A partir d’une revue systématique de la littérature (113 articles), cette étude analyse les facteurs associés au risque de mucite induite par les traitements chez des patients atteints d’un cancer

Prediction of mucositis risk secondary to cancer therapy: a systematic review of current evidence and call to action

H. R. Wardill, S. T. Sonis, N. M. A. Blijlevens, Y. Z. A. Van Sebille (et al.)

Purpose : Despite advances in personalizing the efficacy of cancer therapy, our ability to identify patients at risk of severe treatment side effects and provide individualized supportive care is limited. This is particularly the case for mucositis (oral and gastrointestinal), with no comprehensive risk evaluation strategies to identify high-risk patients. We, the Multinational Association for Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) Mucositis Study Group, [...]

A partir d’une revue systématique de la littérature (28 études qualitatives), cette étude analyse les expériences d’auto-prise en charge de patients âgés atteints d’un cancer et souffrant de comorbidités

Self-management in older people living with cancer and multi-morbidity: A systematic review and synthesis of qualitative studies

Teresa Corbett, Amanda Cummings, Lynn Calman (et al.)

Objective : Many older people with cancer live with multimorbidity. Little is understood about the cumulative impact of old age, cancer and multimorbidity on self-management. This qualitative systematic review and synthesis aimed to identify what influences self-management from the perspective of older adults living with cancer and multimorbidity. Methods : Six databases were systematically searched for primary qualitative research reporting older adults’ experiences of living with cancer and [...]

Menée en Allemagne à partir de données portant sur 4 215 patients atteints d’un lymphome hodgkinien (âge : 18-60 ans), cette étude longitudinale analyse l’évolution de leur qualité de vie, du diagnostic jusqu’à 5 ans après les traitements anticancéreux

Health-Related Quality of Life in Patients With Hodgkin Lymphoma: A Longitudinal Analysis of the German Hodgkin Study Group

Stefanie Kreissl, Horst Müller, Helen Goergen (et al.)

PURPOSE : Many important details of health-related quality of life (HRQoL) after diagnosis and treatment of Hodgkin lymphoma (HL) are still unknown because large longitudinal studies of HRQoL are rare. Therefore, we analyzed a systematically assessed, comprehensive range of HRQoL domains in patients with HL of all stages from diagnosis up to 5 years of survivorship. PATIENTS AND METHODS : We included patients with HL age 18-60 years at diagnosis from the German Hodgkin Study Group trials HD13, [...]

Menée dans 16 pays européens par enquête auprès de 1 174 patients ayant survécu 10 ans à un cancer, de 1 174 partenaires de vie et auprès de témoins, cette étude analyse leur utilisation de soins et de services de santé

Healthcare services and medication use among cancer survivors and their partners: a cross-sectional analysis of 16 European countries

Ana Rute Costa, Luís Alves, Nuno Lunet (et al.)

Purpose : To estimate the association between a cancer diagnosis and the use of healthcare services and medication among cancer survivors (CS) and their partners (PCS), particularly in the first years after diagnosis. Methods : This is a cross-sectional study based on data from the Fourth Wave of the Survey of Health, Ageing and Retirement in Europe—SHARE (2010–2011); it included individuals aged ??50 years and their partners, from 16 European countries. All CS diagnosed with a first primary [...]

Menée à partir des données du registre suédois des cancers portant sur 54 884 patients atteints d’un mélanome cutané primitif diagnostiqué depuis les années 1960, cette étude analyse l’évolution du risque de développer un nouveau mélanome primitif

Multiple primary melanoma incidence trends over five decades, a nation-wide population-based study

Hildur Helgadottir, Karolin Isaksson, Ildiko Fritz (et al.)

Background : Over the past decades many regions have experienced a steady increase in the incidence of cutaneous melanoma. Here, we report on incidence trends for subsequent primary melanoma. Methods : In this nationwide population-based study, patients diagnosed with a first primary cutaneous melanoma reported to the Swedish Cancer Registry, were followed for up to ten years for a diagnosis of subsequent primary melanoma. Patients were grouped with patients diagnosed with first melanoma in the [...]

Menée en Australie dans un contexte de vie réelle à partir de données portant sur 346 patients atteints d’un cancer du poumon non à petites cellules de stade métastatique ou récidivant (144 patients avec mutation KRAS et 65 patients avec mutation G12C du gène KRAS), cette étude analyse les facteurs associés à la présence de métastases cérébrales et à la survie globale

Real world outcomes in KRAS G12C mutation positive non-small cell lung cancer

Wanyuan Cui, Fanny Franchini, Marliese Alexander (et al.)

Background : KRAS mutations are found in 20-30% of non-small cell lung cancers (NSCLC) and were traditionally considered undruggable. KRAS G12C mutation confers sensitivity to KRAS G12C covalent inhibitors, however its prognostic impact remains unclear. This study assesses the frequency, clinical features, prevalence of brain metastases and outcomes in KRAS G12C NSCLC in a real-world setting. Methods : Patients enrolled in the prospective Thoracic Malignancies Cohort (TMC) between July 2012 to [...]

Menée à partir des données des registres américains des cancers portant sur 37 724 patientes âgées de plus de 66 ans et atteintes d’un cancer du sein de stade précoce, cette étude de cohorte rétrospective analyse l’association entre une utilisation de bisphosphonates ou de dénosumab et la survie (durée médiane de suivi : 64 mois)

Survival in older women with early stage breast cancer receiving low?dose bisphosphonates or denosumab

Maria E. Suarez?Almazor, Raul Herrera, Xiudong (et al.)

Background : Bisphosphonates and denosumab, as adjuvant therapy in breast cancer, have been associated in some studies with improved cancer outcomes. The potential benefits of these drugs used at the lower doses commonly given for osteoporosis have not been established. The objective of this study was to investigate the association between therapy with bone?modifying agents (BMAs) and survival in older women with early breast cancer. Methods : The authors conducted a retrospective cohort study [...]

A partir d’une revue systématique de la littérature publiée entre 2010 et 2019 (24 études qualitatives), cette méta-synthèse analyse les facteurs associés à l’adhésion à une thérapie endocrinienne adjuvante chez des patientes ayant survécu à un cancer du sein

Adherence to adjuvant endocrine therapy among breast cancer survivors: a systematic review and meta-synthesis of the qualitative literature using grounded theory

Othman AlOmeir, Nilesh Patel, Parastou Donyai

Purpose : Numerous studies have examined non-adherence to adjuvant endocrine therapy in women recovering from breast cancer, but none provides a comprehensive theory to explain the challenges of long-term medication taking and resilience needed to continue. The aim of this study was to source, appraise, and synthesize data from existing qualitative studies to develop an in-depth explanatory model of non-adherence and discontinuation of hormonal medication among breast cancer survivors. Methods [...]

Menée aux Etats-Unis à partir de données portant sur 1 508 patientes atteintes d’un cancer primitif du sein diagnostiqué en 1996-1997 et sur 1 556 témoins, cette étude analyse l’association entre l’utilisation d’un traitement hormonal substitutif de la ménopause, la mortalité spécifique et toutes causes confondues (durée médiane de suivi : 17,6 mois ; 597 décès par cancer du sein)

Menopausal hormone therapy use and long-term all-cause and cause-specific mortality in the Long Island Breast Cancer Study Project

Tengteng Wang, Patrick T. Bradshaw, Patricia G. Moorman, Sarah J. Nyante (et al.)

Previous studies have observed a reduced mortality risk associated with menopausal hormone therapy (MHT) use among breast cancer survivors. We sought to clarify whether such association could be explained by tumor heterogeneity, specific causes of death, confounding from co-morbidities or health behaviors, and a comparison group of women without breast cancer. We interviewed 1508 women newly diagnosed with first primary breast cancer in 1996-1997 (~3-months after diagnosis), and 1556 [...]

Menée à partir des données de l'Organisation Mondiale de la Santé, cette étude analyse l'évolution de la mortalité par cancer du col de l'utérus dans les pays d'Europe de l'Est, sur la période 1990-2017

Cervical Cancer Mortality in East-Central European Countries

Cezary Wojtyla,Michal Ciebiera,Dariusz Kowalczyk, Grzegorz Panek

Changes that took place in Europe in the early 1990s had an impact on health-associated issues. They were an impulse for the changes in healthcare systems and, consequently, also for the changes in cancer control programmes. Those changes also had an effect on mortality rates due to cervical cancer (CC). Therefore, the aim of this study is to analyse CC mortality trends in east-central Europe after 1990. Data on deaths due to CC were retrieved from the WHO Mortality Database. Trends in [...]

Menée à partir de données portant sur 5 665 adolescents ayant survécu plus de 5 ans à un cancer pédiatrique (âge : 12-18 ans, âge médian : 15 ans) et sur 921 témoins, cette étude de cohorte rétrospective analyse l’association entre une utilisation de médicaments psychoactifs et leurs capacités physiques et psychiques à l’âge adulte (âge : 18-28 ans ; efficacité, sens de l’organisation, mémoire, symptômes de somatisation, capacité à travailler, etc.)

Prescription Psychoactive Medication Use in Adolescent Survivors of Childhood Cancer and Association with Adult Functional Outcomes

Yin Ting Cheung, Ph.D, Wei Liu, Ph.D, Tara M Brinkman (et al.)

Background : This study estimates the prevalence and identifies predictors of psychoactive medication use in adolescent survivors of childhood cancer (age 12–18 years), and its associations with functional outcomes at young adulthood (age 18–28 years).Methods : This retrospective cohort study includes 5665 adolescent survivors of childhood cancer at???5 years post-diagnosis (53.8% male, median age = 15 years, IQR=13-16 years), and 921 adolescent sibling controls. Parent-reported psychoactive [...]

A partir d’une revue de la littérature publiée entre 1981 et 2019 (17 articles), cette étude analyse les effets de la maladie sur l’état de santé psychique des patients atteints d’un mésothéliome et de leurs aidants

What are the psychological effects of mesothelioma on patients and their carers- A scoping review

Virginia Sherborne, Jane Seymour, Bethany Taylor, Angela Tod

Objective : Despite recent advances in research, malignant mesothelioma remains an incurable and devastating disease, typically bringing shock and emotional distress to patients and carers. Little research has addressed the psychological impact on either group. This scoping review examines the current state of evidence on the psychological effects of mesothelioma on patients and carers, and identifies areas for further research. Methods : We searched PubMed, PsychINFO, CINAHL, the Cochrane [...]

Menée par enquête et entretiens auprès de 339 patients atteints d’un cancer du poumon, cette étude analyse l’intérêt d’utiliser les données et mesures déclarées par les patients pour détecter et surveiller en routine le risque d’essoufflement et de difficultés respiratoires

Acceptability and Accuracy of Patient-Reported Outcome Measures (PROMs) for Surveillance of Breathlessness in Routine Lung Cancer Care: A Mixed-Method Study

Ji Hyun Sung, M. Catherine Brown, Andrea Perez-Cosio (et al.)

Background : Breathlessness in lung cancer negatively impacts on quality of life but often goes undetected and undertreated in clinical practice. There is a need for routine surveillance for early identification and proactive management of breathlessness using patient reported outcome measures (PROMs) in clinical care but it unclear what PROMs should be used or are accurate for use in routine care. Methods : We used mixed-methods (quantitative surveys and qualitative interviews) to examine the [...]