Cet article américain présente les recommandations d’experts pour élaborer des stratégies permettant de prévenir et prendre en charge les déficiences fonctionnelles, cognitives et psychosociales liées au cancer, aux traitements anticancéreux et à l’âge chez des patients ayant survécu à la maladie

Strategies to Prevent or Remediate Cancer and Treatment-Related Aging

Jennifer L Guida, Tanya Agurs-Collins, Tim A Ahles (et al.)

Up to 85% of adult cancer survivors and 99% of adult survivors of childhood cancer live with an accumulation of chronic conditions, frailty, and/or cognitive impairments resulting from cancer and its treatment. Thus, survivors often show an accelerated development of multiple geriatric syndromes and need therapeutic interventions. To advance progress in this area, the National Cancer Institute convened the second of two think tanks under the auspices of the Cancer and Accelerated Aging: [...]

Mené au Canada auprès de patients atteints d’un cancer, cet essai randomisé évalue l’efficacité de la lidocaïne dispensée par voie sous-cutanée pour soulager la douleur liée à la maladie

Subcutaneous Lidocaine for Cancer-Related Pain

Philippa Hawley, Gillian Fyles, and Stephen G. Jefferys

Background: Intravenous lidocaine infusions have been shown to be effective for cancer related pain, but access is restricted to acute care settings. If able to be shown to be safe and effective, the subcutaneous route could expand access to residential hospices or patients' homes. Objectives: This randomized, double-blind, placebo controlled, 2×2 crossover trial evaluated the effectiveness, safety, toxicity, and impact on quality of life of a limited duration subcutaneous lidocaine infusion [...]

A partir d’une revue systématique de la littérature (6 essais randomisés, 288 patients), cette étude analyse l’efficacité d’une relaxation musculaire progressive pour prévenir et réduire les nausées et vomissements induits par une chimiothérapie chez des patients atteints d’un cancer

Progressive muscle relaxation is effective in preventing and alleviating of chemotherapy-induced nausea and vomiting among cancer patients: a systematic review of six randomized controlled trials

Xu Tian, Rong-Ying Tang, Ling-Li Xu, Wei Xie (et al.)

Purpose : Previous systematic review suggested a beneficial effect of progressive muscle relaxation (PMR) for cancer patients receiving chemotherapy. However, poor quality of eligible studies which included in previous systematic review impaired the reliability and validity of findings. The aim of the present systematic review was to further assess the value of PMR in chemotherapy-induced nausea and vomiting. Methods : We assigned two independent investigators to search potential studies in [...]

Menée aux Etats-Unis à partir de données portant sur 1 014 patients pédiatriques atteints d’une leucémie myéloïde aiguë traitée entre 2011 et 2016 (durée médiane de suivi : 3,5 ans), cette étude analyse l’effet du dexrazoxane sur la protection de la fonction systolique du ventricule gauche, sur la survie sans événement à 5 ans et sur la survie globale

Effect of Dexrazoxane on Left Ventricular Systolic Function and Treatment Outcomes in Patients With Acute Myeloid Leukemia: A Report From the Children’s Oncology Group

Kelly D. Getz, Lillian Sung, Todd A. Alonzo (et al.)

PURPOSE : To determine whether dexrazoxane provides effective cardioprotection during frontline treatment of pediatric acute myeloid leukemia (AML) without increasing relapse risk or noncardiac toxicities of the chemotherapy regimens. PATIENTS AND METHODS : This was a multicenter study of all pediatric patients with AML without high allelic ratio FLT3/ITD treated in the Children’s Oncology Group trial AAML1031 between 2011 and 2016. Median follow-up was 3.5 years. Dexrazoxane was administered [...]

Menée en Australie auprès de 427 patientes ayant survécu à un cancer du sein, cette étude transversale analyse l’effet, sur leur sexualité et sur leur qualité de vie, d’une salpingo-ovariectomie bilatérale

The impact of bilateral salpingo-oophorectomy on sexuality and quality of life in women with breast cancer

Paige E. Tucker, Paul A. Cohen, Max K. Bulsara, Stephanie Jeffares (et al.)

Objective : To compare sexual function and quality of life (QoL) in breast cancer survivors with and without a history of bilateral salpingo-oophorectomy (BSO). Methods : A cross-sectional study of breast cancer survivors treated at a tertiary referral hospital in Western Australia. The Female Sexual Function Index was used to determine rates of female sexual dysfunction (FSD) and hypoactive sexual desire disorder (HSDD). Participants also completed the Relationship Assessment Scale, [...]

Menée au Japon à partir de données portant sur 131 patients atteints d’un cancer de l’estomac, cette étude de cohorte rétrospective analyse les facteurs associés à une perte de poids pendant une chimiothérapie de première ligne, ainsi que l’association entre cette perte de poids et la survie globale

A retrospective cohort study to investigate the incidence of cancer-related weight loss during chemotherapy in gastric cancer patients

Masaru Fukahori, Masayuki Shibata, Satoshi Hamauchi (et al.)

Purpose : This study aimed to evaluate cancer-related weight loss (WL) after the start of first-line chemotherapy as a surrogate marker for cancer cachexia in patients with advanced gastric cancer. We investigated the incidence of WL and the relationship between WL and overall survival (OS) or adverse events. Methods : We conducted a retrospective cohort study in 131 patients with advanced gastric cancer who received first-line systemic chemotherapy between September 1, 2010, and August 31, [...]

Menée en Italie par questionnaire auprès de 283 patients atteints d’un cancer sur la période 2006-2007 et auprès de 403 patients sur la période 2013-2014, cette étude analyse, selon la période, la sévérité des symptômes en lien avec une chimiothérapie

Survey on symptoms in patients receiving chemotherapy in an Italian department of oncology: a comparison between period prevalences

Francesca Crivelli, Elisa Perfetti, Barbara Sartorello (et al.)

Purpose : The purpose of this study is to evaluate the prevalence over time of the measured side effects using a self-assessment questionnaire in normal clinical practice. Methods : The prevalence of symptoms reported by patients on the questionnaire was evaluated over two 1-year periods: from 1 June 2006 to 31 May 2007 and from 1 July 2013 to 30 June 2014. Descriptive statistics were used to describe population. The 2006–2007 and 2013–2014 datasets were compared with each other using the [...]

Menée à partir des données des registres américains des cancers sur la période 2001-2016, cette étude analyse l’évolution de l’incidence de cancer et de la survie selon le sexe

Sex differences in cancer incidence and survival: a pan-cancer analysis

Michelle Dong, Gino Cioffi, Jacqueline Wang, Kristin A Waite (et al.)

Background:Sex plays an important role in the incidence, prognosis, and mortality of cancers, but often is not considered in disease treatment. Methods:We quantified sex differences in cancer incidence using the USCS public use database and sex differences in cancer survival using SEER public use data from 2001 to 2016. Age-adjusted male-to-female incidence rate ratios with 95% CIs were generated by primary cancer site, race, and age groups. Additionally, age-adjusted hazard ratios with 95% CI [...]

Menée à partir des données 2001-2015 d’un registre australien des cancers portant sur 331 302 patients atteints d'un cancer, cette étude analyse la survie nette à 5 ans en fonction du lieu de résidence (zone rurale ou urbaine)

Differences in cancer survival by remoteness of residence: an analysis of data from a population-based cancer registry

Nina Afshar, Dallas R. English, James A. Chamberlain (et al.)

Purpose : Cancer survival is generally lower for rural compared with urban residents, but findings have been inconsistent. We aimed to assess inequalities in cancer survival by remoteness of residence in Victoria, Australia. Methods : Incident cancer cases diagnosed in 2001–2015 with 30 cancer types (n?=?331,302) were identified through the Victorian Cancer Registry and followed to the end of 2015 through death registries. Five-year net survival was estimated using the Pohar–Perme method and [...]

Menée à partir des données des registres américains des cancers portant sur 521 patients atteints d’un myélome multiple (âge moyen au diagnostic : 76,8 ans), cette étude de cohorte rétrospective analyse l’association entre leur état de santé auto-déclaré avant le diagnostic et la mortalité spécifique et toutes causes confondues

Self-reported health and survival in older patients diagnosed with multiple myeloma

Nadia A. Nabulsi, Ali Alobaidi, Brian Talon (et al.)

Purpose : Patient-reported outcomes such as self-reported health (SRH) are important in understanding quality cancer care, yet little is known about links between SRH and outcomes in older patients with multiple myeloma (MM). We evaluated associations between SRH and mortality among older patients with MM. Methods : We analyzed a retrospective cohort of patients ages???65 years diagnosed with first primary MM using the Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes [...]

Mené aux Etats-Unis sur 10 patients ayant survécu à un cancer de la tête et du cou, cet essai à bras unique évalue l’intérêt et la faisabilité d’une intervention de psychothérapie dispensée en ligne pour prendre en charge les troubles de l’image corporelle

Evaluation of a Novel Telemedicine-Based Intervention to Manage Body Image Disturbance in Head and Neck Cancer Survivors

Evan M. Graboyes, Stacey Maurer, Yeonhee Park (et al.)

Objectives : The study aimed to evaluate the feasibility, acceptability, and preliminary clinical impact of BRIGHT (Building a Renewed ImaGe after Head & neck cancer Treatment), a novel telemedicine?based cognitive?behavioral intervention to manage body image disturbance (BID) in head and neck cancer (HNC) survivors. Methods : HNC survivors with BID were enrolled into a single?arm pilot trial. Participants completed study measures at baseline, 1? and 3?months post?BRIGHT to assess its [...]

Menée aux Etats-Unis par enquête auprès de 46 patients atteints d’un cancer, cette étude analyse l’évolution de leurs fonctions cognitives et neuropsychologiques avant et après une greffe de cellules souches hématopoïétiques

Cognitive complaints by hematopoietic cell transplantation recipients and change in neuropsychological performance over time

Leah LaLonde, Kristen Votruba, Rachel Kentor (et al.)

Purpose : Hematopoietic stem cell transplant (HSCT) recipients are at risk for cognitive decline. Cross-sectional studies show patients’ complaints of cognitive decline do not correlate well with concurrently measured objective neuropsychological performance, but rather with emotional variables and health-related quality of life. This longitudinal study investigated whether patient self-report of cognitive status would be concordant with objectively measured neuropsychological performance after [...]

Menée aux Etats-Unis par enquête auprès de 103 patients ayant survécu à un cancer et bénéficiant d’une couverture sociale, cette étude analyse l’association entre les coûts des traitements et des soins supportés par les patients, les comportements de santé et la qualité de vie

Patient-reported financial toxicity, quality of life, and health behaviors in insured US cancer survivors

Elizabeth S. Ver Hoeve, Leila Ali-Akbarian, Sarah N. Price (et al.)

Purpose : Fighting cancer is a costly battle, and understanding the relationship between patient-reported financial toxicity (FT) and health outcomes can help inform interventions for post-treatment cancer survivors. Methods : Stages I–III solid tumor, insured US cancer survivors (N?=?103) completed a survey addressing FT (as measured by the standardized COST measure) and clinically relevant health outcomes (including health-related quality of life [HRQOL] and adherence to recommended [...]

Menée aux Etats-Unis par enquête auprès de 201 adolescents et jeunes adultes atteints d’un cancer récemment diagnostiqué (âge : 15-29 ans), cette étude analyse les enjeux liés à la communication d’informations sur les effets indésirables tardifs des traitements

Early information needs of adolescents and young adults about late effects of cancer treatment

Katie A. Greenzang, Karen M. Fasciano, Susan D. Block (et al.)

Background : Adolescent and young adult (AYA) cancer survivors have high risks of late effects. Little is known about the late?effect information needs of AYAs early in treatment or their role in treatment decision making. This study evaluated the importance, quality, and implications of information about late effects in AYAs recently diagnosed with cancer. Methods : This study surveyed 201 AYAs with cancer who were 15 to 29 years old and were treated at the Dana?Farber Cancer Institute [...]

Mené en Australie sur 65 patients atteints d’un cancer de stade avancé et traités dans des unités de soins palliatifs, cet essai de phase II évalue l’intérêt d’une intervention non pharmacologique pour prévenir un délire

A Multicomponent Nonpharmacological Intervention to Prevent Delirium for Hospitalized People with Advanced Cancer: A Phase II Cluster Randomized Waitlist Controlled Trial (The PRESERVE Pilot Study)

Annmarie Hosie, Jane Phillips, Lawrence Lam, Slavica Kochovska

Background: Delirium is a common debilitating complication of advanced cancer. Objective: To determine if a multicomponent nonpharmacological delirium prevention intervention was feasible for adult patients with advanced cancer, before a phase III (efficacy) trial. Design: Phase II (feasibility) cluster randomized controlled trial. All sites implemented delirium screening and diagnostic assessment. Strategies within sleep, vision and hearing, hydration, orientation, mobility, and family domains [...]

Menée aux Etats-Unis sur la période 2011-2018, cette étude analyse les facteurs associés à l’utilisation de la radiothérapie et de la chimiothérapie palliatives dans les structures d'accueil des personnes âgées

Trends in Provision of Palliative Radiotherapy and Chemotherapy Among Hospices in the United States, 2011-2018

Sylvia H. Hsu, Shi-Yi Wang

Hospice is central to end-of-life care. Yet to receive hospice services, Medicare beneficiaries need to forgo treatments related to their terminal conditions.Thus, patients with cancer cannot receive radiotherapy or chemotherapy, such as single-fraction radiotherapy for painful bone metastasis, for palliative purposes. To alleviate this constraint, some hospices have developed open-access programs that allow patients to receive care for their terminal conditions.2 These hospices, however, [...]