Menée à partir des données 1992-2014 de la cohorte "the Health Professionals Follow-Up Study" portant sur 33 787 hommes (durée de suivi : 521 221 personnes-années), cette étude analyse l'effet d'exercices physiques en résistance sur le risque de cancer (5 158 cas), en général et par localisation

Resistance training and total and site-specific cancer risk: a prospective cohort study of 33,787 US men

Rezende, Leandro F. M. ; Lee, Dong Hoon ; Keum, NaNa ; Wu, Kana ; Eluf-Neto, Jose ; Tabung, Fred K. ; Giovannucci, Edward L.

Background: Muscle-strengthening activities have been recommended for health benefits. However, it is unclear whether resistance training is associated with cancer risk, independent of total physical activity. Methods: A prospective cohort study followed 33,787 men from the Health Professionals Follow-up Study (1992–2014). Cumulative average of resistance training (hours/week) was assessed through biennial questionnaires up to 2 years before cancer diagnosis. Cox regression model was used to [...]

Menée au Brésil en 2014-2015 par enquête auprès de 95 027 adultes (54% de femmes), cette étude identifie les caractéristiques sociodémographiques associées à 4 modèles de comportement mêlant des facteurs de risque et des facteurs de protection contre le cancer

Behavioral Patterns with the Coexistence of Risk and Protective Factors for Cancer in Brazil

Sales, Jacqueline de Barros ; Granado, Fernanda Serra ; Maia, Emanuella Gomes ; Silva, Luiza Eunice Sá da ; Claro, Rafael Moreira

About one third of the most common cancers could be prevented by the reduction of modifiable behavioral risk factors. We aimed to identify behavioral patterns of risk and protective factors for cancer in Brazil, between 2014 and 2015. Data from Vigitel Survey (n?=?95,027 adults aged ≥ 18?years) from all Brazilian capitals and Federal District were used. Thirteen risk (RBF) and protective behavioral factors (PBF) for cancer were investigated. RBF included the consumption of red meat, meat with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2020 (21 études, 1 404 297 individus), cette méta-analyse évalue l'association entre la capacité antioxydante totale de l'alimentation et le risque de cancer, par localisation

Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis

Abbasalizad Farhangi, Mahdieh ; Vajdi, Mahdi

Objectives: We aimed to evaluate the possible role of dietary TAC against different types of cancers in a systematic review and meta-analyses of observational studies. Methods: A literature search of authentic electronic resources had been performed to obtain the relevant studies up to February 2020. Results: Twenty-one studies including nine prospective and twelve case-control studies were included in the current systematic review and meta-analysis. These studies have included 1404297 [...]

Menée en Espagne sur la période 1999-2016 par questionnaire auprès de 18 424 participants (âge moyen : 48 ans ; 55,4 % de femmes), cette étude analyse l'association entre 3 régimes alimentaires différents et le risque de carcinome basocellulaire (101 cas)

Mediterranean diet, Dietary Approaches to Stop Hypertension, and Pro-vegetarian dietary pattern in relation to the risk of basal cell carcinoma: a nested case-control study within the Seguimiento Universidad de Navarra (SUN) cohort

Leone, Alessandro ; Martínez-González, Miguel A ; Martin-Gorgojo, Alejandro ; Sánchez-Bayona, Rodrigo ; De Amicis, Ramona ; Bertoli, Simona ; Battezzati, Alberto ; Bes-Rastrollo, Maira

The association of dietary pattern with the risk of basal cell carcinoma (BCC) is little understood and has scarcely been investigated.We assessed the association of several complete dietary patterns [Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Pro-vegetarian dietary pattern] with the risk of BCC, conducting a nested case-control study (4 controls for each case).Cases and controls were selected from the SUN (Seguimiento Universidad de Navarra) cohort using risk set [...]

Menée en Espagne auprès de 10 812 femmes (durée médiane de suivi : 11,5 ans), cette étude analyse l'effet d'un régime alimentaire à base de plantes sur le risque de cancer du sein (101 cas)

Healthful and Unhealthful Provegetarian Food Patterns and the Incidence of Breast Cancer: results from a Mediterranean cohort

Romanos-Nanclares, Andrea ; Toledo, Estefanía ; Sánchez-Bayona, Rodrigo ; Sánchez-Quesada, Cristina ; Martínez-González, Miguel Ángel ; Gea, Alfredo

Introduction: Provegetarian diets, also denoted as predominantly plant-based (but not vegetarian or vegan) diets or plant-forward diets, have been associated with health benefits. However, a distinction is needed between high- and low-quality provegetarian dietary patterns (PVG). We sought to examine potential associations between PVG indices and breast cancer (BC) incidence. Methods: We assessed 10,812 women in the Seguimiento Universidad de Navarra (SUN) cohort. We calculated an overall PVG [...]

Menée à partir de données de 8 études observationnelles portant sur 4 322 témoins et sur 3 898 patientes ménopausées et atteintes d'un cancer colorectal (âge moyen : 65,3 ans), cette étude analyse l'association entre un traitement hormonal substitutif et le risque de développer la maladie, en général et en fonction de l'emplacement de la tumeur ou du statut de 4 biomarqueurs moléculaires (MSI, CIMP, BRAF, KRAS)

Post-menopausal hormone therapy and colorectal cancer risk by molecularly-defined subtypes and tumor location

Labadie, Julia D ; Harrison, Tabitha A ; Banbury, Barbara ; Amtay, Efrat L ; Bernd, Sonja ; Brenner, Hermann ; Buchanan, Daniel D ; Campbell, Peter T ; Cao, Yin ; Chan, Andrew T ; Chang-Claude, Jenny ; English, Dallas ; Figueiredo, Jane C ; Gallinger, Steven J ; Giles, Graham G ; Gunter, Marc J ; Hoffmeister, Michael ; Hsu, Li ; Jenkins, Mark A ; Lin, Yi ; Milne, Roger L ; Moreno, Víctor ; Murphy, Neil ; Ogino, Shuji ; Phipps, Amanda I ; Sakoda, Lori C ; Slattery, Martha L ; Southey, Melissa C ; Sun, Wei ; Thibodeau, Stephen N ; Van Guelpen, Bethany ; Zaidi, Syed H ; Peters, Ulrike ; Newcomb, Polly A

Post-menopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogeneous disease, we evaluated whether the association of HT and CRC differs across etiologically-relevant, molecularly-defined tumor subtypes and tumor location.We pooled data on tumor subtypes (microsatellite instability (MSI) status, CpG island methylator phenotype (CIMP) status, BRAF and KRAS mutations, pathway: adenoma-carcinoma, alternate, serrated), tumor location (proximal [...]

Menée aux Etats-Unis, entre 2017 et 2019, par enquête auprès de 3 171 personnes (âge moyen : 47,2 ans), cette étude analyse l'association entre leur implication sur les réseaux sociaux et leurs connaissances concernant le papillomavirus humain (HPV), le vaccin contre le HPV et leur perception de l'efficacité de ce dernier

Social media engagement association with human papillomavirus and vaccine awareness and perceptions: Results from the 2017 US Health Information National Trends Survey

Rosen, Brittany L. ; Wheldon, Christopher ; Thompson, Erika L. ; Maness, Sarah ; Massey, Philip M.

Due to social media's ability to publicize misinformation about vaccines, there is a need to study associations between social media engagement (SME) with human papillomavirus (HPV) and vaccine-related awareness and beliefs. Therefore, the study objectives were to (1) describe the SME of a nationally representative sample of US adults, and (2) determine the associations between SME and HPV-related awareness, HPV-related knowledge, HPV vaccine-related awareness, and perceived HPV vaccine [...]

Menée au Royaume-Uni à partir de données 1994-2016 portant sur 14 992 jeunes âgés de 11 à 15 ans (durée de suivi : 74 960 personnes-années), cette étude analyse les effets, sur leurs comportements tabagiques, de la modification des lois anti-tabac dans les lieux publics et de l'augmentation de l'âge légal pour acheter des cigarettes entre 2006 et 2008

Impact of UK tobacco control policies on inequalities in youth smoking uptake: A natural experiment study

Anyanwu, Philip Emeka ; Craig, Peter ; Katikireddi, Srinivasa Vittal ; Green, Michael James

UK countries implemented smoke-free public places legislation and increased the legal age for tobacco purchase from 16-18 years between 2006 and 2008. We evaluated the immediate and long-term impacts of these UK policy changes on youth smoking uptake, and inequalities therein.We studied 74,960 person-years of longitudinal data from 14,992 youth (aged 11-15 years) in annual UK household surveys between 1994 and 2016. Discrete-time event history analyses examined whether changes in rates of youth [...]

Menée à l'aide d'une modélisation et de données 2017 du registre allemand des cancers notamment, cette étude estime, jusqu'en 2050 et en fonction du sexe, la part évitable des cancers liés au tabac si une combinaison de politiques de lutte contre le tabagisme était mise en œuvre en Allemagne

Impact of tobacco control policies on smoking-related cancer incidence in Germany 2020 to 2050 - a simulation study

Gredner, Thomas ; Niedermaier, Tobias ; Brenner, Hermann ; Mons, Ute

Background: Germany is known for its weak tobacco control. We aimed to provide projections of potentially avoidable cancer cases under different tobacco control policy intervention scenarios. Methods: To estimate numbers and proportions of potentially avoidable cancer cases under different policy intervention scenarios (cigarette price increases, comprehensive marketing ban, plain packaging), we calculated cancer site-specific potential impact fractions by age, sex and year of study period [...]

Mené au Royaume-Uni en 2018 auprès de 1 018 participants (âge moyen : 44 ans ; 71% de femmes), cet essai randomisé évalue l'effet, sur les comportements de santé et la perception du risque de cancer à court terme, d'une information personnalisée sur le risque de développer la maladie et de conseils sur le mode de vie

A randomised controlled trial of the effect of providing online risk information and lifestyle advice for the most common preventable cancers

Masson, Golnessa ; Mills, Katie ; Griffin, Simon J. ; Sharp, Stephen J. ; Klein, William M. P. ; Sutton, Stephen ; Usher-Smith, Juliet A.

Few trial data are available concerning the impact of personalised cancer risk information on behaviour. This study assessed the short-term effects of providing personalised cancer risk information on cancer risk beliefs and self-reported behaviour. We randomised 1018 participants, recruited through the online platform Prolific, to either a control group receiving cancer-specific lifestyle advice or one of three intervention groups receiving their computed 10-year risk of developing one of the [...]

Cette étude passe en revue l'état des connaissances actuel sur les carcinomes épidermoïdes de la cavité buccale et de l'oropharynx puis définit les axes de recherche pour la prévention de ces maladies

An integrated approach for preventing oral cavity and oropharyngeal cancers: two etiologies with distinct and shared mechanisms of carcinogenesis

El-Bayoumy, Karam ; Christensen, Neil D ; Hu, Jiafen ; Viscidi, Raphael ; Stairs, Douglas B ; Walter, Vonn ; Chen, Kun-Ming ; Sun, Yuan-Wan ; Muscat, Joshua E ; Richie, John P.

Head and neck squamous cell carcinoma (HNSCC) was the 7th most common malignancy worldwide in 2018 and despite therapeutic advances, the overall survival rate for oral squamous cell carcinoma (OSCC) (~50%) has remained unchanged for decades. The most common types are OSCC and oropharyngeal squamous cell carcinoma (OPSCC, survival rate ~85%). Tobacco smoking is a major risk factor of HNSCC. In the developed world, the incidence of OSCC is declining as a result of tobacco cessation programs. [...]