Menée au Royaume-Uni à partir de données portant sur 241 patients atteints d'un cancer gastrointestinal, cette étude prospective analyse la nature, la fréquence et la sévérité des symptômes gastrointestinaux, pendant et après la chimiothérapie

The FOCCUS study: a prospective evaluation of the frequency, severity and treatable causes of gastrointestinal symptoms during and after chemotherapy

Andreyev, H. Jervoise N. ; Lalji, Amyn ; Mohammed, Kabir ; Muls, Ann C. G. ; Watkins, David ; Rao, Sheela ; Starling, Naureen ; Chau, Ian ; Cruse, Sarah ; Pitkaaho, Ville ; Matthews, Jennifer ; Caley, Laura ; Pittordou, Victoria ; Adams, Carolyn ; Wedlake, Linda

Background : The underlying mechanisms of chemotherapy-induced gastrointestinal (GI) symptoms are poorly researched. This study characterised the nature, frequency, severity and treatable causes for GI symptoms prospectively in patients undergoing chemotherapy for GI malignancy. Methods : Patients receiving chemotherapy for a GI malignancy were assessed pre-chemotherapy, then monthly for 1 year using the Gastrointestinal Symptom Rating Scale, a validated patient-reported outcome measure. [...]

A partir d'une revue systématique de la littérature publiée entre 2011 et 2019 (1 197 publications), cette étude met à jour les recommandations 2014 de la "Multinational Association of Supportive Care in Cancer" et de l'"International Society for Oral Oncology" pour la prise en charge de la mucite chez les patients atteints d'un cancer

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Elad, Sharon ; Cheng, Karis Kin Fong ; Lalla, Rajesh V. ; Yarom, Noam ; Hong, Catherine ; Logan, Richard M. ; Bowen, Joanne ; Gibson, Rachel ; Saunders, Deborah P. ; Zadik, Yehuda ; Ariyawardana, Anura ; Correa, Maria Elvira ; Ranna, Vinisha ; Bossi, Paolo ; for the Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer ; International Society of Oral Oncology

Background: Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis. Methods: The literature was reviewed systematically to identify interventions for mucositis. Studies were rated according to the presence of major and minor flaws according [...]

Menée par entretien ou enquête réalisés auprès de 61 professionnels de santé et 11 jeunes patients atteints d'un cancer (âge : 19-26 ans), cette étude analyse les besoins d'information et de soutien après la fin des traitements

The support and information needs of adolescents and young adults with cancer when active treatment ends

Lea, Sarah ; Martins, Ana ; Fern, Lorna A. ; Bassett, Matthew ; Cable, Maria ; Doig, Gary ; Morgan, Sue ; Soanes, Louise ; Whelan, Michael ; Taylor, Rachel M.

Background: The end of active treatment is a period of high stress for young people with cancer, but limited literature exists about their information and support needs during this phase. This study aimed to understand the needs of young people with cancer, how these needs are currently being met, and how best to provide information and support at the end of active treatment. Methods: This was a multi-stage, mixed methods study exploring the end of treatment experience from the perspectives of [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2019 (27 études), cette étude identifie les besoins en soins de support chez des patients atteints d'un cancer et souffrant d'une alopécie induite par la chimiothérapie

Identifying the supportive care needs of men and women affected by chemotherapy-induced alopecia? A systematic review

Paterson, C. ; Kozlovskaia, M. ; Turner, M. ; Strickland, K. ; Roberts, C. ; Ogilvie, R. ; Pranavan, G. ; Craft, P.

Purpose : To systematically evaluate evidence regarding the unmet supportive care needs of men and women affected by chemotherapy-induced alopecia (CIA) to inform clinical practice guidelines. Methods : We performed a review of CINAHL, MEDLINE, PsychINFO, Scopus, the Cochrane Library (CCRT and CDSR) controlled trial databases and clinicaltrials.gov from January 1990 to June 2019 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. Twenty-seven [...]

Menée aux Etats-Unis par enquête auprès de 31 patients ayant survécu à un cancer du poumon de stade précoce et auprès de 53 aidants familiaux, cette étude analyse leurs comportements de santé et leurs préférences en matière d'interventions pour promouvoir une activité physique

Lifestyle behaviors and intervention preferences of early-stage lung cancer survivors and their family caregivers

Roddy, McKenzie K. ; Flores, Raja M. ; Burt, Brian ; Badr, Hoda

Purpose : Lung cancer (LC) is a highly prevalent disease with more survivors diagnosed and treated at earlier stages. There is a need to understand psychological and lifestyle behavior needs to design interventions for this population. Furthermore, understanding the needs and role of family caregivers, especially given the risks associated with second-hand smoke, is needed. Methods : Thirty-one early-stage (stages I or IIA) LC survivors of (52% men) and 22 (50% women) caregivers (N = 53 total) [...]

A partir d’une revue de la littérature publiée entre 2010 et 2019, cette étude analyse l’impact d’une activité physique sur la prévention et la réduction des effets indésirables liés à une thérapie anti-androgénique chez des patients atteints d’un cancer de la prostate

The role of exercise in the management of adverse effects of androgen deprivation therapy for prostate cancer: a rapid review

Kim Edmunds, Haitham Tuffaha, Paul Scuffham, Daniel A Galvão, Robert U Newton

Purpose : Prostate cancer (PCa) is the most commonly diagnosed cancer in Australia, accounting for one quarter of all new cancer diagnoses for males. Androgen deprivation therapy (ADT) is the standard first-line therapy for metastatic PCa but is also used across much of the spectrum of disease. Unfortunately, debilitating adverse effects are a significant and largely unavoidable feature of ADT. A recent systematic review of adverse effects of ADT identified 19 sub-groups classified according to [...]

Menée aux Etat-Unis auprès de 431 patients atteints d'un cancer localisé de la prostate, cette étude analyse les facteurs sociaux et médicaux associés à leurs besoins en soins de support pendant la première année suivant les traitements anticancéreux

Social and medical risk factors associated with supportive needs in the first year following localized prostate cancer treatment

Tagai, Erin K. ; Hudson, Shawna V. ; Diefenbach, Michael A. ; Xu, Jenny ; Bator, Alicja ; Marziliano, Allison ; Miller, Suzanne M.

Purpose : Individuals who completed treatment for prostate cancer (PCa) often report poor coping and practical concerns when adapting to new roles in their lives—and strong patient–provider communication is critical for this period. However, there is limited research identifying factors associated with supportive needs after the completion of PCa treatment. This study aimed to identify the social and medical risk factors associated with supportive needs for adapting among individuals who [...]

Menée par questionnaire auprès de 1 316 patients atteints d'un cancer de stade métastatique, cette étude analyse l'association entre leurs symptômes auto-déclarés au moment du diagnostic et la survie globale

Associations between baseline symptom burden as assessed by patient-reported outcomes and overall survival of patients with metastatic cancer

Batra, Atul ; Yang, Lin ; Boyne, Devon J. ; Harper, Andrew ; Cheung, Winson Y. ; Cuthbert, Colleen A.

Background : Serial symptom assessments using patient-reported outcomes may be challenging to implement in routine clinical practices. We aimed to determine if a single measurement of symptom burden at the time of metastatic diagnosis is associated with survival. Methods : We examined baseline patient-reported outcomes (within 90 days of diagnosis) of patients newly diagnosed with metastatic breast, lung, colorectal, or prostate cancer using the revised Edmonton Symptom Assessment System [...]

Menée aux Etats-Unis à partir de données portant sur 87 737 témoins et sur 6 778 adolescents et jeunes adultes ayant survécu 2 ans à un cancer diagnostiqué entre 15 et 39 ans, cette étude de cohorte analyse les facteurs associés au risque de comorbidités chroniques en lien avec les traitements anticancéreux

Chronic Comorbidities Among Survivors of Adolescent and Young Adult Cancer

Chun Chao ; Smita Bhatia ; Lanfang Xu ; Kimberly L. Cannavale ; F. Lennie Wong ; Po-Yin Samuel Huang ; Robert Cooper ; Saro H. Armenian

PURPOSE : To describe the incidence, relative risk, and risk factors for chronic comorbidities in survivors of adolescent and young adult (AYA) cancer. METHODS : This retrospective cohort study included 2-year survivors of AYA cancer diagnosed between age 15 and 39 years at Kaiser Permanente Southern California from 2000 to 2012. A comparison cohort without cancer was individually matched (13:1) to survivors of cancer on age, sex, and calendar year. Using electronic medical records, all [...]

Menée à partir des données de la base GLOBOCAN, cette étude estime l'incidence des cancers chez les personnes âgées d'au moins 80 ans en 2018 en fonction de la localisation géographique, présente les 5 cancers les plus fréquemment diagnostiqués par région et dans le monde chez les femmes et les hommes âgés de 65 à 79 ans et de 80 ans ou plus, puis propose une projection de l'incidence des cancers en 2050 chez les plus âgés

Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050

Pilleron, Sophie ; Soto-Perez-de-Celis, Enrique ; Vignat, Jérôme ; Ferlay, Jacques ; Soerjomataram, Isabelle ; Bray, Freddie ; Sarfati, Diana

Using GLOBOCAN estimates, we describe the estimated cancer incidence among adults aged 80 years or older at the regional and global level in 2018, reporting the number of new cancer cases, and the truncated age-standardised incidence rates (per 100,000) for all cancer sites combined for this age group. We also presented the five most frequent cancers diagnosed by region and globally among females and males aged 65-79 years old and 80 years or older. We, finally, estimated the number of new [...]

Menée au Royaume-Uni à partir de données portant sur 13 457 patients ayant survécu à un cancer pendant l'enfance, cette étude de cohorte analyse les facteurs associés au risque de maladie cérébrovasculaire après l'âge de 50 ans

Risk of cerebrovascular disease among 13,457 five-year survivors of childhood cancer: a population based cohort study

Reulen, Raoul C ; Guha, Joyeeta ; Bright, Chloe J ; Henson, Katherine E ; Feltbower, Richard G ; Hall, Marlous ; Kelly, Julie S ; Winter, David L ; Kwok-Williams, Michelle ; Skinner, Rod ; Cutter, David J ; Frobisher, Clare ; Hawkins, Mike M

Survivors of childhood cancer treated with cranial irradiation are at risk of cerebrovascular disease (CVD), but the risks beyond age 50 are unknown.13,457 survivors of childhood cancer included in the population-based British Childhood Cancer Survivor Study cohort were linked to Hospital Episode Statistics data for England. Risk of CVD related hospitalisation was quantified by standardised hospitalisation ratios (SHR), absolute excess risks (AER), and cumulative incidence. Overall, 315 (2.3%) [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The Art of Oncology: COVID Era

Reynolds, Kerry L. ; Klempner, Samuel J. ; Parikh, Aparna ; Hochberg, Ephraim P. ; Michaelson, M. Dror ; Mooradian, Meghan J. ; Lee, Richard J. ; Soumerai, Tara E. ; Hobbs, Gabriela ; Piotrowska, Zofia ; Sykes, David B. ; Farago, Anna F. ; Bardia, Aditya ; Rosovsky, Rachel P. ; Ryan, David P.

Conversion of a busy inpatient oncology service that typically treats more than 5,000 patients a year to units caring for patients with COVID is a story of teamwork and resilience.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Loneliness and belonging: Exploring experiences with the COVID-19 pandemic in psycho-oncology

Schellekens, Melanie P. J. ; van der Lee, Marije L.

The COVID‐19 pandemic affects people across the world. While the virus appears to infect people of all ages and health status, those with cancer, may be at higher risk for developing critical illness and death (1, 2). Besides physical implications, the psychosocial burden that the pandemic puts on people may be especially high for those whose lives have already been affected by cancer. Although people confronted with cancer can be surprisingly resilient, half of cancer patients suffer from [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Bridging the distance: Continuing psycho-oncological care via video-consults during the COVID-19 pandemic

van der Lee, Marije L. ; Schellekens, Melanie P. J.

The Helen Dowling institute is a mental healthcare institute specialized in psycho‐oncology in the Netherlands. We offer face‐to‐face individual, couple, family and group therapy, to (family members of) cancer out‐patients (n = 2.302 clients in the last year). Clients mainly suffer from severe cancer‐related fatigue, anxiety, trauma, stress‐related and depressive disorders, relationship problems and/or prolonged grief disorder. Since 2009 the institute offers specific internet‐based [...]

Menée auprès de 6 148 patients ayant survécu à une leucémie aiguë lymphoblastique pendant l'enfance et diagnostiquée entre 1970 et 1999 (âge médian : 27,9 ans), cette étude analyse la mortalité tardive selon le type de traitement reçu

Reduced Morbidity and Mortality in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study

Stephanie B. Dixon ; Yan Chen ; Yutaka Yasui ; Ching-Hon Pui ; Stephen P. Hunger ; Lewis B. Silverman ; Kirsten K. Ness ; Daniel M. Green ; Rebecca M. Howell ; Wendy M. Leisenring ; Nina S. Kadan-Lottick ; Kevin R. Krull ; Kevin C. Oeffinger ; Joseph P. Neglia ; Ann C. Mertens ; Melissa M. Hudson ; Leslie L. Robison ; Gregory T. Armstrong ; Paul C. Nathan

PURPOSE: Risk-stratified therapy, which modifies treatment on the basis of clinical and biologic features, has improved 5-year overall survival of childhood acute lymphoblastic leukemia (ALL) to 90%, but its impact on long-term toxicity remains unknown. METHODS: We assessed all-cause and health-related late mortality (including late effects of cancer therapy), subsequent malignant neoplasms (SMNs), chronic health conditions, and neurocognitive outcomes among 6,148 survivors of childhood ALL [...]

Menée aux Etats-Unis à partir de données portant sur 132 patientes atteintes d'un cancer de l'ovaire récidivant et incluses dans des essais de phase I entre 2008 et 2018 (âge médian : 59 ans), cette étude rétrospective analyse les facteurs associés à la survie (caractéristiques de la patiente, traitement subi, toxicités)

Survival and clinical outcomes of patients with ovarian cancer who were treated on phase 1 clinical trials

Corr, Bradley R. ; Moroney, Marisa ; Sheeder, Jeanelle ; Eckhardt, S. Gail ; Sawyer, Brandon ; Behbakht, Kian ; Diamond, Jennifer R.

Background : Patients with ovarian cancer who are enrolled on phase 1 trials typically have platinum-resistant and heavily pretreated disease, with a poor prognosis. In the current study, the authors assessed prognostic factors and survival in women with recurrent ovarian cancer who were treated on phase 1 clinical trials. Methods : The authors performed a retrospective analysis of patients treated from 2008 through 2018 at the University of Colorado Cancer Center. Patient characteristics and [...]

Menée en Autriche à partir de données portant sur 1 608 patients atteints d'un cancer du poumon non à petites cellules et présentant des métastases cérébrales (âge médian : 62 ans), cette étude analyse l'effet, sur la survie, de symptômes neurologiques au moment du diagnostic des métastases cérébrales

Neurological symptom burden impacts survival prognosis in patients with newly diagnosed non–small cell lung cancer brain metastases

Steindl, Ariane ; Yadavalli, Sarah ; Gruber, Katharina-Anna ; Seiwald, Maria ; Gatterbauer, Brigitte ; Dieckmann, Karin ; Frischer, Josa M. ; Klikovits, Thomas ; Zöchbauer-Müller, Sabine ; Grisold, Anna ; Hoda, Mir Ali Reza ; Marosi, Christine ; Widhalm, Georg ; Preusser, Matthias ; Berghoff, Anna Sophie

Background : Brain metastases (BM) are a frequent complication of advanced cancer and are characterized by a variety of neurological symptoms. Although the presence of neurological symptoms is included in the response assessment in patients with primary brain tumors, to the authors' knowledge little is known regarding the prognostic impact of neurological symptoms in patients with BM. Methods : Patients with newly diagnosed BM from non–small cell lung cancer were identified from the Vienna [...]

A partir de données 1980-2015 de l'Organisation Mondiale de la Santé portant sur la mortalité due à un lymphome de Hodgkin, un myélome multiple ou une leucémie au Canada, cette étude analyse l'évolution de la mortalité prématurée liée à ces maladies, en fonction du sexe

Premature Mortality due to Hodgkin’s Lymphoma, Non-Hodgkin’s Lymphoma, Multiple Myeloma, and Leukemia in Canada: A Nationwide Analysis from 1980 to 2015

Pham, Truong-Minh ; Shen-Tu, Grace ; Nguyen, Khanh Hoa ; Lu, Shuang ; Dover, Douglas C ; Duggan, Peter ; Shack, Lorraine ; Cheung, Winson Y

Recently, we introduced a novel measure of average lifespan shortened (ALSS) to improve comparability of premature mortality over time. In this study, we applied this novel measure to examine trends in premature mortality caused by hematological cancers in Canada from 1980 to 2015. Mortality data for Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, multiple myeloma, and leukemia were obtained from the World Health Organization mortality database. Years of life lost was calculated according to [...]

Menée à partir de données portant sur 1 252 patientes porteuses d'une mutation constitutionnelle BRCA et atteintes d'un cancer invasif du sein diagnostiqué entre 2000 et 2012 avant l'âge de 40 ans, cette étude rétrospective internationale analyse l'association entre une grossesse après la maladie et la survie

Pregnancy After Breast Cancer in Patients With Germline BRCA Mutations

Matteo Lambertini ; Lieveke Ameye ; Anne-Sophie Hamy ; Anna Zingarello ; Philip D. Poorvu ; Estela Carrasco ; Albert Grinshpun ; Sileny Han ; Christine Rousset-Jablonski ; Alberta Ferrari ; Shani Paluch-Shimon ; Laura Cortesi ; Claire Senechal ; Gianmaria Miolo ; Katarzyna Pogoda ; Jose Alejandro Pérez-Fidalgo ; Laura De Marchis ; Riccardo Ponzone ; Luca Livraghi ; Maria Del Pilar Estevez-Diz ; Cynthia Villarreal-Garza ; Maria Vittoria Dieci ; Florian Clatot ; Martine Berlière ; Rossella Graffeo ; Luis Teixeira ; Octavi Córdoba ; Amir Sonnenblick ; Helena Luna Pais ; Michail Ignatiadis ; Marianne Paesmans ; Ann H. Partridge ; Olivier Caron ; Claire Saule ; Lucia Del Mastro ; Fedro A. Peccatori ; Hatem A. Azim Jr

PURPOSE : Young women with germline BRCA mutations have unique reproductive challenges. Pregnancy after breast cancer does not increase the risk of recurrence; however, very limited data are available in patients with BRCA mutations. This study investigated the impact of pregnancy on breast cancer outcomes in patients with germline BRCA mutations. PATIENTS AND METHODS : This is an international, multicenter, hospital-based, retrospective cohort study. Eligible patients were diagnosed between [...]

Menée au Danemark à partir des données de registres sur la période 2002-2015, cette étude analyse, chez les femmes âgées de plus de 35 ans et atteintes d'un cancer de l'endomètre, l'évolution de la mortalité prenant en compte les hystérectomies

Trends in hysterectomy-corrected uterine cancer mortality rates during 2002-2015: mortality of non-endometrioid cancer on the rise?

Gustafson, Line W ; Booth, Berit B ; Kahlert, Johnny ; Ørtoft, Gitte ; Mejlgaard, Else ; Clarke, Megan A ; Wentzensen, Nicolas ; Rositch, Anne F ; Hammer, Anne

Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratified by age, stage, and histologic subtype. Using data from nationwide Danish registries, we calculated uncorrected and hysterectomy-corrected age-standardized mortality rates of [...]

Menée aux Etats-Unis à l'aide de données 2004-2015 portant sur 146 256 patients atteints d'un cancer de la tête et du cou, cette étude analyse l'association entre des facteurs de disparités ethniques ou liées au lieu de résidence (zone urbaine ou rurale) et la survie

Head and Neck Cancer Survival Disparities by Race and Rural-Urban Context

Clarke, Jacob A ; Despotis, Alyssa M ; Ramirez, Ricardo J ; Zevallos, Jose P ; Mazul, Angela L

Background: This study aims to examine the relationship between race and rural-urban context in head and neck cancer (HNC) survival and determine factors that potentially drive this disparity. Methods: Using the National Cancer Database from 2004 to 2015, we identified a retrospective cohort of 146,256 HNC patients. Kaplan-Meier survival curves and the Cox proportional hazards regression were used to calculate adjusted hazard ratios (aHR). Results: Median survival by patient subgroup was as [...]

Menée aux Etats-Unis par enquête auprès de 129 aidants familiaux de patients atteints d'un cancer, cette étude longitudinale analyse l'évolution des facteurs associés au sentiment de solitude

Factors influencing loneliness in cancer caregivers: A longitudinal study

Ross, Alyson ; Perez, Avery ; Wehrlen, Leslie ; Lee, Lena Jumin ; Yang, Li ; Robert, Cox ; Bevans, Margaret ; Ding, Alice ; Wiener, Lori ; Wallen, Gwenyth

Objective : to describe levels of loneliness in cancer caregivers over a six month time period, and to examine factors that influence changes in loneliness in caregivers over time. Methods : prospective, repeated measures survey design was utilized to examine levels of loneliness and factors that influence loneliness in 129 family caregivers of individuals undergoing cancer treatment at three time points over a six month period. Measures included: PROMIS global health and sleep disturbance; NIH [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité des médicaments anticancéreux approuvés par la "Food and Drug Admnistration" entre 2012 et 2017 (106 essais, 52 médicaments pour 96 indications)

Clinical benefit and cost of breakthrough cancer drugs approved by the US Food and Drug Administration

Molto, Consolación ; Hwang, Thomas J. ; Borrell, Maria ; Andres, Marta ; Gich, Ignasi ; Barnadas, Agustí ; Amir, Eitan ; Kesselheim, Aaron S. ; Tibau, Ariadna

Background : The clinical benefit and pricing of breakthrough-designated cancer drugs are uncertain. This study compares the magnitude of the clinical benefit and monthly price of new and supplemental breakthrough-designated and non–breakthrough-designated cancer drug approvals. Methods : A cross-sectional cohort comprised approvals of cancer drugs for solid tumors from July 2012 to December 2017. For each indication, the clinical benefit from the pivotal trials was scored via validated [...]

Cette étude analyse la possibilité d'utiliser les registres américains des cancers pour mener des études épidémiologiques incluant des patients ayant survécu à un cancer aux Etats-Unis

Utilizing SEER Cancer Registries for Population-Based Cancer Survivor Epidemiologic Studies: A Feasibility Study

Gallicchio, Lisa ; Elena, Joanne W. ; Fagan, Sarah ; Carter, Marjorie ; Hamilton, Ann S. ; Hastert, Theresa A. ; Hunter, Lisa L. ; Li, Jie ; Lynch, Charles F. ; Milam, Joel ; Millar, Morgan M. ; Modjeski, Denise ; Paddock, Lisa E. ; Reed, Amanda R. ; Moses, Lisa B. ; Stroup, Antoinette M. ; Sweeney, Carol ; Trapido, Edward J. ; West, Michele M. ; Wu, Xiao-Cheng ; Helzlsouer, Kathy J.

Background: While the primary role of central cancer registries in the United States is to provide vital information needed for cancer surveillance and control, these registries can also be leveraged for population-based epidemiologic studies of cancer survivors. This study was undertaken to assess the feasibility of using the NCI's Surveillance, Epidemiology, and End Results (SEER) Program registries to rapidly identify, recruit, and enroll individuals for survivor research studies and to [...]