Menée en Suède par questionnaire auprès de 117 228 femmes (durée médiane de suivi : 20,5 ans), cette étude analyse l'association entre une consommation de café (quantité, type de filtration) et la mortalité toutes causes confondues (16 106 décès) et par cancer

Coffee consumption and overall and cause-specific mortality: the Norwegian Women and Cancer Study (NOWAC)

Lukic, Marko ; Barnung, Runa Borgund ; Skeie, Guri ; Olsen, Karina Standahl ; Braaten, Tonje

Coffee consumption has previously been reported to reduce overall and cause-specific mortality. We aimed to further investigate this association by coffee brewing methods and in a population with heavy coffee consumers. The information on total, filtered, instant, and boiled coffee consumption from self-administered questionnaires was available from 117,228 women in the Norwegian Women and Cancer (NOWAC) Study. We used flexible parametric survival models to calculate hazard ratios (HR) and 95% [...]

A partir de données de la cohorte européenne EPIC portant sur 270 112 participants (durée moyenne de suivi : 13,7 ans), cette étude analyse l'association entre une consommation d'agrumes et le risque de cancer de la peau (8 448 cas)

Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)

Mahamat-Saleh, Yahya ; Cervenka, Iris ; Al-Rahmoun, Marie ; Mancini, Francesca R. ; Severi, Gianluca ; Ghiasvand, Reza ; Veierod, Marit B. ; Caini, Saverio ; Palli, Domenico ; Botteri, Edoardo ; Sacerdote, Carlotta ; Ricceri, Fulvio ; Trichopoulou, Antonia ; Peppa, Eleni ; La Vecchia, Carlo ; Overvad, Kim ; Dahm, Christina C. ; Olsen, Anja ; Tjønneland, Anne ; Perez-Cornago, Aurora ; Jakszyn, Paula ; Grioni, Sara ; Schulze, Matthias B. ; Skeie, Guri ; Lasheras, Cristina ; Colorado-Yohar, Sandra ; Rodriguez-Barranco, Miguel ; Kühn, Tilman ; Katzke, Verena A. ; Amiano, Pilar ; Tumino, Rosario ; Panico, Salvatore ; Ezponda, Ana ; Sonestedt, Emily ; Scalbert, Augustin ; Weiderpass, Elisabete ; Boutron-Ruault, Marie-Christine ; Kvaskoff, Marina

Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific [...]

Cette étude passe en revue les preuves actuelles sur les facteurs de risque modifiables du cancer de l'ovaire, en particulier les facteurs liés au mode de vie tels que la nutrition et l'activité physique mais aussi les interventions chirurgicales et la chimioprévention

Ovarian Cancer: Lifestyle, Diet and Nutrition

El-Sherif, Ahmed ; El-Sherif, Sherif ; Taylor, Anthony Henry ; Ayakannu, Thangesweran

Background and aims: Ovarian cancer is the leading cause of female reproductive cancer death. It is estimated that dietary habits accounts for 30% of all cancers. This review sets out what we know about the food, nutrition and lifestyle factors that cause ovarian cancer, affect women with ovarian cancer and the problems associated with study design that may affect its prevention and patient survival. Methods: Studies reporting lifestyle, diet, nutritional benefits in ovarian cancer patients [...]

Menée en Europe par entretiens auprès de 1 053 patients atteints d'un cancer rare et 3 146 témoins (âge : 35-69 ans), cette étude identifie les expositions professionnelles associées au risque de développer un cancer de l'intestin grêle, du thymus, des voies biliaires et du sein chez l'homme ainsi qu'un sarcome osseux et un mélanome uvéal

Rare cancers of unknown etiology: lessons learned from a European multi-center case–control study

Lynge, Elsebeth ; Kaerlev, Linda ; Olsen, Jørn ; Sabroe, Svend ; Afonso, Noemia ; Ahrens, Wolfgang ; Eriksson, Mikael ; Merletti, Franco ; Morales-Suarez-Varelas, Maria ; Stengrevics, Aivars ; Guénel, Pascal

Rare cancers together constitute one fourth of cancers. As some rare cancers are caused by occupational exposures, a systematic search for further associations might contribute to future prevention. We undertook a European, multi-center case–control study of occupational risks for cancers of small intestine, bone sarcoma, uveal melanoma, mycosis fungoides, thymus, male biliary tract and breast. Incident cases aged 35–69 years and sex-and age-matched population/colon cancer controls were [...]

Menée à partir des données 1992-2010 des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" portant sur 17 904 femmes et sur 25 582 hommes, cette étude analyse l'association entre une maladie parodontale, le nombre de dents perdues et le risque de développer des polypes dentelés (2 336 cas) ou des adénomes colorectaux (4 102 cas), en fonction du statut tabagique

Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas

Lo, Chun-Han ; Nguyen, Long H. ; Wu, Kana ; Ogino, Shuji ; Chan, Andrew T. ; Giovannucci, Edward L. ; Song, Mingyang

Growing data indicate an association between periodontal disease and the development of cancer. However, the evidence for colorectal cancer has been inconsistent and longitudinal study examining its precursor lesions is lacking. We prospectively collected information on periodontal disease and number of tooth loss in the Nurses' Health Study (1992–2002) and the Health Professionals Follow-up Study (1992–2010). Polyp diagnosis was acquired via self-reported questionnaires and confirmed through [...]

Menée aux Etats-Unis à partir de données 2003-2017 de la cohorte "Sister study" portant sur 49 968 femmes (âge : 35-74 ans ; durée moyenne de suivi : 9,3 ans), cette étude analyse l'association entre une maladie parodontale et le risque de cancer du sein (3 339 cas)

The association between periodontal disease and breast cancer in a prospective cohort study

Jia, Mengmeng ; Wu, Zeni ; Vogtmann, Emily ; O'Brien, Katie M. ; Weinberg, Clarice R. ; Sandler, Dale P. ; Gierach, Gretchen L.

Periodontal disease may be associated with increased breast cancer risk, but studies have not considered invasive breast cancer and ductal carcinoma in situ (DCIS) separately in the same population. We assessed the relationship between periodontal disease and breast cancer in a large prospective cohort study. The Sister Study followed women without prior breast cancer aged 35-74 years from 2003-2017 (N=49,968). Baseline periodontal disease was self-reported, and incident breast cancer was [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2020 (9 études, 826 patients et 898 témoins), cette méta-analyse évalue l'association entre une infection par le virus de la leucémie bovine et le risque de cancer du sein

Bovine Leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies

Khatami, Alireza ; Pormohammad, Ali ; Farzi, Rana ; Saadati, Hassan ; Mehrabi, Maryam ; Kiani, Seyed Jalal ; Ghorbani, Saied

Background: Breast cancer is reported as one of the most common cancers among females worldwide. Infectious agents especially viruses have been considered as role players in the development of breast cancer. Although some investigations suggest an association between bovine leukemia virus (BLV) and breast cancer, the involvement of this virus as a risk factor remains controversial. The present study aimed to find out any possible association between BLV and breast cancer through conducting a [...]

Menée au Danemark auprès de 6 809 femmes (âge médian : 27-28 ans), cette étude analyse l'association entre l'indice de masse corporelle et le risque d'infection par le papillomavirus humain ou de la persistence de ce dernier

The role of body mass index in incidence and persistence of cervical human papillomavirus infection

Urbute, Aivara ; Thomsen, Louise T. ; Belmonte, Federica ; Kesmodel, Ulrik Schiøler ; Frederiksen, Kirsten ; Kjaer, Susanne K.

Purpose: To assess the association between body mass index (BMI) and incident or persistent cervical high-risk human papillomavirus (hrHPV) infection. Methods: This cohort study included 6,809 women from the general Danish population who participated in two clinical visits (in 1991–1993 and 1993–1995). Height and weight were measured by nurses, lifestyle data were obtained by structured interviews, and cervical cytology samples were obtained for hrHPV DNA testing. We conducted log-binomial [...]

Menée en Corée du Sud à partir de données de l'assurance maladie portant sur 351 701 individus, cette étude analyse le risque de cancer chez des patients utilisant des opioïdes pour traiter des douleurs chroniques non liées à la maladie

Chronic opioid use and risk of cancer in patients with chronic non-cancer pain: A nationwide historical cohort study

Oh, Tak Kyu ; Song, In-Ae

Background: To investigate whether chronic opioid therapy is associated with a higher risk of cancer among non-cancer patients with chronic pain. Methods: A population-based historical cohort study of the South Korean adult population was conducted using data from the National Health Insurance Service. We included patients registered with a diagnostic code of M00-M99 (musculoskeletal system and connective tissue diseases) according to the International Classification of Diseases, 10th revision, [...]

Menée au Canada à l'aide de données portant sur 2 cohortes incluant 2 260 participants, cette étude analyse l'association entre les tatouages et le risque de lymphome non hodgkinien (737 cas) et de myélome multiple (373 cas)

Tattoos and hematological malignancies in British Columbia, Canada

Warner, Freda M ; Darvishian, Maryam ; Boyle, Terry ; Brooks-Wilson, Angela R ; Connors, Joseph M ; Lai, Agnes S ; Le, Nhu D ; Song, Kevin ; Sutherland, Heather ; Woods, Ryan R ; Bhatti, Parveen ; Spinelli, John J.

Background: Tattoos may cause a variety of adverse reactions in the body, including immune reactions and infections. However, it is unknown whether tattoos may increase the risk of lymphatic cancers such as non-Hodgkin Lymphoma (NHL) and multiple myeloma (MM). Methods: Participants from two population-based case-control studies were including in logistic regression models to examine the association between tattoos and risk of NHL and MM. Results: A total of 1518 participants from the NHL study [...]

Menée en France à partir de données du SNDS portant sur 122 373 patientes ayant survécu à un cancer du sein diagnostiqué entre 2007 et 2015 et traité par chimiothérapie adjuvante avec ou sans G-CSF (âge médian : 55 ans ; durée médiane de suivi : 4,9 ans), cette étude analyse le risque de cancer hématologique lié au traitement (781 cas)

Risk of secondary hematologic malignancies associated with breast cancer chemotherapy and G-CSF support: a nationwide population-based cohort

Jabagi, M-J. ; Vey, N. ; Goncalves, A. ; Le Tri, T. ; Zureik, M. ; Dray-spira, R.

This study aimed to analyze the risk of hematologic malignancies (HM) associated with the use of G-CSF with chemotherapy for BC. Using the French National Health Data System, we examined the HM risks in patients diagnosed with an incident breast cancer between 2007 and 2015, who received chemotherapy for BC. Main outcomes were acute myeloid leukemia (AML), Myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), multiple myeloma (MM), Hodgkin lymphoma or non–Hodgkin lymphoma [...]

Menée à partir de données portant sur 1 464 femmes ayant survécu à un cancer hématologique au moins 2 ans après avoir reçu, entre 1974 et 2014, une greffe de cellules souches hématopoïétiques (durée médiane de suivi : 9,3 ans), cette étude analyse l'association entre un traitement par irradiation corporelle totale et le risque de cancer du sein (37 cas)

Total Body Irradiation and Risk of Breast Cancer After Blood or Marrow Transplantation: A Blood or Marrow Transplantation Survivor Study Report

Andrew M. McDonald ; Yanjun Chen ; Jessica Wu ; Lindsey Hageman ; Liton Francisco ; Michelle Kung ; F. Lennie Wong ; Emily Ness ; Wendy Landier ; Kevin Battles ; Donna Salzman ; Daniel J. Weisdorf ; Stephen J. Forman ; Mukta Arora ; Saro H. Armenian ; Smita Bhatia

PURPOSE: To examine the association between total body irradiation (TBI) and subsequent breast cancer in women treated with blood or marrow transplantation (BMT) for hematologic malignancies. PATIENTS AND METHODS: Participants were drawn from the BMT Survivor Study (BMTSS), a retrospective cohort study that included patients who underwent transplantation between 1974 and 2014 and survived for ≥ 2 years after BMT. Patients with pre-BMT chest radiation or a history of breast cancer were excluded. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2019 (22 études), cette méta-analyse évalue l'association quantitative entre la protéine C-réactive et la mortalité par cancer

Dose-response Association between C-Reactive Protein and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Meta-Analysis of Cohort Studies

Ni, Peng ; Yu, Mingyang ; Zhang, Rongguang ; Cheng, Cheng ; He, Mengya ; Wang, Haiyan ; Chen, Shuaiyin ; Duan, Guangcai

Purpose: To quantitatively assess the association between CRP and all-cause, cardiovascular disease (CVD), and cancer mortality, a dose-response meta-analysis was performed on data from cohort studies in general population. Methods: The published relevant articles were searched for in PubMed, Web of Science, and Embase until September 21, 2019. The pooled relative risk (RR) was estimated by random effects of generalized least square regression models. The dose-response relationship was modeled [...]

Menée au Royaume-Uni à partir de données de la "UK Biobank" portant sur 425 793 personnes (durée moyenne de suivi : 7,1 ans), cette étude analyse l'association entre le niveau sérique de différentes hormones sexuelles et le risque de cancer du pancréas (225 cas), du rein (749 cas) et du cerveau (467 cas)

Association of Sex Hormones with Risk of Cancers of the Pancreas, Kidney, and Brain in the UK Biobank Cohort Study

Peila, Rita ; Arthur, Rhonda S. ; Rohan, Thomas E.

Background: There is some evidence to suggest that endogenous levels of sex hormones might influence the etiology of cancers of the pancreas, kidney, and brain, but epidemiologic data are lacking. Methods: We evaluated the association of circulating levels of total and free testosterone, and of sex hormone–binding globulin (SHBG), with the risk of cancers of the pancreas, kidney, and brain, and of total and free estradiol with the risk of kidney cancer, in the UK Biobank cohort study (n = [...]

Menée en Chine à l'aide d'échantillons sanguins collectés auprès de 26 540 adultes, cette étude analyse l'association entre la longueur des télomères leucocytaires et le risque de cancer (4 353 cas) ou la mortalité toutes causes confondues (7 609 décès)

Leukocyte Telomere Length, Cancer Incidence and All-cause Mortality among Chinese Adults: Singapore Chinese Health Study

Samavat, Hamed ; Luu, Hung N. ; Beckman, Kenneth B. ; Jin, Aizhen ; Wang, Renwei ; Koh, Woon-Puay ; Yuan, Jian-Min

Telomeres play a key role in chromosomal maintenance and stability. To date, few studies have investigated the association of leukocyte telomere length with risk of cancer incidence and allcause mortality in a large prospective cohort, particularly of the Asian population. Relative telomere lengths in genomic DNA from peripheral blood samples were quantified using a validated quantitative real-time PCR among 26,540 middle-aged or older Chinese adults. Hazard ratios (HRs) and 95% confidence [...]

Menée au Royaume-Uni à partir de données 2006-2016 de la "UK Biobank" portant sur 390 575 individus (âge : 37-73 ans ; durée médiane de suivi : 7,8 ans), cette étude analyse l'association entre le syndrome métabolique et le risque de cancer lié à l'obésité

Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study

Cao, Zhi ; Zheng, Xiaomin ; Yang, Hongxi ; Li, Shu ; Xu, Fusheng ; Yang, Xilin ; Wang, Yaogang

Background: Obesity and metabolic syndrome (MetS) appear in clusters and are both associated with an increased risk of cancer. However, it remains unknown whether obesity status with or without MetS increases the risk of site-specific cancers. Methods: We used data derived from 390,575 individuals (37–73 years old) from the UK Biobank who were enrolled from 2006–2016 with a median of 7.8 years of follow-up. Obesity was defined by BMI ≥ 30 kg/m2 and MetS was defined by the criteria of the Adult [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2019 (124 articles), cette étude analyse le rôle du microbiome dans la carcinogenèse

The human microbiome in relation to cancer risk: a systematic review of epidemiological studies

Huybrechts, Inge ; Zouiouich, Semi ; Loobuyck, Astrid ; Vandenbulcke, Zeger ; Vogtmann, Emily ; Pisanu, Silvia ; Iguacel, Isabel ; Scalbert, Augustin ; Indave, Iciar ; Smelov, Vitaly ; Gunter, Marc J. ; Michels, Nathalie

The microbiome has been hypothesized to play a role in cancer development. Due to the diversity of published data, an overview of available epidemiological evidence linking the microbiome with cancer is now needed. We conducted a systematic review using a tailored search strategy in Medline and EMBASE databases to identify and summarize the current epidemiologic literature on the relationship between the microbiome and different cancer outcomes published until December 2019. One hundred and [...]

Menée en Corée à partir de données de l'assurance maladie portant sur 1 953 123 patients ayant réalisé un bilan de santé entre 2012 et 2013 (âge : au moins 18 ans ; durée médiane de suivi : 4,4 ans), cette étude analyse l'association entre une hyperfiltration glomérulaire et le risque de cancer digestif et hépatique

Glomerular hyperfiltration and cancer: a nationwide population-based study

Kim, Yaerim ; Lee, Soojin ; Lee, Yeonhee ; Kang, Min Woo ; Park, Sehoon ; Park, Sanghyun ; Han, Kyung-Do ; Paek, Jin Hyuk ; Park, Woo Yeong ; Jin, Kyubok ; Han, Seungyeup ; Han, Seung Seok ; Lee, Hajeong ; Lee, Jung Pyo ; Joo, Kwon Wook ; Lim, Chun Soo ; Kim, Yon Su ; Kim, Dong Ki

Background: Glomerular hyperfiltration is associated with all-cause mortality. Herein, we evaluated the association between glomerular hyperfiltration and the development of cancer, the most common cause of death, in an Asian population. Methods: We retrospectively reviewed the National Health Insurance Service database of Korea for people who received national health screenings from 2012 to 2013. Glomerular hyperfiltration was defined as the 95th percentile and greater after stratification by [...]

Menée à partir de données de 15 cohortes incluant au total 891 731 femmes, cette étude compare les facteurs de risque associés au cancer de l'ovaire, du péritoine et de la trompe de Fallope

Ovarian cancer risk factor associations by primary anatomic site: the Ovarian Cancer Cohort Consortium

Fortner, Renée Turzanski ; Rice, Megan S. ; Knutsen, Synnove F. ; Orlich, Michael J ; Visvanathan, Kala ; Patel, Alpa V. ; Gaudet, Mia M. ; Tjonneland, Anne ; Kvaskoff, Marina ; Kaaks, Rudolf ; Trichopoulou, Antonia ; Pala, Valeria ; Onland-Moret, N. Charlotte ; Gram, Inger T. ; Amiano, Pilar ; Idahl, Annika ; Allen, Naomi E ; Weiderpass, Elisabete ; Poynter, Jenny N ; Robien, Kim ; Giles, Graham G. ; Milne, Roger L ; Setiawan, V. Wendy ; Merritt, Melissa A. ; van den Brandt, Piet A. ; Zeleniuch-Jacquotte, Anne ; Arslan, Alan A ; O'Brien, Katie M. ; Sandler, Dale P. ; Wolk, Alicja ; Håkansson, Niclas ; Harris, Holly R ; Trabert, Britton ; Wentzensen, Nicolas ; Tworoger, Shelley S. ; Schouten, Leo J.

Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancer have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and [...]

Menée en Suède auprès de 777 patients atteints d'un cancer de la prostate et 777 témoins (durée de suivi : au moins 5 ans), cette étude identifie des métabolites plasmatiques associés au risque de développer la maladie, par catégorie d'âges et en fonction de l'agressivité de la tumeur

Identification of metabolites associated with prostate cancer risk: a nested case-control study with long follow-up in the Northern Sweden Health and Disease Study

Röhnisch, Hanna E. ; Kyrø, Cecilie ; Olsen, Anja ; Thysell, Elin ; Hallmans, Göran ; Moazzami, Ali A.

Background: Prostate cancer is the second most frequently diagnosed cancer in men. Metabolomics can potentially provide new insights into the aetiology of prostate cancer by identifying new metabolic risk factors. This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. Methods: In a case-control study nested in the Northern Sweden Health and Disease Study, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2019 (28 études), cette étude analyse l'association entre des facteurs nutritionnels et le statut mutationnel du gène KRAS chez des patients atteints d'un cancer colorectal

Associations between nutritional factors and KRAS mutations in colorectal cancer: a systematic review

El Asri, Achraf ; Zarrouq, Btissame ; El Kinany, Khaoula ; Bouguenouch, Laila ; Ouldim, Karim ; El Rhazi, Karima

Background: Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific associations between KRAS mutations in CRC and diet are sparse. Here, we conducted a systematic review to summarize the current epidemiological evidence on the association between various dietary factors and KRAS mutations. Methods: PubMed, Science Direct, and Cochrane [...]

Menée à partir de données d'examens mammographiques réalisés auprès de plus d'1 million d'Américaines sur la période 1994-2016 (âge : 35-84 ans ; durée médiane de suivi : 5,2 ans), cette étude estime la part des cancers du sein attribuable à l'indice de masse corporelle et à la densité mammaire, en fonction de l'origine ethnique et du statut ménopausique

Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status

Bissell, Michael C.S. ; Kerlikowske, Karla ; Sprague, Brian L. ; Tice, Jeffrey A. ; Gard, Charlotte C. ; Tossas, Katherine Y ; Rauscher, Garth H. ; Trentham-Dietz, Amy ; Henderson, Louise M. ; Onega, Tracy ; Keegan, Theresa H.M. ; Miglioretti, Diana L

Background: Overweight/obesity and dense breasts are strong breast cancer risk factors whose prevalences vary by race/ethnicity. The breast cancer population attributable risk proportions (PARPs) explained by these factors across racial/ethnic groups are unknown. Methods: We analyzed data collected from 3,786,802 mammography examinations (1,071,653 women) in the Breast Cancer Surveillance Consortium, associated with 21,253 invasive breast cancers during a median of 5.2 years follow-up. Hazard [...]