Menée aux Etats-Unis à partir de données 2006-2016 des registres des cancers portant sur l'incidence de 12 types de cancers associés au tabac, cette étude estime l'effet du sevrage tabagique complet sur l'incidence de ces maladies

Cancer rates not explained by smoking: a county-level analysis

Myers, Douglas J. ; Hoppin, Polly ; Jacobs, Molly ; Clapp, Richard ; Kriebel, David

Background: Debates over the importance of “lifestyle” versus “environment” contributions to cancer have been going on for over 40 years. While it is clear that cigarette smoking is the most significant cancer risk factor, the contributions of occupational and environmental carcinogens in air, water and food remain controversial. In practice, most cancer prevention messaging focuses on reducing cigarette smoking and changing other personal behaviors with little mention of environmental [...]

Menée au Japon auprès de 32 793 témoins et 179 660 patients atteints d'une des 42 maladies étudiées (dont 13 types de cancers), cette étude d'association sur le génome entier identifie des loci de susceptibilité spécifiques à la population asiatique

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Ishigaki, Kazuyoshi ; Akiyama, Masato ; Kanai, Masahiro ; Takahashi, Atsushi ; Kawakami, Eiryo ; Sugishita, Hiroki ; Sakaue, Saori ; Matoba, Nana ; Low, Siew-Kee ; Okada, Yukinori ; Terao, Chikashi ; Amariuta, Tiffany ; Gazal, Steven ; Kochi, Yuta ; Horikoshi, Momoko ; Suzuki, Ken ; Ito, Kaoru ; Koyama, Satoshi ; Ozaki, Kouichi ; Niida, Shumpei ; Sakata, Yasushi ; Sakata, Yasuhiko ; Kohno, Takashi ; Shiraishi, Kouya ; Momozawa, Yukihide ; Hirata, Makoto ; Matsuda, Koichi ; Ikeda, Masashi ; Iwata, Nakao ; Ikegawa, Shiro ; Kou, Ikuyo ; Tanaka, Toshihiro ; Nakagawa, Hidewaki ; Suzuki, Akari ; Hirota, Tomomitsu ; Tamari, Mayumi ; Chayama, Kazuaki ; Miki, Daiki ; Mori, Masaki ; Nagayama, Satoshi ; Daigo, Yataro ; Miki, Yoshio ; Katagiri, Toyomasa ; Ogawa, Osamu ; Obara, Wataru ; Ito, Hidemi ; Yoshida, Teruhiko ; Imoto, Issei ; Takahashi, Takashi ; Tanikawa, Chizu ; Suzuki, Takao ; Sinozaki, Nobuaki ; Minami, Shiro ; Yamaguchi, Hiroki ; Asai, Satoshi ; Takahashi, Yasuo ; Yamaji, Ken ; Takahashi, Kazuhisa ; Fujioka, Tomoaki ; Takata, Ryo ; Yanai, Hideki ; Masumoto, Akihide ; Koretsune, Yukihiro ; Kutsumi, Hiromu ; Higashiyama, Masahiko ; Murayama, Shigeo ; Minegishi, Naoko ; Suzuki, Kichiya ; Tanno, Kozo ; Shimizu, Atsushi ; Yamaji, Taiki ; Iwasaki, Motoki ; Sawada, Norie ; Uemura, Hirokazu ; Tanaka, Keitaro ; Naito, Mariko ; Sasaki, Makoto ; Wakai, Kenji ; Tsugane, Shoichiro ; Yamamoto, Masayuki ; Yamamoto, Kazuhiko ; Murakami, Yoshinori ; Nakamura, Yusuke ; Raychaudhuri, Soumya ; Inazawa, Johji ; Yamauchi, Toshimasa ; Kadowaki, Takashi ; Kubo, Michiaki ; Kamatani, Yoichiro

The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals across 42 diseases. We detected 320 independent signals in 276 loci for 27 diseases, with 25 novel loci (P < 9.58 × 10−9). East Asian–specific missense variants were identified as candidate causal variants for three novel loci, and we successfully replicated [...]

Menée aux Etats-Unis à partir de données de registres portant sur 15 110 enfants atteints d'un cancer, 539 569 présentant des anomalies congénitales et 2 124 cumulant les 2 affections, cette étude analyse le rôle des maladies congénitales dans l'association entre le sexe et le risque de cancer pédiatrique

Male sex and the risk of childhood cancer: the mediating effect of birth defects

Marcotte, Erin L ; Schraw, Jeremy M ; Desrosiers, Tania A ; Nembhard, Wendy N ; Langlois, Peter H ; Canfield, Mark A ; Meyer, Robert E ; Plon, Sharon E ; Lupo, Philip J

There is a persistent, unexplained disparity in sex ratio among childhood cancer cases, whereby males are more likely to develop most cancers. This male predominance is also seen for most birth defects, which are strongly associated with risk of childhood cancer. We conducted mediation analysis to estimate whether the increased risk of cancer among males is partially explained by birth defect status.We used a population-based birth cohort with linked data from birth certificates, birth defects [...]

Menée en Suède à partir du registre des cancers jusqu'en 2016 et de données portant sur 431 902 hommes (durée moyenne de suivi : 28 ans), cette étude analyse l'association entre la taille ou l'indice de masse corporelle et le risque de cancer de la prostate (32 871 cas ; âge moyen au diagnostic : 69 ans), ainsi que la mortalité associée (6 748 décès)

Height, body mass index, and prostate cancer risk and mortality by way of detection and cancer risk category

Jochems, Sylvia H J ; Stattin, Pär ; Häggström, Christel ; Järvholm, Bengt ; Orho-Melander, Marju ; Wood, Angela M ; Stocks, Tanja

Obesity is a risk factor for advanced, but not localised, prostate cancer (PCa), and for poor prognosis. However, the detection of localised PCa through asymptomatic screening might influence these associations. We investigated height and body mass index (BMI) among 431 902 men in five Swedish cohorts in relation to PCa risk, according to cancer risk category and detection mode, and PCa-specific mortality using Cox regression. Statistical tests were two-sided. Height was positively associated [...]

Menée à partir de données portant sur 732 hommes atteints d'un cancer de la prostate et sur 779 témoins, cette étude analyse le rôle des polymorphismes des gènes liés au rythme circadien dans l'association entre le travail de nuit et le risque de développer la maladie

Circadian genes polymorphisms, night work and prostate cancer risk: findings from the EPICAP study

Wendeu-Foyet, Méyomo G. ; Cenée, Sylvie ; Koudou, Yves ; Tretarre, Brigitte ; Rebillard, Xavier ; Cancel-Tassin, Geraldine ; Cussenot, Olivier ; Boland, Anne ; Olaso, Robert ; Deleuze, Jean-Francois ; Blanche, Helene ; Lamy, Pierre-Jean ; Mulot, Claire ; Laurent-Puig, Pierre ; Truong, Thérèse ; Menegaux, Florence

Over the past two decades, several studies have attempted to understand the hypothesis that disrupting the circadian rhythm may promote the development of cancer. Some have suggested that night work and some circadian genes polymorphisms are associated with cancer, including prostate cancer. This study aims to test the hypothesis that prostate cancer risk among night workers may be modulated by genetic polymorphisms in the circadian pathway genes based on data from the EPICAP study, a [...]