A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2020 (24 études de cohorte, 10 études cas-témoins), cette méta-analyse évalue l'association entre des facteurs liés au mode de vie, notamment les pratiques tabagiques, la consommation d'alcool, le surpoids, l'utilisation de produits capillaires de coloration, et le risque de lymphome folliculaire

Lifestyle and risk of follicular lymphoma: a systematic review and meta-analysis of observational studies

Odutola, Michael K. ; Nnakelu, Eriobu ; Giles, Graham G. ; van Leeuwen, Marina T. ; Vajdic, Claire M.

Purpose : To investigate the relationship between follicular lymphoma (FL) risk and common modifiable lifestyle factors, specifically smoking, alcohol, body mass index (BMI), and hair dye use. Methods : We performed a systematic review and meta-analysis of observational studies published prior to 01 January 2020. We searched Ovid MEDLINE, Ovid EMBASE, and Web of Science and the reference lists of original studies and review articles. We used random-effects models to generate meta-estimates of [...]

Menée à partir des données de 10 études de cohortes japonaises incluant 363 409 participants au total (47 % d'hommes ; durée de suivi : 2,7 millions de personnes-années), cette étude analyse l'association entre le tabac et le risque de cancer colorectal (9 232 cas), en fonction du sexe et de l'intensité du tabagisme

Smoking and colorectal cancer: a pooled analysis of ten population-based cohort studies in Japan

Akter, Shamima ; Islam, Zobida ; Mizoue, Tetsuya ; Sawada, Norie ; Ihira, Hikaru ; Tsugane, Shoichiro ; Koyanagi, Yuriko N. ; Ito, Hidemi ; Wang, Chaochen ; Tamakoshi, Akiko ; Wada, Keiko ; Nagata, Chisato ; Tanaka, Kenta ; Kitamura, Yuri ; Utada, Mai ; Ozasa, Kotaro ; Sugawara, Yumi ; Tsuji, Ichiro ; Shimazu, Taichi ; Matsuo, Keitaro ; Naito, Mariko ; Tanaka, Keitaro ; Inoue, Manami

Smoking has been consistently associated with the risk of colorectal cancer (CRC) in Western populations; however, evidence is limited and inconsistent in Asian people. To assess the association of smoking status, smoking intensity, and smoking cessation with colorectal risk in the Japanese population, we performed a pooled analysis of ten population-based cohort studies. Study-specific hazard ratios (HR) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards model and [...]

Menée en Corée par questionnaire auprès de 161 069 participants (âge moyen : 34 ans), cette étude analyse l’association entre l’évolution de leurs pratiques tabagiques sur la période 1992-2005 et le risque de cancer de la vessie (durée de suivi : 2 280 143 personnes-années, 14,2 ans ; 263 cas)

Trajectory of smoking and early bladder cancer risk among Korean young adult men

Yongho Jee, Keum Ji Jung, Joung Hwan Back, Sun Mi Lee, Seung Hwan Lee

Objectives : The aim of this study was to examine the risk of bladder cancer according to the trajectory pattern of amount of smoking among Korean young adult men. Methods : Smoking status was assessed with a standardized questionnaire in the Korean Life Course Health Study (KLCHS). Trajectory analyses were performed among young adult men using seven repeated surveys of cigarette per day (CPD) every two years from 1992 to 2005. The occurrence of bladder cancer was tracked from 2006 to 2016. The [...]

A partir des données de 26 études cas-témoins incluant 24 234 témoins, 4 085 patients atteints d’un cancer de la cavité buccale, 3 359 patients atteints d’un cancer de l’oropharynx, 983 patients atteints d’un cancer de l’hypopharynx et 3 340 patients atteints d’un cancer du larynx, cette étude analyse l’association entre une consommation d’alcool (intensité et durée) et le risque de cancer des voies aérodigestives supérieures

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Gioia Di Credico, Jerry Polesel, Valeria Edefonti (et al.)

Background : Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods : Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ?10 drinks/day for ?54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship [...]

Menée à partir de données portant sur 388 467 adultes américains (durée médiane de suivi : 15,5 ans), cette étude analyse l'association entre une consommation d'agrumes et le risque de mélanome (3 894 cas), en fonction de l'âge et des habitudes d'exposition au soleil

Association between Citrus Consumption and Melanoma Risk in the NIH-AARP Diet and Health Study

Melough, Melissa M. ; Sakaki, Junichi ; Liao, Linda M. ; Sinha, Rashmi ; Cho, Eunyoung ; Chun, Ock K.

It has been hypothesized that consumption of citrus, a group of foods particularly rich in a class of photoactive compounds known as furocoumarins, may increase the risk of malignant melanoma. However, this hypothesis has not been rigorously studied in a general sample of US men and women. This study examined the relationship between citrus intake and melanoma risk in subjects of the NIH-AARP Diet and Health Study. Among 388,467 adults, 3,894 melanoma cases were identified during a median [...]

Menée à partir de données des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" portant sur 112 818 femmes et sur 46 207 hommes (âge moyen : 59,4/64,7 ans), cette étude analyse l'association entre un diabète accompagné d'une perte de poids et le risque de cancer du pancréas (1 116 cas)

Diabetes, Weight Change, and Pancreatic Cancer Risk

Yuan, Chen ; Babic, Ana ; Khalaf, Natalia ; Nowak, Jonathan A. ; Brais, Lauren K. ; Rubinson, Douglas A. ; Ng, Kimmie ; Aguirre, Andrew J. ; Pandharipande, Pari V. ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Stampfer, Meir J. ; Rosenthal, Michael H. ; Sander, Chris ; Kraft, Peter ; Wolpin, Brian M.

Pancreatic cancer is the third-leading cause of cancer death in the United States; however, few high-risk groups have been identified to facilitate early diagnosis strategies.To evaluate the association of diabetes duration and recent weight change with subsequent risk of pancreatic cancer in the general population.This cohort study obtained data from female participants in the Nurses’ Health Study and male participants in the Health Professionals Follow-Up Study, with repeated exposure [...]

Menée à partir des données de la cohorte "NIH-AARP Diet and Health Study" portant sur 162 816 participants (durée de suivi : 14 ans), cette étude analyse l'association entre la consommation, entre 12 et 13 ans, de lait, de fromage, de crème glacée, l'apport total en produits laitiers ou en calcium et le risque de cancer de la prostate (17 729 cas)

Adolescent dairy product and calcium intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study

Lan, Tuo ; Park, Yikyung ; Colditz, Graham A. ; Liu, Jingxia ; Wang, Molin ; Wu, Kana ; Giovannucci, Edward ; Sutcliffe, Siobhan

Purpose: Although a growing body of evidence supports an early-life contribution to prostate cancer (PCa) development, few studies have investigated early-life diet, and only three have examined early-life dairy product intake, a promising candidate risk factor because of its known/suspected influence on insulin-like growth factor levels and height. Methods: We used recalled dietary data from 162,816 participants in the NIH-AARP Diet and Health Study to investigate associations for milk, [...]

Menée à partir d'une revue systématique de la littérature publiée jusqu'en septembre 2019 (15 articles, 2,5 millions de participants), cette méta-analyse évalue l'association entre l'indice de masse corporelle du jeune adulte (moins de 30 ans) et le risque de cancer colorectal

Excessive Body Fat at a Young Age Increases the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis

Lei, Xuelian ; Song, Shuailing ; Li, Xiao ; Geng, Chong ; Wang, Chunhui

Overweight and obesity was considered as a risk factor for colorectal cancer (CRC), and CRC development may be due to exposure during one?s youth. Metabolic syndrome and insulin resistance seem to play an important role in the underlying mechanisms. Even though several studies indicated the association between BMI at young age and CRC risks, an identified founding is still lacked. Therefore, we conducted a meta-analysis and a dose-response analysis to quantify the association between BMI at [...]

Menée aux Etats-Unis par questionnaire auprès d'une cohorte de 57 075 femmes ménopausées (durée moyenne de suivi : 16 ans), cette étude analyse l'association entre une consommation de café (décaféiné ou non, quantité par jour ou par mois) et le risque de cancer du sein invasif (2 980 cas), en fonction du statut des récepteurs hormonaux (ER/PR)

Coffee Consumption and Invasive Breast Cancer Incidence among Postmenopausal Women in the Cancer Prevention Study II Nutrition Cohort

McCullough, Marjorie L ; Gapstur, Susan M. ; Gaudet, Mia M. ; Wang, Ying ; Hodge, Rebecca A ; Um, Caroline Y ; Hartman, Terryl J

Background: There is limited evidence of a potential inverse association between coffee, particularly caffeinated coffee, consumption and postmenopausal breast cancer risk, and few studies have examined this association by tumor hormone receptor status. To provide further evidence, we examined total, caffeinated and decaffeinated coffee consumption in relation to postmenopausal invasive breast cancer incidence overall, and by tumor estrogen receptor (ER) and/or progesterone receptor (PR) [...]

Menée à partir de données européennes 1968-1997 portant sur 833 hommes français, cette étude de cohorte analyse l'association entre une exposition professionnelle au dioxyde de titane et la mortalité liée au cancer du poumon

Lung cancer mortality in the French cohort of titanium dioxide workers: some aetiological insights

Guseva Canu, Irina ; Gaillen-Guedy, Alan ; Wild, Pascal ; Straif, Kurt ; Luce, Danièle

Objectives: Titanium dioxide (TiO2) is widely used in construction, food, cosmetic and medical industry. The current evidence on TiO2 carcinogenicity in humans is considered inadequate. As French participants of the European cohort of TiO2 workers exhibited an increase in mortality from lung cancer, we aimed at investigating whether TiO2 exposure, co-exposures or smoking can explain this increase. Methods: We reanalysed the data of 833 French male workers (follow-up period 1968–1997) and used [...]

Cette étude fait le point sur l'association entre la pollution atmosphérique, le risque de cancer et la mortalité spécifique ainsi que sur les recommandations de santé publique

Outdoor air pollution and cancer: An overview of the current evidence and public health recommendations

Turner, Michelle C. ; Andersen, Zorana J. ; Baccarelli, Andrea ; Diver, W. Ryan ; Gapstur, Susan M. ; Pope III, C. Arden ; Prada, Diddier ; Samet, Jonathan ; Thurston, George ; Cohen, Aaron

Outdoor air pollution is a major contributor to the burden of disease worldwide. Most of the global population resides in places where air pollution levels, because of emissions from industry, power generation, transportation, and domestic burning, considerably exceed the World Health Organization's health-based air-quality guidelines. Outdoor air pollution poses an urgent worldwide public health challenge because it is ubiquitous and has numerous serious adverse human health effects, including [...]

Menée en Suède auprès de 17 200 femmes présentant un hémangiome pendant la petite enfance et ayant été exposées aux rayonnements ionisants (âge médian lors du 1er traitement : 5 mois), cette étude analyse le risque de cancer du sein radio-induit chez les patientes ayant des antécédents familiaux de la maladie (1 079 cas)

Evidence for Increased Susceptibility for Breast Cancer from Exposure to Ionizing Radiation Due to Familial Breast Cancer History: Results from the Swedish Hemangioma Cohort

Eidemüller, Markus ; Holmberg, Erik ; Lundell, Marie ; Karlsson, Per

Women with breast cancer among family members are at increased risk for breast cancer. However, it is unknown whether familial breast cancer history (FBCH) also increases individual susceptibility for breast cancer from radiation exposure. In this cohort study, 17,200 female Swedish hemangioma patients with 1,079 breast cancer cases between 1958–2013, exposed by ionizing radiation in infancy, were linked to their first-degree relatives. The association between FBCH and radiation-induced breast [...]

Menée en Pologne auprès de 648 témoins et 648 patients atteints d'un cancer du sein, du poumon ou d'un cancer colorectal, cette étude analyse l'association entre 5 polymorphismes à simple nucléotide de protéases liées au zinc (métalloprotéases matricielles et métallothionéines) et le risque de développer ces maladies

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Białkowska, Katarzyna ; Marciniak, Wojciech ; Muszyńska, Magdalena ; Baszuk, Piotr ; Gupta, Satish ; Jaworska-Bieniek, Katarzyna ; Sukiennicki, Grzegorz ; Durda, Katarzyna ; Gromowski, Tomasz ; Lener, Marcin ; Prajzendanc, Karolina ; Łukomska, Alicja ; Cybulski, Cezary ; Huzarski, Tomasz ; Gronwald, Jacek ; Dębniak, Tadeusz ; Lubinski, Jan ; Jakubowska, Anna

Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon [...]

Menée au Royaume-Uni à partir de données portant sur 460 224 participants, cette étude analyse l’association entre la présence de la mutation constitutionnelle G84E du gène HOXB13 et le risque de 20 types de cancers

Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank

Jun Wei, Zhuqing Shi, Rong Na, Chi-Hsiung Wang (et al.)

Germline HOXB13 G84E mutation has been consistently associated with prostate cancer (PCa) risk, but its association with other cancers is controversial. We systematically tested its association with the 20 most common cancer types in subjects from the UK Biobank. The G84E mutation was found in 1,545 (0.34%) of 460,224 participants of European ancestry. While mutation status did not associate with cancer risk in females, it was significantly associated with increased risk in males; odds ratio [...]

Menée à l'aide des données de 15 études internationales portant au total sur 10 470 patientes atteintes d'un cancer épithélial invasif de l'ovaire et sur 16 942 témoins, cette étude analyse l'association entre une grossesse interrompue (de manière provoquée ou spontanée) et le risque de développer la maladie

Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies

Lee, Alice W ; Rosenzweig, Stacey ; Wiensch, Ashley ; the Australian Ovarian Cancer Study Group ; Ramus, Susan J ; Menon, Usha ; Gentry-Maharaj, Aleksandra ; Ziogas, Argyrios ; Anton-Culver, Hoda ; Whittemore, Alice S ; Sieh, Weiva ; Rothstein, Joseph H ; McGuire, Valerie ; Wentzensen, Nicolas ; Bandera, Elisa V ; Qin, Bo ; Terry, Kathryn L ; Cramer, Daniel W ; Titus, Linda ; Schildkraut, Joellen M ; Berchuck, Andrew ; Goode, Ellen L ; Kjaer, Susanne K ; Jensen, Allan ; Jordan, Susan J ; Ness, Roberta B ; Modugno, Francesmary ; Moysich, Kirsten ; Thompson, Pamela J ; Goodman, Marc T ; Carney, Michael E ; Chang-Claude, Jenny ; Rossing, Mary Anne ; Harris, Holly R ; Doherty, Jennifer Anne ; Risch, Harvey A ; Khoja, Lilah ; Alimujiang, Aliya ; Phung, Minh Tung ; Brieger, Katharine ; Mukherjee, Bhramar ; Pharoah, Paul D P ; Wu, Anna H ; Pike, Malcolm C ; Webb, Penelope M ; Pearce, Celeste Leigh

Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.A pooled analysis of 10,470 invasive epithelial ovarian cancer cases and 16,942 controls was [...]

A partir d’une revue systématique de la littérature publiée jusqu’en octobre 2019 (85 études), cette méta-analyse évalue les disparités géographiques dans l’association entre des antécédents familiaux de cancer du poumon et le risque de développer la maladie

Association between family history of lung cancer and lung cancer risk: a systematic review and meta-analysis

Lina Ang, Cheryl Pui Yi Chan, Wai-Ping Yau, Wei Jie Seow (et al.)

Background : Familial risk of lung cancer has been widely studied but the effects of socio-demographic factors and geographical regions are largely unknown. Methods : PubMed and Embase were systematically searched until 1 st October 2019. A total of 85 studies (19 cohort and 66 case control studies) were included in this systematic review and meta-analysis. Pooled summary estimates and 95% confidence intervals were estimated, and the analysis was stratified by socio-demographics and [...]

Mené en Suède à partir de données portant sur 699 125 participants sur la période 1972-1985, cette étude de cohorte analyse l’association entre la santé cardiorespiratoire mesurée à la fin de l’adolescence et le risque de cancer de la prostate (période de suivi : 38, 8 millions personnes-années ; 10 782 cas de cancer de la prostate)

Early-Life Cardiorespiratory Fitness and Long-Term Risk of Prostate Cancer

Casey Crump, Par Stattin, James D. Brooks, Tanja Stocks

Background: Adolescence is a period of rapid prostatic growth, yet is understudied for susceptibility for future risk of prostate cancer (PC). We examined cardiorespiratory fitness (CRF) in late adolescence in relation to long-term PC risk. Methods: A population-based cohort study was conducted of all 699,125 Swedish military conscripts during 1972-1985 (97-98% of 18-year-old men) in relation to risk of PC overall, aggressive PC, and PC mortality during 1998-2017 (ages 50-65 years). CRF was [...]

Menée à l'aide de données d'études d'association sur le génome entier portant sur 10 784 patients atteints d'un carcinome à cellules rénales et sur 20 406 témoins, puis validée notamment à l'aide de 2 autres sources de données génétiques portant au total sur 1 220 patients et sur 501 872 témoins, cette étude identifie plusieurs nouveaux gènes de susceptibilité à la maladie

Pathway analysis of renal cell carcinoma genome-wide association studies identifies novel associations

Purdue, Mark P. ; Song, Lei ; Scelo, Ghislaine ; Houlston, Richard S. ; Wu, Xifeng ; Sakoda, Lori C. ; Thai, Khanh ; Graff, Rebecca E. ; Rothman, Nathaniel ; Brennan, Paul ; Chanock, Stephen J. ; Yu, Kai

Background: Much of the heritable risk of renal cell carcinoma (RCC) associated with common genetic variation is unexplained. New analytic approaches have been developed to increase the discovery of risk variants in genome-wide association studies (GWAS), including multi-locus testing through pathway analysis. Methods: We conducted a pathway analysis using GWAS summary data from six previous scans (10,784 cases and 20,406 controls) and evaluated 3,678 pathways and gene sets drawn from the [...]

Menée en Chine entre 2010 et 2014 à l'aide d'échantillons sanguins collectés auprès de 402 femmes atteintes d'un cancer du sein et de 557 témoins (âge moyen : 52 ans), puis validée à l'aide de données de la cohorte EPIC-Italie portant sur 233 patientes et 340 témoins, cette étude analyse l'association entre la méthylation des gènes WT1 et CA10 des leucocytes du sang périphérique et le risque de développer la maladie

Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study

Ge, Anqi ; Gao, Song ; Liu, Yupeng ; Zhang, Hui ; Wang, Xuan ; Zhang, Lei ; Pang, Da ; Zhao, Yashuang

Background: Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown. Methods: The methylation of WT1 and CA10 was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) in a case-control study with female subjects (N = 959). Logistic regression was used to analyze the [...]

Menée à l'aide de données de l'assurance maladie coréenne portant sur plus de 13 millions de femmes âgées d'au moins 20 ans, cette étude analyse l'association entre un syndrome métabolique et le risque de cancer du sein, par catégorie d'âge (plus ou moins de 50 ans)

Influence of Metabolic Syndrome on Risk of Breast Cancer: A Study Analyzing Nationwide Data from Korean National Health Insurance Service

Hwang, Ki-Tae ; Han, Kyung-Do ; Oh, Sohee ; Koo, Bo Kyung ; Lee, Se Kyung ; Kim, Jongjin ; Seo, Hwa Jeong ; Jung, Jiwoong ; Kim, Byoung Hyuck ; Hur, Ho

Background: To investigate the influence of metabolic syndrome and its components on the risk of breast cancer. Methods: Retrospective nationwide cohort study analyzing data of 13,377,349 women older than 19 years from Korean National Health Insurance Service was performed. Cox proportional hazards model was used to calculate hazard ratio (HR) and 95% confidence interval (CI) of breast cancer risk. Results: The presence of metabolic syndrome decreased the risk of all breast cancer types in all [...]

Menée à partir des données d'une étude d'association sur le génome entier et à l'aide du génotypage des polymorphismes nucléotidiques auprès de 3 620 témoins et 1 380 hommes atteints d'un cancer du sein, puis validée auprès de 810 patients et 1 026 témoins, cette étude identifie 3 nouveaux loci de sensibilité à la maladie

Common susceptibility loci for male breast cancer

Maguire, Sarah ; Perraki, Eleni ; Tomczyk, Katarzyna ; Jones, Michael E ; Fletcher, Olivia ; Pugh, Matthew ; Winter, Timothy ; Thompson, Kyle ; Cooke, Rosie ; kConFab Consortium ; Trainer, Alison ; James, Paul ; Bojesen, Stig ; Flyger, Henrik ; Nevanlinna, Heli ; Mattson, Johanna ; Friedman, Eitan ; Laitman, Yael ; Palli, Domenico ; Masala, Giovanna ; Zanna, Ines ; Ottini, Laura ; Silvestri, Valentina ; Hollestelle, Antoinette ; Hooning, Maartje J ; Novakovic, Srdjan ; Krajc, Mateja ; Gago-Dominguez, Manuela ; Castelao, Jose Esteban ; Olsson, Håkan ; Hedenfalk, Ingrid ; Saloustros, Emmanouil ; Georgoulias, Vasilios ; Easton, Douglas F ; Pharoah, Paul ; Dunning, Alison M ; Bishop, D Timothy ; Neuhausen, Susan L ; Steele, Linda ; Ashworth, Alan ; Closas, Montserrat Garcia ; Houlston, Richard ; Swerdlow, Anthony ; Orr, Nick

The aetiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association study (GWAS) of MBC identified two predisposition loci for the disease, both of which were also associated with risk of FBC.We performed genome-wide single nucleotide polymorphism (SNP) genotyping of European ancestry MBC case subjects and controls, in three stages. Associations between [...]

A partir d'une revue systématique de la littérature publiée entre 1978 et 2019 (19 études), cette méta-analyse évalue l'association entre l'hypothyroïdisme et le risque de cancer du sein

Does hypothyroidism increase the risk of breast cancer: evidence from a meta-analysis

Wang, Bolin ; Lu, Zhong ; Huang, Yan ; Li, Ruobao ; Lin, Tao

Purpose: At present, the relationship between hypothyroidism and the risk of breast cancer is still inconclusive. This meta-analysis was used to systematically assess the relationship between hypothyroidism and breast cancer risk, and to assess whether thyroid hormone replacement therapy can increase breast cancer risk. Methods: The relevant articles about hypothyroidism and the risk of breast cancer were obtained on the electronic database platform. Relevant data were extracted, and odd ratios [...]