Menée aux Pays-Bas à l'aide de données portant sur 580 768 participants dont 3 401 sont atteints d'un cancer de la vessie (durée médiane de suivi : 11,4 ans ; 67 % de femmes), cette étude analyse l'association entre l'adhésion à un régime alimentaire de type occidental (caractérisé par des apports élevés en viande rouge et transformée, boissons gazeuses sucrées,

Adherence to a Western dietary pattern and risk of bladder cancer: a pooled analysis of 13 Cohort Studies of the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Study

Dianatinasab, Mostafa ; Wesselius, Anke ; Salehi-Abargouei, Amin ; Yu, Evan Y.W. ; Brinkman, Maree ; Fararouei, Mohammad ; van den Brandt, Piet ; White, Emily ; Weiderpass, Elisabete ; Le Calvez-Kelm, Florence ; Gunter, Marc ; Huybrechts, Inge ; Liedberg, Fredrik ; Skeie, Guri ; Tjonneland, Anne ; Riboli, Elio ; Giles, Graham G. ; Milne, Roger L. ; Zeegers, Maurice P.

Little is known about the association of diet with risk of bladder cancer. This might be due to the fact that the majority of studies have focused on single food items, rather than dietary patterns, which may better capture any influence of diet on bladder cancer risk. We aimed to investigate the association between a measure of Western dietary pattern and bladder cancer risk. Associations between adherence to a Western dietary pattern and risk of developing bladder cancer were assessed by [...]

Menée au Canada à l'aide d'une modélisation, cette étude estime la part des cancers attribuables à une exposition à 23 cancérogènes environnementaux

An approach to estimating the environmental burden of cancer from known and probable carcinogens: application to Ontario, Canada

Greco, Susan Lavinia ; MacIntyre, Elaina ; Young, Stephanie ; Warden, Hunter ; Drudge, Christopher ; Kim, JinHee ; Candido, Elisa ; Demers, Paul ; Copes, Ray

Background: Quantifying the potential cancer cases associated with environmental carcinogen exposure can help inform efforts to improve population health. This study developed an approach to estimate the environmental burden of cancer and applied it to Ontario, Canada. The purpose was to identify environmental carcinogens with the greatest impact on cancer burden to support evidence-based decision making. Methods: We conducted a probabilistic assessment of the environmental burden of cancer in [...]

Menée à l'aide de données sérologiques portant sur 357 témoins, 74 patients atteints d'un cancer des voies biliaires et sur 105 patients atteints d'un cancer du foie, tous inclus dans l'essai "Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial", cette étude analyse l'association entre la présence de 13 protéines de Helicobacter pylori et le risque de développer l'un de ces cancers

Seropositivity for Helicobacter pylori and hepatobiliary cancers in the PLCO study

Makkar, Rishi ; Butt, Julia ; Huang, Wen-Yi ; McGlynn, Katherine A. ; Koshiol, Jill ; Pawlita, Michael ; Waterboer, Tim ; Freedman, Neal D. ; Murphy, Gwen

Helicobacter has been suggested to play a possible role in hepatitis, gallstones, and hepatobiliary tumours. We assessed whether seropositivity to 15 H. pylori proteins was associated with subsequent incidence of 74 biliary tract and 105 liver cancer cases vs. 357 matched controls in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Odds ratios and 95% confidence intervals were computed by conditional logistic regression after adjustment for known hepatobiliary cancer [...]

Menée en Thaïlande à l'aide de 226 échantillons de tissus fixés au formaldéhyde et inclus en paraffine après prélèvement sur des patients atteints d'un papillome inversé ou d'un carcinome épidermoïde nasosinusien, cette étude analyse la prévalence du virus d'Epstein-Barr dans le développement de ces tumeurs nasosinusiennes

Prevalence and association of Epstein-Barr virus infection with sinonasal inverted papilloma and sinonasal squamous cell carcinoma in the northeastern Thai population

Nukpook, Thawaree ; Ekalaksananan, Tipaya ; Teeramatwanich, Watchareporn ; Patarapadungkit, Natcha ; Chaiwiriyakul, Surachat ; Vatanasapt, Patravoot ; Aromseree, Sirinart ; Pientong, Chamsai

Aims: Sinonasal inverted papillomas (SIP) and sinonasal squamous cell carcinomas (SNSCC) are sinonasal tumors with unclear etiology and pathogenesis. Epstein-Barr virus (EBV) has been detected in these tumors but information concerning their association is still limited. This study aimed to investigate the prevalence in, and association of EBV infection with SIP and SNSCC in northeastern Thailand. Methods: DNA was extracted from 226 formalin-fixed, paraffin-embedded tissues including 80 nasal [...]

A partir de données de l'"UK Biobank" portant sur 474 929 individus non atteints d'un cancer (durée médiane de suivi : 6,6 ans), cette étude analyse l'association entre des composantes du syndrome métabolique et le risque de cancer du pancréas (565 cas)

Metabolic Syndrome and Risk of Pancreatic Cancer: a Population-based Prospective Cohort Study

Xia, Bin ; He, Qiangsheng ; Pan, Yihang ; Gao, Fang ; Liu, Anran ; Tang, Yan ; Chong, Charing ; Teoh, Anthony Y. B. ; Li, Fangping ; He, Yulong ; Zhang, Changhua ; Yuan, Jinqiu

Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk, however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out the prospective cohort study of 474 929 participants without a diagnosis of cancer based on UK Biobank dataset. MetS was defined according to the International Diabetes Federation criteria and pancreatic cancer was identified through linkage to U.K. [...]

Menée en Allemagne auprès de 1 405 femmes présentant des lésions cervicales, 1 042 femmes atteintes d'un cancer du col de l'utérus et de 1 556 témoins (âge médian au diagnostic : 31-44 ans), cette étude analyse l'association entre 2 polymorphismes à simple nucléotide de gènes du système HLA et le risque de développer la maladie, en fonction du statut HPV

Association of genomic variants at the Human Leukocyte Antigen locus with cervical cancer risk, HPV status, and gene expression

Ramachandran, Dhanya ; Schürmann, Peter ; Mao, Qianqian ; Wang, Yingying ; Bretschneider, Lisa-Marie ; Speith, Lisa-Marie ; Hülse, Fabienne ; Enßen, Julia ; Bousset, Kristine ; Jentschke, Matthias ; Böhmer, Gerd ; Strauß, Hans-Georg ; Hirchenhain, Christine ; Schmidmayr, Monika ; Tarbiat, Johanna ; Runnebaum, Ingo ; Dürst, Matthias ; Hein, Alexander ; Koch, Martin ; Ruebner, Matthias ; Ekici, Arif ; Beckmann, Matthias W. ; Fasching, Peter A. ; Luyten, Alexander ; Petry, Karl-Ulrich ; Hillemanns, Peter ; Dörk, Thilo

The HLA locus on chromosome 6 has been reported to be associated with cervical cancer. We investigated two independent single-nucleotide polymorphisms in a large case-control series of cervical dysplasia and carcinoma that has been newly established by the German Cervigen Consortium, comprising a total of 2481 cases and 1556 healthy females. We find significant associations for both variants, rs9272117 at HLA-DQA1, and rs2844511 at MICA and HCP5, with cervical disease. Both variants showed [...]