Cet article plaide pour le développement de la prise en charge des soins de support par les patients eux-mêmes et par leur famille après les traitements anticancéreux

Management of cancer and health after the clinic visit: A call to action for self-management in cancer care

Doris Howell, Deborah K Mayer, Richard Fielding, Manuela Eicher (et al.)

Individuals with cancer and their families assume responsibility for management of cancer as an acute and chronic disease. Yet, cancer lags other chronic diseases in its provision of proactive self-management support (SMS) in routine ‘everyday’ care leaving this population vulnerable to worse health status, long-term disability and poorer survival. Enabling cancer patients to manage the medical, emotional consequences, and lifestyle/work changes due to cancer and treatment is essential to [...]

Mené sur 41 patientes ayant survécu à un cancer du sein ou à un cancer gynécologique, cet essai randomisé évalue l’intérêt du yoga pour soulager une neuropathie périphérique induite par la chimiothérapie

Yoga for Chemotherapy-Induced Peripheral Neuropathy and Fall Risk: A Randomized Controlled Trial

Ting Bao, Iris Zhi, Raymond Baser (et al.)

BACKGROUND : Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect that worsens quality of life and increases the risk of falls in cancer survivors. Evidence of yoga’s safety and efficacy in treating CIPN is lacking. METHODS : In a randomized controlled study, we assigned breast and gynecological cancer survivors with persistent moderate-to-severe CIPN pain, numbness, or tingling ?4 (0-10 Numeric Rating Scale (NRS)) for ?3 months after chemotherapy to eight [...]

Mené sur 49 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l’efficacité d’une intervention de réadaptation, dispensée après une mastectomie ou une quadrantectomie, pour retrouver la fluidité et la rapidité des mouvements

The sequelae of mastectomy and quadrantectomy with respect to the reaching movement in breast cancer survivors: evidence for an integrated rehabilitation protocol during oncological care

Teresa Paolucci, Andrea Bernetti, Arianna V. Bai (et al.)

Background : Breast cancer (BC) is the most common cancer among women in developed countries. Several types of surgical interventions are commonly used in BC, such as mastectomy and quadrantectomy, followed by radiation or not. Today, BC rehabilitation can help survivors obtain and maintain the highest physical, social, psychological, and vocational functioning possible, within the limits that are created by cancer and its treatments. Objective : To verify, before and after a specific [...]

Menée aux Etats-Unis auprès de patients atteints d’une tumeur germinale du testicule, cet essai analyse les caractéristiques associées à une neuropathie périphérique induite par un traitement à base de cisplatine, et compare ces données avec celles de patients recevant d’autres chimiothérapies neurotoxiques (paclitaxel, seul ou combiné avec du carboplatine, oxaliplatine, doxorubicine combinée avec du cyclophosphamide)

Cisplatin-associated neuropathy characteristics compared with those associated with other neurotoxic chemotherapy agents (Alliance A151724)

Costantine Albany, Travis Dockter, Eric Wolfe (et al.)

Purpose : The current project was developed to obtain natural history information regarding cisplatin-induced peripheral neuropathy in males with testicular/germ cell cancers and to compare such neuropathy data with similarly obtained data in patients receiving other chemotherapy drugs in similarly conducted clinical trials. Methods : Patients without baseline neuropathy symptoms, who were initiating cisplatin-based chemotherapy, completed the EORTC CIPN 20 patient-reported instrument to [...]

A partir d’une revue de la littérature, cette étude analyse la survenue d’événements thrombo-emboliques chez des patients atteints d’un cancer du testicule après leur participation à un entraînement fractionné de haute intensité pendant une chimiothérapie à base de cisplatine

Thromboembolic events after high -intensity training during cisplatin -based chemotherapy for testicular cancer: Case reports and review of the literature

Lene Thorsen, Hege S. Haugnes, Sophie D. Fosså (et al.)

The randomized “Testicular cancer and Aerobic? and Strength Training trial” (TAST -trial) aimed to evaluate the effect of high -intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin -based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 -60?years [...]

Menée en Italie auprès de 31 patients atteints d’une tumeur solide (autre que tumeur de la cavité buccale), cette étude de cohorte prospective analyse les changements dans la perception des goûts durant le premier mois de la chimiothérapie

Prospective observational study of taste assay in patients with solid tumors treated with standard chemotherapy (POTATO)

Riccardo Giampieri, Elisa Pelati, Aurora Anna Mobili, Cecilia Copparoni (et al.)

Purpose : The aim of our study is to evaluate taste changes in patients affected by solid tumors not involving oral cavity within the first month of standard chemotherapy. : Methods : In this monocentric, prospective, cohort study, we enrolled patients treated at our institution for different types of solid tumors between February and July 2019. Taste cotton swabs assay was used to assess taste changes. Results : Thirty-one patients were enrolled and most of them had at least one change in [...]

Menée à partir des données de registres américains et japonais sur la période 1995-2015, cette étude compare, dans ces deux pays, l’évolution de l’incidence du myélome multiple et de la mortalité spécifique (74 972 décès au Japon par myélome multiple et 229 290 décès aux Etats-Unis)

Changing trend in mortality rate of multiple myeloma after introduction of novel agents: a population-based study

Yoshiaki Usui, Hidemi Ito, Yuriko Koyanagi (et al.)

Previously, the main treatment for multiple myeloma (MM) was cytotoxic chemotherapies, including autologous stem-cell transplantation (ASCT), but survival benefit in the elderly was limited. More recently, clinical trials and practical experience with novel agents with superior efficacy have shown improved survival, including in the elderly. However, this improvement cannot be simply interpreted as a decline of mortality rate that is an important public health measure of progress against [...]

Menée aux Etats-Unis à partir de données portant sur 55 315 patients atteints d’un cancer du poumon non à petites cellules diagnostiqué entre 2000 et 2011, cette étude de cohorte rétrospective analyse l’association entre des troubles mentaux antérieurs au diagnostic de cancer (schizophrénie, troubles bipolaires, dépression, stress post-traumatique, addictions), leur participation à des programmes thérapeutiques pour la prise en charge de ces pathologies psychiques et le stade du cancer au diagnostic, la mortalité toutes causes confondues et la mortalité spécifique

Association of Mental Health Treatment With Outcomes for US Veterans Diagnosed With Non–Small Cell Lung Cancer

Jacob E. Berchuck, Craig S. Meyer, Ning Zhang (et al.)

Importance : Preexisting mental health disorders (MHDs) are associated with increased mortality in people diagnosed with cancer, yet few data exist on the efficacy of interventions to mitigate this disparity. Objective : To evaluate the association of participation in mental health treatment programs (MHTPs), housing support programs, or employment support programs with stage at cancer diagnosis, receipt of stage-appropriate treatment, and mortality among patients with a preexisting MHD. [...]

Menée aux Etats-Unis à partir de données portant sur 5 929 patients atteints d’un cancer de la prostate, cette étude analyse les disparités ethniques dans l’association entre l’indice de masse corporelle, la survie et la mortalité spécifique (durée médiane de suivi : 7,4 ans)

Obesity, race, and long -term prostate cancer outcomes

Adriana C. Vidal, Taofik Oyekunle, Lauren E. Howard (et al.)

Background : The authors previously found that obesity was linked with prostate cancer (PC)–specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association between obesity and long -term PC outcomes, including PCSM, differed by race. Methods : Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed. Prior to RP, body mass [...]

Menée à partir des données de 19 registres des cancers de 7 pays (Australie, Canada, Danemark, Irlande, Nouvelle-Zélande, Norvège et Royaume-Uni) portant sur 386 870 patients atteints d'un cancer du côlon ou du rectum diagnostiqué entre 2010 et 2014, cette étude estime la survie nette à 1 et 5 ans en fonction du stade au diagnostic, de l'âge du patient et du pays

Colon and rectal cancer survival in seven high-income countries 2010–2014: variation by age and stage at diagnosis (the ICBP SURVMARK-2 project)

Marzieh Araghi, Melina Arnold,Mark J Rutherford (et al.)

Objectives : As part of the International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 project, we provide the most recent estimates of colon and rectal cancer survival in seven high-income countries by age and stage at diagnosis. Methods : Data from 386870 patients diagnosed during 2010–2014 from 19 cancer registries in seven countries (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK) were analysed. 1-year and 5-year net survival from colon and rectal cancer were [...]

A partir d’une revue systématique de la littérature (20 articles), cette étude analyse l’évolution, au niveau mondial sur la période 1973-2009, de la survie des adolescents et jeunes adultes (âge : 15-39 ans) atteints d’une tumeur astrocytaire et analyse les disparités géographiques

Global trends in survival from astrocytic tumours in adolescents and young adults: a systematic review

Fabio Girardi, Claudia Allemani, Michel P Coleman

Background : Brain tumours represent an important cause of cancer-related death in adolescents and young adults. Most are diagnosed in low-income and middle-income countries. We aimed to conduct the first systematic review of time trends and geographical variation in survival in this age group. Methods : We included observational studies describing population-based survival from astrocytic tumours in patients aged 15-39 years. We queried six electronic databases from database inception to 31 [...]

Menée en Australie à partir de données portant sur 675 patients atteints d’un mélanome cutané primitif à haut risque de récidive, cette étude longitudinale analyse les facteurs associés à des symptômes d’anxiété et de dépression durant les 4 années suivant le diagnostic de la maladie

Anxiety and depression after diagnosis of high-risk primary cutaneous melanoma: a 4-year longitudinal study

Vanessa L. Beesley, Maria Celia B. Hughes, B. Mark Smithers (et al.)

Purpose :To quantify the prevalence of anxiety or depression (overall; melanoma-related) among people with high-risk primary melanoma, their related use of mental health services and medications, and factors associated with persistent new-onset symptoms across 4 years post-diagnosis. Methods : A longitudinal study of 675 patients newly diagnosed with tumor-stage 1b–4b melanoma. Participants completed the Hospital Anxiety and Depression Scale and answered questions about fear of cancer [...]

Menée aux Etats-Unis à partir de données portant sur 120 patients ayant survécu à un cancer colorectal (durée depuis la fin des traitements : de 6 à 36 mois), cette étude analyse l’association entre la peur de la récidive et des caractéristiques modifiables (comportementales, sociales, cognitives) et non modifiables (âge, sévérité de la maladie, etc.) des patients

An examination of the relationship of patient modifiable and non-modifiable characteristics with fear of cancer recurrence among colorectal cancer survivors

Julie M. Cessna Palas, Kelly A. Hyland, Ashley M. Nelson (et al.)

Purpose : Fear of cancer recurrence (FCR) is one of the most common and distressing issues affecting cancer survivors. This study examined (1) the association between modifiable cognitive, behavioral, and social characteristics and FCR, (2) the association between non-modifiable characteristics and FCR, and (3) the relative contributions of modifiable and non-modifiable characteristics to FCR. Methods : Participants (n=120) had been diagnosed with colorectal cancer and completed cancer [...]

Menée aux Etats-Unis par enquête auprès de 302 patientes atteintes d’un cancer du sein diagnostiqué avant l’âge de 40 ans entre 2006 et 2016, cette étude de cohorte prospective analyse les facteurs associés à des symptômes de stress post-traumatique

Posttraumatic Stress in Breast Cancer Survivors Diagnosed at a Young Age

Danny Vazquez, Shoshana Rosenberg, Shari Gelber (et al.)

Objective : Young breast cancer patients experience greater psychosocial distress compared with older patients, which raises concern for their risk of posttraumatic stress disorder (PTSD). We sought to characterize the prevalence of clinically significant symptoms of PTSD and associated factors among breast cancer survivors diagnosed at a young age. Methods : The Young Women’s Breast Cancer Study, an ongoing prospective cohort study, enrolled 1302 women diagnosed with breast cancer at age 40 [...]

Menée en Australie par questionnaire auprès de 209 patientes atteintes d’un cancer du sein (âge : inférieur à 50 ans), cette étude analyse l’association entre leurs besoins en information et leur anxiété dans les 13 mois suivant le diagnostic

Unmet information needs predict anxiety in early survivorship in young women with breast cancer

Kristen Barr, David Hill, Ashley Farrelly, Meron Pitcher & Victoria White

Purpose : To examine variations in anxiety and longitudinal associations between unmet supportive care needs and elevated anxiety in young women (< 50 years) within 13 months of their breast cancer diagnosis. Methods : Two hundred and nine women recruited through Victorian Cancer Registry completed questionnaires at study entry (T1) (average 7 months post-diagnosis) then 3 (T2) and 6 months later (T3). Women completed the Hospital Anxiety and Depression Scale (HADS) and Supportive Care Needs [...]

Menée à Taïwan par questionnaire auprès de 103 patientes atteints d’un cancer de la tête et du cou, cette étude analyse l’impact de la peur de la récidive sur l’association entre des symptômes physiques et la qualité de vie

Fear of recurrence: A mediator of the relationship between physical symptoms and quality of life in head and neck cancer patients

Shiow-Luan Tsay, Ju-Yi Wang, Yun-Hsiang Lee, Yen-Ju Chen

Objective : Head and neck cancer (HNC) patients suffer from symptoms and fear of recurrence (FoR), which both affect their quality of life (QoL). Based on a self?regulation model, the purpose of the study was to examine patients’ FoR as a mediator of the relation between symptoms and QoL, and to identify which symptoms may trigger FoR. Methods : A cross?sectional study was conducted, using convenience sampling. Structured questionnaires were used to collect data at a medical centre in Northern [...]

Menée à partir des données des registres américains des cancers portant sur des patients ayant survécu à un cancer diagnostiqué entre 2000 et 2012, cette étude présente une estimation pour l’année 2019 et une projection pour la période 2015-2030 des coûts associés aux soins de santé et aux prescriptions médicamenteuses orales liés au cancer

Medical Care Costs Associated with Cancer Survivorship in the United States

Angela B. Mariotto, Lindsey Enewold, Jingxuan Zhao (et al.)

Background: The prevalence of cancer survivorship is increasing. In this study, we provide contemporary population–based estimates and projections of the overall and site-specific cancer-attributable medical care costs in the United States. Methods: We identified survivors aged 65 years diagnosed with cancer between 2000 and 2012 from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database and used 2007 to 2013 claims to estimate costs by cancer site, phases of care, and stage [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité de l’ibrutinib dispensé en traitement de première ou de troisième ligne chez des patients atteints d’une leucémie lymphoïde chronique

Cost-Effectiveness of First-Line Ibrutinib versus Third-Line in Patients with Untreated Chronic Lymphocytic Leukemia

Kishan Patel, Iris Isufi, Shalin Kothari, Amy J Davidoff, Cary P Gross, Scott F Huntington

The ALLIANCE trial found that continuously administered ibrutinib in the first-line setting significantly prolonged progression-free survival compared to a fixed-duration treatment of rituximab and bendamustine in older adults with CLL. In this study, we created a Markov model to assess the cost-effectiveness of ibrutinib in the first-line setting, compared to a strategy of using ibrutinib in the third-line after failure of time-limited bendamustine and venetoclax-based regimens. We estimated [...]