A partir d'une revue de la littérature (3 études, 1 086 patients), cette méta-analyse évalue l'efficacité du granisétron, dispensé par voie orale ou par voie transdermique, pour traiter les nausées et vomissements induits par la chimiothérapie

Transdermal versus oral granisetron in controlling chemotherapy-induced nausea and vomiting: a meta-analysis

Chua, Alfredo V. ; Hernandez, Aylmer Rex B. ; Real, Irisyl O.

Purpose : To compare the efficacy of transdermal granisetron versus oral granisetron in controlling chemotherapy-induced nausea and vomiting (CINV) in patients with cancer Methods : Data sources were CENTRAL, MEDLINE, EMBASE, Clinicaltrials.gov, and Google Scholar. Inclusion criteria included randomized controlled trials comparing transdermal versus oral granisetron in patients with CINV. For data extraction, two authors independently analyzed the methodological quality and extracted data. A [...]

Menée auprès de 94 patients atteints d'un cancer, cette étude de cohorte rétrospective évalue l'efficacité de la méthadone pour réduire l'intensité de la douleur liée à la maladie

The role of methadone in cancer-induced bone pain: a retrospective cohort study

Sulistio, Merlina ; Wojnar, Robert ; Key, Seraphina ; Kwok, Justin ; Al-Rubaie, Ziad ; Michael, Natasha

Purpose : Cancer-induced bone pain (CIBP) can be challenging to manage in advanced cancer. The unique properties of methadone may have a role in refractory CIBP. We aimed to evaluate the analgesic effects of methadone for CIBP when other opioids are ineffective or intolerable. Methods : A retrospective study of palliative care inpatients rotated to methadone from another opioid for CIBP over a 4-year period. Primary outcome was ≥ 30% reduction in pain intensity (11-point numeric rating scale) [...]

Menée en Allemagne auprès de 232 aidants familiaux de patients atteints d'un cancer de stade avancé, cette étude prospective longitudinale analyse leurs besoins en soins psychosociaux pendant les soins palliatifs du patient, au moment du décès et pendant le deuil

Supportive care needs and service use during palliative care in family caregivers of patients with advanced cancer: a prospective longitudinal study

Ullrich, Anneke ; Marx, Gabriella ; Bergelt, Corinna ; Benze, Gesine ; Zhang, Youyou ; Wowretzko, Feline ; Heine, Julia ; Dickel, Lisa-Marie ; Nauck, Friedemann ; Bokemeyer, Carsten ; Oechsle, Karin

Purpose : This study aimed to investigate the supportive care needs of family caregivers (FCs) of advanced cancer patients and their support service use at the beginning of specialist inpatient palliative care (SIPC), near the patient’s death, and during bereavement. Methods : FCs reported their needs using the Family Inventory of Needs (FIN), along with their utilization of psychosocial and bereavement support services at the beginning (N = 232) and 6–9 months after SIPC (N = 160). Results : [...]

Menée aux Etats-Unis par enquête auprès de 485 patientes atteintes d’un cancer du sein HR+, cette étude analyse l’association entre la pratique d’une activité physique, leur qualité de vie et leurs symptômes liés à une thérapie endocrinienne adjuvante

Physical activity, health-related quality of life, and adjuvant endocrine therapy–related symptoms in women with hormone receptor–positive breast cancer

Vanessa B. Sheppard, Chiranjeev Dash, Sarah Nomura (et al.)

Background : Physical activity (PA) is recommended for women with breast cancer (BC); however, data are sparse on the association of PA with quality of life (QOL) and patient?reported symptoms for women on adjuvant endocrine therapy (AET). Methods : Women with hormone receptor–positive BC who were taking AET completed standardized surveys about their health?related QOL, AET?related symptoms, and levels of PA using validated measures. A Wald chi?square test and an analysis of variance were used [...]

A partir des données de la base GLOBOCAN, cette étude présente une estimation mondiale de l'incidence du cancer de l'œsophage et de l'estomac par sous-type pour l'année 2018

Global burden of oesophageal and gastric cancer by histology and subsite in 2018

Arnold, Melina ; Ferlay, Jacques ; van Berge Henegouwen, Mark I ; Soerjomataram, Isabelle

Objectives :To provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type. Methods :Using data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC) out of all oesophageal as well as cardia gastric cancer (CGC) and non-CGC (NCGC) out of all gastric cancer cases were computed by country, sex and age group. Proportions were subsequently applied to the estimated numbers of oesophageal [...]

Menée aux Etats-Unis à partir des données d'une enquête portant sur 26 742 répondants (âge moyen : 51 ans), cette étude analyse les comportements tabagiques des patients ayant survécu à un cancer (3 068 cas), qu'il soit lié au tabagisme ou non

Smoking Behaviors in Survivors of Smoking-Related and Non–Smoking-Related Cancers

Gritz, Ellen R. ; Talluri, Rajesh ; Fokom Domgue, Joël ; Tami-Maury, Irene ; Shete, Sanjay

The population of cancer survivors is rapidly growing in the US. Tobacco smoking is associated with many cancers; however, whether cigarette smoking behaviors among cancer survivors vary according to cancer type—that is, smoking-related cancers (SRCs) vs non–smoking-related cancers (NSRCs)—remains unclear.To examine cigarette smoking prevalence and behaviors (ie, continuing or quitting smoking) among cancer survivors and to compare them between survivors of SRCs and NSRCs.This study was a [...]

Menée en Allemagne à partir de données portant sur des patientes ayant survécu à un cancer du sein (âge : 50-74 ans), cette étude de cohorte prospective analyse l'association entre des changements de poids après le diagnostic, la survie sans récidive et la mortalité

Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: a prospective population-based patient cohort study

Jung, Audrey Y. ; Hüsing, Anika ; Behrens, Sabine ; Krzykalla, Julia ; Obi, Nadia ; Becher, Heiko ; Chang-Claude, Jenny

More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective population-based patient cohort study (MARIE) conducted in two geographical regions of Germany. Breast cancer patients diagnosed 50-74 years of age with an incident invasive breast cancer [...]

Menée à partir des données du registre danois des cancers portant sur 261 745 patients atteints d'un cancer primitif diagnostiqué entre 2005 et 2015 (20 types de cancers), cette étude analyse la prévalence de comorbidités et l'utilisation d'une polypharmacie au moment du diagnostic

Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication

Loeppenthin, Katrine ; Dalton, Susanne Oksbjerg ; Johansen, Christoffer ; Andersen, Elisabeth ; Christensen, Mikkel Bring ; Pappot, Helle ; Petersen, Lone Nørgaard ; Thisted, Lise Bjerrum ; Frølich, Anne ; Mortensen, Christiane Ehlers ; Lassen, Ulrik ; Ørsted, Jytte ; Bidstrup, Pernille Envold

Background : Multimorbidity is a growing challenge worldwide. In this nationwide study, we investigated the prevalence of multimorbidity and polypharmacy at the time of diagnosis across 20 cancers. Methods : We conducted a nationwide register-based cohort study of all Danish residents with a first primary cancer diagnosed between 1 January 2005 and 31 December 2015. Multimorbidity was defined as one or more of 20 conditions (131 specific diagnoses) registered in the Danish National Patient [...]

A partir d'une revue systématique de la littérature (12 études, 28 626 patients), cette méta-analyse évalue la fréquence d'une embolie pulmonaire chez des patients atteints d'un cancer, en fonction de la localisation

Incidental pulmonary embolism in oncologic patients—a systematic review and meta-analysis

Meyer, Hans-Jonas ; Wienke, Andreas ; Surov, Alexey

Purpose : Incidental pulmonary embolism (IPE) is a common finding on computed tomography (CT). IPE is frequent in oncologic patients undergoing staging CT. The aim of this analysis was to provide the pooled frequency of IPE and frequencies of IPE in different primary tumors. Methods : MEDLINE, SCOPUS, and EMBASE databases were screened for studies investigating frequency of IPE in oncologic staging CT up to February 2020. Overall, 12 studies met the inclusion criteria and were included into the [...]

Menée au Canada par entretiens auprès de 25 jeunes adultes ayant survécu à un cancer pédiatrique, cette étude qualitative analyse leurs expériences face au sentiment d’incertitude vis-à-vis de leur fertilité

Facing the unknown: uncertain fertility in young adult survivors of childhood cancer

Kelly Newton, A. Fuchsia Howard, Sally Thorne, Mary T. Kelly, Karen Goddard

Purpose : The purpose of this research was to describe the challenges young adult childhood cancer survivors (ACCS) experience of living with an unknown fertility status. Methods : In this qualitative study, we analyzed data from in-depth interviews with 25 ACCS (15 females, 10 males) using content-driven inductive thematic analysis and constant comparative techniques. Results : Three themes provide insight into ACCS’ experiences of living with an uncertain fertility status. (1) The marked [...]

Mené sur 269 patientes ayant survécu à un cancer, cet essai randomisé évalue l'intérêt, pour réduire leur détresse émotionnelle, leur stress post-traumatique et améliorer leur croissance post-traumatique, d'une psychothérapie dispensée par vidéo conférence ou en face à face en groupe

Video Conference vs Face-to-Face Group Psychotherapy for Distressed Cancer Survivors: A Randomized Controlled Trial

Lleras de Frutos, María ; Medina, Joan Carles ; Vives, Jaume ; Casellas-Grau, Anna ; Marzo, Jose Luis ; Borràs, Josep M. ; Ochoa-Arnedo, Cristian

Objective : This study assesses the effectiveness of face‐to‐face group positive psychotherapy for cancer survivors (PPC) compared to its online adaptation, online group positive psychotherapy for cancer survivors (OPPC), which is held via videoconference. A two‐arm, pragmatic RCT was conducted to examine the effects of both interventions on emotional distress, posttraumatic stress (PTSS) and posttraumatic growth (PTG) among cancer survivors and analyze attrition to treatment. Methods : Adult [...]

Menée en Australie par questionnaire auprès de 213 231 participants sur la période 2006-2009, cette étude analyse la présence de déficiences physiques et d’une détresse psychologique chez des patients ayant survécu à un cancer colorectal (2 395 cas)

Physical functional limitations and psychological distress in people with and without colorectal cancer: findings from a large Australian study

Yuehan Zhang, Grace Joshy, Kathryn Glass, Emily Banks (et al.)

Purpose : To quantify physical disability and psychological distress in people with and without colorectal cancer (CRC).Methods : Questionnaire data (2006–2009) from 267,153 Australian general population members aged ? 45 years participating in the 45 and Up Study (n = 213,231 following exclusions) were linked to cancer registry and hospital admission data, to ascertain CRC status. Modified Poisson regression estimated adjusted prevalence ratios (PRs) for physical disability and psychological [...]

Menée en France à partir de données portant sur 264 patientes atteintes d’un cancer du sein de stade invasif et sur 132 témoins, cette étude prospective analyse leurs déficiences cognitives avant un traitement (chirurgie ou traitement néoadjuvant)

Cognitive impairment in breast cancer patients before surgery: results from a CANTO cohort subgroup

Marie Lange, Isabelle Hardy-Léger, Idlir Licaj, Barbara Pistilli (et al.)

Background:20-30% of breast cancer patients have cognitive impairment after surgery and before adjuvant treatment, but very few studies have focused on cognition before any treatment. The present study used a subgroup of women with newly diagnosed breast cancer patients from the French cancer and toxicities (CANTO) cohort to describe cognition before any treatment in comparison to a group of healthy controls (HC). Methods:Cognitive assessment was performed before any breast cancer treatment [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2019 (29 études observationnelles), cette étude analyse l'association entre des périodes d'interruption dans la couverture de santé, l'utilisation des soins en oncologie (prévention, dépistage, traitements) et la survie

Health Insurance Coverage Disruptions and Cancer Care and Outcomes: Systematic Review of Published Research

Yabroff, K Robin ; Reeder-Hayes, Katherine ; Zhao, Jingxuan ; Halpern, Michael T ; Lopez, Ana Maria ; Bernal-Mizrachi, Leon ; Collier, Anderson B ; Neuner, Joan ; Phillips, Jonathan ; Blackstock, William ; Patel, Manali

Background : Lack of health insurance coverage is associated with poor access and receipt of cancer care and survival in the United States. Disruptions in coverage are common among low-income populations, but little is known about associations of disruptions with cancer care, including prevention, screening, and treatment, as well as outcomes of stage at diagnosis and survival. Methods : We conducted a systematic review of studies of health insurance coverage disruptions and cancer care and [...]

Menée en Chine à partir de données portant sur 7 436 patientes atteintes d'un cancer invasif du sein diagnostiqué entre 2009 et 2016, cette étude de cohorte prospective analyse l'association entre les caractéristiques de l'assurance individuelle de santé et la mortalité spécifique (durée médiane de suivi : 3,1 ans ; 326 décès)

Public health insurance and cancer-specific mortality risk among patients with breast cancer: a prospective cohort study in China

Xie, Yuxin ; Valdimarsdóttir, Unnur A. ; Wang, Chengshi ; Zhong, XiaoRong ; Gou, Qiheng ; Zheng, Hong ; Deng, Ling ; He, Ping ; Hu, Kejia ; Fall, Katja ; Fang, Fang ; Tamimi, Rulla M. ; Luo, Ting ; Lu, Donghao

Little is known about how health insurance policies, particularly in developing countries, influence breast cancer prognosis. Here, we examined the association between individual health insurance and breast cancer-specific mortality in China. We included 7436 women diagnosed with invasive breast cancer between 2009 and 2016, at West China Hospital, Sichuan University. The health insurance plan of patient was classified as either urban or rural schemes and was also categorized as reimbursement [...]

Menée au Canada auprès de 430 patients atteints d’un cancer de la tête et du cou, cette étude analyse l’intérêt d’un outil pour identifier et mesurer les difficultés financières induites par les traitements anticancéreux

Measuring financial toxicity incurred after treatment of head and neck cancer: Development and validation of the Financial Index of Toxicity questionnaire

Katrina Hueniken, Catriona M. Douglas, MBChB, Ashok R. Jethwa (et al.)

Background : The treatment of head and neck cancer (HNC) may cause significant financial toxicity to patients. Herein, the authors have presented the development and validation of the Financial Index of Toxicity (FIT) instrument. Methods : Items were generated using literature review and were based on expert opinion. In item reduction, items with factor loadings of a magnitude <0.3 in exploratory factor analysis and inverse correlations (r < 0) in test?retest analysis were eliminated. Retained [...]

Menée en Belgique par entretiens auprès de 25 patients atteints d’un cancer incurable, cette étude qualitative analyse leur volonté de discuter avec leur médecin au sujet des soins palliatifs

The perception of people with cancer of starting a conversation about palliative care: A qualitative interview study

Anne-Lore Scherrens, Joachim Cohen, Annick Mahieu, Luc Deliens (et al.)

Objective : Communication and patient?centred care are important determinants for timely initiation of palliative care. Therefore, we aimed to understand and explain the behaviour “starting a conversation about palliative care with a professional carer” from the perspective of people with incurable cancer. Methods : A qualitative study using semi?structured face?to?face interviews with 25 people with incurable cancer: 13 not (yet) receiving palliative care and 12 receiving palliative care; 4 [...]

Menée aux Etats-Unis, cette étude analyse l’état actuel de l’intégration des services de soins palliatifs dans deux types de centres de lutte contre les cancers

State of Integration of Palliative Care at National Cancer Institute–Designated and Nondesignated Cancer Centers

David Hui, Allison De La Rosa, Eduardo Bruera

Timely integration of specialist palliative care (PC) to oncologic care is associated with improved patient outcomes.Although several studies have examined supportive and palliative care services at US cancer centers, none to our knowledge have assessed the level of integration using a standardized set of indicators. In this study, we compared the level of integration between National Cancer Institute (NCI)–designated and non–NCI-designated cancer centers.

Menée à partir des données des registres américains des cancers et de la base Medicare portant sur 139 191 personnes décédées d’un cancer hématologique entre 2001 et 2015 (leucémie, lymphome, myélome, syndrome myélodysplasique), cette étude analyse l’utilisation précoce de soins palliatifs et l’association entre cette utilisation et l’agressivité des soins de fin de vie

Early Palliative Care Services and End-of-Life Care in Medicare Beneficiaries with Hematologic Malignancies: A Population-Based Retrospective Cohort Study

Vinay B. Rao, Emmanuelle Belanger, Pamela C. Egan, Thomas W. LeBlanc, and Adam J. Olszewski

Background: Patients with hematologic malignancies (HM) often receive aggressive care at the end of life (EOL). Early palliative care (PC) has been shown to improve EOL care outcomes, but its benefits are less established in HM than in solid tumors. Objectives: We sought to describe the use of billed PC services among Medicare beneficiaries with HM. We hypothesized that receipt of early PC services (rendered >30 days before death) may be associated with less aggressive EOL care. Design: [...]