population-based cohort data of more than 2.2 million men and women aged between 20 and 39 who were without previous cancer diagnosis and underwent two consecutive biennial national health screening between 2002 and 2005 from the National Health Insurance [...]

Menée à partir de données de la "UK Biobank" portant sur 414 923 personnes (durée médiane de suivi : 6 ans), cette étude analyse, en fonction du sexe et de la concentration des facteurs de croissance analogues à l'insuline IGF-1, l'association entre la taille et le risque de cancer (24 localisations)

Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?

Parra-Soto, Solange ; Ho, Frederick K. ; Pell, Jill P. ; Celis-Morales, Carlos

Background: Whether the association of height with cancers differs by insulin-like growth factors has not been fully elucidated. Therefore, this study aimed to investigate the sex-specific associations between height and 24 site-specific cancers and to assess whether the association differed by IGF-1. Methods: In total, 414,923 participants from the UK Biobank prospective cohort study were included. The association of height (per 5-cm increment) with incidence and mortality from 24 cancer sites [...]

Menée sur la période 1993-2018 auprès de 109 024 femmes ménopausées (âge : 50-79 ans ; durée moyenne de suivi : 15,6 ans), cette étude analyse l'association entre les habitudes de sommeil (durée, qualité, insomnie) et le risque de cancer de l'ovaire par sous-type (1 000 cas)

Sleep characteristics and risk of ovarian cancer among postmenopausal women

Liang, Xiaoyun ; Harris, Holly R ; Hendryx, Michael ; Shadyab, Aladdin H. ; Hale, Lauren ; Li, Yueyao ; Crane, Tracy E. ; Cespedes Feliciano, Elizabeth M. ; Stefanick, Marcia L. ; Luo, Juhua

Several studies have assessed the relationship between sleep duration and ovarian cancer risk, but the results are conflicting. Importantly, no studies addressed the relationship between sleep disturbance or sleep quality and ovarian cancer incidence. Moreover, few studies have examined the relationships between sleep measures and subtypes of ovarian cancer. This study included 109,024 postmenopausal women aged 50-79 from the Women's Health Initiative (WHI) during 1993-1998 and followed through [...]