Menée au Canada à partir de données portant sur 788 patients atteints d’un cancer métastatique de l’estomac diagnostiqué entre 2007 et 2014, cette étude de cohorte rétrospective analyse l’évolution de leurs symptômes durant les 6 derniers mois de vie

Patient-reported symptoms in metastatic gastric cancer patients in the last 6 months of life

Lev D. Bubis, Victoria Delibasic, Laura E. Davis, Yunni Jeong (et al.)

Background : Patients with metastatic gastric cancer have poor survival outcomes and may experience high symptom burden. We evaluated symptom trajectory and risk factors for increased symptom severity among metastatic gastric cancer patients during the last 6 months of life. Methods : We conducted a retrospective cohort study among patients ??18 years diagnosed with metastatic gastric cancer from January 2007 to December 2014 in the province of Ontario, Canada. We included patients who died [...]

Cette étude internationale présente les développements récents et l’utilisation des technologies de e-santé dans les soins de support en cancérologie

Advances and future directions in the use of mobile health in supportive cancer care: proceedings of the 2019 MASCC Annual Meeting symposium

Raymond J. Chan, Doris Howell, Maryam B. Lustberg, Karen Mustian (et al.)

Purpose : The role of mobile health (mHealth) technology in cancer care has evolved alongside the rapid development in digital technology. Its use can come with significant potential benefits; however, such use may also be associated with risks. This paper summarizes the latest developments around mHealth use in cancer care presented by a panel of experts at the 2019 Annual Meeting of the Multinational Association of Supportive Care in Cancer. Methods : Through lectures, case studies, and panel [...]

Menée en Italie à partir de données portant sur 236 patients atteints d’un cancer de stade avancé, cette étude analyse l’association entre des difficultés financières, des symptômes physiques et psychiques liés à la maladie et la qualité de vie

Financial distress and its impact on symptom expression in advanced cancer patients

Sebastiano Mercadante, Federica Aielli, Claudio Adile (et al.)

Aim : To assess financial distress (FD) and its impact on symptom expression and other quality of life issues. Patients and methods : Advanced cancer patients admitted to inpatient and outpatient clinics were selected. Standard epidemiological data including age, gender, primary cancer diagnosis, and Karnofsky level were recorded. Data regarding marital status, number of cohabitants, religious belief, educational level, and family income (?3000 euros), as well as extra [...]

A partir d’une revue systématique de la littérature (2 607 patients), cette méta-analyse évalue l’efficacité des anticoagulants oraux directs pour réduire le risque de maladie thromboembolique veineuse chez des patients atteints d’un cancer

Direct oral anticoagulants for cancer-associated venous thromboembolism: a systematic review and meta-analysis

Frits I. Mulder, Floris T.M. Bosch, Annie M. Young, Andrea Marshall (et al.)

Direct oral anticoagulants (DOACs) are an emerging treatment option for cancer patients with acute venous thromboembolism (VTE), but studies have reported inconsistent results. This systematic review and meta-analysis compared the efficacy and safety of DOACs and low-molecular-weight heparins (LMWH) in these patients. MEDLINE, Embase, CENTRAL, and conference proceedings were searched to identify relevant randomized controlled trials. Additional data were obtained from the original authors to [...]

Mené sur 30 patients atteints d’un cancer de stade avancé (âge moyen : 63 ans), cet essai randomisé évalue l’efficacité de l’olanzapine pour réduire et traiter les nausées et vomissements chroniques (non liés à la chimiothérapie)

Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or Vomiting : A Randomized Pilot Trial

Rudolph M. Navari, Cameron M. Pywell, Jennifer G. Le-Rademacher (et al.)

Importance : Nausea and vomiting, unrelated to chemotherapy, can be substantial symptoms in patients with advanced cancer. Objective : To evaluate the utility of olanzapine for treating chronic nausea/vomiting, unrelated to chemotherapy, in patients with advanced cancer. Design, Setting, and Participants : This study is a double-line, placebo-controlled, randomized clinical trial conducted from July 2017 through April 2019, with analysis conducted in 2019. Eligible participants were outpatients [...]

Mené sur 218 patients atteints d’un cancer du poumon inopérable de stade avancé, cet essai randomisé évalue l’efficacité, du point de vue de la modification de l'absorption maximale d'oxygène, de l’amélioration de la force musculaire et des capacités fonctionnelles, de la réduction des symptômes d’anxiété et de dépression, d’un programme à base d’exercices physiques pendant 12 semaines

Effects of an exercise intervention for patients with advanced inoperable lung cancer undergoing chemotherapy: a randomized clinical trial

Morten Quist, Seppo W. Langer, Christian Lillelund (et al.)

Objective : Exercise can improve treatment-related side effects, quality of life, and function in patients with various types of cancer; however, more evidence is needed for patients with advanced inoperable lung cancer. Material and methods : We randomized 218 patients with advanced inoperable lung cancer to a 12-week supervised, structured exercise training program (aerobic, strength, and relaxation training) twice weekly versus usual care. Primary outcome was change in maximal oxygen uptake [...]

A partir d’une revue systématique de la littérature publiée entre 1998 et 2019 (10 études, 835 patients), cette étude analyse les effets des exercices physiques sur les symptômes et la qualité de vie chez des patients atteints d’un cancer du poumon

Exercise prescription for symptoms and quality of life improvements in lung cancer patients: a systematic review

Alberto Codima, Willian das Neves Silva, Ana Paula de Souza Borges (et al.)

Purpose :The purpose of this study was to conduct a systematic review to assess the effect of exercise on symptoms and quality of life in lung cancer patients. Methods : We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Medline, Embase, Scopus, Web of Science, and SciELO were searched for studies published from January 1998 to January 2019. The review included all randomized controlled trials that evaluated the [...]

Menée aux Etats-Unis à partir de données portant sur 89 patients ayant survécu à un cancer de la prostate, cette étude de cohorte rétrospective analyse les facteurs cliniques et psychosociaux associés à la pratique d’une activité physique

Social and clinical determinants of physical activity in prostate cancer survivors

Chanita Hughes Halbert, Melanie S. Jefferson, Richard Drake, Michael Lilly (et al.)

Purpose : Physical activity is important for enhancing quality of life and cancer control among prostate cancer survivors. The purpose of this study was to characterize adherence to physical activity guidelines among African American and white prostate cancer survivors based on social and clinical determinants and psychosocial factors. Methods : Observational study of meeting guidelines for moderate intensity physical activity in a retrospective cohort of African American and white prostate [...]

Menée aux Etats-Unis par entretiens téléphoniques auprès de 403 patients ayant survécu plus de 5 ans à un cancer colorectal et menée auprès de 401 témoins, cette étude analyse l’impact de comorbidités sur la qualité de vie

Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based comparison

Amy Pate, Jan Lowery, Kristin Kilbourn, Patrick J. Blatchford (et al.)

Purpose : Colorectal cancer (CRC) is the third most common cancer in the USA. The objective of this study was to compare quality of life (QoL) across long-term colorectal cancer survivors and unaffected matched controls while adjusting for comorbidities. Methods : The National Cancer Institute (NCI)-funded Colon Cancer Family Registry (CCFR) was used to randomly select and recruit CRC survivors (??5 years from diagnosis) and matched controls for a cross-sectional survey. Nine geographically [...]

Menée au Canada par enquête auprès de 463 patients ayant survécu à un cancer du rein, cette étude analyse l’effet de l'augmentation de l'activité physique ou du sommeil sur la qualité de vie

Replacing sedentary time with physical activity and sleep: associations with quality of life in kidney cancer survivors

Allyson Tabaczynski, Kerry S. Courneya, Linda Trinh

Purpose : Kidney cancer survivors spend large quantities of time sedentary and little time physically active, which negatively impacts quality of life (QoL). This study examined (1) the association of reallocating sedentary time to sleep, light physical activity (PA), or moderate-to-vigorous PA (MVPA) on QoL in kidney cancer survivors and (2) the threshold at which results are clinically meaningful. Methods : Kidney cancer survivors (N?=?463) completed a survey including the Godin Leisure-Time [...]

Menée au Japon auprès de 143 patientes atteintes d’un cancer du sein, cette étude prospective évalue l’efficacité, pour prévenir le risque d'alopécie, d’un dispositif de refroidissement du cuir chevelu pendant une chimiothérapie adjuvante ou néoadjuvante

Scalp cooling for hair loss prevention in female Japanese breast cancer patients receiving (neo)adjuvant chemotherapy

Shozo Ohsumi, Sachiko Kiyoto, Mina Takahashi (et al.)

Purpose : Scalp cooling during chemotherapy infusion has been recently reported to have moderate efficacy in the mitigation of chemotherapy-induced alopecia; however, there are few reports on Asian patients. We aimed to clarify the effects of scalp cooling in Japanese women. Patients and methods : Female Japanese breast cancer patients who planned to receive (neo)adjuvant chemotherapy participated in this prospective study on the efficacy of scalp cooling using the Paxman Scalp Cooling System [...]

Menée à partir de l'analyse, à l’aide d’un algorithme d’apprentissage automatique, de données génomiques portant sur 2 799 patientes ayant survécu à un cancer du sein de stade précoce, cette étude de cohorte identifie les facteurs prédictifs d’une fatigue liée aux traitements anticancéreux

Prediction of Breast Cancer Treatment-Induced Fatigue by Machine Learning Using Genome Wide Association Data

Sangkyu Lee, PhD, Joseph O Deasy, PhD, Jung Hun Oh, PhD, Antonio Di Meglio (et al.)

Background : We aimed at predicting fatigue after breast cancer (BC) treatment, using machine learning on clinical covariates and germline genome-wide data. Methods : We accessed germline genome-wide data of 2799 early-stage BC patients from CANTO (NCT01993498). The primary endpoint was defined as scoring zero at diagnosis and higher than quartile-3 at 1 year after primary treatment completion, on EORTC-QLQ-C30 for overall fatigue and on the multidimensional EORTC-QLQ-FA12 for physical, [...]

Menée aux Etats-Unis à partir de données portant sur 28 060 patients atteints d’un cancer et hospitalisés pour une fièvre neutropénique, cette étude de cohorte rétrospective analyse l’effet de comorbidités cardiovasculaires sur le risque de décès durant l'hospitalisation

Impact of cardiovascular comorbidities on inpatient mortality in patients hospitalized with neutropenic fever

Suheil Albert Atallah-Yunes, Anis John Kadado, Faris Haddadin, Khalid Sawalha (et al.)

Introduction : Concomitant cardiovascular comorbidities in patients with cancer are not uncommon. There is limited data on the impact of cardiovascular comorbidities on in-hospital mortality in patients admitted with neutropenic fever. Methods : This is a retrospective cohort study using the 2016 NIS database of adults (>?18 years old) hospitalized for neutropenic fever as the primary diagnosis. The primary outcome studied is all-cause mortality in patients with neutropenic fever. ICD-10-CM [...]

Menée aux Etats-Unis à partir de données portant sur 630 patients ayant survécu à un myélome multiple et ayant reçu une greffe autologue de cellules souches hématopoïétiques, cette étude analyse le risque à 10 ans de maladies chroniques et de nouveaux cancers

Morbidity burden in survivors of multiple myeloma who underwent autologous transplantation: A Bone Marrow Transplantation Survivor Study

Mukta Arora, Yanjun Chen, Lindsey Hageman (et al.)

BACKGROUND : Autologous blood or bone marrow transplantation (aBMT) is considered the standard of care for patients with multiple myeloma (MM). Significantly improved survival necessitates an understanding of the morbidity burden borne by the growing survivor population. METHODS : The authors evaluated severe and/or life?threatening chronic health conditions (CHCs) and subsequent neoplasms (SNs) in patients with MM who were treated with aBMT using the Bone Marrow Transplant Survivor Study. A [...]

Menée aux Etats-Unis par enquête sur la période 2013-2017 auprès de 12 648 patients ayant survécu à un cancer, cette étude analyse leurs comportements de santé (tabagisme, activité physique, consommation d’alcool, durée du sommeil, etc.)

Prevalence of Healthy Behaviors among Cancer Survivors in the United States: How Far Have We Come?

Hannah Arem, Scherezade K. Mama, Xuejing Duan, Julia H. Rowland, Keith M. Bellizzi and Diane K. Ehlers

Background: The 16.9 million cancer survivors in the United States are at increased risk for comorbidities and recurrence. However, this risk may be attenuated by a healthy lifestyle. This study describes health behaviors by cancer history to inform behavior change priorities. Methods: We analyzed 2013–2017 data from the National Health Interview Survey. There were 164,692 adults, of whom 12,648 reported a cancer history. We calculated prevalence of smoking, physical activity, alcohol [...]

Menée aux Etats-Unis à partir de données portant sur 2 444 enfants (âge : 0-14 ans) et sur 13 459 adolescents et jeunes adultes (âge : 15-39 ans) atteints d’un cancer diagnostiqué entre 1986 et 2015, cette étude analyse l’association entre la pollution atmosphérique par les particules fines et la mortalité par type de cancer

Fine Particulate Matter Air Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients

Judy Y. Ou, Heidi A. Hanson, Joemy M. Ramsay, Heydon K. Kaddas (et al.)

Background: Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM2.5) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM2.5.Methods: We followed 2,444 pediatric (diagnosed ages 0–14) and 13,459 AYA (diagnosed ages 15–39) patients diagnosed in 1986–2015 from diagnosis to 5 and 10 years [...]

A partir d’une revue de la littérature (20 articles), cette étude analyse l’effet, sur la composition corporelle, d’une greffe allogénique de cellules souches hématopoïétiques suivie d’une radiothérapie du corps entier chez des enfants, adolescents et jeunes adultes atteints d'une leucémie (âge : 0-24 ans)

Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review

Ava Lorenc, Julian Hamilton-Shield, Rachel Perry, Michael Stevens (et al.)

Purpose : To collate evidence of changes in body composition following treatment of leukaemia in children, teenagers and young adults (CTYA, 0–24 years) with allogeneic haematopoietic stem cell transplant and total body irradiation (HSCT+TBI). Methods : Papers were identified by searching Medline and Google Scholar, reference lists/citations and contacting key authors, with no date or language restrictions. Inclusion criteria were as follows: leukaemia, HSCT+TBI, aged ??24 years at HSCT and [...]

Menée à partir des données des registres des cancers de 68 pays sur la période 1983-2012, cette étude internationale analyse les disparités géographiques dans l’évolution de l’incidence du cancer de la vulve et du cancer du vagin

Geographic and temporal variations in the incidence of vulvar and vaginal cancers

Freddie Bray, Mathieu Laversanne, Elisabete Weiderpass, Marc Arbyn MD (et al.)

Vulvar and vaginal cancers are relatively rare cancers, together responsible for 1.5% of the global cancer incidence among women in 2018. The majority of vaginal cancers, and a lesser proportion of vulvar cancers are associated with HPV. Various reports have indicated rising incidence rates of vulvar cancer in younger women, possibly due to an increased prevalence of high?risk HPV types. This report assesses recent international variations in the incidence rates of vulvar and vaginal cancer [...]

Menée dans les 50 Etats américains sur la période 2001-2016, cette étude analyse l’évolution de l’incidence de l’adénocarcinome du pancréas, en fonction du sexe et de l’origine ethnique

Trends in the incidence of pancreatic adenocarcinoma in all 50 United States examined through an age-period-cohort analysis

Wilson L da Costa, Jr, Abiodun O Oluyomi, Aaron P Thrift

Background : Pancreatic ductal adenocarcinoma (PDAC) is a major contributor to cancer-related mortality in the U.S. We aimed to investigate trends in incidence rates from all 50 states from 2001 to 2016, overall and by race, sex, and state, and using age-period-cohort analyses. Methods : Age-adjusted incidence rates and trends in adults aged ?35 years were calculated using data from the U.S. Cancer Statistics registry. We used joinpoint regression to compute annual percent changes (APC) and [...]

Menée à partir des données 2004-2012 des registres américains des cancers portant sur 458 132 patients atteints d’un cancer du poumon, cette étude analyse l’évolution des facteurs associés au risque de développer la maladie en fonction du sexe

Gender and Lung Cancer- SEER based analysis

Yaakov Tolwin, Roni Gillis, Nir Peled

Background : Lung cancer remains a major cause of death worldwide. While in the past it was considered to primarily afflict males, in recent decades the number of female patients has risen, such that rates among females are similar to those among males. Nevertheless, it has been found previously (e.g. in cardiovascular disease) that when there is a sex specific stereotype to a disease, it may remain entrenched in medical diagnostic processes, so as to cause belated diagnosis among the other [...]

Menée en Angleterre à partir des données d’un registre des cancers portant sur 57 373 patients atteints d’un cancer du poumon non à petites cellules de stade I à IIIA diagnostiqué entre 2012 et 2016, cette étude analyse l’association entre les disparités géographiques dans les taux de résection, la présence de comorbidités cardiovasculaires et la survie à 1 an

Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study

Catherine A. Welch, Michael J. Sweeting, Paul C. Lambert (et al.)

Background : The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. Methods :Cancer registry data consisted of English patients diagnosed with NSCLC from 2012 to 2016. Linked hospital records identified CVD comorbidities. We investigated resection rate [...]

A partir d’une revue systématique de la littérature (20 articles, 3 553 patients), cette étude analyse les facteurs associés aux troubles neurocognitifs chez des patients atteints d’un cancer du poumon traité par irradiation crânienne prophylactique

Risk factors for neurocognitive decline in lung cancer patients treated with prophylactic cranial irradiation: A systematic review

Haiyan Zeng,Lizza E.L. Hendriks, Wouter H. van Geffen

Background : Prophylactic cranial irradiation (PCI) reduces brain metastasis incidence in lung cancer, however with risk of neurocognitive decline. Nevertheless, risk factors for neurocognitive decline after PCI remain unclear. Methods : We systematically reviewed the PubMed database according to the PRISMA guideline. Included were: randomized clinical trials (RCTs) and observational/single arm trials evaluating PCI, including ?20 patients, reporting neurocognitive test results for lung cancer. [...]

Menée au Royaume-Uni à partir de données portant sur 1 224 patients atteints d’un cancer du poumon non à petites cellules traité par radiothérapie radicale entre 2010 et 2016, cette étude de cohorte rétrospective analyse le risque de développer une maladie cardiovasculaire en lien avec la radiothérapie, puis évalue la mortalité par maladie cardiovasculaire

Cardiovascular mortality and morbidity following radical radiotherapy for lung cancer: is cardiovascular death under-reported?

F. Sun, K. Franks, L. Murray (et al.)

Background : Lung cancer is the most common malignancy worldwide. Radical radiotherapy is an essential treatment in the management of early and locally advanced lung cancer. Cardiac events are known to occur following radical radiotherapy for lung cancer. This study examines the burden of cardiac events post radiotherapy, and estimates the accuracy of death certification in patients who received radical radiotherapy for lung cancer. Methods : We conducted a retrospective observational cohort [...]

Menée à partir des données des registres américains des cancers portant sur 109 608 patientes atteintes d’un cancer du sein diagnostiqué après 65 ans entre 2000 et 2011, cette étude analyse l’association entre le lieu de résidence (zone rurale ou urbaine) et l’utilisation des soins de santé ainsi que la survie globale

Urban versus Rural Residence and Outcomes in Older Patients with Breast Cancer

Kelly M. Kenzik, Gabrielle B. Rocque, Wendy Landier, Smita Bhatia

Background: A total of 20% of the U.S. population resides in rural areas, yet is served by 3% of oncologists, and 7% of nononcology specialists. Access to care issues can be compounded by lower socioeconomic status (SES) in rural areas, yet this issue is unexplored among older patients with breast cancer. Methods: Using Surveillance Epidemiology and End Results-Medicare, 109,608 patients diagnosed at ?65 years with breast cancer between 2000 and 2011 were identified. Residence status was [...]

Menée aux Etats-Unis à partir des données de 51 registres des cancers portant sur 126 575 patients atteints d’une tumeur à cellules germinales du testicule, cette étude analyse les disparités ethniques dans l’évolution de l’incidence de la maladie sur la période 2001-2016

Increasing Incidence of Testicular Germ Cell Tumors Among Racial/Ethnic Minorities in the United States

Armen A. Ghazarian, Katherine A. McGlynn

Background: The incidence of testicular germ cell tumors (TGCT) has been rising in the United States and is notably higher among white men. Previously, our group reported that rates were rising among Hispanic men in certain areas. This study sought to determine whether the patterns noted in our prior publication remained evident in more recent years and to determine whether any new patterns have emerged. Methods: Data from 51 U.S. cancer registries were examined. Racial/ethnic-specific [...]

A partir d’une revue systématique de la littérature publiée jusqu’en 2019 (26 articles), cette méta-analyse évalue le risque de développer un second cancer métachrone chez des patients ayant survécu à un cancer des voies aérodigestives supérieures

Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta-analysis of the literature

Ilda Hoxhaj, Ola Hysaj, Vladimir Vukovic, Emanuele Leoncini (et al.)

Objective : Head and neck cancer (HNC) is the sixth leading cancer worldwide with approximately 600,000 new cases per year. Several studies suggest that HNC survivors may have an increased risk of developing second primary cancers (SPCs). A systematic review and meta?analysis was performed aiming to quantify the overall and site?specific risk of metachronous SPCs in HNC survivors. Methods : PubMed, Web of Science and Scopus were searched to identify studies published until October 2019. Studies [...]

Cette étude présente le modèle élaboré par "The American Psychosocial Oncology Society" pour permettre l’accès aux soins psychosociaux dans les services d’oncologie

Framework for Planning the Delivery of Psychosocial Oncology Services: An American Psychosocial Oncology Society Task Force Report

William F. Pirl, Joseph A. Greer, Sharla Wells?Di Gregorio (et al.)

Objective: While screening for psychosocial distress is now standard of care in oncology, little guidance is available for how best to deliver services in response to identified needs. The American Psychosocial Oncology Society (APOS) convened a task force with the goal of creating a framework which could aid in planning services and justifying requests for resources. Methods: Ten experts from multiple disciplines within psychosocial oncology served on the task force, first meeting together as [...]

Menée aux Etats-Unis, au Canada, au Royaume-Uni et en Australie par enquête en ligne auprès de femmes porteuses de mutations BRCA mais non atteintes d'un cancer (576 répondantes ; âge moyen : 40,8 ans), cette étude analyse les facteurs associés à une détresse psychologique induite par le risque de développer la maladie

Predictors of long-term cancer-related distress among female BRCA1 and BRCA2 mutation carriers without a cancer diagnosis: an international analysis

Kelly A. Metcalfe, Melanie A. Price, Carol Mansfield, David C. Hallett (et al.)

Background : Women with a BRCA1 or BRCA2 mutation have high lifetime risks of developing breast and ovarian cancers. We sought to estimate the prevalence of cancer-related distress and to identify predictors of distress in an international sample of unaffected women with a BRCA mutation. Methods : Women with a BRCA1/2 mutation and no previous cancer diagnosis were recruited from the United States, Canada, the United Kingdom, Australia and from a national advocacy group. Using an online survey, [...]

A partir d’une revue de la littérature (15 articles), cette étude évalue l’efficacité des interventions psychosociales destinées aux enfants (âge : 0-18 ans) dont un parent est atteint d’un cancer

How psychosocial interventions meet the needs of children of parents with cancer: A review and critical evaluation

Jeneva L. Ohan, Hayley M. Jackson, Samantha Bay (et al.)

Introduction : The aim of this study was to evaluate how psychosocial interventions for children aged 0–18 years of a parent with cancer meet their needs, using key needs as consumer?based “standards.” Methods : A systematic literature review was conducted. Fifteen interventions met inclusion criteria and were assessed against six key needs identified by Ellis et al. (Eur. J. Cancer Care, 26, 2017, e12432): (1) provide children with age?appropriate information about their parent's cancer; (2) [...]

Menée sur la période 2003-2015, cette étude internationale analyse le rapport coût-efficacité des médicaments anticancéreux en Australie, en France, au Royaume-Uni et aux Etats-Unis

Relationship Between Costs and Clinical Benefits of New Cancer Medicines in Australia, France, the UK, and the US

SebastianSalas-Vega, EmilyShearer, EliasMossialosc

As cancer drug prices rise, it remains unclear whether the cost of new interventions is related to their beneficial impact for patients at a societal-level. Using data for 2003- 2015 from the IQVIA MIDAS® dataset, the relationship between cancer drug costs and drug clinical benefits was studied in four countries with different approaches to drug pricing. Summary measures of drug clinical effects on overall survival, quality of life, and safety were obtained from a review of health technology [...]

Menée en Australie par enquête auprès de 777 patients atteints d’un cancer de stade avancé, cette étude analyse les facteurs associés à leurs perceptions vis-à-vis de l’intérêt et de la valeur financière d’un profilage moléculaire tumoral et leur capacité à payer ce test

Assessment of the Value of Tumor Variation Profiling Perceived by Patients With Cancer

Phyllis Butow, Grace Davies, Christine E. Napier (et al.)

Importance : Use of tumor molecular profiling (MP) is entering routine clinical practice; however, little is known about how much and why patients value MP. Objective : To examine the perceived value of MP to patients with advanced cancer and factors associated with perceived value. Design, Setting, and Participants : A cross-sectional survey that included willingness-to-pay trade-off scenarios was administered to participants after consent and before MP. A total of 777 participants (94% [...]

Menée aux Etats-Unis, cette étude analyse l’association entre l’extension de la couverture Medicaid dans le cadre la loi sur la protection des patients et les soins abordables ("Obamacare") et la survie chez des patients atteints d’un cancer du poumon non à petites cellules

Association of Medicaid Expansion Under the Patient Protection and Affordable Care Act With Non–Small Cell Lung Cancer Survival

Ying Liu, Graham A. Colditz, Benjamin D. Kozower (et al.)

Advances in lung cancer care have improved survival,1 but this has not reached all socioeconomic groups.2,3 Insurance status affects access to early detection and stage-appropriate cancer treatments, which drive survival outcomes. The Patient Protection and Affordable Care Act (ACA) and Medicaid expansion provide health care access to individuals with incomes near federal poverty levels. Medicaid expansion under the ACA was implemented in 2014, substantially reduced the numbers of uninsured [...]

Menée aux Pays-Bas par questionnaire auprès de 296 patients atteints d’un cancer localisé de la prostate traité entre 2014 et 2016, cette étude prospective analyse l’association entre leurs besoins en informations concernant les effets indésirables des traitements et leurs regrets vis-à-vis de la décision thérapeutique

Unmet expectations in prostate cancer patients and their association with decision regret

Barbara M. Wollersheim, Marie-Anne van Stam, Ruud J.L.H. Bosch (et al.)

Purpose : Information about prostate cancer patients’ experiences with their treatment is crucial to optimize shared decision-making. This study examined unmet expectations in prostate cancer patients and their association with decision regret. Methods : We conducted a prospective, observational, multi-center study of men diagnosed with localized prostate cancer between 2014 and 2016. Questionnaires were completed at baseline (pre-treatment), and up to 12 months after treatment. Unmet [...]

Mené aux Etats-Unis sur 702 patientes atteintes d’un cancer du sein de stade précoce, cet essai randomisé évalue l’intérêt de textos envoyés deux fois par semaine pour améliorer l’adhésion à un traitement adjuvant par inhibiteurs de l’aromatase

Randomized Trial of Text Messaging to Reduce Early Discontinuation of Adjuvant Aromatase Inhibitor Therapy in Women With Early-Stage Breast Cancer: SWOG S1105

Dawn L. Hershman, Joseph M. Unger, Grace Clarke Hillyer (et al.)

PURPOSE : Nonadherence to aromatase inhibitors (AIs) for breast cancer is common and increases the risk of recurrence. Text messaging increases adherence to medications for chronic conditions. METHODS : We conducted a randomized clinical trial of text messaging (TM) versus no text messaging (No-TM) at 40 sites in the United States. Eligible patients were postmenopausal women with early-stage breast cancer taking an AI for > 30 days with a planned duration of ? 36 months. Test messages were sent [...]

Menée en Corée à partir de données portant sur plus de 600 patients atteints d’un cancer en phase terminale et pris en charge dans des unités de soins palliatifs, cette étude de cohorte rétrospective analyse l’association entre une sédation profonde continue et la durée de survie

Association between continuous deep sedation and survival time in terminally ill cancer patients

So-Jung Park, Hee Kyung Ahn, Hong Yup Ahn, Kyu-Tae Han, In Cheol Hwang

Purpose : Our study aimed to evaluate the association between CDS and survival time using the likelihood of receiving CDS to select a matched non-CDS group through an accurate measurement of survival time based on initiation of CDS. Methods : A retrospective cohort study was performed using an electronic database to collect data regarding terminally ill cancer patients admitted to a specialized palliative care unit from January 2012 to December 2016. We first used a Cox proportional hazard [...]

Mené en République tchèque sur 126 patients atteints d’une tumeur solide de stade avancé, cet essai randomisé évalue l’intérêt, du point de vue de la qualité de vie, d’adresser les patients de façon anticipée et systématique à un médecin spécialisé dans les soins palliatifs

Effects of Early and Systematic Integration of Specialist Palliative Care in Patients with Advanced Cancer: Randomized Controlled Trial PALINT

Ondrej Slama, Lukas Pochop, Jiri Sedo, Jan Svancara, Petra Sedova (et al.)

Background: A broad consensus on the optimal structure, intensity, and timing of early specialist palliative care (SPC) intervention is lacking. Objective: To evaluate the benefit of an early and systematic palliative intervention alongside standard oncology care compared with standard oncology care alone in patients with advanced solid tumors. Design: PALINT, a single-center RCT, conducted at the Masaryk Memorial Cancer Institute, the largest comprehensive cancer center in the Czech Republic [...]