Menée au Japon auprès de 237 patientes atteintes d’un cancer du sein, cette étude analyse les facteurs associés au risque de déficience des fonctions de l’épaule après un curage ganglionnaire axillaire

Risk factors of impairment of shoulder function after axillary dissection for breast cancer

Masato Kikuuchi, Yoshiteru Akezaki, Eiji Nakata (et al.)

Objectives : Postoperative shoulder joint dysfunction has been observed at a certain rate after breast cancer surgery with axillary lymph node dissection. The purposes of this study were to verify the feasibility and effects of home-based exercise using a DVD and clarify the target of intensive intervention with physiotherapy by identifying the factors that cause postoperative shoulder dysfunction. Methods : The study comprised 237 female patients who underwent breast cancer surgery with [...]

A partir d’une revue systématique de la littérature publiée jusqu’en décembre 2019 (12 études, 516 patients), cette méta-analyse évalue l’efficacité, pour améliorer la santé cardiorespiratoire chez des patients atteints d’un cancer ou ayant survécu à la maladie, d’un entraînement fractionné de haute intensité

High-intensity interval training improves cardiorespiratory fitness in cancer patients and survivors: A meta-analysis

Matthew P. Wallen, Declan Hennessy, Stephen Brown (et al.)

Objective : The primary objective of this systematic review and meta?analysis was to compare the effects of high?intensity interval training (HIIT) versus moderate?intensity continuous training (MICT) and usual care (UC) on cardiorespiratory fitness (peak V?O2) in cancer patients and survivors. Secondary objectives were to compare the effects of HIIT versus MICT and UC on other cardiopulmonary exercise testing (CPET) indices. Safety and adherence to HIIT were also evaluated. Methods : A [...]

Menée en Allemagne par questionnaire auprès de 181 patients atteints d’un cancer, cette étude transversale analyse leurs préférences et leur motivation concernant la pratique d’une activité physique

Motivation and preferences of cancer patients to perform physical training

Sabine Felser, Martin Behrens, Hans Lampe, Larissa Henze (et al.)

Objective : The aims of this cross?sectional study were to investigate the knowledge about and experience with exercise as well as the motivation and preferences (e.g. availability) of cancer patients to participate in training groups. Methods : From 11/2017?06/2018, 181 cancer patients undergoing or completing treatment responded to a compiled questionnaire. The stage of motivation (transtheoretical model of behavioural change), exercise?related knowledge, experience and preferences were [...]

Mené au Royaume-Uni sur 131 patients ayant survécu à un myélome multiple, cet essai de phase II évalue l’efficacité d’un programme d’exercices physiques pendant 6 mois pour réduire la fatigue et améliorer la force musculaire et la santé cardiovasculaire

Fatigue, quality of life and physical fitness following an exercise intervention in multiple myeloma survivors (MASCOT): an exploratory randomised Phase 2 trial utilising a modified Zelen design

Dimitrios A. Koutoukidis, Joanne Land, Allan Hackshaw, Malgorzata Heinrich (et al.)

Background : Exercise may improve fatigue in multiple myeloma survivors, but trial evidence is limited, and exercise may be perceived as risky in this older patient group with osteolytic bone destruction. Methods : In this Phase 2 Zelen trial, multiple myeloma survivors who had completed treatment at least 6 weeks ago, or were on maintenance only, were enrolled in a cohort study and randomly assigned to usual care or a 6-month exercise programme of tailored aerobic and resistance training. [...]

Menée aux Etats-Unis à partir de données portant sur 1 617 patients atteints d’un cancer de la prostate, cette étude analyse l’effet de la maladie sur les fonctions urinaire et sexuelle et sur la gêne occasionnée, puis compare l’intérêt de ces deux critères (fonctions et gêne) dans l’évaluation de la qualité de vie

The relative impact of urinary and sexual function versus bother on health utility for men with prostate cancer

Chang Wook Jeong, Annika Herlemann, Janet E Cowan (et al.)

Function and bother are related but distinct aspects of health-related quality of life (HRQoL). The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of HRQoL in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1,617 men. Linear regression on the [...]

Mené au Royaume-Uni sur 130 patientes atteintes d’un cancer du sein, cet essai randomisé évalue l’efficacité d’une intervention de psychothérapie comportementale conduite par des infirmier(e)s pour réduire les bouffées de chaleur et les sueurs nocturnes et pour diminuer leurs effets sur la qualité de vie

Effectiveness of nurse-led group CBT for hot flushes and night sweats in women with breast cancer: results of the MENOS4 randomised controlled trial

Deborah Fenlon, Tom Maishman, Laura Day (et al.)

Objective : Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and quality of life. Cognitive behavioural therapy (CBT) is known to be effective for the alleviation of HFNS. However, it is not known if it can effectively be delivered by specialist nurses. We investigated whether group CBT delivered by breast care nurses (BCNs) can reduce the impact of HFNS. Methods : We recruited women with primary [...]

Menée en Australie auprès de 231 patientes atteintes d’un cancer du sein, cette étude analyse les effets d’une chirurgie mammaire reconstructrice sur les fonctions physiques et le niveau d'activité

Physical side-effects following breast reconstructive surgery impact physical activity and function

Deirdre E. McGhee, Julie R. Steele

Purpose : To investigate the incidence and severity of physical side-effects experienced by women following breast reconstructive surgery and the effect of these side-effects on physical activity and function. Methods : Two hundred and thirty-one Australian women (55 years SD 6.5) who had previously had breast reconstruction surgery retrospectively self-reported the incidence and severity of eight physical side-effects and the perceived effect of these side effects on six physical functions, at [...]

Mené sur 49 patients atteints un cancer de la tête et du cou, cet essai randomisé évalue l’efficacité d’un dispositif à compression pneumatique pour soulager eux-mêmes un lymphœdème associé à la maladie

Advanced pneumatic compression for treatment of lymphedema of the head and neck: a randomized wait-list controlled trial

Sheila H. Ridner, Mary S. Dietrich, Jie Deng (et al.)

Purpose : Lymphedema associated with head and neck cancer (HNC) therapy causes adverse clinical outcomes. Standard treatment includes professionally administered complete decongestive therapy (CDT). Cost and availability of trained therapists are known barriers to therapy. Advanced pneumatic compression devices (APCD) may address these issues. A randomized, wait-list controlled trial was undertaken to evaluate an APCD in post-treatment HNC patients with lymphedema. Material and methods : [...]

Menée aux Etats-Unis sur la période 1992-2011 par enquêtes auprès de 505 500 participants (âge : 18-103 ans), cette étude analyse le risque de décès lié aux comportements tabagiques, toutes causes confondues (47 000 décès) et par cancer

Dose-Response Association of Low-Intensity and Nondaily Smoking With Mortality in the United States

Inoue-Choi, Maki ; Christensen, Carol H. ; Rostron, Brian L. ; Cosgrove, Candace M. ; Reyes-Guzman, Carolyn ; Apelberg, Benjamin ; Freedman, Neal D.

An increasing proportion of US smokers smoke at low intensity and not every day. Some nondaily smokers have always had this pattern, whereas others previously smoked daily. The effect of reducing the level of smoking from daily to nondaily smoking and the dose response at low smoking levels are poorly understood.To evaluate risk of all-cause and cause-specific mortality among nondaily and daily cigarette smokers, by cigarettes per month, years after reducing from daily to nondaily smoking, and [...]

Menée aux Etats-Unis à partir de données portant sur 16 728 adolescents et jeunes adultes (âge : 15-39 ans) ayant survécu 5 ans à un cancer diagnostiqué entre 1970 et 2005, cette étude analyse les facteurs associés à l’évolution de la survie globale sur le long terme (durée médiane de suivi : 20 ans)

Long-term survival among 5-year survivors of adolescent and young adult cancer

Amy M. Berkman, J. A. Livingston, Kelly Merriman PhD (et al.)

Background : Although there are a growing number of survivors of adolescent and young adult (AYA) cancer, to the authors' knowledge the long?term overall survival (OS) patterns for AYA cancer survivors are underreported. The objective of the current study was to assess the long?term survival of AYA cancer survivors and identify factors associated with diminished long?term survival. Methods : The authors used The University of Texas MD Anderson Cancer Center's tumor registry to identify 5?year [...]

Menée aux Etats-Unis auprès de 251 820 médecins généralistes et de 14 210 oncologues, cette étude analyse l’évolution, sur la période 2013-2017, de leurs pratiques de prescriptions d’opioïdes pour soulager la douleur chez des patients atteints d’un cancer et bénéficiant de la couverture Medicare

Changes in Opioid Prescribing Patterns Among Generalists and Oncologists for Medicare Part D Beneficiaries From 2013 to 2017

Ankit Agarwal, Andrew Roberts, Stacie B. Dusetzina (et al.)

Importance : In response to the opioid epidemic, policies aiming to reduce opioid prescribing, misuse, and abuse may have the unintended consequence of restricting access to necessary opioid therapy for cancer-related pain. It is unknown how opioid prescribing patterns have changed among generalists and oncologists during this era. Objective : To examine trends in opioid prescription rates for Medicare Part D beneficiaries from 2013 to 2017 among oncologists and generalists. Design, Setting, [...]

Menée au Canada à partir de données portant sur 11 842 patients ayant survécu à un cancer pédiatrique et sur 59 210 témoins, cette étude analyse les facteurs associés au risque d’une perte d’audition significative et à l’utilisation d’un appareil auditif

Long-Term Incidence and Predictors of Significant Hearing Loss Requiring Hearing Assistive Devices Among Childhood Cancer Survivors: A Population-Based Study

Jason A. Beyea, Cindy Lau, Bonnie Cooke (et al.)

PURPOSE : Hearing loss is a significant late effect among childhood cancer survivors. Recent guidelines note insufficient evidence to quantify its natural history or risk associated with specific exposures. We examined the long-term incidence and predictors of hearing loss requiring hearing amplification devices (HADs) using population-based health care data. METHODS : In Ontario, Canada, HAD costs are subsidized by the Assistive Devices Program (ADP). Ontario children < 18 years of age at [...]

Menée aux Etats-Unis par enquête auprès de 635 539 participants entre 1987 et 2014, cette étude de cohorte analyse l’association entre une exposition aux particules fines, une pratique tabagique et la mortalité par cancer

Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults

Nathan C. Coleman, Richard T. Burnett, Joshua D. Higbee (et al.)

Purpose : Air pollution and smoking are associated with various types of mortality, including cancer. The current study utilizes a publicly accessible, nationally representative cohort to explore relationships between fine particulate matter (PM2.5) exposure, smoking, and cancer mortality. Methods : National Health Interview Survey and mortality follow-up data were combined to create a study population of 635,539 individuals surveyed from 1987 to 2014. A sub-cohort of 341,665 never-smokers from [...]

Menée à partir d’une revue systématique de la littérature (68 essais), cette étude présente les recommandations pour la pratique clinique concernant la prophylaxie antifongique systémique chez les patients pédiatriques atteints d’un cancer et chez les patients ayant reçu une greffe de cellules souches hématopoïétiques

Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients

Thomas Lehrnbecher, Brian T. Fisher, Bob Phillips (et al.)

PURPOSE : To develop a clinical practice guideline for systemic antifungal prophylaxis in pediatric patients with cancer and hematopoietic stem-cell transplantation (HSCT) recipients. METHODS : Recommendations were developed by an international multidisciplinary panel that included a patient advocate. We conducted a systematic review of systemic antifungal prophylaxis in children and adults with cancer and HSCT recipients. The Grading of Recommendations Assessment, Development, and Evaluation [...]

Menée en Allemagne à partir de données portant sur 815 patients atteints d’un myélome multiple, cette étude analyse les facteurs associés à la survie conditionnelle à 5 ans

Risk of disease recurrence and survival in patients with multiple myeloma: A German study group analysis using a conditional survival approach with long-term follow-up of 815 patients

Maximilian Schinke, Gabriele Ihorst, Justus Duyster (et al.)

Background : Unlike the traditional method of overall survival prediction in patients with cancer, conditional survival predicts the survival of patients dynamically throughout the course of disease, identifying how a prognosis evolves over time. Methods : The authors assessed 815 consecutive patients with multiple myeloma through the German Study Group on Multiple Myeloma (Deutsche Studiengruppe Multiples Myelom; DSMM) incentive. Over 10 variables, including patient?specific and multiple [...]

Menée en Angleterre à partir de données portant sur 5 024 patientes atteintes d’un carcinome canalaire in situ diagnostiqué entre 1988 et 2014 dans le cadre du programme de dépistage, cette étude de cohorte analyse les facteurs associés au risque de développer un cancer invasif du sein ainsi qu’au risque de décès par cancer du sein

Invasive breast cancer and breast cancer mortality after ductal carcinoma in situ in women attending for breast screening in England, 1988-2014: population based observational cohort study

Gurdeep S Mannu, Zhe Wang, John Broggio, Jackie Charman (et al.)

Objective To evaluate the long term risks of invasive breast cancer and death from breast cancer after ductal carcinoma in situ (DCIS) diagnosed through breast screening. Design Population based observational cohort study. Setting Data from the NHS Breast Screening Programme and the National Cancer Registration and Analysis Service. Participants All 35 024 women in England diagnosed as having DCIS by the NHS Breast Screening Programme from its start in 1988 until March 2014. Main outcome [...]

A partir d’une revue de la littérature (9 études, 446 patients), cette méta-analyse évalue les effets de l’art-thérapie sur les symptômes d’anxiété et de dépression chez des patientes atteintes d’un cancer du sein

The effects of art therapy on anxiety and depression in breast cancer patients: An updated meta-analysis

Linlin Xu, Pengfei Cheng, Yu Wu, Junxiang Zhang, Jiaying Zhu (et al.)

Objective : In this meta?analysis, we aimed to investigate the effects of art therapy on anxiety and depression in patients with breast cancer. Methods : Electronic databases were searched for relevant studies through December 2019. Standardised mean differences (SMDs) were calculated as the effects of art therapy on improvement of anxiety and depression in women with breast cancer. The meta?analysis included nine studies involving a total of 446 participants. Results : The summary SMD of art [...]

Menée aux Etats-Unis, cette étude analyse les disparités ethniques dans les années potentielles de vies perdues et dans les pertes de revenus liées aux décès prématurés par cancer en 2015

Racial/Ethnic Disparities in Lost Earnings from Cancer Deaths in the United States

Jingxuan Zhao, Kimberly D Miller, Farhad Islami (et al.)

Background : Little is known about disparities in economic burden due to premature cancer deaths by race/ethnicity in the United States. This study aimed to compare person-years of life lost (PYLL) and lost earnings due to premature cancer deaths by race/ethnicity. Methods : PYLL was calculated using recent national cancer death and life expectancy data. PYLL was combined with annual median earnings to generate lost earnings. We compared PYLL and lost earnings among individuals who died at age [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité d’un traitement de consolidation par durvalumab après une chimioradiothérapie chez des patients atteints d’un cancer du poumon non à petites cellules de stade III

Durvalumab vs placebo consolidation therapy after chemoradiotherapy in stage III non-small-cell lung cancer: An updated PACIFIC trial-based cost-effectiveness analysis

Jiaqi Hana, Kun Tianb, Jiangping Yanga, Youling Gong (et al.)

Introduction : Recently updated three-year survival data from the PACIFIC trial showed that durvalumab consolidation therapy improved OS rates versus placebo for patients with unresectable stage III non-small cell lung cancer (NSCLC) after chemoradiotherapy. Considering the impact of the high cost of durvalumab, its cost-effectiveness should be updated to see if its cost-effectiveness has changed from the US payers’ perspective. Methods : A comprehensive Markov model was used to evaluate mean [...]

A partir d’une revue de la littérature (7 études), cette étude analyse l’efficacité des interventions pédagogiques destinées aux oncologues pour améliorer leurs connaissances concernant la qualité de la vie sexuelle des patients atteints d’un cancer

Can the provision of sexual healthcare for oncology patients be improved? A literature review of educational interventions for healthcare professionals

L.F. Albers, L.A. Grondhuis Palacios, R.C.M. Pelger (et al.)

Purpose : Sexual health is an important quality-of-life concern for cancer patients and survivors, but a difficult discussion topic for patients and healthcare professionals. The most important barriers causing healthcare professionals to avoid the topic are lack of education and lack of knowledge. How effective education about sexual health is for oncology healthcare professionals is not clear. The aim of this review is to examine the effectiveness of interventions in improving the provision [...]

Menée à partir des données des registres américains portant sur des patients atteints d’un cancer métastatique du poumon diagnostiqué sur la période 2001-2015, cette étude analyse les disparités géographiques dans l’utilisation des soins palliatifs

Geographic variation in palliative care delivery among patients diagnosed with metastatic lung cancer in the USA: Medicare population-based study

Jinhai Huo, Young-Rock Hong, Kea Turner, Cheng Chen, Yi Guo (et al.)

Purpose : The USA has observed a significant increase in the use of palliative care for patients diagnosed with advanced cancer. However, it is unknown how geographic variation affects patients’ use of palliative care services. We examined temporal and demographic trends in receipt of and timing of palliative care by state and region. Methods : A retrospective cohort study of the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. Study sample included community-dwelling [...]

Menée en France par enquête en 2015-2016 auprès de 4 174 patients ayant survécu 5 ans à un cancer, cette étude analyse leur utilisation de médecines non conventionnelles et l’impact de celles-ci sur la qualité de vie et sur les comportements de santé

Use of non-conventional medicine and lifestyle change among cancer survivors: evidence from the national VICAN survey

Aline Sarradon-Eck, Dominique Rey, Rajae Touzani (et al.)

Purpose : This study aimed to investigate the use of non-conventional medicine (NCM) among long-term cancer survivors and its links with healthy behavior. Methods : This study used data from the VICAN survey, conducted in 2015–2016 on a representative sample of French cancer survivors 5 years after diagnosis. Results : Among the 4174 participants, 21.4% reported using NCM at the time of the survey, including 8.4% who reported uses not associated with cancer. The most frequently cited reasons [...]

Cette étude souligne l’importance, au niveau mondial, de l’enregistrement des données concernant les cancers de l’enfant pour disposer des données de survie de qualité, notamment dans les pays les moins développés économiquement

Scaling up the surveillance of childhood cancer: a global roadmap

Marion Piñeros, Les Mery, Isabelle Soerjomataram (et al.)

The World Health Organization recently launched the Global Initiative for Childhood Cancer (GICC) aiming to substantially increase survival among children with cancer by 2030. The ultimate goal concerns particularly less developed countries where survival estimates are considerably lower than in high-income countries where children with cancer attain approximately 80% survival. Given the vast gap in high-quality data availability between more and less developed countries, measuring the success [...]