A partir d'une revue de la littérature publiée entre 1990 et 2018 (15 études de cohortes), cette méta-analyse évalue l'association entre le statut tabagique et le risque de cancer de la peau

The association between smoking and risk of skin cancer: a meta-analysis of cohort studies

Arafa, Ahmed ; Mostafa, Alshimaa ; Navarini, Alexander A. ; Dong, Jia-Yi

Purpose: The association between smoking and the risk of skin cancers has been studied without reaching consistent findings. This study aims to assess this association through an updated meta-analysis of cohort studies. Methods: We retrieved cohort studies that investigated the temporal association between smoking and the risk of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM). Pooled relative risks (RRs) and confidence intervals (CIs) of the included [...]

Menée au Japon par questionnaire auprès de 32 934 hommes et 40 253 femmes (âge : 45-74 ans ; durée médiane de suivi : 16 ans), cette étude analyse l'association entre une consommation de viande rouge ou d'acides gras saturés et le risque de cancer du poumon (1 315 cas)

Association between Meat and Saturated Fatty Acid Intake and Lung Cancer Risk: The Japan Public Health Center-based Prospective Study

Cai, Honglin ; Sobue, Tomotaka ; Kitamura, Tetsuhisa ; Ishihara, Junko ; Sawada, Norie ; Iwasaki, Motoki ; Shimazu, Taichi ; Tsugane, Shoichiro

Red meat or saturated fatty acid (SFA) intake has been reported to increase lung cancer (LC) risk in several western countries. However, in Asia, studies on the relationship of meat and SFA intake with LC incidence are still relatively insufficient, and their conclusions are inconsistent. We investigated the association of meat and SFA intake with LC incidence in a population-based prospective cohort study in Japan. Cox regression was used to estimate the hazard ratio (HR) and 95% confidence [...]

Menée à partir de données japonaises, cette étude analyse l'association entre les niveaux de pollens aéroportés mesurés sur la période 1975-2015 et l'incidence de 24 cancers

The Relationship between Annual Airborne Pollen Levels and Occurrence of All Cancers, and Lung, Stomach, Colorectal, Pancreatic and Breast Cancers: A Retrospective Study from the National Registry Database of Cancer Incidence in Japan, 1975–2015

Awaya, Akira ; Kuroiwa, Yoshiyuki

Suppression of risk factors including smoking, overdrinking and infections by human papilloma and hepatitis B and C viruses has been recommended for cancer prevention; however, identification of other environmental risk factors has not been enough. Besides the 2003 report that Kawasaki disease may be triggered by pollen exposure, 40 Japanese specific intractable diseases have recently been reported as “pollen diseases,” also potentially triggered by pollen exposure

Menée en Estonie à partir de données 1992-2015 du registre national des cancers portant sur les cancers du poumon, du rein, de la vessie, du sein, la leucémie et le lymphome non hodgkinien, cette étude analyse l'incidence de ces cancers dans les zones exposées à l'industrie du schiste bitumineux (6 752 cas) et la compare aux chiffres nationaux (51 525 cas)

Cancer Incidence Trends in the Oil Shale Industrial Region in Estonia

Idavain, Jane ; Lang, Katrin ; Tomasova, Jelena ; Lang, Aavo ; Orru, Hans

Large oil shale resources are found in Eastern Estonia, where the mineral resource is mined, excavated, and used for electricity generation and shale oil extraction. During industrial activities in the last 100 years, pollutants have been emitted in large amounts, some of which are toxic and carcinogenic. The current study aims to analyse time trends in cancer incidence in the oil shale industry-affected areas and compare them with overall cancer incidence rates and trends in Estonia. We [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2018 (16 études, 187 585 personnes), cette méta-analyse évalue l'association entre une exposition résidentielle à l'industrie pétrochimique et l'incidence des cancers hématologiques

A systematic review and meta-analysis of haematological malignancies in residents living near petrochemical facilities

Jephcote, Calvin ; Brown, David ; Verbeek, Thomas ; Mah, Alice

The petrochemical industry is a major source of hazardous and toxic air pollutants that are recognised to have mutagenic and carcinogenic properties. A wealth of occupational epidemiology literature exists around the petrochemical industry, with adverse haematological effects identified in employees exposed to ‘low’ concentrations of aromatic hydrocarbons (benzene, toluene, ethylbenzene, and xylene). Releases from the petrochemical industry are also thought to increase the risk of cancer [...]

Menée en France à l'aide d'échantillons sanguins prélevés, entre 1994 et 1999, sur 197 femmes atteintes d'un cancer du sein et 197 témoins de la cohorte E3N (âge médian au diagnostic : 68 ans), cette étude analyse l'association entre la concentration plasmatique de 2 groupes de retardateurs de flamme bromés (pentabromodiphényléthers et polybromobiphényles) et le risque de développer la maladie après la ménopause

Plasma concentration of brominated flame retardants and postmenopausal breast cancer risk: a nested case-control study in the French E3N cohort

Mancini, Francesca Romana ; Cano-Sancho, German ; Mohamed, Oceane ; Cervenka, Iris ; Omichessan, Hanane ; Marchand, Philippe ; Boutron-Ruault, Marie-Christine ; Arveux, Patrick ; Severi, Gianluca ; Antignac, Jean-Philippe ; Kvaskoff, Marina

Background: Brominated flame retardants (BFRs) are lipophilic substances with endocrine-disrupting properties. To date, only few investigations, mainly retrospective case-control studies, have explored the link between internal levels of BFRs and the risk of breast cancer, leading to conflicting results. We investigated the associations between plasma concentrations of two main groups of BFRs, PBDEs (pentabromodiphenyl ethers) and PBBs (polybrominated biphenyls), and the risk of breast cancer [...]

Menée à l'aide de données de l'assurance maladie coréenne portant sur plus de 4,5 millions de femmes ménopausées ayant réalisé au moins un examen de dépistage du cancer du sein entre 2009 et 2014 (durée médiane de suivi : 5,4 ans), cette étude analyse l'association entre un traitement hormonal substitutif (696 064 femmes) et le risque de cancer du sein (26 797 cas), en fonction de différents facteurs de risque (indice de masse corporelle, densité mammaire, durée du THS, etc.)

Hormone Replacement Therapy, Breast Cancer Risk Factors, and Breast Cancer Risk: A Nationwide Population-Based Cohort

Yoo, Tae-Kyung ; Han, Kyung Do ; Kim, Dahye ; Ahn, Juneyoung ; Park, Woo-Chan ; Chae, Byung Joo

Background: Hormone replacement therapy (HRT) increases the risk of breast cancer, but the association may vary according to patient factors. We investigated the association between HRT and breast cancer in a nationwide cohort with risk stratification according to risk factors for breast cancer. Methods: Using the Korean National Health Insurance Service database, 4,558,376 postmenopausal women who underwent breast cancer screening and regular health checkups from 2009 to 2014 were analyzed. [...]

Menée à l'aide de données de la cohorte EPIC portant sur 333 919 femmes (âge médian : 51 ans ; durée moyenne de suivi : 15 ans), cette étude analyse l'association entre des facteurs hormonaux et le risque de carcinome urothélial, en fonction de l'agressivité de la tumeur, de son grade et du statut tabagique (529 cas ; âge médian au diagnostic : 68 ans)

Menstrual factors, reproductive history, hormone use, and Urothelial carcinoma risk: A prospective study in the EPIC cohort

Luján-Barroso, Leila ; Botteri, Edoardo ; Caini, Saverio ; Ljungberg, Börje ; Roswall, Nina ; Tjonneland, Anne ; Bueno-de-Mesquita, Bas ; Gram, Inger T. ; Tumino, Rosario ; Kiemeney, Lambertus A ; Liedberg, Fredrik ; Stocks, Tanja ; Gunter, Marc J. ; Murphy, Neil ; Cervenka, Iris ; Fournier, Agnès ; Kvaskoff, Marina ; Häggström, Christel ; Overvad, Kim ; Lund, Eiliv ; Waaseth, Marit ; Fortner, Renée Turzanski ; Kühn, Tilman ; Menéndez, Virginia ; Sánchez, María-José ; Santiuste, Carmen ; Perez-Cornago, Aurora ; Zamora-Ros, Raul ; Cross, Amanda J ; Trichopoulou, Antonia ; Karakatsani, Anna ; Peppa, Eleni ; Palli, Domenico ; Krogh, Vittorio ; Sciannameo, Veronica ; Mattiello, Amalia ; Panico, Salvatore ; van Gils, Carla H. ; Onland-Moret, N. Charlotte ; Barricarte, Aurelio ; Amiano, Pilar ; Khaw, Kay-Tee ; Boeing, Heiner ; Weiderpass, Elisabete ; Duell, Eric J.

Background: Urothelial carcinoma (UC) is the predominant (95%) bladder cancer subtype in industrialised nations. Animal and epidemiological human studies suggest that hormonal factors may influence UC risk. Methods: We used an analytic cohort of 333 919 women from the European Prospective Investigation into Cancer and Nutrition Cohort (EPIC). Associations between hormonal factors and incident UC (overall and by tumour grade, tumour aggressiveness, and non-muscle invasive UC) risk were evaluated [...]

Menée aux Etats-Unis à partir de données de registres portant sur 262 455 patients ayant reçu une greffe d'organe entre 1987 et 2014 (durée de suivi : 1 393 047 personnes-années ; 60 % d'hommes), cette étude analyse le risque de développer un cancer rare après la transplantation

Risk of rare cancers among solid organ transplant recipients

D’Arcy, Monica E ; Castenson, David ; Lynch, Charles F ; Kahn, Amy R ; Morton, Lindsay M ; Shiels, Meredith S ; Pfeiffer, Ruth M ; Engels, Eric A

Immunosuppressed solid organ transplant recipients [SOTRs] have elevated rates of certain rare cancers caused by viruses. Evaluating risk of rare cancers among SOTRs may provide etiological clues for additional cancers linked to poor immunity and viral infections.We performed a cohort study of 262,455 SOTRs (1987-2014) from the US SOTR registry linked to 17 population-based cancer registries. First cancers in SOTRs were categorized using an established classification scheme based on site and [...]

Menée à partir de données des rapport annuels de l'incidence pour 59 cancers, cette étude estime la part des cancers attribuables à une infection par le papillomavirus humain entre 2005 et 2015 en Chine, ainsi que la mortalité associée

Cancer attributable to human papillomavirus infection in China: Burden and trends

Lu, Yong ; Li, Peiyang ; Luo, Ganfeng ; Liu, Di ; Zou, Huachun

Background: Human papillomavirus (HPV) is associated with a substantial percentage of cervical cancer, and a significant percentage of anal, penile, vaginal, vulvar, oral cavity, oropharyngeal, and laryngeal cancers. Understanding the burden and trends of HPV-attributable cancers is crucial to HPV prevention strategies. In the current study, the authors estimated the latest burden and trends of HPV-attributable cancers in China. Methods: Data from the following sources were used. The number of [...]

Menée en Chine sur la période 2008-2016 auprès de 50 392 patients atteints d'un cancer et 11 361 témoins (âge médian : 57,7 ans) et à l'aide d'une revue systématique de la littérature publiée entre 2000 et 2019 (53 articles), cette étude analyse l'association entre une infection par le virus de l'hépatite B, révelée par la séropositivité à l'antigène HBsAg, et le risque de cancers autres que le carcinome hépatocellulaire

Hepatitis B virus infection and the risk of cancer among the Chinese population

Tian, Ting ; Song, Ci ; Jiang, Longfeng ; Dai, Jingjing ; Lin, Yuan ; Xu, Xin ; Yu, Chengxiao ; Ge, Zijun ; Ding, Yuqing ; Wen, Yang ; Liu, Bo ; Shao, Yuyun ; Shi, Ping ; Zhu, Chuanlong ; Liu, Yuan ; Jing, Shenqi ; Wang, Zhongmin ; Hu, Zhibin ; Li, Jun

The relationship between hepatitis B virus (HBV) and non-hepatocellular cancers remains inconclusive. This large case-control study aimed to assess the associations between HBV infection status and multiple cancers. Cases (N = 50 392) and controls (N = 11 361) were consecutively recruited from 2008 to 2016 at the First Affiliated Hospital of Nanjing Medical University. Multivariable adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression by [...]

Menée en Chine sur la période 2012-2019 auprès de 5 880 femmes infectées par le papillomavirus humain HPV et présentant un résultat normal à l'examen cytologique (âge médian : 39 ans), cette étude rétrospective analyse l'association entre les génotypes HPV à haut risque cancérogène, la charge virale et la gravité des lésions cervicales

Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China

Wang, Zhiling ; Liu, Ting ; Wang, Yunjian ; Gu, Ying ; Wang, Hui ; Liu, Jingkang ; Cui, Baoxia ; Yang, Xingsheng

Background: To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology. Methods: In this cross-sectional study, the result of the hr-HPV test and biopsy of colposcopy of women with normal cytology from January 2012 to January 2019 were analyzed. The detection rate of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer were calculated among different hr-HPV [...]

Menée à partir des données des cohortes "the Nurses’ Health Studies" portant sur 3 675 femmes, cette étude analyse l'association entre une utilisation d'aspirine ou d'autres anti-inflammatoires non stéroïdiens et la densité mammaire ou le risque de cancer du sein

Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk

Yaghjyan, Lusine ; Wijayabahu, Akemi ; Eliassen, A. Heather ; Colditz, Graham ; Rosner, Bernard ; Tamimi, Rulla M.

Purpose: We investigated the associations of aspirin and other non-steroid anti-inflammatory drugs with mammographic breast density (MBD) and their interactions in relation to breast cancer risk. Methods: This study included 3,675 cancer-free women within the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII) cohorts. Percent breast density (PD), absolute dense area (DA), and non-dense area (NDA) were measured from digitized film mammograms using a computer-assisted thresholding [...]

Menée en Chine à l'aide notamment de données de l'assurance maladie portant sur 57 066 témoins et sur 57 066 patientes atteintes de fibromes utérins diagnostiqués entre 2000 et 2012 (âge moyen : 42,2 ans ; durée de suivi : 1 à 5 ans), cette étude analyse l'association entre la présence de ces fibromes et le risque de cancer de la thyroïde

Uterine Fibroids Increase the Risk of Thyroid Cancer

Sun, Li-Min ; Chung, Li-Min ; Lin, Cheng-Li ; Kao, Chia-Hung

Objectives: The formation of uterine fibroids (UF) is potentially linked to the development of thyroid cancer through a common factor: female sex hormones. Methods: We conducted a nationwide population-based cohort study to determine whether Taiwanese women with UF have an increased risk of thyroid cancer. The data of both the UF and control groups were derived from the National Health Insurance Research Database (NHIRD) of Taiwan. Groups were matched by the year of UF diagnosis, age, income, [...]

A partir d'une revue systématique de la littérature (20 études, 1 289 patients et 1 081 témoins), cette méta-analyse évalue l'association entre le gène babA2 de Helicobacter pylori et le risque de cancer de l'estomac

Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis

Kpoghomou, Marce-Amara ; Wang, Jinchen ; Wang, Tianpei ; Jin, Guanfu

Background: The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk. Methods: Case-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) [...]

Menée à partir de données d'un registre allemand des cancers intestinaux portant sur 1 830 personnes atteintes d'un syndrome de Lynch, d'un syndrome de "Lynch-like" ou d'un syndrome X (âge médian : 38 ans ; durée médiane de suivi : 6,5 personnes-années), cette étude analyse, pour chaque syndrome, le risque de développer un cancer (482 cas)

Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study

Bucksch, Karolin ; Zachariae, Silke ; Aretz, Stefan ; Büttner, Reinhard ; Holinski-Feder, Elke ; Holzapfel, Stefanie ; Hüneburg, Robert ; Kloor, Matthias ; von Knebel Doeberitz, Magnus ; Morak, Monika ; Möslein, Gabriela ; Nattermann, Jacob ; Perne, Claudia ; Rahner, Nils ; Schmiegel, Wolff ; Schulmann, Karsten ; Steinke-Lange, Verena ; Strassburg, Christian P. ; Vangala, Deepak B. ; Weitz, Jurgen ; Loeffler, Markus ; Engel, Christoph ; on behalf of the German Consortium for Familial Intestinal, Cancer

Background: Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have extensively described cancer risks in LS, cancer risks in individuals from families without detectable MMR gene defects despite MMR deficiency (Lynch-like syndrome, LLS), and in individuals from families fulfilling the Amsterdam-II criteria without any signs of MMR deficiency [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études d'association sur le génome entier portant sur 3 vitamines et sur 373 316 patients atteints d'un cancer (cancer colorectal, cancer du sein, de la prostate, mélanome malin ou carcinome épidermoïde de la peau), cette étude analyse l'association entre un apport en vitamines D, E ou B12 et le risque de développer ces maladies

Are vitamins relevant to cancer risks? A Mendelian randomization investigation

Cheng, Wen-Wen ; Wang, Ze-Kun ; Shangguan, Huang-Fang ; Zhu, Qiang ; Zhang, Hong-Yu

Objective: The relationship between vitamin intake and occurrence of cancer is controversial. To address this issue, this study examined the genetic associations between vitamins D, E, B12 and five cancers, i.e., colorectal cancer, breast cancer, prostate cancer, malignant melanoma and squamous cell carcinoma. Methods: This study started from genome-wide association data for three vitamins (n ​​= 11,238) and five cancers (n = 373,316), and analyzed their associations using Mendelian [...]

Menée en Allemagne auprès de 321 enfants atteints d'un syndrome de Beckwith-Wiedemann confirmé par diagnostic moléculaire (durée de suivi : 2 307 personnes-années), cette étude analyse l'association entre ce syndrome et le risque de cancer (13 cas)

Cancer incidence and spectrum among children with genetically confirmed Beckwith-Wiedemann spectrum in Germany: a retrospective cohort study

Cöktü, Sümeyye ; Spix, Claudia ; Kaiser, Melanie ; Beygo, Jasmin ; Kleinle, Stephanie ; Bachmann, Nadine ; Kohlschmidt, Nicolai ; Prawitt, Dirk ; Beckmann, Alf ; Klaes, Ruediger ; Nevinny-Stickel-Hinzpeter, Claudia ; Döhnert, Steffi ; Kraus, Cornelia ; Kadgien, Gundula ; Vater, Inga ; Biskup, Saskia ; Kutsche, Michael ; Kohlhase, Jürgen ; Eggermann, Thomas ; Zenker, Martin ; Kratz, Christian P.

Background: Beckwith-Wiedemann syndrome (BWS) is a cancer predisposition syndrome caused by defects on chromosome 11p15.5. The quantitative cancer risks in BWS patients depend on the underlying (epi)genotype but have not yet been assessed in a population-based manner. Methods: We identified a group of 321 individuals with a molecularly confirmed diagnosis of BWS and analysed the cancer incidence up to age 15 years and cancer spectrum by matching their data with the German Childhood Cancer [...]

Menée à partir des données 1986-2014 de la cohorte "the Health Professionals Follow-Up Study" portant sur 49 392 hommes (durée de suivi : 28 ans), cette étude analyse l'association entre un diabète et le risque de cancer de la prostate (6 377 cas), par sous-type moléculaire

The association of diabetes with risk of prostate cancer defined by clinical and molecular features

Feng, Xiaoshuang ; Song, Mingyang ; Preston, Mark A. ; Ma, Wenjie ; Hu, Yang ; Pernar, Claire H. ; Stopsack, Konrad H. ; Ebot, Ericka M. ; Fu, Benjamin C. ; Zhang, Yiwen ; Li, Ni ; Dai, Min ; Liu, Lydia ; Giovannucci, Edward L. ; Mucci, Lorelei A.

Background: To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. Methods: A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and updated biennially. Clinical features of prostate cancer included localised, advanced, lethal, low-grade, intermediate-grade, and high-grade. Molecular features included TMPRSS2: [...]